Contact Lens Sensors in Ocular Diagnostics
Abstract
Contact lenses as a minimally invasive platform for diagnostics and drug delivery have emerged in recent years. Contact lens sensors have been developed for analyzing the glucose composition of tears as a surrogate for blood glucose monitoring and for the diagnosis of glaucoma by measuring intraocular pressure. However, the eye offers a wider diagnostic potential as a sensing site and therefore contact lens sensors have the potential to improve the diagnosis and treatment of many diseases and conditions. With advances in polymer synthesis, electronics and micro/nanofabrication, contact lens sensors can be produced to quantify the concentrations of many biomolecules in ocular fluids. Non‐ or minimally invasive contact lens sensors can be used directly in a clinical or point‐of‐care setting to monitor a disease state continuously. This article reviews the state‐of‐the‐art in contact lens sensor fabrication, their detection, wireless powering, and readout mechanisms, and integration with mobile devices and smartphones. High‐volume manufacturing considerations of contact lenses are also covered and a case study of an intraocular pressure contact lens sensor is provided as an example of a successful product. This Review further analyzes the contact lens market and the FDA regulatory requirements for commercialization of contact lens sensors.
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Blood and tear fluid have a compositional difference due to the blood-tear barrier; however, the concentrations of analytes in both fluids have a relationship as a result of plasma leakage.
“Blood and tear fluid have a compositional difference due to the blood–tear barrier; however, the concentrations of analytes in both fluids have a relationship as a result of plasma leakage.57”
From Wearables in Medicine (2018) · cites this paper as [57]
Tear analysis presents opportunities for the diagnosis of ocular disease.
“Not only do biomarker molecules in tears diffuse directly from the blood and exhibit close tear–blood concentration correlations, but also tear analysis presents opportunities for the diagnosis of ocular disease.”
From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [94]
Biomarker molecules in tears diffuse directly from the blood and exhibit close tear-blood concentration correlations.
“Not only do biomarker molecules in tears diffuse directly from the blood and exhibit close tear–blood concentration correlations, but also tear analysis presents opportunities for the diagnosis of ocular disease.”
From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [94]
Tear glucose concentrations have been demonstrated to exhibit good correlation with blood glucose levels, reflecting diffusion from the lachrymal artery when tears are sampled without eye irritation or stimulation, which can compromise the relationship.
“In particular, tear glucose concentrations have been demonstrated to exhibit good correlation with blood glucose levels, reflecting the diffusion from the lachrymal artery when the tears are sampled without any eye irritation or stimulation, which can compromise the relationship94, 95, 99-101.”
From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [94]
A smart contact lens is a promising wearable health monitoring device.
“Given this background, a smart contact lens is a promising example of a wearable, health monitoring device (13, 14).”
From Soft, smart contact lenses with integrations of wireless circuits, glucose sensors, and displays (2018) · cites this paper as [13]
By considering the correlation between tear glucose level and blood glucose level, a glucose sensor fitted on a contact lens can provide noninvasive monitoring of a user's glucose levels from tear fluids, with a lag time between tear glucose and blood glucose in the range of 10 to 20 min.
“By considering the correlation between the tear glucose level and blood glucose level (15), a glucose sensor fitted on a contact lens can provide the noninvasive monitoring of user’s glucose levels from tear fluids with a consideration of the lag time between tear glucose level and blood glucose level in the range of 10 to 20 min (13–16).”
From Soft, smart contact lenses with integrations of wireless circuits, glucose sensors, and displays (2018) · cites this paper as [13]
The user's tears can be collected in a contact lens by natural means such as normal secretion and blinking and used to assess biomarkers found in the blood, such as glucose, cholesterol, sodium ions, and potassium ions.
“In addition, the user’s tears can be collected in the contact lens by completely natural means, such as normal secretion and blinking, and used to assess various biomarkers found in the blood, such as glucose, cholesterol, sodium ions, and potassium ions (13).”
From Soft, smart contact lenses with integrations of wireless circuits, glucose sensors, and displays (2018) · cites this paper as [13]
Cites
The present and future role of microfluidics in biomedical research
Sackmann, E. K., Fulton, A. L., & Beebe, D. J. (2014) · Nature · doi:10.1038/nature13118 · Cited by 2,995 · see citing works
Fluorescence Spectroscopy of Single Biomolecules
Weiss, S. (1999) · Science · doi:10.1126/science.283.5408.1676 · Cited by 2,050 · see citing works
Clinical Methods: The History, Physical, and Laboratory Examinations
Kruse, J. A. (1990) · JAMA · doi:10.1001/jama.1990.03450210108045 · Cited by 2,040 · see citing works
Paper-based microfluidic point-of-care diagnostic devices
Yetisen, A. K., Akram, M. S., & Lowe, C. R. (2013) · Lab on a Chip · doi:10.1039/c3lc50169h · Cited by 1,972 · see citing works
Self-citationClinical Methods: The History, Physical, and Laboratory Examinations
(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-7-563_2 · Cited by 1,406 · see citing works
Geigy, J. R. (1981) · Medical Entomology and Zoology · Cited by 1,221 · see citing works
The renaissance of fluorescence resonance energy transfer.
Selvin, P. R. (2000) · Nature Structural Biology · doi:10.1038/78948 · Cited by 998 · see citing works
Functional aspects of the tear film lipid layer
Bron, A. J., Tiffany, J. M., Gouveia, S. M., Yokoi, N., & Voon, L. W. (2003) · Experimental Eye Research · doi:10.1016/j.exer.2003.09.019 · Cited by 784 · see citing works
Solomon, A., Dursun, D., Liu, Z., Xie, Y., Macrì, A., & Pflugfelder, S. C. (2001) · PubMed · Cited by 725 · see citing works
Pflugfelder, S. C., Jones, D., Ji, Z., Afonso, A. A., & Monroy, D. C. (1999) · Current Eye Research · doi:10.1076/ceyr.19.3.201.5309 · Cited by 616 · see citing works
Fluorescence-based glucose sensors
Pickup, J. C., Hussain, F., Evans, N. D., Rolinski, O. J., & Birch, D. J. S. (2005) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2004.10.002 · Cited by 616 · see citing works
Kratz (2004) · doi:10.1056/nejmcpc049016 · Cited by 593 · see citing works
Human body fluid proteome analysis
Hu, S., Loo, J. A., & Wong, D. T. (2006) · PROTEOMICS · doi:10.1002/pmic.200600284 · Cited by 530 · see citing works
A contact lens with embedded sensor for monitoring tear glucose level
Yao, H., Shum, A. J., Cowan, M., Lähdesmäki, I., & Parviz, B. A. (2011) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2010.12.042 · Cited by 513 · see citing works
Definition of glaucoma: clinical and experimental concepts
Casson, R. J., Chidlow, G., Wood, J. P. M., Crowston, J. G., & Goldberg, I. (2012) · Clinical and Experimental Ophthalmology · doi:10.1111/j.1442-9071.2012.02773.x · Cited by 510 · see citing works
Berman, E. R. (1991) · Springer eBooks · doi:10.1007/978-1-4757-9441-0 · Cited by 476 · see citing works
Commercialization of microfluidic devices
Volpatti, L. R., & Yetisen, A. K. (2014) · Trends in biotechnology · doi:10.1016/j.tibtech.2014.04.010 · Cited by 437 · see citing works
Self-citationPhotonic Crystal Glucose-Sensing Material for Noninvasive Monitoring of Glucose in Tear Fluid
Alexeev, V. L., Das, S., Finegold, D. N., & Asher, S. A. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2004.039701 · Cited by 370 · see citing works
Russell, R. J., Pishko, M. V., Gefrides, C. C., McShane, M. J., & Coté, G. L. (1999) · Analytical Chemistry · doi:10.1021/ac990060r · Cited by 354 · see citing works
Fluid, Electrolyte, and Acid-Base Disorders in Small Animal Practice
DiBartola, S. P. (2012) · Elsevier eBooks · doi:10.1016/c2009-0-60133-1 · Cited by 351 · see citing works
Tear analysis in ocular surface diseases
Zhou, L., & Beuerman, R. W. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.06.002 · Cited by 318 · see citing works
Wireless contact lens sensor for intraocular pressure monitoring: assessment on enucleated pig eyes
Leonardi, M., Pitchon, E. M., Bertsch, A., Renaud, P., & Mermoud, A. (2009) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.2008.01404.x · Cited by 300 · see citing works
Imaging of the Dynamics of Glucose Uptake in the Cytosol of COS-7 Cells by Fluorescent Nanosensors
Fehr, M., Lalonde, S., Lager, I., Wolff, M. W., & Frommer, W. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301333200 · Cited by 295 · see citing works
Fast Responsive Crystalline Colloidal Array Photonic Crystal Glucose Sensors
Ben-Moshe, M., Alexeev, V. L., & Asher, S. A. (2006) · Analytical Chemistry · doi:10.1021/ac060643i · Cited by 292 · see citing works
A smartphone algorithm with inter-phone repeatability for the analysis of colorimetric tests
Yetisen, A. K., Martinez-Hurtado, J. L., Garcia-Melendrez, A., da Cruz Vasconcellos, F., & Lowe, C. R. (2014) · Sensors and Actuators B: Chemical · doi:10.1016/j.snb.2014.01.077 · Cited by 285 · see citing works
Self-citationChu, M. X., Miyajima, K., Takahashi, D., Arakawa, T., Sano, K., Sawada, S.-I., Kudo, H., Iwasaki, Y., Akiyoshi, K., Mochizuki, M., et al. (2011) · Talanta · doi:10.1016/j.talanta.2010.10.055 · Cited by 279 · see citing works
Design and Analysis of Clinical Trials: Concepts and Methodologies
Chow, S., & Liu, J. (2013) · Cited by 272 · see citing works
Protein levels in nonstimulated and stimulated tears of normal human subjects.
Fullard, R. J., & Snyder, C. (1990) · PubMed · Cited by 250 · see citing works
24-Hour Monitoring of Intraocular Pressure in Glaucoma Management: A Retrospective Review
Hughes, E. H., Spry, P., & Diamond, J. P. (2003) · Journal of Glaucoma · doi:10.1097/00061198-200306000-00009 · Cited by 242 · see citing works
Tears as a source of biomarkers for ocular and systemic diseases
Hohenstein-Blaul, N. V. T. U., Funke, S., & Grus, F. H. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.07.015 · Cited by 236 · see citing works
Laboratory findings in tear fluid analysis
Ohashi, Y., Doğru, M., & Tsubota, K. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.12.035 · Cited by 236 · see citing works
Inflammatory Markers in the Tears of Patients with Ocular Surface Disease
Acera, A., Rocha, G., Vecino, E., Lema, I., & Durán, J. A. (2008) · Ophthalmic Research · doi:10.1159/000150445 · Cited by 229 · see citing works
Holographic Sensors: Three-Dimensional Analyte-Sensitive Nanostructures and Their Applications
Yetisen, A. K., Naydenova, I., da Cruz Vasconcellos, F., Blyth, J., & Lowe, C. R. (2014) · Chemical Reviews · doi:10.1021/cr500116a · Cited by 224 · see citing works
Self-citationA contact lens with an integrated lactate sensor
Thomas, N., Lähdesmäki, I., & Parviz, B. A. (2012) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2011.12.049 · Cited by 220 · see citing works
24-hour monitoring of intraocular pressure in glaucoma management: a retrospective review
Hughes, E. L., Spry, P., & Diamond, J. (2003) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2003.10.008 · Cited by 216 · see citing works
Biofuel cell as a power source for electronic contact lenses
Falk, M., Andoralov, V., Blum, Z., Sotres, J., Suyatin, D. B., Ruzgas, T. A., Arnebrant, T., & Shleev, S. (2012) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2012.04.030 · Cited by 211 · see citing works
Tear glucose analysis for the noninvasive detection and monitoring of diabetes mellitus
Baca, J. T., Finegold, D. N., & Asher, S. A. (2007) · The Ocular Surface · doi:10.1016/s1542-0124(12)70094-0 · Cited by 187 · see citing works
Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues
Tuchin, V. V. (2008) · CRC Press eBooks · doi:10.1201/9781584889755 · Cited by 186 · see citing works
Investigation of the human tear film proteome using multiple proteomic approaches.
Green‐Church, K. B., Nichols, K. K., Kleinholz, N. M., Zhang, L., & Nichols, J. J. (2008) · PubMed Central · Cited by 184 · see citing works
Kabilan, S., Marshall, A. J., Sartain, F. K., Lee, M., Hussain, A., Yang, X., Blyth, J., Karangu, N., James, K., Zeng, J., et al. (2004) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2004.07.005 · Cited by 168 · see citing works
Self-citationGaras, A., Vargha, P., & Holló, G. (2010) · Eye · doi:10.1038/eye.2010.139 · Cited by 158 · see citing works
初, 明. (2011) · Medical Entomology and Zoology · Cited by 157 · see citing works
The effect of collection technique on tear composition.
Stuchell, R. N., Feldman, J. J., Farris, R. L., & Mandel, I. D. (1984) · PubMed · Cited by 155 · see citing works
Tensile properties of soft contact lens materials
Tranoudis, I., & Efron, N. (2004) · Contact Lens and Anterior Eye · doi:10.1016/j.clae.2004.08.002 · Cited by 150 · see citing works
Proteomic analysis of human meibomian gland secretions
Tsai, P.-I. (2006) · British Journal of Ophthalmology · doi:10.1136/bjo.2005.080846 · Cited by 141 · see citing works
Contact lens interactions with the tear film
Mann, A., & Tighe, B. J. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.07.013 · Cited by 138 · see citing works
Capacitive contact lens sensor for continuous non-invasive intraocular pressure monitoring
Chen, G.-Z., Chan, I.-S., & Lam, D. C. C. (2013) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2013.08.029 · Cited by 133 · see citing works
Koo, B.-S., Lee, D., Ha, H.-S., Kim, J., & Kim, C. (2005) · Journal of Proteome Research · doi:10.1021/pr0498133 · Cited by 132 · see citing works
Levels of lactoferrin, secretory IgA and serum albumin in the tear film of people with keratoconus
Balasubramanian, S. A., Pye, D. C., & Willcox, M. D. P. (2011) · Experimental Eye Research · doi:10.1016/j.exer.2011.12.010 · Cited by 132 · see citing works
Water properties of soft contact lens materials
Tranoudis, I., & Efron, N. (2004) · Contact Lens and Anterior Eye · doi:10.1016/j.clae.2004.08.003 · Cited by 129 · see citing works
Reusable, Robust, and Accurate Laser-Generated Photonic Nanosensor
Yetisen, A. K., Montelongo, Y., da Cruz Vasconcellos, F., Martinez-Hurtado, J. L., Neupane, S., Butt, H., Qasim, M. M., Blyth, J., Burling, K., Carmody, J. B., et al. (2014) · Nano Letters · doi:10.1021/nl5012504 · Cited by 123 · see citing works
Self-citationLight‐Directed Writing of Chemically Tunable Narrow‐Band Holographic Sensors
Yetisen, A. K., Butt, H., da Cruz Vasconcellos, F., Montelongo, Y., Davidson, C. A. B., Blyth, J., Chan, L., Carmody, J. B., Vignolini, S., Steiner, U., et al. (2014) · Advanced Optical Materials · doi:10.1002/adom.201300375 · Cited by 123 · see citing works
Self-citationMalvitte, L., Montange, T., Véjux, A., Baudouin, C., Bron, A. M., Creuzot-Garcher, C. P., & Lizard, G. (2006) · British Journal of Ophthalmology · doi:10.1136/bjo.2006.101485 · Cited by 122 · see citing works
The regulation of mobile medical applications
Yetisen, A. K., Martinez-Hurtado, J. L., Vasconcellos, F. D. C., Simsekler, M. C. E., Akram, M. S., & Lowe, C. R. (2014) · Lab on a Chip · doi:10.1039/c3lc51235e · Cited by 115 · see citing works
Self-citationLab-on-a-Chip Devices and Micro-Total Analysis Systems
Castillo-León, J., & Svendsen, W. E. (2014) · Springer eBooks · doi:10.1007/978-3-319-08687-3 · Cited by 111 · see citing works
Stanková, L., Riddle, M. C., Larned, J., Burry, K., Menashe, D., Hart, J., & Bigley, R. H. (1984) · Metabolism · doi:10.1016/0026-0495(84)90197-5 · Cited by 109 · see citing works
Electromagnetic fields (EMF): Do they play a role in children's environmental health (CEH)?
Otto, M., & von Mühlendahl, K. E. (2007) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2007.07.007 · Cited by 109 · see citing works
Liu, R., Meng, F., Zhang, L., Liu, A., Qin, H., Lan, X., Li, L., & Du, G. (2011) · Molecules · doi:10.3390/molecules16032084 · Cited by 104 · see citing works
Yang, X., Pan, X., Blyth, J., & Lowe, C. R. (2008) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2007.09.016 · Cited by 103 · see citing works
Self-citationHypomagnesemia and Inflammation: Clinical and Basic Aspects
Weglicki, W. B. (2012) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071811-150656 · Cited by 103 · see citing works
Two-dimensional analysis of tear protein patterns of diabetic patients
Herber, S., Grus, F. H., Sabuncuo, P., & Augustin, A. J. (2001) · Electrophoresis · doi:10.1002/1522-2683(200105)22:9 · Cited by 102 · see citing works
Gehrmann, C., Persson, J., & Smeets, B. (2004) · Cited by 102 · see citing works
Analysis of tear glucose concentration with electrospray ionization mass spectrometry
Taormina, C. R., Baca, J. T., Asher, S. A., Grabowski, J. J., & Finegold, D. N. (2006) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2006.10.002 · Cited by 99 · see citing works
Tear fluid levels of MMP-8 are elevated in ocular rosacea—treatment effect of oral doxycycline
Määttã, M., Kari, O., Tervahartiala, T. I., Peltonen, S., Kari, M., Saari, M., & Sorsa, T. A. (2006) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-005-0212-3 · Cited by 98 · see citing works
Mottet, B., Aptel, F., Romanet, J.-P., Hubanova, R., Pépin, J.-L., & Chiquet, C. (2013) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2013.5297 · Cited by 94 · see citing works
Excretion of Urea, Sodium, Potassium and Chloride in Human Tears
Thaysen, J. H., & Thorn, N. A. (1954) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1954.178.1.160 · Cited by 93 · see citing works
Glucose‐sensitive holographic sensors
Kabilan, S., Blyth, J., Lee, M. C., Marshall, A. J., Hussain, A., Yang, X., & Lowe, C. R. (2004) · Journal of Molecular Recognition · doi:10.1002/jmr.663 · Cited by 91 · see citing works
Self-citationLacryglobin in human tears, a potential marker for cancer
Evans, V., Vockler, C., Friedlander, M. L., Walsh, B. J., & Willcox, M. D. P. (2001) · Clinical and Experimental Ophthalmology · doi:10.1046/j.1442-9071.2001.00408.x · Cited by 90 · see citing works
Grus, F. H., Joachim, S. C., & Pfeiffer, N. (2007) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200700105 · Cited by 83 · see citing works
Initial Clinical Testing of a Holographic Non-Invasive Contact Lens Glucose Sensor
Domschke, A., March, W. F., Kabilan, S., & Lowe, C. (2006) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2006.8.89 · Cited by 81 · see citing works
Self-citationTherapeutic uses of contact lenses
McDermott, M. L., & Chandler, J. (1989) · Survey of Ophthalmology · doi:10.1016/0039-6257(89)90015-5 · Cited by 80 · see citing works
Alterations in the Tear Proteome of Dry Eye Patients—A Matter of the Clinical Phenotype
Boehm, N., Funke, S., Wiegand, M., Wehrwein, N., Pfeiffer, N., & Grus, F. H. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8751 · Cited by 80 · see citing works
Intra- and inter-day variation of cytokines and chemokines in tears of healthy subjects
Benito, M. J., González-García, M. J., Tesón, M., García, N., Fernández, I., Calonge, M., & Enríquez‐de‐Salamanca, A. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2013.12.017 · Cited by 79 · see citing works
Haeringen, N. J. V., & Glasius, E. (1977) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/bf00496763 · Cited by 75 · see citing works
Clinical Trial of a Noninvasive Contact Lens Glucose Sensor
March, W. F., Mueller, A., & Herbrechtsmeier, P. (2004) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2004.6.782 · Cited by 74 · see citing works
1968 International Solid-State Circuits Conference
(1968) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.1968.1049838 · Cited by 74 · see citing works
Printable Surface Holograms via Laser Ablation
Vasconcellos, F. D. C., Yetisen, A. K., Montelongo, Y., Butt, H., Grigore, A., Davidson, C. A. B., Blyth, J., Monteiro, M. J., Wilkinson, T. D., & Lowe, C. R. (2014) · ACS Photonics · doi:10.1021/ph400149m · Cited by 72 · see citing works
Self-citationUltrasensitive Piezoresistive All‐Organic Flexible Thin Films
Laukhina, E. E., Pfattner, R., Ferreras, L. R., Galli, S., Mas‐Torrent, M., Masciocchi, N., Laukhin, V. N., Rovira, C., & Veciana, J. (2009) · Advanced Materials · doi:10.1002/adma.200902639 · Cited by 71 · see citing works
Pulsed laser writing of holographic nanosensors
Yetisen, A. K., Qasim, M. M., Nosheen, S., Wilkinson, T. D., & Lowe, C. R. (2014) · Journal of Materials Chemistry C · doi:10.1039/c3tc32507e · Cited by 67 · see citing works
Self-citationComplex Antibody Profile Changes in an Experimental Autoimmune Glaucoma Animal Model
Joachim, S. C., Grus, F. H., Kraft, D., White-Farrar, K., Barnes, G., Barbeck, M., Ghanaati, S., Cao, S., Li, B., & Wax, M. B. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-3144 · Cited by 67 · see citing works
The Fall and Rise of Tear Albumin Levels: A Multifactorial Phenomenon
Eden, G. R., Mann, A., & Tighe, B. J. (2013) · The Ocular Surface · doi:10.1016/j.jtos.2013.03.001 · Cited by 65 · see citing works
A microsystem-based assay for studying pollen tube guidance in plant reproduction
Yetisen, A. K., Jiang, L., Cooper, J., Qin, Y., Palanivelu, R., & Zohar, Y. (2011) · Journal of Micromechanics and Microengineering · doi:10.1088/0960-1317/21/5/054018 · Cited by 63 · see citing works
Self-citationZhou, L., Beuerman, R. W., Ang, L. P. K., Chan, C. M., Li, S. F. Y., Chew, F. T., & Tan, D. T. H. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2604 · Cited by 63 · see citing works
The effect of an artificially elevated intraocular pressure on the central corneal curvature
Lam, A. K. C. (1997) · Ophthalmic and Physiological Optics · doi:10.1016/s0275-5408(96)00033-6 · Cited by 63 · see citing works
Tolerability of 24-Hour Intraocular Pressure Monitoring of a Pressure-sensitive Contact Lens
Lorenz, K., Korb, C. A., Herzog, N., Vetter, J. M., Elflein, H. M., Keilani, M. M., & Pfeiffer, N. (2013) · Journal of Glaucoma · doi:10.1097/ijg.0b013e318241b874 · Cited by 58 · see citing works
Fluorescent Measurement in the Non-Invasive Contact Lens Glucose Sensor
March, W., Lazzaro, D., & Rastogi, S. (2006) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2006.8.312 · Cited by 58 · see citing works
Laukhin, V., Sánchez, I., Moya, A., Laukhina, E., Martin, R., Ussa, F., Rovira, C., Guimera, A., Villa, R., Aguiló, J., et al. (2011) · Sensors and Actuators A: Physical · doi:10.1016/j.sna.2011.05.021 · Cited by 57 · see citing works
DAUM, K. M., & Hill, R. M. (1982) · PubMed · Cited by 56 · see citing works
Vitamin C Levels in Human Tears
Paterson, C. A., & O'Rourke, M. C. (1987) · Archives of Ophthalmology · doi:10.1001/archopht.1987.01060030096034 · Cited by 56 · see citing works
Computational modelling and characterisation of nanoparticle-based tuneable photonic crystal sensors
Tsangarides, C. P., Yetisen, A. K., Vasconcellos, F. D. C., Montelongo, Y., Qasim, M. M., Wilkinson, T. D., Lowe, C. R., & Butt, H. (2014) · RSC Advances · doi:10.1039/c3ra47984f · Cited by 55 · see citing works
Self-citationGlaucoma: diagnosis and management
Infeld, D. A., & O'shea, J. G. (1998) · Postgraduate Medical Journal · doi:10.1136/pgmj.74.878.709 · Cited by 54 · see citing works
Lack of Compliance With Home Blood Glucose Monitoring Predicts Hospitalization in Diabetes
Burge, M. R. (2001) · Diabetes Care · doi:10.2337/diacare.24.8.1502 · Cited by 54 · see citing works
Changes in Tear Protein Profile in Patients With Conjunctivochalasis
Acera, A., Suárez, T., Rodríguez-Agirretxe, I., Vecino, E., & Durán, J. A. (2010) · Cornea · doi:10.1097/ico.0b013e3181dea7d7 · Cited by 53 · see citing works
Proteomic analysis of dog tears for potential cancer markers
Campos, C. D. F., Cole, N., Dyk, D. D. V., Walsh, B. J., Diakos, P., de Almeida, D. E., Torrecilhas, A., Laus, J. L., & Willcox, M. D. P. (2008) · Research in Veterinary Science · doi:10.1016/j.rvsc.2007.11.006 · Cited by 52 · see citing works
Hubanova, R., Aptel, F., Chiquet, C., Mottet, B., & Romanet, J. (2014) · Acta Ophthalmologica · doi:10.1111/aos.12241 · Cited by 51 · see citing works
Eye Blink Rate as a biological marker of Mild Cognitive Impairment
Ladas, A. I., Frantzidιs, C. A., Bamidis, P. D., & Vivas, A. B. (2013) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2013.07.010 · Cited by 50 · see citing works
Mathew, M. E., & Sandhyarani, N. (2013) · Electrochimica Acta · doi:10.1016/j.electacta.2013.07.010 · Cited by 50 · see citing works
In-eye performance of soft contact lenses made from different materials
Tranoudis, I., & Efron, N. (2004) · Contact Lens and Anterior Eye · doi:10.1016/j.clae.2004.02.004 · Cited by 48 · see citing works
Naroo, S. A. (2016) · Cited by 48 · see citing works
Frauscher, B., Ehrmann, L., & Högl, B. (2012) · Sleep Medicine · doi:10.1016/j.sleep.2012.09.028 · Cited by 46 · see citing works
Proteomics in Autoimmune Thyroid Eye Disease
Okrojek, R., Grus, F. H., Matheis, N., & Kahaly, G. J. (2009) · Hormone and Metabolic Research · doi:10.1055/s-0029-1214413 · Cited by 45 · see citing works
Immunoglobulin concentrations in human tears in ocular diseases.
Sen, D., & Gs, S. (1979) · British Journal of Ophthalmology · doi:10.1136/bjo.63.5.297 · Cited by 45 · see citing works
Patent protection and licensing in microfluidics
Yetisen, A. K., & Volpatti, L. R. (2014) · Lab on a Chip · doi:10.1039/c4lc00399c · Cited by 40 · see citing works
Self-citationCompositional Profiling and Biomarker Identification of the Tear Film
Jacob, J. T., & Ham, B. M. (2008) · The Ocular Surface · doi:10.1016/s1542-0124(12)70178-7 · Cited by 37 · see citing works
A Wireless Health Monitoring System based on Android Operating System
Lou, D., Chen, X., Zhao, Z., Xuan, Y., Xu, Z., Jin, H., Guo, X., & Fang, Z. (2013) · IERI Procedia · doi:10.1016/j.ieri.2013.11.030 · Cited by 35 · see citing works
Malik, B. H., & Coté, G. L. (2010) · Journal of Biomedical Optics · doi:10.1117/1.3447923 · Cited by 35 · see citing works
Surface enhanced Raman scattering of herpes simplex virus in tear film
Reyes-Goddard, J., Barr, H., & Stone, N. (2008) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2008.01.002 · Cited by 34 · see citing works
Computational modelling of a graphene Fresnel lens on different substrates
Deng, S., Yetisen, A. K., Jiang, K. S., & Butt, H. (2014) · RSC Advances · doi:10.1039/c4ra03991b · Cited by 34 · see citing works
Self-citationAndoralov, V., Shleev, S., Arnebrant, T., & Ruzgas, T. A. (2013) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-013-6756-x · Cited by 34 · see citing works
Corneal thickness after overnight wear of an intraocular pressure fluctuation contact lens sensor
Freiberg, F. J., Lindell, J., Thederan, L., Leippi, S., Shen, Y., & Klink, T. (2012) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.2012.02495.x · Cited by 33 · see citing works
Cerebrospinal fluid lactate and pyruvate concentrations and their ratio
Zhang, W., & Natowicz, M. R. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.11.008 · Cited by 31 · see citing works
Powering electronic contact lenses: current achievements, challenges, and perspectives
Blum, Z., Pankratov, D., & Shleev, S. (2014) · Expert Review of Ophthalmology · doi:10.1586/17469899.2014.922873 · Cited by 31 · see citing works
Fibre optics sensors in tear electrolyte analysis: Towards a novel point of care potassium sensor
Harvey, D., Hayes, N. W., & Tighe, B. J. (2012) · Contact Lens and Anterior Eye · doi:10.1016/j.clae.2012.02.004 · Cited by 28 · see citing works
Torgrip, R. J. O., Lindberg, J., Linder, M., Karlberg, B., Jacobsson, S. P., Kolmert, J., Gustafsson, I., & Schuppe‐Koistinen, I. (2006) · Metabolomics · doi:10.1007/s11306-005-0013-z · Cited by 27 · see citing works
Singh, D., & Saxena, R. (2012) · Expert Review of Ophthalmology · doi:10.1586/eop.12.35 · Cited by 26 · see citing works
Changes in the Tear Protein Patterns of Diabetic Patients Using Two-Dimensional Electrophoresis
Herber, S., Grus, F. H., Sabuncuo, P., & Augustin, A. J. (2002) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0717-8_88 · Cited by 25 · see citing works
Contact Lens Optics and Lens Design
(2006) · Elsevier eBooks · doi:10.1016/b978-0-7506-8879-6.x5001-5 · Cited by 24 · see citing works
Enhanced reflection from inverse tapered nanocone arrays
Kong, X., Butt, H., Yetisen, A. K., Kangwanwatana, C., Montelongo, Y., Deng, S., Vasconcellos, F. D. C., Qasim, M. M., Wilkinson, T. D., & Dai, Q. (2014) · Applied Physics Letters · doi:10.1063/1.4892580 · Cited by 24 · see citing works
Self-citationFarkas, Á., Vámos, R., Bajor, T., Müllner, N., Lazar, A. C., & Hrabá, A. (2003) · Experimental Eye Research · doi:10.1016/s0014-4835(02)00276-2 · Cited by 21 · see citing works
Nanomedical Device and Systems Design
Boehm, F. (2013) · CRC Press eBooks · doi:10.1201/b15626 · Cited by 19 · see citing works
Antibodies in human tears during and after infection
Friedman, M. G. (1990) · Survey of Ophthalmology · doi:10.1016/0039-6257(90)90070-c · Cited by 18 · see citing works
Patel, J. N., Gray, B. L., Kaminska, B., & Gates, B. D. (2011) · Journal of Diabetes Science and Technology · doi:10.1177/193229681100500503 · Cited by 18 · see citing works
van Delft, J. L., MEIJER, F., van Best, J. A., & Haeringen, N. J. V. (1997) · Mediators of Inflammation · doi:10.1080/09629359791532 · Cited by 18 · see citing works
Auvray, P., Rousseau, L., Lissorgues, G., Soulier, F., Potin, O., Bernard, S., de Dieuleveult, F., Scorsone, E., Bergonzo, P., Chicaud, L., et al. (2012) · IRBM · doi:10.1016/j.irbm.2012.01.002 · Cited by 16 · see citing works
HIV-specific IgA antibodies in tears of children with aids or at risk of AIDS
Renom, G., Bouquety, J. C., Lanckriet, C., Georges, A. J., Siopathis, M. R., & Martin, P. M. V. (1990) · Research in Virology · doi:10.1016/0923-2516(90)90007-6 · Cited by 16 · see citing works
Time series analysis of age related cataract hospitalizations and phacoemulsification
Leong, A. M., Crighton, E., Moineddin, R., Mamdani, M., & Upshur, R. E. G. (2006) · BMC Ophthalmology · doi:10.1186/1471-2415-6-2 · Cited by 15 · see citing works
Quantitative Analyse der Tränenproteinmuster bei weichen Kontaktlinsen - Klinische Studie1
Grus, F. H., Sabuncuo, P., & Augustin, A. J. (2001) · Klinische Monatsblätter für Augenheilkunde · doi:10.1055/s-2001-14920 · Cited by 14 · see citing works
Contact lens optics and lens design
Whittle, J. P. (2007) · Eye · doi:10.1038/sj.eye.6702607 · Cited by 13 · see citing works
Detection of Antichlamydial Antibodies in Tears
Haller, E.-M., Auer‐Grumbach, P., Stünzner, D., Kessler, H. H., Pierer, K., Müllner, K., & Zenz, H. (1997) · Ophthalmology · doi:10.1016/s0161-6420(97)30350-9 · Cited by 10 · see citing works
A personal perspective on the history of contact lenses
GOODLAW, E. I. (2000) · International Contact Lens Clinic · doi:10.1016/s0892-8967(02)00085-8 · Cited by 10 · see citing works
March, W. F. (2002) · Diabetes Technology & Therapeutics · doi:10.1089/15209150252924085 · Cited by 6 · see citing works
Fink, B. A., Mitchell, G. L., & Hill, R. M. (2006) · Optometry and Vision Science · doi:10.1097/01.opx.0000232806.06677.97 · Cited by 5 · see citing works
[Do you wear contact lenses?].
Dm, W., & Pratt-Johnson, J. A. (1965) · PubMed · Cited by 1 · see citing works
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Wearable biosensors for healthcare monitoring
Kim, J., Campbell, A. S., de Ávila, B. E.-F., & Wang, J. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0045-y · Cited by 3,373 · see citing works
Advanced Carbon for Flexible and Wearable Electronics
Wang, C., Xia, K., Wang, H., Liang, X., Yin, Z., & Zhang, Y. (2018) · Advanced Materials · doi:10.1002/adma.201801072 · Cited by 1,304 · see citing works
Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics
Kim, J., Kim, M., Lee, M.-S., Kim, K., Ji, S., Kim, Y.-T., Park, J., Na, K., Bae, K.-H., Kyun Kim, H., et al. (2017) · Nature Communications · doi:10.1038/ncomms14997 · Cited by 951 · see citing works
Electrochemical glucose sensors in diabetes management: an updated review (2010–2020)
Teymourian, H., Barfidokht, A., & Wang, J. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00304b · Cited by 890 · see citing works
Enzyme‐Based Glucose Sensor: From Invasive to Wearable Device
Lee, H., Hong, Y. J., Baik, S., Hyeon, T., & Kim, D. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201701150 · Cited by 778 · see citing works
Electrospinning for drug delivery applications: A review
Luraghi, A., Peri, F., & Moroni, L. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.03.033 · Cited by 766 · see citing works
Accessing analytes in biofluids for peripheral biochemical monitoring
Heikenfeld, J., Jajack, A., Feldman, B., Granger, S. W., Gaitonde, S., Begtrup, G., & Katchman, B. A. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0040-3 · Cited by 758 · see citing works
Yetisen, A. K., Qu, H., Manbachi, A., Butt, H., Dokmeci, M. R., Hinestroza, J. P., Skorobogatiy, M., Khademhosseini, A., & Yun, S. H. (2016) · ACS Nano · doi:10.1021/acsnano.5b08176 · Cited by 752 · see citing works
Self-citationEmerging Technologies for Next-Generation Point-of-Care Testing
Vashist, S. K., Luppa, P. B., Yeo, L. Y., Özcan, A., & Luong, J. H. T. (2015) · Trends in biotechnology · doi:10.1016/j.tibtech.2015.09.001 · Cited by 706 · see citing works
Soft, smart contact lenses with integrations of wireless circuits, glucose sensors, and displays
Park, J., Kim, J., Kim, S.-Y., Cheong, W. H., Jang, J., Park, Y.-G., Na, K., Kim, Y.-T., Heo, J. H., Lee, C. Y., et al. (2018) · Science Advances · doi:10.1126/sciadv.aap9841 · Cited by 671 · see citing works
Yetisen, A. K., Martinez‐Hurtado, J. L., Ünal, B., Khademhosseini, A., & Butt, H. (2018) · Advanced Materials · doi:10.1002/adma.201706910 · Cited by 569 · see citing works
Self-citationShrivastava, S., Trung, T. Q., & Lee, N. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00319c · Cited by 495 · see citing works
Commercial hydrogels for biomedical applications
Aswathy, S. H., NarendraKumar, U., & Manjubala, I. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03719 · Cited by 487 · see citing works
Toward a new generation of smart skins
Someya, T., & Amagai, M. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0079-1 · Cited by 485 · see citing works
Wireless smart contact lens for diabetic diagnosis and therapy
Keum, D. H., Kim, S.-K., Koo, J., Lee, G.-H., Jeon, C., Mok, J. W., Mun, B. H., Lee, K. J., Kamrani, E., Joo, C.-K., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba3252 · Cited by 483 · see citing works
Self-citationFlexible Wearable Sensors for Cardiovascular Health Monitoring
Chen, S., Qi, J., Fan, S., Qiao, Z., Yeo, J. C., & Lim, C. T. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202100116 · Cited by 453 · see citing works
Wearable Electrochemical Glucose Sensors in Diabetes Management: A Comprehensive Review
Saha, T., Del Caño, R., Mahato, K., De la Paz, E., Chen, C., Ding, S., Yin, L., & Wang, J. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00078 · Cited by 442 · see citing works
Applications of nanotechnology in smart textile industry: A critical review
Shah, M. A., Pirzada, B. M., Price, G. J., Shibiru, A. L., & Qurashi, A. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.01.008 · Cited by 426 · see citing works
Wearable Biosensors: An Alternative and Practical Approach in Healthcare and Disease Monitoring
Sharma, A., Badea, M., Tiwari, S., & Marty, J. (2021) · Molecules · doi:10.3390/molecules26030748 · Cited by 373 · see citing works
From Diagnosis to Treatment: Recent Advances in Patient-Friendly Biosensors and Implantable Devices
Li, P., Lee, G., Kim, S. Y., Kwon, S. Y., Kim, H., & Park, S. (2021) · ACS Nano · doi:10.1021/acsnano.0c06688 · Cited by 362 · see citing works
The Era of Digital Health: A Review of Portable and Wearable Affinity Biosensors
Tu, J., Torrente-Rodríguez, R. M., Wang, M., & Gao, W. F. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201906713 · Cited by 359 · see citing works
Wearable and Miniaturized Sensor Technologies for Personalized and Preventive Medicine
Tricoli, A., Nasiri, N., & De, S. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201605271 · Cited by 347 · see citing works
Graphene-Based Sensors for Human Health Monitoring
Huang, H., Su, S., Wu, N., Wan, H., Wan, S., Bi, H., & Sun, L. (2019) · Frontiers in Chemistry · doi:10.3389/fchem.2019.00399 · Cited by 336 · see citing works
Fog Computing in Healthcare–A Review and Discussion
Kraemer, F. A., Bråten, A. E., Tamkittikhun, N., & Palma, D. (2017) · IEEE Access · doi:10.1109/access.2017.2704100 · Cited by 335 · see citing works
Wearable potentiometric ion sensors
Parrilla, M., Cuartero, M., & Crespo, G. A. (2018) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2018.11.024 · Cited by 334 · see citing works
Stretchable wireless system for sweat pH monitoring
Dang, W., Manjakkal, L., Navaraj, W. T., Lorenzelli, L., Vinciguerra, V., & Dahiya, R. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2018.02.025 · Cited by 326 · see citing works
Yao, S., Ren, P., Song, R., Liu, Y., Huang, Q., Dong, J., O’Connor, B. T., & Zhu, Y. (2019) · Advanced Materials · doi:10.1002/adma.201902343 · Cited by 326 · see citing works
Eyeglasses-based tear biosensing system: Non-invasive detection of alcohol, vitamins and glucose
Sempionatto, J. R., Brazaca, L. C., García-Carmona, L., Bolat, G., Campbell, A. S., Martin, A., Tang, G., Shah, R., Mishra, R. K., Kim, J., et al. (2019) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2019.04.058 · Cited by 315 · see citing works
Progress and challenges in fabrication of wearable sensors for health monitoring
Nasiri, S., & Khosravani, M. R. (2020) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2020.112105 · Cited by 301 · see citing works
Electrochemical Glucose Sensing: Is There Still Room for Improvement?
Nery, E. W., Kundys, M., Jeleń, P. S., & Jönsson‐Niedziółka, M. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b03151 · Cited by 292 · see citing works
Smart, soft contact lens for wireless immunosensing of cortisol
Ku, M., Kim, J., Won, J., Kang, W., Park, Y., Park, J., Lee, J., Cheon, J., Lee, H. H., & Park, J. (2020) · Science Advances · doi:10.1126/sciadv.abb2891 · Cited by 274 · see citing works
Contact Lens Technology: From Fundamentals to Applications
Moreddu, R., Vigolo, D., & Yetisen, A. K. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900368 · Cited by 266 · see citing works
Self-citationLee, S., Jo, I., Kang, S., Jang, B., Moon, J., Park, J. B., Lee, S., Rho, S. K., Kim, Y., & Hong, B. H. (2017) · ACS Nano · doi:10.1021/acsnano.7b00370 · Cited by 255 · see citing works
Wearable artificial intelligence biosensor networks
Zhang, Y., Hu, Y., Jiang, N., & Yetisen, A. K. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114825 · Cited by 241 · see citing works
Self-citationThree-dimensional curvy electronics created using conformal additive stamp printing
Sim, K., Chen, S., Li, Z., Rao, Z., Liu, J., Lu, Y., Jang, S., Ershad, F., Chen, J., Xiao, J., et al. (2019) · Nature Electronics · doi:10.1038/s41928-019-0304-4 · Cited by 231 · see citing works
Hong, Y. J., Lee, H., Kim, J., Lee, M., Choi, H. J., Hyeon, T., & Kim, D. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201805754 · Cited by 229 · see citing works
Bioadhesive Technology Platforms
Wu, S. J., & Zhao, X. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00380 · Cited by 228 · see citing works
Chitosan in Biomedical Engineering: A Critical Review
Mohebbi, S., Nasirinezhad, M., Zarrintaj, P., Jafari, S. H., Gholizadeh, S. S., Saeb, M. R., & Mozafari, M. (2018) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x13666180912142028 · Cited by 227 · see citing works
Biomolecular sensors for advanced physiological monitoring
Flynn, C. D., Chang, D., Mahmud, A., Yousefi, H., Das, J., Riordan, K. T., Sargent, E. H., & Kelley, S. O. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00067-z · Cited by 226 · see citing works
Recent Advances in Transparent Electronics with Stretchable Forms
Kim, K., Park, Y., Hyun, B. G., Choi, M., & Park, J. (2018) · Advanced Materials · doi:10.1002/adma.201804690 · Cited by 223 · see citing works
Yao, Y., Chen, J., Guo, Y., Lv, T., Chen, Z., Li, N., Cao, S., Chen, B., & Chen, T. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113078 · Cited by 212 · see citing works
Molecular Semiconductors for Logic Operations: Dead‐End or Bright Future?
Schweicher, G., Garbay, G., Jouclas, R., Vibert, F., Devaux, F., & Geerts, Y. H. (2020) · Advanced Materials · doi:10.1002/adma.201905909 · Cited by 204 · see citing works
Wearable Biofuel Cells: A Review
Bandodkar, A. J., & Wang, J. (2016) · Electroanalysis · doi:10.1002/elan.201600019 · Cited by 193 · see citing works
Yetisen, A. K., Butt, H., Volpatti, L. R., Pavlichenko, I., Humar, M., Kwok, S. J. J., Koo, H., Kim, K. S., Naydenova, I., Khademhosseini, A., et al. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.10.005 · Cited by 192 · see citing works
Self-citationWearable flexible microfluidic sensing technologies
Chen, S., Zheng, Q., Niu, Y., Yeo, J. C., Liu, Y., Qi, J., Fan, S., Liu, X., Lee, J. Y., & Lim, C. T. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00094-w · Cited by 189 · see citing works
de Castro, L. F., de Freitas, S. V., Duarte, L. C., de Souza, J. A. C., Paixão, T. R. L. C., & Coltro, W. K. T. (2019) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-019-01788-0 · Cited by 187 · see citing works
Graphene-enabled wearable sensors for healthcare monitoring
Zhang, H., He, R., Niu, Y., Han, F., Li, J., Zhang, X., & Xu, F. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113777 · Cited by 185 · see citing works
Kim, S., Lee, G., Jeon, C., Han, H. H., Kim, S., Mok, J. W., Joo, C., Shin, S., Sim, J., Myung, D. J., et al. (2022) · Advanced Materials · doi:10.1002/adma.202110536 · Cited by 184 · see citing works
eHealth in the future of medications management: personalisation, monitoring and adherence
Car, J., Tan, W. S., Huang, Z., Sloot, P., & Franklin, B. D. (2017) · BMC Medicine · doi:10.1186/s12916-017-0838-0 · Cited by 179 · see citing works
Integrated contact lens sensor system based on multifunctional ultrathin MoS2 transistors
Guo, S., Wu, K., Li, C., Wang, H., Sun, Z., Xi, D., Zhang, S., Ding, W., Zaghloul, M. E., Wang, C., et al. (2020) · Matter · doi:10.1016/j.matt.2020.12.002 · Cited by 178 · see citing works
Glaucoma: Current treatment and impact of advanced drug delivery systems
Yadav, K. S., Rajpurohit, R., & Sharma, S. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.02.029 · Cited by 177 · see citing works
Recent Progress in Manufacturing Techniques of Printed and Flexible Sensors: A Review
Maddipatla, D., Narakathu, B. B., & Atashbar, M. Z. (2020) · Biosensors · doi:10.3390/bios10120199 · Cited by 175 · see citing works
Ocular Complications of Diabetes and Therapeutic Approaches
Vieira‐Potter, V. J., Karamichos, D., & Lee, D. J. (2016) · BioMed Research International · doi:10.1155/2016/3801570 · Cited by 167 · see citing works
Recent Progress in Wireless Sensors for Wearable Electronics
Park, Y., Lee, S.-I., & Park, J. (2019) · Sensors · doi:10.3390/s19204353 · Cited by 161 · see citing works
Wen, F., He, T., Liu, H., Chen, H., Zhang, T., & Lee, C. (2020) · Nano Energy · doi:10.1016/j.nanoen.2020.105155 · Cited by 160 · see citing works
Fog Computing-Based IoT for Health Monitoring System
Paul, A., Pinjari, H., Hong, W.-H., Seo, H. C., & Rho, S. (2018) · Journal of Sensors · doi:10.1155/2018/1386470 · Cited by 155 · see citing works
Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor
Nightingale, A. M., Leong, C. L., Burnish, R., Hassan, S.-U., Zhang, Y., Clough, G. F., Boutelle, M. G., Voegeli, D., & Niu, X. (2019) · Nature Communications · doi:10.1038/s41467-019-10401-y · Cited by 155 · see citing works
Tseng, R. C., Chen, C.-C., Hsu, S., & Chuang, H.-S. (2018) · Sensors · doi:10.3390/s18082651 · Cited by 153 · see citing works
Electrospun hybrid nanofibers: Fabrication, characterization, and biomedical applications
Abadi, B., Goshtasbi, N., Bolourian, S., Tahsili, J., Adeli‐Sardou, M., & Forootanfar, H. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.986975 · Cited by 153 · see citing works
Yang, C. G., Wu, Q., Liu, J., Mo, J., Li, X., Yang, C., Liu, Z., Yang, J., Jiang, L., Chen, W., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29860-x · Cited by 152 · see citing works
Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management
Seo, H., Chung, W. G., Kwon, Y. W., Kim, S., Hong, Y., Park, W., Kim, E., Lee, J., Lee, S., Kim, M., et al. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00290 · Cited by 152 · see citing works
Paper-based microfluidic system for tear electrolyte analysis
Yetisen, A. K., Jiang, N., Tamayol, A., Ruiz-Esparza, G. U., Zhang, Y. S., Medina-Pando, S., Gupta, A., Wolffsohn, J. S., Butt, H., Khademhosseini, A., et al. (2017) · Lab on a Chip · doi:10.1039/c6lc01450j · Cited by 151 · see citing works
Self-citationThe impact of diabetes on corneal nerve morphology and ocular surface integrity
Markoulli, M. P., Flanagan, J., Tummanapalli, S. S., Wu, J., & Willcox, M. D. P. (2017) · The Ocular Surface · doi:10.1016/j.jtos.2017.10.006 · Cited by 149 · see citing works
Printing Flexible and Hybrid Electronics for Human Skin and Eye‐Interfaced Health Monitoring Systems
Kim, K., Kim, B., & Lee, C. H. (2019) · Advanced Materials · doi:10.1002/adma.201902051 · Cited by 146 · see citing works
Recent Progress in Wearable Biosensors: From Healthcare Monitoring to Sports Analytics
Ye, S., Feng, S., Huang, L. J., & Bian, S. (2020) · Biosensors · doi:10.3390/bios10120205 · Cited by 146 · see citing works
Inkjet‐Printing: A New Fabrication Technology for Organic Transistors
Mattana, G., Loi, A., Woytasik, M., Barbaro, M., Noël, V., & Piro, B. (2017) · Advanced Materials Technologies · doi:10.1002/admt.201700063 · Cited by 140 · see citing works
Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications
Santiago, G. T., Sharifi, R., Yue, K., Sani, E. S., Kashaf, S. S., Álvarez, M. M., Leijten, J., Khademhosseini, A., Dana, R., & Annabi, N. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.01.011 · Cited by 139 · see citing works
Non-invasive wearable chemical sensors in real-life applications
Promphet, N., Ummartyotin, S., Ngeontae, W., Puthongkham, P., & Rodthongkum, N. (2021) · Analytica Chimica Acta · doi:10.1016/j.aca.2021.338643 · Cited by 138 · see citing works
Pankratov, D., González‐Arribas, E., Blum, Z., & Shleev, S. (2016) · Electroanalysis · doi:10.1002/elan.201501116 · Cited by 135 · see citing works
Recent advances in organic sensors for health self-monitoring systems
Lee, Y. H., Kweon, O. Y., Kim, H., Yoo, J. H., Han, S. G., & Oh, J. H. (2018) · Journal of Materials Chemistry C · doi:10.1039/c8tc02230e · Cited by 135 · see citing works
Organic Bioelectronic Devices for Metabolite Sensing
Koklu, A., Ohayon, D., Wustoni, S., Druet, V., Saleh, A., & Inal, S. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00395 · Cited by 134 · see citing works
Jeon, H., Kim, H. S., Chung, E., & Lee, D. Y. (2022) · Theranostics · doi:10.7150/thno.72152 · Cited by 127 · see citing works
Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care
Zhang, J., Kim, K., Kim, H. J., Meyer, D., Park, W., Lee, S. A., Dai, Y., Kim, B., Moon, H., Shah, J. V., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33254-4 · Cited by 126 · see citing works
Review—The Development of Wearable Polymer-Based Sensors: Perspectives
Harito, C., Utari, L., Putra, B. R., Yuliarto, B., Purwanto, S., Zaidi, S. Z. J., Bavykin, D. V., Marken, F., & Walsh, F. C. (2020) · Journal of The Electrochemical Society · doi:10.1149/1945-7111/ab697c · Cited by 123 · see citing works
Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics
Zhu, Y., Li, S., Li, J., Falcone, N., Cui, Q., Shah, S., Hartel, M. C., Yu, N., Young, P., de Barros, N. R., et al. (2022) · Advanced Materials · doi:10.1002/adma.202108389 · Cited by 123 · see citing works
Hybrid Integration of Wearable Devices for Physiological Monitoring
Zhang, Y., Zheng, X. T., Zhang, X., Pan, J., & Thean, A. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00471 · Cited by 122 · see citing works
Mechano‐Based Transductive Sensing for Wearable Healthcare
Wang, T., Yang, H., Qi, D., Liu, Z., Cai, P., Zhang, H., & Chen, X. (2018) · Small · doi:10.1002/smll.201702933 · Cited by 121 · see citing works
Highly self-healable and flexible cable-type pH sensors for real-time monitoring of human fluids
Yoon, J. H., Kim, S., Park, H. J., Kim, Y. K., Oh, D. X., Cho, H.-W., Lee, K. G., Hwang, S. Y., Park, J., & Choi, B. G. (2019) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2019.111946 · Cited by 120 · see citing works
Recent Advances in Smart Contact Lenses
Kim, J., Cha, E., & Park, J. (2019) · Advanced Materials Technologies · doi:10.1002/admt.201900728 · Cited by 118 · see citing works
AI-Enabled Wearable Medical Internet of Things in Healthcare System: A Survey
Subhan, F., Mirza, A., Su’ud, M. B. M., Alam, M. M., Nisar, S., Habib, U., & Iqbal, M. Z. (2023) · Applied Sciences · doi:10.3390/app13031394 · Cited by 117 · see citing works
Soft Electronics for Health Monitoring Assisted by Machine Learning
Qiao, Y., Luo, J., Cui, T., Liu, H., Tang, H., Zeng, Y.-F., Liu, C., Li, Y., Jian, J., Wu, J., et al. (2023) · Nano-Micro Letters · doi:10.1007/s40820-023-01029-1 · Cited by 116 · see citing works
Biofluid‐Activated Biofuel Cells, Batteries, and Supercapacitors: A Comprehensive Review
Garland, N. T., Rajaram, K., & Bandodkar, A. J. (2023) · Advanced Materials · doi:10.1002/adma.202303197 · Cited by 115 · see citing works
Wearable devices for continuous monitoring of biosignals: Challenges and opportunities
Stuart, T., Hanna, J., & Gutruf, P. (2022) · APL Bioengineering · doi:10.1063/5.0086935 · Cited by 114 · see citing works
System Architectures in Wearable Electrochemical Sensors
Steinberg, M. D., Kassal, P., & Steinberg, I. M. (2016) · Electroanalysis · doi:10.1002/elan.201600094 · Cited by 107 · see citing works
Hong, M., Choi, G., Kim, J., Jang, J., Choi, B., Kim, J., Jeong, S., Leem, S., Kwon, H. Y., Hwang, H., et al. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201705480 · Cited by 106 · see citing works
Bioinspired hydrogels for drug-eluting contact lenses
Alvarez‐Lorenzo, C., Anguiano-Igea, S., Varela-García, A., Vivero-Lopez, M., & Concheiro, Á. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.11.020 · Cited by 106 · see citing works
Park, H., Park, W., & Lee, C. H. (2021) · NPG Asia Materials · doi:10.1038/s41427-020-00280-x · Cited by 104 · see citing works
Wearable fluorescent contact lenses for monitoring glucose via a smartphone
Deng, M., Song, G., Zhong, K., Wang, Z., Xi, X., & Tian, Y. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.131067 · Cited by 104 · see citing works
Blood glucose sensors and recent advances: A review
Peng, Z., Xie, X., Tan, Q., Hu, K., Cui, J., Zhang, X., Li, W., & Feng, G. (2022) · Journal of Innovative Optical Health Sciences · doi:10.1142/s1793545822300038 · Cited by 102 · see citing works
Recent advances in flexible and wearable sensors for monitoring chemical molecules
Zhao, H., Su, R., Teng, L., Tian, Q., Han, F., Li, H., Cao, Z., Xie, R., Li, G., Liu, X., et al. (2021) · Nanoscale · doi:10.1039/d1nr06244a · Cited by 101 · see citing works
BCLA CLEAR – Contact lens technologies of the future
Jones, L., Hui, A., Phan, C., Read, M., Azar, D. T., Buch, J. R., Ciolino, J. B., Naroo, S. A., Pall, B., Romond, K., et al. (2021) · Contact Lens and Anterior Eye · doi:10.1016/j.clae.2021.02.007 · Cited by 100 · see citing works
Advanced wearable biosensors for the detection of body fluids and exhaled breath by graphene
Singh, S. U., Chatterjee, S., Lone, S. A., Ho, H.-H., Kaswan, K., Peringeth, K., Khan, A., Chiang, Y., Lee, S., & Lin, Z. (2022) · Microchimica Acta · doi:10.1007/s00604-022-05317-2 · Cited by 100 · see citing works
Manikkath, J., & Subramony, J. A. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113997 · Cited by 98 · see citing works
Recent developments in wearable biosensors for healthcare and biomedical applications
Erdem, A., Ekşin, E., Senturk, H., Yildiz, E., & Maral, M. (2023) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2023.117510 · Cited by 96 · see citing works
Influence of nanotechnology in polymeric textiles, applications, and fight against COVID-19
Idumah, C. I. (2020) · Journal of the Textile Institute · doi:10.1080/00405000.2020.1858600 · Cited by 95 · see citing works
Smart Skin‐Adhesive Patches: From Design to Biomedical Applications
Wong, S. H. D., Deen, G. R., Bates, J. S., Maiti, C., Lam, C. Y. K., Pachauri, A., AlAnsari, R., Bělský, P., Yoon, J., & Dodda, J. M. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202213560 · Cited by 95 · see citing works
Photonic Nanosensor for Colorimetric Detection of Metal Ions
Yetisen, A. K., Montelongo, Y., Qasim, M. M., Butt, H., Wilkinson, T. D., Monteiro, M. J., & Yun, S. H. (2015) · Analytical Chemistry · doi:10.1021/ac504274q · Cited by 94 · see citing works
Self-citationKazemi, N., Abdolrazzaghi, M., Light, P. E., & Musı́lek, P. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115668 · Cited by 93 · see citing works
Ultra-sensitive microfluidic wearable strain sensor for intraocular pressure monitoring
Ağaoğlu, S., Diep, P., Martini, M., Samudhyatha, K. T., Baday, M., & Araci, I. E. (2018) · Lab on a Chip · doi:10.1039/c8lc00758f · Cited by 92 · see citing works
Soft and flexible material-based affinity sensors
Meng, L., Turner, A. P. F., & Mak, W. C. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.05.004 · Cited by 91 · see citing works
- Authors
- Farandos, N. M., Yetisen, A. K., Monteiro, M. J., Lowe, C. R., & Yun, S. H.
- Affiliations
- Imperial College London (GB)
- University of Cambridge (GB)
- The University of Queensland (AU)
- Harvard University (US)
- Corresponding author
- Yetisen, Ali K.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2014-11-17
- Volume
- 4
- Issue
- 6
- Pages
- 792-810
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W2055793978
- Cited by
- 466
- References
- 133
- Citations by year
- 2026: 16 · 2025: 29 · 2024: 42 · 2023: 48 · 2022: 47 · 2021: 51 · 2020: 52 · 2019: 50 · 2018: 44 · 2017: 37 · 2016: 24 · 2015: 18 · 2014: 8
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Healthcare Materials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ocular Surface and Contact Lens
- Keywords
- contact lens sensor, ocular diagnostics, glucose monitoring, tear glucose, glaucoma diagnosis, intraocular pressure, minimally invasive diagnosis, point-of-care monitoring, wireless power transfer, smartphone integration, contact lens manufacturing, FDA regulation, ocular drug delivery
- MeSH terms
- Contact Lenses, Electronics, Glaucoma, Humans, Intraocular Pressure, Biosensing Techniques
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