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Mucopenetrating micelles with a PEG corona
Abstract
The mucopenetrating properties of cargo-loaded micelles with a PEG corona are characterized in a microfluidic set-up and in cell culture.
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“On the contrary, micelles with positive zeta potential are characterized by very low stability in biological fluids due to a non-specific protein binding and in an increased aggregation in vivo [63,64].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [64]
In the citing paper
“As size and surface charge are involved in the regulation of the biodistribution and pharmacokinetic properties of micellar systems, their determination by DLS is fundamental to predict micelles behavior when in contact with body fluids and tissues [22,64].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [64]
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Metadata
- Authors
- Taipaleenmäki, E. M., Mouritzen, S. A., Schattling, P. S., Zhang, Y., & Städler, B.
- Affiliations
- Aarhus University (DK)
- Corresponding author
- Städler, Brigitte
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2017
- Volume
- 9
- Issue
- 46
- Pages
- 18438-18448
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W2765235227
- Cited by
- 31
- References
- 57
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 7 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 5 · 2019: 1 · 2018: 1
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanoscale (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Innovationsfonden
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- polycaprolactone, oral drug delivery, mucus penetration, absorption enhancers, Nile Red, epithelial cells, microfluidics
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