The PI3K/AKT/mTOR interactive pathway

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

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Phosphatidylinositol-3-OH kinase direct target of Ras

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NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

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Signaling mechanisms of the epithelial-mesenchymal transition

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

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Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

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Life at the Leading Edge

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Cancer Cell Metabolism: One Hallmark, Many Faces

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Essential role for nuclear PTEN in maintaining chromosomal integrity

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Modulation of Akt kinase activity by binding to Hsp90

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AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

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CREB Is a Regulatory Target for the Protein Kinase Akt/PKB

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Regulation of PTEN Transcription by p53

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PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

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Direct control of the Forkhead transcription factor AFX by protein kinase B

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TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver

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PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization

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Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

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Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

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Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis

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Akt Enhances Mdm2-mediated Ubiquitination and Degradation of p53

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Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in Mice

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Tumor adaptation and resistance to RAF inhibitors

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Akt‐mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt

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Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation

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PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

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Regulation of Protein Kinase B/Akt-Serine 473 Phosphorylation by Integrin-linked Kinase

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Akt Protein Kinase Enhances Human Telomerase Activity through Phosphorylation of Telomerase Reverse Transcriptase Subunit

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Interactome3D: adding structural details to protein networks

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PI3K Pathway Activation Mediates Resistance to MEK Inhibitors in KRAS Mutant Cancers

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mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling

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The Clinical Effect of the Dual-Targeting Strategy Involving PI3K/AKT/mTOR and RAS/MEK/ERK Pathways in Patients with Advanced Cancer

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Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress

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PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

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PTEN: a new guardian of the genome

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Identification of a tumour suppressor network opposing nuclear Akt function

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Regulation of Raf-Akt Cross-talk

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Akt-Dependent Phosphorylation of p21Cip1 Regulates PCNA Binding and Proliferation of Endothelial Cells

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MEK Inhibition Leads to PI3K/AKT Activation by Relieving a Negative Feedback on ERBB Receptors

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Heat Shock Protein 27 Controls Apoptosis by Regulating Akt Activation

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Inositol Pyrophosphates Inhibit Akt Signaling, Thereby Regulating Insulin Sensitivity and Weight Gain

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Akt-dependent Phosphorylation of p27Kip1Promotes Binding to 14-3-3 and Cytoplasmic Localization

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Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair

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Negative Regulation of the Serine/Threonine Kinase B-Raf by Akt

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Akt Phosphorylation of p300 at Ser-1834 Is Essential for Its Histone Acetyltransferase and Transcriptional Activity

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Interleukin (IL) 1β Induction of IL-6 Is Mediated by a Novel Phosphatidylinositol 3-Kinase-dependent AKT/IκB Kinase α Pathway Targeting Activator Protein-1

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Evidence That Ser87 of BimEL Is Phosphorylated by Akt and Regulates BimEL Apoptotic Function

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A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability

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