Cited by 324Coffee research and impactsPhytochemicals and Antioxidant ActivitiesGenomics, phytochemicals, and oxidative stress

Chlorogenic Acid Compounds from Coffee Are Differentially Absorbed and Metabolized in Humans ,

Open access
Monteiro, Mariana, Farah, Adriana, Perrone, Daniel, Trugo, Luiz C., Donangelo, Carmen·2007·The Journal of Nutrition

Abstract

Chlorogenic acids (CGA) are abundant phenolic compounds in coffee, with caffeoylquinic (CQA), feruloylquinic (FQA), and dicaffeoylquinic (diCQA) acids being the major subclasses. Despite the potential biopharmacological properties attributed to these compounds, little is known about their bioavailability in humans. In this study, we evaluated the distribution profile of the major CGA isomers and metabolites in plasma and urine of 6 healthy adults for 4 h after brewed coffee consumption. Three CQA isomers and 3 diCQA isomers were identified in the plasma of all subjects after coffee consumption, whereas 2 FQA were identified in only 1 subject. Two plasma concentration peaks were observed, the first at 0.5-1.0 h and the second at 1.5-4.0 h after coffee consumption. The molar ratio CQA:diCQA was 12.2 in the brewed coffee, whereas in plasma it ranged from 0.6-2.9. The molar ratios 5-CQA:3-CQA and 5-CQA:4-CQA were consistently higher in plasma than in the brew. The main CGA metabolites identified in urine after coffee consumption were: dihydrocaffeic, gallic, isoferulic, ferulic, vanillic, caffeic, 5-CQA, sinapic, rho-hydroxybenzoic, and rho-coumaric acids (gallic and dihydrocaffeic acids being the major ones). This study indicates that the major CGA compounds present in coffee are differentially absorbed and/or metabolized in humans, with a large inter-individual variation. Moreover, urine does not appear to be a major excretion pathway of intact CGA compounds in humans.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/jn/137.10.2196

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Monteiro, M., Farah, A., Perrone, D., Trugo, L. C., & Donangelo, C.
Affiliations
Universidade Federal do Rio de Janeiro (BR)
Corresponding author
Farah, Adriana
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2007-10
Volume
137
Issue
10
Pages
2196-2201
ISSN
0022-3166 (ISSN-L)
OpenAlex
W2130794819
Cited by
324
References
43
Citations by year
2026: 13 · 2025: 11 · 2024: 14 · 2023: 8 · 2022: 22 · 2021: 24 · 2020: 17 · 2019: 17 · 2018: 18 · 2017: 18 · 2016: 21 · 2015: 14 · 2014: 22 · 2013: 19 · 2012: 19
FWCI
11.13
Type
journal article
Language
en
Open access
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords
chlorogenic acid, coffee, caffeoylquinic acids, feruloylquinic acids, dicaffeoylquinic acids, bioavailability, metabolism, plasma distribution, urinary excretion, gallic acid, dihydrocaffeic acid, interindividual variability, phenolic compounds
MeSH terms
Adult, Chlorogenic Acid, Coffee, Female, Humans, Male, Middle Aged, Area Under Curve

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review