The PI3K/AKT/mTOR interactive pathway

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Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression

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Neutrophil diversity and function in health and disease

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Targeting autophagy-related protein kinases for potential therapeutic purpose

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Impairment of insulin signaling pathway PI3K/Akt/mTOR and insulin resistance induced AGEs on diabetes mellitus and neurodegenerative diseases: a perspective review

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IL-6/STAT3 Is a Promising Therapeutic Target for Hepatocellular Carcinoma

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Liver Regeneration after Hepatectomy and Partial Liver Transplantation

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LAMB3 mediates apoptotic, proliferative, invasive, and metastatic behaviors in pancreatic cancer by regulating the PI3K/Akt signaling pathway

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Sunitinib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers

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Long non-coding RNAs in Oral squamous cell carcinoma: biologic function, mechanisms and clinical implications

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Mechanism of cyclosporine A nephrotoxicity: Oxidative stress, autophagy, and signalings

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Nanotoxicity of different sizes of graphene (G) and graphene oxide (GO) in vitro and in vivo

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Salvianolic acid A attenuates CCl4-induced liver fibrosis by regulating the PI3K/AKT/mTOR, Bcl-2/Bax and caspase-3/cleaved caspase-3 signaling pathways

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Macrophage-based nanotherapeutic strategies in ulcerative colitis

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Mechanisms of and Potential Medications for Oxidative Stress in Ovarian Granulosa Cells: A Review

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The potential role of leptin in tumor invasion and metastasis

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Therapeutic Targeting of NF-κB in Acute Lung Injury: A Double-Edged Sword

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Role of MAPK/MNK1 signaling in virus replication

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Modulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response

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A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient

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Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications

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Targeting the PI3K/AKT/mTOR pathway in biliary tract cancers: A review of current evidences and future perspectives

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Hybrid membrane camouflaged copper sulfide nanoparticles for photothermal-chemotherapy of hepatocellular carcinoma

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CD25 : A potential tumor therapeutic target

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Titanium particles in peri-implantitis: distribution, pathogenesis and prospects

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Idebenone: When an antioxidant is not an antioxidant

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Lineage Commitment, Signaling Pathways, and the Cytoskeleton Systems in Mesenchymal Stem Cells

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The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art

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Acquired resistance mechanisms to osimertinib: The constant battle

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PI3K/AKT/mTOR Dysregulation and Reprogramming Metabolic Pathways in Renal Cancer: Crosstalk with the VHL/HIF Axis

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MicroRNA-21's role in PTEN suppression and PI3K/AKT activation: Implications for cancer biology

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Drosophila insulin‐like peptides: from expression to functions – a review

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SNAIL1: Linking Tumor Metastasis to Immune Evasion

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Phytochemical insights into flavonoids in cancer: Mechanisms, therapeutic potential, and the case of quercetin

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From LncRNA to metastasis: The MALAT1-EMT axis in cancer progression

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Crosstalk between the mTOR and Nrf2/ARE signaling pathways as a target in the improvement of long-term potentiation

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Role of the JAK-STAT Pathway in Bovine Mastitis and Milk Production

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Glycyrrhizic Acid Inhibits Proliferation of Gastric Cancer Cells by Inducing Cell Cycle Arrest and Apoptosis

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Combining Gemcitabine-Loaded Macrophage-like Nanoparticles and Erlotinib for Pancreatic Cancer Therapy

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Targeting PI3K/AKT/mTOR signaling to overcome drug resistance in cancer

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From immune dysregulation to organ dysfunction: understanding the enigma of Sepsis

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Mechanism of Bazhen decoction in the treatment of colorectal cancer based on network pharmacology, molecular docking, and experimental validation

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Cardamonin inhibits the proliferation and metastasis of non-small-cell lung cancer cells by suppressing the PI3K/Akt/mTOR pathway

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Scutellarin inhibits human renal cancer cell proliferation and migration via upregulation of PTEN

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Multi-model functionalization of disease-associated PTEN missense mutations identifies multiple molecular mechanisms underlying protein dysfunction

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Pharmacological Effects of Urolithin A and Its Role in Muscle Health and Performance: Current Knowledge and Prospects

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Conditional reprogramming: next generation cell culture

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BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling‐dependent tumor growth in mouse models

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Kaempferitrin inhibits proliferation, induces apoptosis, and ameliorates inflammation in human rheumatoid arthritis fibroblast‐like synoviocytes

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Curcumin in Cancer and Inflammation: An In-Depth Exploration of Molecular Interactions, Therapeutic Potentials, and the Role in Disease Management

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Four-octyl itaconate improves osteoarthritis by enhancing autophagy in chondrocytes via PI3K/AKT/mTOR signalling pathway inhibition

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Conjunctival Melanoma: Genetic and Epigenetic Insights of a Distinct Type of Melanoma

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Signaling pathways involved in paraquat-induced pulmonary toxicity: Molecular mechanisms and potential therapeutic drugs

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Transcriptome sequencing to detect the potential role of long non-coding RNAs in bovine mammary gland during the dry and lactation period

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MicroRNAs as the critical regulators of Cisplatin resistance in ovarian cancer cells

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To Investigate the Occurrence and Development of Colorectal Cancer Based on the PI3K/AKT/mTOR Signaling Pathway

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Long noncoding RNA H19: functions and mechanisms in regulating programmed cell death in cancer

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“Double-Edged Sword” Effect of Reactive Oxygen Species (ROS) in Tumor Development and Carcinogenesis

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Molecular insights into hormone regulation via signaling pathways in Sertoli cells: With discussion on infertility and testicular tumor

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The Configuration of GRB2 in Protein Interaction and Signal Transduction

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The evolving (epi)genetic landscape of pancreatic neuroendocrine tumours

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Preparation of Novel Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine Sulfonamides and Their Experimental and Computational Biological Studies

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Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015–2021)

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HER2-Positive Gastric Cancer and Antibody Treatment: State of the Art and Future Developments

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Autophagy modulation in bladder cancer development and treatment (Review)

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The regulation of shrimp metabolism by the white spot syndrome virus (WSSV)

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miR-200a-3p modulates gene expression in comorbid pain and depression: Molecular implication for central sensitization

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Exploring the Genetic Orchestra of Cancer: The Interplay Between Oncogenes and Tumor-Suppressor Genes

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Overexpression of p-Akt, p-mTOR and p-eIF4E proteins associates with metastasis and unfavorable prognosis in non-small cell lung cancer

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Macrophage Signaling Pathways in Health and Disease: From Bench to Bedside Applications

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Synergistic targeted inhibition of MEK and dual PI 3K/ mTOR diminishes viability and inhibits tumor growth of canine melanoma underscoring its utility as a preclinical model for human mucosal melanoma

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Changes in Oviductal Cells and Small Extracellular Vesicles miRNAs in Pregnant Cows

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Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography

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Energy metabolism in skin cancers: A therapeutic perspective

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Resistance to anoikis in transcoelomic shedding: the role of glycolytic enzymes

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New Targets and Strategies for Rheumatoid Arthritis: From Signal Transduction to Epigenetic Aspect

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Bacillus licheniformis ameliorates Aflatoxin B1-induced testicular damage by improving the gut-metabolism-testis axis

Zhang, F., Ma, H., Dong, P.-Y., Yan, Y. C., Chen, Y., Yang, G.-M., Shen, W., & Zhang, X. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.133836 · Cited by 44

Immunomodulatory effects of curcumin on macrophage polarization in rheumatoid arthritis

Deng, T., Xu, J., Wang, Q., Wang, X., Jiao, Y., Cao, X., Geng, Q., Zhang, M., Zhao, L., & Xiao, C. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1369337 · Cited by 49

MicroRNAs Modulate Drug Resistance-Related Mechanisms in Hepatocellular Carcinoma

Liang, Y., Liang, Q., Qiao, L., & Xiao, F. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00920 · Cited by 43

Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status

Durmaz, İ., Güven, E. B., Erşahin, T., Öztürk, M., Çalış, İ., & Çetin-Atalay, R. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.11.012 · Cited by 41

Pva-miR-252 participates in ammonia nitrogen-induced oxidative stress by modulating autophagy in Penaeus vannamei

Wang, F., Huang, L., Liao, M., Dong, W., Liu, C., Zhuang, X., Liu, Y., Yin, X., Liang, Q., & Wang, W. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112774 · Cited by 41

Prediction of HER2 expression in breast cancer by combining PET/CT radiomic analysis and machine learning

Chen, Y., Wang, Z., Yin, G., Sui, C., Liu, Z., Li, X., & Chen, W. (2021) · Annals of Nuclear Medicine · doi:10.1007/s12149-021-01688-3 · Cited by 41

Neurodevelopmental disorders and cancer networks share pathways, but differ in mechanisms, signaling strength, and outcome

Yavuz, B. R., Arici, M. K., Demirel, H. C., Tsai, C., Jang, H., Nussinov, R., & Tunçbağ, N. (2023) · npj Genomic Medicine · doi:10.1038/s41525-023-00377-6 · Cited by 41

Targeting the PI3K/AKT/mTOR pathway in lung cancer: mechanisms and therapeutic targeting

Qiang, M., Chen, Z., Liu, H., Dong, J., Gong, K., Zhang, X., Huo, P., Zhu, J., Shao, Y., Ma, J., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1516583 · Cited by 45

Differential Characterization of Temozolomide-Resistant Human Glioma Cells

Lai, S., Huang, B., Liu, Y.-S., Lin, H., Chen, C.-C., Tsai, C., Lu, D., & Lin, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010127 · Cited by 40

Therapeutic approach of Cancer stem cells (CSCs) in gastric adenocarcinoma; DNA methyltransferases enzymes in cancer targeted therapy

Norollahi, S. E., Mansour‐Ghanaei, F., Joukar, F., Ghadarjani, S., Mojtahedi, K., Nejad, K. G., Hemmati, H., Gharibpoor, F., Khaksar, R., & Samadani, A. A. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108958 · Cited by 41

Flavones: Six Selected Flavones and Their Related Signaling Pathways That Induce Apoptosis in Cancer

Jeong, S. H., Kim, H. H., Ha, S. E., Park, M. Y., Bhosale, P. B., Abusaliya, A., Park, K., Heo, J., Kim, H. W., & Kim, G. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810965 · Cited by 40

Integrin-α5 promoted the progression of oral squamous cell carcinoma and modulated PI3K/AKT signaling pathway

Fan, Q., Tian, H., Wang, Y., & Liu, X.-B. (2019) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2019.03.007 · Cited by 38

Activation of the PI3K-AKT Pathway by Old World Alphaviruses

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Grape seed proanthocyanidins protect PC12 cells from hydrogen peroxide-induced damage via the PI3K/AKT signaling pathway

He, X., Guo, X., Ma, Z., Li, Y., Kang, J., Zhang, G., Gao, Y., Liu, M., Chen, H., & Kang, X. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135793 · Cited by 38

FOXP1 inhibits high glucose-induced ECM accumulation and oxidative stress in mesangial cells

Xiang, H., Xue, W., Wu, X., Zheng, J., Ding, C., Li, Y., & Dou, M. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.108818 · Cited by 37

Effect of the Large and Small T-Antigens of Human Polyomaviruses on Signaling Pathways

Moens, U. L., & Macdonald, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163914 · Cited by 38

Insulin facilitates corneal wound healing in the diabetic environment through the RTK-PI3K/Akt/mTOR axis in vitro

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Role of PI3K/AKT/mTOR in Cancer Signaling

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PI3K-Akt-mTOR Signaling in Cancer and Cancer Therapeutics

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Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer

Yu, L., Wei, J., & Liu, P. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.06.019 · Cited by 818

Targeting PI3K/Akt/mTOR Signaling in Cancer

Porta, C., Paglino, C., & Mosca, A. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00064 · Cited by 1,547

PA: Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist Updat 2008

LoPiccolo, J., Blumenthal, G. M., Bernstein, W. B., & Dennis, P. A. (2013)