Metals in infectious diseases and nutritional immunity
Abstract
This editorial introduces the ‘Metals in infectious diseases and nutritional immunity’ themed issue for Metallomics, guest edited by Eric Skaar and Manuela Raffatellu.
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Mechanisms for the acquisition of iron from hemoproteins such as HB and for the uptake of heme iron or ionic iron determine the virulence of human pathogens.
“Therefore, mechanisms for the acquisition of iron from hemoproteins such as HB and for the uptake of heme iron or ionic iron determine the virulence of human pathogens (Nairz et al., 2010;Skaar and Raffatellu, 2015).”
From Iron in infection and immunity (2020) · cites this paper as Skaar and Raffatellu, 2015
In “Metals in infectious diseases and nutritional immunity” (page not provided), the paper says pathogens use metal-acquisition mechanisms and that iron and other metal transporters promote virulence in Yersinia pestis. It does not identify hemoglobin or other hemoproteins as iron sources, or specifically link heme-iron or ionic-iron uptake to virulence. (LLM, conf=0.85)
Experimental — accuracy not yet measuredMany bacteria employ high-affinity iron acquisition pathways to sequester host iron.
“Many bacteria also employ high-affinity iron acquisition pathways to sequester host iron (Skaar and Raffatellu, 2015).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Skaar and Raffatellu, 2015
Iron is essential for multiple cellular processes for eucaryotes and for microbes including viruses.
“Indeed, iron is not only essential for multiple cellular processes for eucaryotes but also for microbes including viruses [8–13].”
Anemia of inflammation is highly prevalent in patients with infections because immune-mediated iron restriction is considered an important host defense mechanism.
“AI is highly prevalent in patients with infections since the underlying immune-mediated iron restriction is considered as an important host defense mechanism to limit microbial proliferation and pathogenicity.”
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Cited by
Sorted by citations
Transition Metals and Virulence in Bacteria
Palmer, L. D., & Skaar, E. P. (2016) · Annual Review of Genetics · doi:10.1146/annurev-genet-120215-035146 · Cited by 449 · see citing works
Self-citationIron in infection and immunity
Nairz, M., & Weiss, G. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100864 · Cited by 359 · see citing works
The Role of Iron Regulation in Immunometabolism and Immune-Related Disease
Cronin, S. J. F., Woolf, C. J., Weiss, G., & Penninger, J. M. (2019) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00116 · Cited by 299 · see citing works
Sonnweber, T., Boehm, A., Sahanic, S., Pizzini, A., Aichner, M., Sonnweber, B., Kurz, K., Koppelstätter, S., Haschka, D., Petzer, V., et al. (2020) · Respiratory Research · doi:10.1186/s12931-020-01546-2 · Cited by 177 · see citing works
Iron in the Tumor Microenvironment-Connecting the Dots
Pfeifhofer-Obermair, C., Tymoszuk, P., Petzer, V., Weiss, G., & Nairz, M. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00549 · Cited by 151 · see citing works
Role of divalent metals in infectious disease susceptibility and outcome
Weiss, G., & Carver, P. L. (2018) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2017.01.018 · Cited by 123 · see citing works
Price, S. L., Vadyvaloo, V., DeMarco, J. K., Brady, A., Gray, P. A., Kehl-Fie, T. E., Garneau-Tsodikova, S., Perry, R. D., & Lawrenz, M. B. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2104073118 · Cited by 49 · see citing works
<i>Candida albicans</i> reprioritizes metal handling during fluconazole stress
Hunsaker, E. W., & Franz, K. J. (2019) · Metallomics · doi:10.1039/c9mt00228f · Cited by 22 · see citing works
- Authors
- Skaar, E. P., & Raffatellu, M.
- Affiliations
- Vanderbilt University (US)
- University of California, Irvine (US)
- Corresponding author
- Skaar, Eric P.
- Raffatellu, Manuela
- Venue
- Metallomics
- Publisher
- Oxford University Press (OUP)
- Published
- 2015
- Volume
- 7
- Issue
- 6
- Pages
- 926-928
- ISSN
- 1756-5901 (ISSN-L)
- 1756-591X
- OpenAlex
- W1902964315
- Cited by
- 101
- References
- 0
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 7 · 2023: 15 · 2022: 9 · 2021: 10 · 2020: 14 · 2019: 16 · 2018: 5 · 2017: 7 · 2016: 5 · 2015: 1
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metallomics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- metals, infectious diseases, nutritional immunity, host-pathogen interaction, metal homeostasis
- MeSH terms
- Animals, Bacteria, Communicable Diseases, Humans, Immunity, Metals, Nutritional Physiological Phenomena
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