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Viscoelastic hydrogels for 3D cell culture
Abstract
This mini-review discusses newly developed approaches to tuning hydrogel viscoelasticity and recent studies demonstrating an impact of viscoelasticity on cells.
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“The mechanical properties, such as elastic modulus, pore size, stress relaxation, and creep56–59, cannot be easily separated from the chemical cues in the Matrigel-based culture systems.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [56]
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Metadata
- Authors
- Chaudhuri, O.
- Affiliations
- Stanford University (US)
- Corresponding author
- Chaudhuri, Ovijit
- ORCID
- Chaudhuri, Ovijit
- Venue
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2017
- Volume
- 5
- Issue
- 8
- Pages
- 1480-1490
- ISSN
- 2047-4830 (ISSN-L)
- 2047-4849
- OpenAlex
- W2623649881
- Cited by
- 353
- References
- 102
- Citations by year
- 2026: 31 · 2025: 45 · 2024: 50 · 2023: 39 · 2022: 40 · 2021: 62 · 2020: 43 · 2019: 25 · 2018: 14 · 2017: 3
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Defense Advanced Research Projects Agency (D14AP00044)
- Division of Civil, Mechanical and Manufacturing Innovation (CMMI-1536736)
- American Cancer Society (RSG-16-028-01-CSM)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- viscoelastic hydrogels, 3D cell culture, extracellular matrix mechanics, stress relaxation, creep, synthetic extracellular matrix, mesenchymal stem cells, cell spreading, cell proliferation, cell differentiation, cell-matrix interactions
- MeSH terms
- Elasticity, Humans, Stress, Mechanical, Viscosity, Cell Culture Techniques, Hydrogels
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