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A riboflavin–ultraviolet light A-crosslinked decellularized heart valve for improved biomechanical properties, stability, and biocompatibility
Abstract
Riboflavin–ultraviolet light A could effectively crosslink a decellularized heart valve to improve its biomechanical properties, stability and biocompatibility.
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In a preclinical study, subcutaneous implantation of riboflavin-UV-treated decellularized porcine heart valves in rats demonstrated a significant reduction in the number of inflammatory cells compared to untreated dECM scaffolds.
“In a preclinical study, subcutaneous implantation of riboflavin-UV-treated decellularized porcine heart valves in rats demonstrated a significant reduction in the number of inflammatory cells compared to untreated dECM scaffolds [215].”
From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [215]
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Metadata
- Authors
- Liu, C., Qiao, W., Cao, H., Dai, J., Li, F., Shi, J., & Dong, N.
- Affiliations
- Tongji University (CN)
- Corresponding author
- Shi, Jiawei
- Dong, Nianguo
- Venue
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2020
- Volume
- 8
- Issue
- 9
- Pages
- 2549-2563
- ISSN
- 2047-4830 (ISSN-L)
- 2047-4849
- OpenAlex
- W3010602414
- Cited by
- 38
- References
- 45
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 11 · 2021: 5 · 2020: 2
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Basic Research Program of China (2016YFA0101103)
- National Natural Science Foundation of China (31330029, 81930052, 81873502, 81900351)
- Natural Science Foundation of Hubei Province (2017CFB647, 2019CFB151)
- Health and Family Planning Commission of Hubei Province (WJ2019Q034)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Keywords
- decellularized heart valves, tissue-engineered heart valves, riboflavin, photocrosslinking, tissue mechanics, enzyme resistance, thermal denaturation, endothelial cell adhesion, calcification resistance, pro-inflammatory response, scaffold stability, biocompatibility
- MeSH terms
- Animals, Biocompatible Materials, Biomechanical Phenomena, Cell Survival, Cells, Cultured, Collagen, Cross-Linking Reagents, Female, Heart Valve Prosthesis, Heart Valves, Humans, Riboflavin, Swine, Ultraviolet Rays, Rats, Sprague-Dawley, Tissue Engineering, Cell Proliferation, Tissue Scaffolds, Human Umbilical Vein Endothelial Cells
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