Biodegradable pH-responsive hydrogels for controlled dual-drug release

Xu, Liang; Qiu, Linzi; Sheng, Yang; Sun, Yixin; Deng, Linhong; Li, Xinqing; Bradley, Mark; Zhang, Rong

doi:10.1039/c7tb01851g

Cited by 128Hydrogels: synthesis, properties, applicationsAdvanced Drug Delivery SystemsNanoparticle-Based Drug Delivery

Biodegradable pH-responsive hydrogels for controlled dual-drug release

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Xu, Liang, Qiu, Linzi, Sheng, Yang, Sun, Yixin, Deng, Linhong, Li, Xinqing, Bradley, Mark, Zhang, Rong·2018·Journal of Materials Chemistry B

DOI 10.1039/c7tb01851g

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Abstract

Dual-drug loaded pH-responsive hydrogels were prepared as a delivery system carrying, as exemplars, both anti-cancer and anti-bacterial agents for pH controlled drug release. The hydrogels were composed of poly(l-lactide)-co-polyethyleneglycol-co-poly(l-lactide) dimethacrylates (with various molecular weights of l-lactide oligomers) as a macromolecular crosslinker and copolymerized with acrylic acid and N-isopropylacrylamide. The biodegradability, biocompatibility and mechanical properties of the hydrogels were characterized with the hydrogels being nontoxic to cells, while showing a reversible >80% reduction in volume at pH 1.2 compared to pH 7.4. Drug release profiles showed differential release of tetracycline over doxorubicin at pH 1.2, with both drugs being released equally at pH 7.4. Biodegradability was tunable by altering the crosslinking density and pH, with the total degradation of the best gels observed within 2 weeks at pH 7.4.

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The swelling-shrinking behavior of pH-responsive polymers in response to an external pH condition makes them suitable for drug delivery applications.
“The swelling-shrinking behavior of pH-responsive polymers in response to an external pH condition makes them suitable for drug delivery applications [38,39,40].”
From Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application (2019) · cites this paper as [39]

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Stimuli-Sensitive Pyrenylated Hydrogels as Optical Sensing Platform for Multiple Metal Ions
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Refillable anti-icing SBS composite films
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Water Uptake, Thin-Film Characterization, and Gravimetric pH-Sensing of Poly(vinylphosphonate)-Based Hydrogels
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pH‐Responsive Polyacrylic Acid Hydrogels Cross‐Linked with Functionalized Collagen Peptide for Controlled Drug Release
Ye, X., Peng, Y., Hou, Y., Huang, J., Cao, W., & Jiang, Y. D. (2025) · ChemistrySelect · doi:10.1002/slct.202503021 · Cited by 2 · see citing works
Biodegradable and pH-Sensitive Hydrogels for Cell Encapsulation and Controlled Drug Release
Wu, D., Sun, Y., Xu, X., Cheng, S., Zhang, X., & Zhuo, R. (2008) · Biomacromolecules · doi:10.1021/bm7010328 · Cited by 102 · see citing works
Self-citation

Authors: Xu, L., Qiu, L., Sheng, Y., Sun, Y., Deng, L., Li, X., Bradley, M., & Zhang, R.
Affiliations: Changzhou University (CN)
Changzhou No.2 People's Hospital (CN)
University of Edinburgh (GB)
Corresponding author: Zhang, Rong
ORCID: Xu, Liang
Sheng, Yang
Sun, Yixin
Deng, Linhong
Bradley, Mark
Zhang, Rong
Venue: Journal of Materials Chemistry B
Publisher: Royal Society of Chemistry (RSC)
Published: 2018
Volume: 6
Issue: 3
Pages: 510-517
ISSN: 2050-750X (ISSN-L)
2050-7518
DOI: 10.1039/c7tb01851g
OpenAlex: W2772877544
Cited by: 128
References: 46
Citations by year: 2026: 13 · 2025: 16 · 2024: 15 · 2023: 21 · 2022: 12 · 2021: 22 · 2020: 13 · 2019: 13 · 2018: 3
FWCI: 3.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: rsc.li/journals-terms-of-use (am, 351 d)
Locations: Journal of Materials Chemistry B (publishedVersion)
PubMed (publishedVersion)
Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
Funders: Natural Science Foundation of Guangxi Province (2015GXNSFAA139255)
Natural Science Foundation of Jiangsu Province (BK20160278)
National Natural Science Foundation of China (11532003, 21374012, 51563003)
Changzhou University (ZMF15020107)
European Research Council (ERC-2013-ADG 340469 ADREEM)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: pH-responsive hydrogels, dual drug release, controlled drug delivery, poly(L-lactic acid), polyethylene glycol, N-isopropylacrylamide, acrylic acid, biodegradable polymers, tetracycline, doxorubicin, anticancer agents, antibacterial agents, crosslink density, biocompatibility, mechanical properties

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Biodegradable pH-responsive hydrogels for controlled dual-drug release

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