Paper-based microfluidic system for tear electrolyte analysis
Open accessAbstract
This article describes a paper-based microfluidic system that quantifies the concentrations of tear electrolytes using a smartphone-based reader.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Phenylboronic acids form reversible covalent bonds with glucose molecules.
“Phenylboronic acids form reversible covalent bonds with glucose molecules.70”
From Wearables in Medicine (2018) · cites this paper as [70]
The Results and discussion passages describe crown ethers binding metal ions, not phenylboronic acids binding glucose. The Experimental section lists glucose as a material but does not discuss its bonding chemistry. Searches for phenylboronic acid–glucose bonding and reversible boronic acid binding found no passage addressing the claim; page numbers were unavailable in our copy. (LLM, conf=0.75)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Paper-based microfluidic point-of-care diagnostic devices
Yetisen, A. K., Akram, M. S., & Lowe, C. R. (2013) · Lab on a Chip · doi:10.1039/c3lc50169h · Cited by 1,972 · see citing works
Self-citationLigand design for selective complexation of metal ions in aqueous solution
Hancock, R. D., & Martell, A. E. (1989) · Chemical Reviews · doi:10.1021/cr00098a011 · Cited by 1,180 · see citing works
Gokel, G. W. (1991) · Royal Society of Chemistry eBooks · doi:10.1039/9781788010917 · Cited by 754 · see citing works
Importance of the Lipid Layer in Human Tear Film Stability and Evaporation
Craig, J. P., & Tomlinson, A. (1997) · Optometry and Vision Science · doi:10.1002/j.1538-9235.1997.tb04573.x · Cited by 472 · see citing works
Contact Lens Sensors in Ocular Diagnostics
Farandos, N. M., Yetisen, A. K., Monteiro, M. J., Lowe, C. R., & Yun, S. H. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201400504 · Cited by 466 · see citing works
Self-citationImpaired functional visual acuity of dry eye patients
Goto, E., Yagi, Y., Matsumoto, Y., & Tsubota, K. (2002) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(01)01365-4 · Cited by 428 · see citing works
Tear Film, Contact Lens, and Patient-Related Factors Associated with Contact Lens–Related Dry Eye
Nichols, J. J., & Sinnott, L. T. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1392 · Cited by 410 · see citing works
Chotikavanich, S., de Paiva, C. S., Li, D., Chen, J. J., Bian, F., Farley, W. J., & Pflugfelder, S. C. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2476 · Cited by 405 · see citing works
Studien zur Physiologie und Pathologie der Tränenabsonderung und Tränenabfuhr
Schirmer, O. (1903) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/bf01946264 · Cited by 400 · see citing works
The Ocular Surface and Tear Film and Their Dysfunction in Dry Eye Disease
Rolando, M., & Zierhut, M. (2001) · Survey of Ophthalmology · doi:10.1016/s0039-6257(00)00203-4 · Cited by 371 · see citing works
Importance of the lipid layer in human tear film stability and evaporation
(1997) · International Contact Lens Clinic · doi:10.1016/s0892-8967(97)90017-1 · Cited by 371 · see citing works
Photonic Crystal Glucose-Sensing Material for Noninvasive Monitoring of Glucose in Tear Fluid
Alexeev, V. L., Das, S., Finegold, D. N., & Asher, S. A. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2004.039701 · Cited by 370 · see citing works
Tear analysis in ocular surface diseases
Zhou, L., & Beuerman, R. W. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.06.002 · Cited by 318 · see citing works
The Lacrimal Secretory System and its Treatment
Jones, L. T. (1966) · American Journal of Ophthalmology · doi:10.1016/0002-9394(66)91676-x · Cited by 296 · see citing works
A smartphone algorithm with inter-phone repeatability for the analysis of colorimetric tests
Yetisen, A. K., Martinez-Hurtado, J. L., Garcia-Melendrez, A., da Cruz Vasconcellos, F., & Lowe, C. R. (2014) · Sensors and Actuators B: Chemical · doi:10.1016/j.snb.2014.01.077 · Cited by 285 · see citing works
Self-citationPerformance of Tear Osmolarity Compared to Previous Diagnostic Tests for Dry Eye Diseases
Versura, P., Profazio, V., & Campos, E. C. (2010) · Current Eye Research · doi:10.3109/02713683.2010.484557 · Cited by 265 · see citing works
The thickness of the human precorneal tear film: evidence from reflection spectra.
King-Smith, P. E., Fink, B. A., Fogt, N., Nichols, K. K., Hill, R. M., & WILSON, G. S. (2000) · PubMed · Cited by 257 · see citing works
Responses of Contact Lens Wearers to a Dry Eye Survey
Begley, C. G., Caffery, B. E., Nichols, K. K., & Chalmers, R. L. (2000) · Optometry and Vision Science · doi:10.1002/j.1538-9235.2000.tb01021.x · Cited by 248 · see citing works
The Incidence and Risk Factors for Developing Dry Eye After Myopic LASIK
de Paiva, C. S., Chen, Z., Koch, D. D., Hamill, M. B., Manuel, F. K., Hassan, S., Wilhelmus, K. R., & Pflugfelder, S. C. (2006) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2005.10.006 · Cited by 240 · see citing works
The effect of hinge position on corneal sensation and dry eye after LASIK
Donnenfeld, E. D., Solomon, K. D., Perry, H. D., Doshi, S. J., Ehrenhaus, M. P., Solomon, R., & Biser, S. A. (2003) · Ophthalmology · doi:10.1016/s0161-6420(03)00100-3 · Cited by 189 · see citing works
Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3
(2002) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0717-8 · Cited by 189 · see citing works
Physical chemistry of the normal and disordered tear film.
Holly, F. J. (1985) · PubMed · Cited by 174 · see citing works
Dry eye after refractive surgery
Ang, R. E. T., Dartt, D. A., & Tsubota, K. (2001) · Current Opinion in Ophthalmology · doi:10.1097/00055735-200108000-00013 · Cited by 163 · see citing works
Benelli, U., Nardi, M., Posarelli, C., & Albert, T. G. (2010) · Contact Lens and Anterior Eye · doi:10.1016/j.clae.2010.01.003 · Cited by 145 · see citing works
Tiffany, J. M. (2003) · Eye · doi:10.1038/sj.eye.6700566 · Cited by 143 · see citing works
Pankratov, D., González‐Arribas, E., Blum, Z., & Shleev, S. (2016) · Electroanalysis · doi:10.1002/elan.201501116 · Cited by 135 · see citing works
Goto, E. (2002) · British Journal of Ophthalmology · doi:10.1136/bjo.86.12.1403 · Cited by 130 · see citing works
Human Tear Film Electrolyte Concentrations in Health and Dry-Eye Disease
Gilbard, J. P. (1994) · International Ophthalmology Clinics · doi:10.1097/00004397-199403410-00005 · Cited by 122 · see citing works
Yamada, K., Takaki, S., Komuro, N., Suzuki, K., & Citterio, D. (2014) · The Analyst · doi:10.1039/c3an01926h · Cited by 114 · see citing works
Sambursky, R. P., Davitt, W. F., Friedberg, M. L., & Tauber, S. (2014) · Cornea · doi:10.1097/ico.0000000000000175 · Cited by 103 · see citing works
Diagnostic Tests in Patients with Symptoms of Keratoconjunctivitis Sicca
Goren, M. B., & Goren, S. B. (1988) · American Journal of Ophthalmology · doi:10.1016/0002-9394(88)90587-9 · Cited by 97 · see citing works
Variability of Tear Osmolarity in Patients With Dry Eye
Bunya, V. Y., Fuerst, N. M., Pistilli, M., McCabe, B. E., Salvo, R., Macchi, I., Ying, G., & Massaro‐Giordano, M. (2015) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2015.0429 · Cited by 91 · see citing works
Dynamics of ocular surface pH.
Coles, W. H., & Jaros, P. A. (1984) · British Journal of Ophthalmology · doi:10.1136/bjo.68.8.549 · Cited by 89 · see citing works
Human Tear Protein Analysis Enabled by an Alkaline Microfluidic Homogeneous Immunoassay
Karns, K., & Herr, A. E. (2011) · Analytical Chemistry · doi:10.1021/ac202061v · Cited by 89 · see citing works
Kaufman, H. E. (2012) · Cornea · doi:10.1097/ico.0b013e3182541e9a · Cited by 88 · see citing works
Lacrimal Gland, Tear Film, and Dry Eye Syndromes
Sullivan, D. A. (1994) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2417-5 · Cited by 80 · see citing works
Desiccating stress-induced disruption of ocular surface immune tolerance drives dry eye disease
Guzmán, M., Keitelman, I. A., Sabbione, F., Trevani, A. S., Giordano, M., & Galletti, J. G. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12759 · Cited by 70 · see citing works
Lacrimal Gland, Tear Film, and Dry Eye Syndromes: Basic Science and Clinical Relevance
Mathers, W. D. (1996) · Archives of Ophthalmology · doi:10.1001/archopht.1996.01100140364035 · Cited by 43 · see citing works
Baudouin, C., Bourcier, T., Brignole‐Baudouin, F., Bertel, F., Moldovan, M., Goldschild, M., & Goguel, A. F. (2000) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s004170000179 · Cited by 40 · see citing works
A window to beyond the orbit: the value of optical coherence tomography in non‐ocular disease
Cameron, J. R., & Tatham, A. J. (2016) · Acta Ophthalmologica · doi:10.1111/aos.12978 · Cited by 14 · see citing works
Flagged first, then by citations
Research works printed but not linked: 32
- Guzmán M. Keitelman I. Sabbione F. Trevani A. S. Giordano M. Galletti J. Clin. Exp. Immunol. 2016 184 248 256 26690299 PMC4837231
- Cameron J. R. Tatham A. J. Acta Ophthalmol. 2016 94 533 539 26803923
- Craig J. P. Tomilnson A. Optom. Vis. Sci. 1997 74 8 13 9148269
- Holly F. Trans. Ophthalmol. Soc. U. K. 1984 104 374 380 3862270
- Rolando M. Zierhut M. Surv. Ophthalmol. 2001 45 S203 S210 11587144
- Zhou L. Beuerman R. W. Prog. Retinal Eye Res. 2012 31 527 550 22732126
- King-Smith P. E. Fink B. A. Fogt N. Nichols K. K. Hill R. M. Wilson G. S. Invest. Ophthalmol. Visual Sci. 2000 41 3348 3359 11006224
- Goto E. Monden Y. Takano Y. Mori A. Shimmura S. Shimazaki J. Tsubota K. Br. J. Ophthalmol. 2002 86 1403 1407 12446375 PMC1771385
- Jones L. T. Am. J. Ophthalmol. 1966 62 47 60 5936526
- Goto E. Yagi Y. Matsumoto Y. Tsubota K. Am. J. Ophthalmol. 2002 133 181 186 11812420
- De Paiva C. S. Chen Z. Koch D. D. Hamill M. B. Manuel F. K. Hassan S. S. Wilhelmus K. R. Pflugfelder S. C. Am. J. Ophthalmol. 2006 141 438 445 16490488
- Donnenfeld E. D. Solomon K. Perry H. D. Doshi S. J. Ehrenhaus M. Solomon R. Biser S. Ophthalmology 2003 110 1023 1029 12750107
- Ang R. T. Dartt D. A. Tsubota K. Curr. Opin. Ophthalmol. 2001 12 318 322 11507347
- Nichols J. J. Sinnott L. T. Invest. Ophthalmol. Visual Sci. 2006 47 1319 16565363
- Begley C. G. Caffery B. Nichols K. K. Chalmers R. Optom. Vis. Sci. 2000 77 40 46 10654857
- Benelli U. Nardi M. Posarelli C. Albert T. G. Cont. Lens Anterior Eye 2010 33 61 67 20153684
- Bunya V. Y. Fuerst N. M. Pistilli M. McCabe B. E. Salvo R. Macchi I. Ying G.-S. Massaro-Giordano M. JAMA Ophthalmol. 2015 133 662 667 25811641 PMC4466048
- Sambursky R. Davitt III W. F. Friedberg M. Tauber S. Cornea 2014 33 812 818 24977985
- Kaufman H. E. Cornea 2013 32 211 216 22673852
- Chotikavanich S. de Paiva C. S. Chen J. J. Bian F. Farley W. J. Pflugfelder S. C. Invest. Ophthalmol. Visual Sci. 2009 50 3203 3209 19255163 PMC3594995
- Goren M. B. Goren S. B. Am. J. Ophthalmol. 1988 106 570 574 2461083
- Baudouin C. Bourcier T. Brignole F. Bertel F. Moldovan M. Goldschild M. Goguel A. Graefe's Arch. Clin. Exp. Ophthalmol. 2000 238 900 904 11148813
- Karns K. Herr A. E. Anal. Chem. 2011 83 8115 8122 21910436
- Yamada K. Takaki S. Komuro N. Suzuki K. Citterio D. Analyst 2014 139 1637 1643 24482793
- Farandos N. M. Yetisen A. K. Monteiro M. J. Lowe C. R. Yun S. H. Adv. Healthcare Mater. 2015 4 792 810 25400274
- Gilbard J. P. Int. Ophthalmol. Clin. 1994 34 27 36 8169071
- Alexeev V. L. Das S. Finegold D. N. Asher S. A. Clin. Chem. 2004 50 2353 2360 15459093
- Yetisen A. K. Akram M. S. Lowe C. R. Lab Chip 2013 13 2210 2251 23652632
- Tiffany J. M. Eye 2003 17 923 926 14631398
- Gilbard J. P. Int. Ophthalmol. Clin. 1994 34 27 36 8169071
- Coles W. H. Jaros P. A. Br. J. Ophthalmol. 1984 68 549 552 6743624 PMC1040411
- Versura P. Profazio V. Campos E. Curr. Eye Res. 2010 35 553 564 20597641
Cited by
Sorted by citations
Supramolecular Luminescent Sensors
Mako, T. L., Racicot, J. M., & Levine, M. S. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00260 · Cited by 733 · see citing works
Yetisen, A. K., Martinez‐Hurtado, J. L., Ünal, B., Khademhosseini, A., & Butt, H. (2018) · Advanced Materials · doi:10.1002/adma.201706910 · Cited by 569 · see citing works
Self-citationPoint-of-care testing based on smartphone: The current state-of-the-art (2017–2018)
Liu, J., Geng, Z., Fan, Z., Liu, J., & Chen, H. (2019) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2019.01.068 · Cited by 334 · see citing works
Yang, S., Lv, S., Zhang, W., & Cui, Y. (2022) · Sensors · doi:10.3390/s22041620 · Cited by 313 · see citing works
Paper-Based Sensors: Emerging Themes and Applications
Singh, A. T., Lantigua, D., Meka, A., Taing, S., Pandher, M., & Camci‐Unal, G. (2018) · Sensors · doi:10.3390/s18092838 · Cited by 284 · see citing works
Wang, B., Li, Y., Zhou, M., Han, Y., Zhang, M., Gao, Z., Liu, Z., Chen, P., Du, W., Zhang, X., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36017-x · Cited by 269 · see citing works
Gold nanoparticles (AuNPs): A versatile material for biosensor application
Kumalasari, M. R., Alfanaar, R., & Andreani, A. S. (2024) · Talanta Open · doi:10.1016/j.talo.2024.100327 · Cited by 259 · see citing works
Xiao, M., Liu, Z., Xu, N., Jiang, L., Yang, M., & Yi, C. (2020) · ACS Sensors · doi:10.1021/acssensors.0c00219 · Cited by 219 · see citing works
Smartphone‐based clinical diagnostics: towards democratization of evidence‐based health care
Hernández-Neuta, I., Neumann, F., Brightmeyer, J., Tis, T. B., Madaboosi, N., Wei, Q., Özcan, A., & Nilsson, M. F. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12820 · Cited by 207 · see citing works
Lateral and Vertical Flow Assays for Point‐of‐Care Diagnostics
Jiang, N., Ahmed, R., Damayantharan, M., Ünal, B., Butt, H., & Yetisen, A. K. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900244 · Cited by 201 · see citing works
Self-citationApplication of smartphone-based spectroscopy to biosample analysis: A review
Chen, W., Yao, Y., Chen, T., Shen, W., Tang, S. N., & Lee, H. K. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112788 · Cited by 154 · see citing works
Wang, Z., Dong, Y., Sui, X., Shao, X., Li, K., Zhang, H., Xu, Z., & Zhang, D. (2024) · npj Flexible Electronics · doi:10.1038/s41528-024-00321-3 · Cited by 154 · see citing works
Recent Progress in Optical Biosensors Based on Smartphone Platforms
Geng, Z., Zhang, X., Fan, Z., Lv, X., Su, Y., & Chen, H. (2017) · Sensors · doi:10.3390/s17112449 · Cited by 153 · see citing works
Integrated Devices for Non‐Invasive Diagnostics
Ates, H. C., Brunauer, A., von Stetten, F., Urban, G. A., Güder, F., Merkoçi, A., Früh, S. M., & Dincer, C. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202010388 · Cited by 149 · see citing works
Sasikala, A., Nguyen, N., & Sreejith, K. R. (2024) · Lab on a Chip · doi:10.1039/d4lc00089g · Cited by 139 · see citing works
Point‐of‐Care Smartphone‐based Electrochemical Biosensing
Sun, A. C., & Hall, D. A. (2018) · Electroanalysis · doi:10.1002/elan.201800474 · Cited by 132 · see citing works
Laser-inscribed contact lens sensors for the detection of analytes in the tear fluid
Moreddu, R., Wolffsohn, J. S., Vigolo, D., & Yetisen, A. K. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.128183 · Cited by 124 · see citing works
Self-citationLab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics
Zhu, Y., Li, S., Li, J., Falcone, N., Cui, Q., Shah, S., Hartel, M. C., Yu, N., Young, P., de Barros, N. R., et al. (2022) · Advanced Materials · doi:10.1002/adma.202108389 · Cited by 123 · see citing works
Self-citationLow-Cost Optical Assays for Point-of-Care Diagnosis in Resource-Limited Settings
Jiang, N., Tansukawat, N. D., Gonzalez‐Macia, L., Ates, H. C., Dincer, C., Güder, F., Taşoğlu, S., & Yetisen, A. K. (2021) · ACS Sensors · doi:10.1021/acssensors.1c00669 · Cited by 106 · see citing works
Self-citationUpadhyay, S., Kumar, A., Srivastava, M., Srivastava, A., Dwivedi, A., Singh, R. K., & Srivastava, S. (2024) · Talanta · doi:10.1016/j.talanta.2024.126080 · Cited by 106 · see citing works
Droplet Precise Self‐Splitting on Patterned Adhesive Surfaces for Simultaneous Multidetection
Li, H., Fang, W. P., Zhao, Z., Li, A., Li, Z., Li, M., Li, Q., Feng, X., & Song, Y. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202003839 · Cited by 105 · see citing works
Near-Field Communication Sensors
Cao, Z., Chen, P., Ma, Z., Li, S., Gao, X., Wu, R., Pan, L., & Shi, Y. (2019) · Sensors · doi:10.3390/s19183947 · Cited by 102 · see citing works
Integration of paper microfluidic sensors into contact lenses for tear fluid analysis
Moreddu, R., Elsherif, M., Adams, H., Moschou, D. C., Cordeiro, M. F., Wolffsohn, J. S., Vigolo, D., Butt, H., Cooper, J. M., & Yetisen, A. K. (2020) · Lab on a Chip · doi:10.1039/d0lc00438c · Cited by 97 · see citing works
Self-citationDermal Tattoo Biosensors for Colorimetric Metabolite Detection
Yetisen, A. K., Moreddu, R., Seifi, S., Jiang, N., Vega, K. C., Dong, X., Dong, J., Butt, H., Jakobi, M., Elsner, M., et al. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201904416 · Cited by 91 · see citing works
Self-citationBio-inspired wettability patterns for biomedical applications
Chi, J., Zhang, X., Wang, Y., Shao, C., Shang, L., & Zhao, Y. (2020) · Materials Horizons · doi:10.1039/d0mh01293a · Cited by 91 · see citing works
Tseng, C., Kung, C., Chen, R., Tsai, M., Chao, H., Wang, Y.-N., & Fu, L. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.130078 · Cited by 90 · see citing works
Smartphone-based colorimetric detection system for portable health tracking
Balbach, S., Jiang, N., Moreddu, R., Dong, X., Kurz, W., Wang, C., Dong, J., Yin, Y., Butt, H., Brischwein, M., et al. (2021) · Analytical Methods · doi:10.1039/d1ay01209f · Cited by 84 · see citing works
Self-citationHe, W., You, M., Li, Z., Cao, L., Xu, F., Li, F., & Li, A. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.129673 · Cited by 79 · see citing works
Soda, Y., Citterio, D., & Bakker, E. (2019) · ACS Sensors · doi:10.1021/acssensors.8b01521 · Cited by 75 · see citing works
Jiang, N., Montelongo, Y., Butt, H., & Yetisen, A. K. (2018) · Small · doi:10.1002/smll.201704363 · Cited by 73 · see citing works
Self-citationOphthalmic Sensors and Drug Delivery
Savariraj, A. D., Salih, A. E., Alam, F., Elsherif, M., AlQattan, B., Khan, A. A., Yetisen, A. K., & Butt, H. (2021) · ACS Sensors · doi:10.1021/acssensors.1c00370 · Cited by 68 · see citing works
Self-citationScleral Lens Sensor for Ocular Electrolyte Analysis
Yetisen, A. K., Jiang, N., González, C. M. C., Erenoglu, Z. I., Dong, J., Dong, X., Stößer, S., Brischwein, M., Butt, H., Cordeiro, M. F., et al. (2019) · Advanced Materials · doi:10.1002/adma.201906762 · Cited by 65 · see citing works
Self-citationDevelopment of Paper-Based Analytical Devices for Minimizing the Viscosity Effect in Human Saliva
Noiphung, J., Nguyen, M., Punyadeera, C., Wan, Y., Laiwattanapaisal, W., & Henry, C. S. (2018) · Theranostics · doi:10.7150/thno.24941 · Cited by 64 · see citing works
Sensing of electrolytes in urine using a miniaturized paper-based device
Ghaderinezhad, F., Koydemir, H. C., Tseng, D. K., Karinca, D., Liang, K., Özcan, A., & Taşoğlu, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-70456-6 · Cited by 64 · see citing works
Flexible, wearable microfluidic contact lens with capillary networks for tear diagnostics
Yang, X., Yao, H., Zhao, G., Ameer, G. A., Sun, W., Yang, J. H., & Mi, S. (2020) · Journal of Materials Science · doi:10.1007/s10853-020-04688-2 · Cited by 64 · see citing works
Fluorescence Sensing Technologies for Ophthalmic Diagnosis
Shi, Y., Hu, Y., Jiang, N., & Yetisen, A. K. (2022) · ACS Sensors · doi:10.1021/acssensors.2c00313 · Cited by 63 · see citing works
Self-citationCheng, J., Huang, J., Xiang, Q., & Dong, H. (2023) · Analytica Chimica Acta · doi:10.1016/j.aca.2023.341101 · Cited by 63 · see citing works
Noiphung, J., & Laiwattanapaisal, W. (2019) · Scientific Reports · doi:10.1038/s41598-018-38159-1 · Cited by 60 · see citing works
Microfluidics-Based Sensing of Biospecies
Xing, Y., Zhao, L., Cheng, Z., Lv, C., Yu, F., & Yu, F. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c01271 · Cited by 59 · see citing works
Paper-based fluorogenic devices for in vitro diagnostics
Wu, M., Lai, Q., Ju, Q., Li, L., Yu, H., & Huang, W. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2017.11.006 · Cited by 59 · see citing works
Tan, W., Zhang, L., Jarujamrus, P., Doery, J. C. G., & Shen, W. (2022) · Microchemical Journal · doi:10.1016/j.microc.2022.107562 · Cited by 58 · see citing works
Wearable Near-Field Communication Sensors for Healthcare: Materials, Fabrication and Application
Sun, X., Zhao, C., Li, H., Yu, H., Zhang, J., Qiu, H., Liang, J., Wu, J., Su, M., Shi, Y., et al. (2022) · Micromachines · doi:10.3390/mi13050784 · Cited by 57 · see citing works
Optical flexible biosensors: From detection principles to biomedical applications
Wu, W., Wang, L., Yang, Y. F., Du, W., Ji, W., Fang, Z., Hou, X., Wu, Q., Zhang, C., & Li, L. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114328 · Cited by 56 · see citing works
Microenvironment-Controlled Micropatterned Microfluidic Model (MMMM) for Biomimetic In Situ Studies
Wang, Y., Lu, L., Zheng, G., & Zhang, X. (2020) · ACS Nano · doi:10.1021/acsnano.0c02701 · Cited by 56 · see citing works
Direct Laser Writing of Nanophotonic Structures on Contact Lenses
AlQattan, B., Yetisen, A. K., & Butt, H. (2018) · ACS Nano · doi:10.1021/acsnano.8b00222 · Cited by 54 · see citing works
Self-citationTear-Based Ocular Wearable Biosensors for Human Health Monitoring
Arunima Rajan, S., Vishnu, J., & Shankar, B. (2024) · Biosensors · doi:10.3390/bios14100483 · Cited by 53 · see citing works
Shibata, H., Henares, T. G., Yamada, K., Suzuki, K., & Citterio, D. (2017) · The Analyst · doi:10.1039/c7an01952a · Cited by 53 · see citing works
Recent advances in lab-on-paper diagnostic devices using blood samples
Lee, W., Ng, H., Hou, C., Lee, C., & Fu, L. (2021) · Lab on a Chip · doi:10.1039/d0lc01304h · Cited by 53 · see citing works
Fan, Z., Geng, Z., Fang, W., Lv, X., Su, Y., Wang, S., & Chen, H. (2020) · Sensors · doi:10.3390/s20020446 · Cited by 52 · see citing works
Moving toward smart biomedical sensing
Naghdi, T., Ardalan, S., Adib, Z. A., Sharifi, A. R., & Golmohammadi, H. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.115009 · Cited by 51 · see citing works
Ophthalmic sensing technologies for ocular disease diagnostics
Shi, Y., Jiang, N., Bikkannavar, P., Cordeiro, M. F., & Yetisen, A. K. (2021) · The Analyst · doi:10.1039/d1an01244d · Cited by 48 · see citing works
Self-citationBennet, D., Khorsandian, Y., Pelusi, J., Mirabella, A., Pirrotte, P., & Zenhausern, F. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.461 · Cited by 47 · see citing works
Lab-on-Paper Devices for Diagnosis of Human Diseases Using Urine Samples—A Review
Tai, W.-C., Chang, Y., Chou, D., & Fu, L. (2021) · Biosensors · doi:10.3390/bios11080260 · Cited by 47 · see citing works
Brazaca, L. C., Imamura, A. H., Blasques, R. V., Camargo, J. R., Janegitz, B. C., & Carrilho, E. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115846 · Cited by 46 · see citing works
Dermal Tattoo Biosensors for Colorimetric Metabolite Detection
Yetisen, A. K., Moreddu, R., Seifi, S., Jiang, N., Vega, K. C., Dong, X., Dong, J., Butt, H., Jakobi, M., Elsner, M., et al. (2019) · Angewandte Chemie · doi:10.1002/ange.201904416 · Cited by 46 · see citing works
Self-citationLin, C.-T., Kuo, S.-H., Lin, P.-H., Chiang, P.-H., Lin, W.-H., Chang, C.-H., Tsou, P., & Li, B. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.128003 · Cited by 45 · see citing works
Chen, T., Sun, C., Abbas, S. C., Alam, N., Qiang, S., Tian, X., Fu, C., Zhang, H., Xia, Y., Liu, L., et al. (2024) · Analytica Chimica Acta · doi:10.1016/j.aca.2024.342877 · Cited by 44 · see citing works
Advances in Reagents Storage and Release in Self‐Contained Point‐of‐Care Devices
Deng, J., & Jiang, X. (2019) · Advanced Materials Technologies · doi:10.1002/admt.201800625 · Cited by 43 · see citing works
Measures of disease activity in glaucoma
Wu, Y., Szymanska, M., Hu, Y., Fazal, M. I., Jiang, N., Yetisen, A. K., & Cordeiro, M. F. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113700 · Cited by 37 · see citing works
Self-citationContact lens sensor for ocular inflammation monitoring
Shi, Y., Wang, L., Hu, Y., Zhang, Y., Le, W., Liu, G., Tomaschek, M., Jiang, N., & Yetisen, A. K. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116003 · Cited by 34 · see citing works
Self-citationReal Time Analysis of Bioanalytes in Healthcare, Food, Zoology and Botany
Wang, T., Ramnarayanan, A., & Cheng, H. (2017) · Sensors · doi:10.3390/s18010005 · Cited by 34 · see citing works
Fluorescent dermal tattoo biosensors for electrolyte analysis
Jiang, N., Yetisen, A. K., Linhart, N., Flisikowski, K., Dong, J., Dong, X., Butt, H., Jakobi, M., Schnieke, A., & Koch, A. W. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.128378 · Cited by 34 · see citing works
Self-citationNano-functionalized paper-based IoT enabled devices for point-of-care testing: a review
Kishnani, V., Park, S., Nakate, U. T., Mondal, K., & Gupta, A. (2021) · Biomedical Microdevices · doi:10.1007/s10544-021-00588-7 · Cited by 34 · see citing works
Self-citationCurrent and Future Perspectives on Microfluidic Tear Analytic Devices
Li, M. S., Wong, H. L., Ip, Y. L., Peng, Z., Yiu, R. S. W., Yuan, H. R., Wong, J. K. W., & Chan, Y. K. (2022) · ACS Sensors · doi:10.1021/acssensors.2c00569 · Cited by 34 · see citing works
A non-enzymatic nanoceria electrode for non-invasive glucose monitoring
Jiang, L., Xue, Q., Jiao, C., Liu, H., Zhou, Y., Ma, H., & Yang, Q. (2018) · Analytical Methods · doi:10.1039/c8ay00433a · Cited by 32 · see citing works
Modern evolution of paper-based analytical devices for wearable use: from disorder to order
Chu, T., Chu, J., Gao, B., & He, B. (2020) · The Analyst · doi:10.1039/d0an00994f · Cited by 30 · see citing works
Electrochemical Sensing in Contact Lenses
Liu, H., Yan, X., Gu, Z., Xiu, G., & Xiao, X. (2021) · Electroanalysis · doi:10.1002/elan.202100342 · Cited by 29 · see citing works
Establishment of a Tear Ferning Test Protocol in the Mouse Model
Tang, Y.-J., Chang, H., Tsai, C.-Y., Chen, L., & Lin, D. P. (2020) · Translational Vision Science & Technology · doi:10.1167/tvst.9.13.1 · Cited by 27 · see citing works
Advanced Microfluidic‐Based Wearable Electrochemical Sensors for Continuous Biochemical Monitoring
Park, S., Kim, S., Lee, S.-J., Tsukruk, V. V., Park, S., & Lim, H. (2025) · Advanced Electronic Materials · doi:10.1002/aelm.202500010 · Cited by 27 · see citing works
The marriage of biochemistry and nanotechnology for non-invasive real-time health monitoring
Ji, D., Guo, X., Fu, W., Ding, Z., Wang, C., Zhang, Q., Ramakrishna, S., & Qin, X. (2022) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2022.100681 · Cited by 27 · see citing works
Badugu, R., Szmacinski, H., Reece, E. A., Jeng, B. H., & Lakowicz, J. R. (2020) · Analytical Biochemistry · doi:10.1016/j.ab.2020.113902 · Cited by 26 · see citing works
Sodium-sensitive contact lens for diagnostics of ocular pathologies
Badugu, R., Szmacinski, H., Reece, E. A., Jeng, B. H., & Lakowicz, J. R. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.129434 · Cited by 24 · see citing works
Small-volume detection: platform developments for clinically-relevant applications
Sung, W.-H., Tsao, Y., Shen, C., Tsai, C., & Cheng, C. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00852-1 · Cited by 24 · see citing works
Policy Considerations for Mobile Biosensors
Russell, S. M., & de la Rica, R. (2018) · ACS Sensors · doi:10.1021/acssensors.8b00289 · Cited by 24 · see citing works
Doubly Photopolymerized Holographic Sensors
Jiang, N., Davies, S., Jiao, Y., Blyth, J., Butt, H., Montelongo, Y., & Yetisen, A. K. (2021) · ACS Sensors · doi:10.1021/acssensors.0c02109 · Cited by 24 · see citing works
Self-citationRecent advances in the study of tear biomarkers and contact lens-based biosensors
Bai, W., Yu, X., Li, Q., Tan, H., Ma, K., Bai, H., Li, S., Hu, J. H., Yao, Y., Zhuang, W., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.156540 · Cited by 23 · see citing works
Temirel, M., Dabbagh, S. R., & Taşoğlu, S. (2021) · Micromachines · doi:10.3390/mi12020182 · Cited by 22 · see citing works
Recent advances in microfluidics by tuning wetting behaviors
Zeng, Q., Wang, B., & Guo, Z. (2023) · Materials Today Physics · doi:10.1016/j.mtphys.2023.101324 · Cited by 22 · see citing works
Liu, Z.-G., Xiao, M., Yang, R.-Z., Zhou, Q., Ye, H., & Yi, C. (2021) · Journal of Analysis and Testing · doi:10.1007/s41664-021-00163-2 · Cited by 21 · see citing works
Wearable sensors for health monitoring: Current applications, trends, and future directions
Kurul, F., Aydoğan, D., Janat, S., Kirlangiç, İ. A., Kaya, H. O., & Topkaya, S. N. (2025) · Biosensors and Bioelectronics X · doi:10.1016/j.biosx.2025.100727 · Cited by 20 · see citing works
Droplet Precise Self‐Splitting on Patterned Adhesive Surfaces for Simultaneous Multidetection
Li, H., Fang, W. P., Zhao, Z., Li, A., Li, Z., Li, M., Li, Q., Feng, X., & Song, Y. (2020) · Angewandte Chemie · doi:10.1002/ange.202003839 · Cited by 20 · see citing works
Wu, Y., Hu, Y., Jiang, N., Anantharanjit, R., Yetisen, A. K., & Cordeiro, M. F. (2022) · Lab on a Chip · doi:10.1039/d2lc00431c · Cited by 20 · see citing works
Self-citationBiomechanical analysis of ocular diseases and its in vitro study methods
Zhao, Y., Hu, G., Yan, Y., Wang, Z., Liu, X., & Shi, H. (2022) · BioMedical Engineering OnLine · doi:10.1186/s12938-022-01019-1 · Cited by 19 · see citing works
Raposo, A. C., Portela, R. W., Masmali, A. M., Cardoso‐Brito, V., Bernardo, M., Oliveira, D. C., & Oriá, A. P. (2018) · Journal of Medical Primatology · doi:10.1111/jmp.12368 · Cited by 19 · see citing works
Jia, Z., Wei, W., Tu, K., Fang, B., Zhang, M., & Shi, L. (2022) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2022.133179 · Cited by 18 · see citing works
Integrated paper-based sensing devices for diagnostic applications
Brunauer, A., Ates, H. C., Dincer, C., & Früh, S. M. (2020) · Comprehensive analytical chemistry · doi:10.1016/bs.coac.2020.03.003 · Cited by 18 · see citing works
Mukhopadhyay, M., Subramanian, S. G., Durga, K. V., Sarkar, D., & DasGupta, S. (2022) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2022.132599 · Cited by 18 · see citing works
Puneeth, S. B., Munigela, N., Puranam, S. A., & Goel, S. (2020) · IEEE Transactions on Electron Devices · doi:10.1109/ted.2020.2989727 · Cited by 17 · see citing works
Wang, R., Zhou, Y., Ghalehjoughi, N. G., Mawaldi, Y., & Wang, X. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c03394 · Cited by 15 · see citing works
Advances in point-of-care testing based on microfluidic chips towards small molecular biomarkers
Hu, W., Zhao, Y. C., Qi, H., Sun, H., Xie, Y., Wang, Y., & Liang, Q. (2025) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2025.118596 · Cited by 14 · see citing works
Luminescence Probes in Bio-Applications: From Principle to Practice
Yan, T., Weng, F., Ming, Y., Zhu, S., Zhu, M., Wang, C., Guo, C., & Zhu, K. (2024) · Biosensors · doi:10.3390/bios14070333 · Cited by 14 · see citing works
Recent progress of continuous intraocular pressure monitoring
Xu, J., Li, R., Xu, H., Yang, Y., Zhang, S., & Ren, T. (2021) · Nano Select · doi:10.1002/nano.202100137 · Cited by 14 · see citing works
Ma, T., He, Q.-Y., Li, X., Zhang, B., Li, Y., Chen, L., You, X., & Liu, J. (2024) · Microchemical Journal · doi:10.1016/j.microc.2024.110933 · Cited by 12 · see citing works
Wearable Devices for Biofluid Monitoring in a Body: from Lab to Commercialization
Yang, Y. J., Lee, S. G., & Kim, T. (2024) · Korean Journal of Chemical Engineering · doi:10.1007/s11814-024-00295-y · Cited by 12 · see citing works
Zhu, J., Yang, L., Yang, Q., Huang, Y., Li, Y., He, Y., Yang, X., Yang, Z., Jiao, Y., Wei, W., et al. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202402148 · Cited by 12 · see citing works
Paper integrated microfluidic contact lens for colorimetric glucose detection
İşgör, P. K., Abbasiasl, T., Das, R., Istif, E., Yener, U. C., & Beker, L. (2024) · Sensors & Diagnostics · doi:10.1039/d4sd00135d · Cited by 11 · see citing works
Liu, H., Jia, Y., Jiang, Y., Nie, Y., & Hao, R. (2026) · Diagnostics · doi:10.3390/diagnostics16020251 · Cited by 11 · see citing works
Monodispersed silk fibroin microdroplets for protein stabilization
Liu, Q., Jiang, N., Liu, D., Ying, G., Shi, Q., Yetisen, A. K., Liu, H., & Fan, Y. (2018) · Applied Physics Letters · doi:10.1063/1.5026759 · Cited by 11 · see citing works
Self-citationHe, S., Qin, X., Zhu, X., Mu, G., Yang, G., Ma, J., & Zhang, Z. (2025) · Journal of Analysis and Testing · doi:10.1007/s41664-025-00370-1 · Cited by 10 · see citing works
A Robust and User-Friendly Alternative to Densitometry Using Origami Biosensors and Digital Logic
Russell, S. M., Alba-Patiño, A., Borges-Sa, M., & de la Rica, R. (2018) · ACS Sensors · doi:10.1021/acssensors.8b00452 · Cited by 10 · see citing works
- Authors
- Yetisen, A. K., Jiang, N., Tamayol, A., Ruiz-Esparza, G. U., Zhang, Y. S., Medina-Pando, S., Gupta, A., Wolffsohn, J. S., Butt, H., Khademhosseini, A., & Yun, S.-H.
- Affiliations
- Brigham and Women's Hospital (US)
- Biomaterials Innovation Research Center
- Harvard–MIT Division of Health Sciences and Technology (US)
- Aston University (GB)
- University of Birmingham (GB)
- Harvard University (US)
- Corresponding author
- Yetisen, Ali K.
- Yun, Seok-Hyun
- ORCID
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2017
- Volume
- 17
- Issue
- 6
- Pages
- 1137-1148
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- PMC
- PMC5433427
- OpenAlex
- W2588545273
- Cited by
- 151
- References
- 40
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 17 · 2023: 8 · 2022: 17 · 2021: 26 · 2020: 21 · 2019: 16 · 2018: 14 · 2017: 5
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Lab on a Chip (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Aston Publications Explorer (Aston University) (acceptedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, cc-by)
- Spiral (Imperial College London) (submittedVersion, cc-by)
- Funders
- Wellcome Trust (201929/Z/16/Z)
- Royal Society
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ocular Surface and Contact Lens
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrowetting and Microfluidic Technologies
- Keywords
- paper-based microfluidics, dry eye, pH measurement
- MeSH terms
- Electrolytes, Equipment Design, Humans, Paper, Potassium, Sodium, Tears, Dry Eye Syndromes, Microfluidic Analytical Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review