The DOI matches its Crossref record; 124 of the 125 references it cites were found in a registry or an index.
The PI3K/AKT/mTOR interactive pathway
Open accessAbstract
The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR) signalling pathway is hyperactivated or altered in many cancer types and regulates a broad range of cellular processes including survival, proliferation, growth, metabolism, angiogenesis and metastasis. The PI3K/AKT/mTOR pathway is regulated by a wide-range of upstream signalling proteins and it regulates many downstream effectors by collaborating with various compensatory signalling pathways, primarily with RAF/MEK/ERK pathway. Limited clinical success of the available targeted therapeutic agents and challenges mediated by tumour heterogeneity across different cancer types emphasize the importance of alterations in the PI3K/AKT/mTOR pathway in the design of effective personalized treatment strategies. Here we report a comprehensive PI3K/AKT/mTOR network that represents the intricate crosstalk between compensatory pathways, which can be utilized to study the AKT signalling mechanism in detail and improve the personalized combinatorial therapeutic strategies.
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“PI3K inhibition, shown to increase autophagy38.”
From APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia (2024) · cites this paper as [38]
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1 retracted
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1 of the 125 references couldn’t be matched to a known paper.
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Cited by
Sorted by citations
PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers
Liu, R., Chen, Y., Liu, G., Li, C., Song, Y., Cao, Z., Li, W., Hu, J., Lu, C., & Liu, Y. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-02998-6 · Cited by 923
APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia
Haney, M. S., Pálovics, R., Munson, C. N., Long, C., Johansson, P. K., Yip, O., Dong, W., Rawat, E., West, E., Schlachetzki, J. C. M., et al. (2024) · Nature · doi:10.1038/s41586-024-07185-7 · Cited by 536
“One strategy to clear LD accumulation in microglia, which we present here, is PI3K inhibition, shown to increase autophagy 38 .”
Signaling pathways in rheumatoid arthritis: implications for targeted therapy
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Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease
Zaplatić, E., Bule, M. H., Shah, S. Z. A., Uddin, M. S., & Niaz, K. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.03.055 · Cited by 306
Metadata
- Authors
- Ersahin, T., Tuncbag, N., & Cetin-Atalay, R.
- Affiliations
- Cancer Systems Biology Laboratory, Graduate School of Informatics, ODTU a , 06800 Ankara, Turkey rengul@metu.edu.tr +90-312-210-3745 +90-312-210-7887
- Venue
- Molecular BioSystems
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-04-20
- Volume
- 11
- Issue
- 7
- Pages
- 1946-1954
- ISSN
- 1742-2051 (ISSN-L)
- 1742-206X
- OpenAlex
- W2062689336
- Cited by
- 683
- References
- 125
- Citations by year
- 2026: 62 · 2025: 110 · 2024: 119 · 2023: 96 · 2022: 82 · 2021: 71 · 2020: 56 · 2019: 43 · 2018: 30 · 2017: 8 · 2016: 5 · 2015: 1
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Molecular BioSystems (publishedVersion)
- PubMed (publishedVersion)
- OpenMETU (Middle East Technical University) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- PI3K/AKT/mTOR pathway, Raf/MEK/ERK pathway, pathway crosstalk, cancer, tumor heterogeneity, precision oncology, combination therapy, targeted therapy resistance
- MeSH terms
- Humans, Phosphatidylinositol 3-Kinases, MAP Kinase Signaling System, Proto-Oncogene Proteins c-akt, TOR Serine-Threonine Kinases, Protein Interaction Maps
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