Cited by 684PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase Signaling

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The PI3K/AKT/mTOR interactive pathway

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Ersahin, Tulin, Tuncbag, Nurcan, Cetin-Atalay, Rengul·2015·Molecular BioSystems

DOI 10.1039/c5mb00101c

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Abstract

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR) signalling pathway is hyperactivated or altered in many cancer types and regulates a broad range of cellular processes including survival, proliferation, growth, metabolism, angiogenesis and metastasis. The PI3K/AKT/mTOR pathway is regulated by a wide-range of upstream signalling proteins and it regulates many downstream effectors by collaborating with various compensatory signalling pathways, primarily with RAF/MEK/ERK pathway. Limited clinical success of the available targeted therapeutic agents and challenges mediated by tumour heterogeneity across different cancer types emphasize the importance of alterations in the PI3K/AKT/mTOR pathway in the design of effective personalized treatment strategies. Here we report a comprehensive PI3K/AKT/mTOR network that represents the intricate crosstalk between compensatory pathways, which can be utilized to study the AKT signalling mechanism in detail and improve the personalized combinatorial therapeutic strategies.

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Authors: Ersahin, T., Tuncbag, N., & Cetin-Atalay, R.
Affiliations: Cancer Systems Biology Laboratory, Graduate School of Informatics, ODTU a , 06800 Ankara, Turkey rengul@metu.edu.tr +90-312-210-3745 +90-312-210-7887
Venue: Molecular BioSystems
Publisher: Oxford University Press (OUP)
Published: 2015-04-20
Volume: 11
Issue: 7
Pages: 1946-1954
ISSN: 1742-2051 (ISSN-L)
1742-206X
DOI: 10.1039/c5mb00101c
OpenAlex: W2062689336
Cited by: 683
References: 125
Citations by year: 2026: 62 · 2025: 110 · 2024: 119 · 2023: 96 · 2022: 82 · 2021: 71 · 2020: 56 · 2019: 43 · 2018: 30 · 2017: 8 · 2016: 5 · 2015: 1
FWCI: 6.37
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-nd
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Molecular BioSystems (publishedVersion)
PubMed (publishedVersion)
OpenMETU (Middle East Technical University) (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: PI3K/AKT/mTOR pathway, Raf/MEK/ERK pathway, pathway crosstalk, cancer, tumor heterogeneity, precision oncology, combination therapy, targeted therapy resistance
MeSH terms: Humans, Phosphatidylinositol 3-Kinases, MAP Kinase Signaling System, Proto-Oncogene Proteins c-akt, TOR Serine-Threonine Kinases, Protein Interaction Maps

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The PI3K/AKT/mTOR interactive pathway

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