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Cited by 45Tissue Engineering and Regenerative MedicineCardiac Valve Diseases and TreatmentsHydrogels: synthesis, properties, applications

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A method for simultaneously crosslinking and functionalizing extracellular matrix-based biomaterials as bioprosthetic heart valves with enhanced endothelialization and reduced inflammation

Guo, Gaoyang, Jin, Linhe, Wu, Binggang, He, Haiyang, Yang, Fan, Xu, Liangpeng, Lei, Yang, Wang, Yunbing·2021·Acta Biomaterialia
DOI 10.1016/j.actbio.2020.10.029
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Abstract

With the coming of an aging society and the emergence of transcatheter valve technology, the implantation of bioprosthetic heart valves (BHVs) in patients with valvular disease has significantly increased worldwide. Currently, most clinically available BHVs are crosslinked with glutaraldehyde (GLUT). However, the GLUT treated BHV is less durable due to the combined effect of multiple factors such as cytotoxicity, immune responses, and calcification. In this study, the in-situ polymerization of sulfonic monomers with a decellularized extracellular matrix (ECM) was performed to simultaneously achieve the crosslinking and functionalization of ECM. Subsequently, the feasibility of the hybrid ECM used as leaflet material of BHV was evaluated. In in-vitro tests, the results indicated that the hybrid ECM fixed collagen efficiently and the introduction of sulfonic polymer promoted the proliferation and migration of human umbilical vein endothelial cells (HUVECs). In in-vivo tests, after being implanted in SD rats and mice, the hybrid ECM significantly inhibited immune response and calcification compared with the non-hybrid counterpart and GLUT crosslinked tissue. These results indicated that the hybrid ECM exhibited more competitive stability and better biocompatibility compared to these features in GLUT-crosslinked valve. Therefore, the sulfonic polymer hybrid ECM provides a potential material for more durable BHV and the in-situ polymerization strategy can serve as a general treatment method for tissue crosslinking as well as tailoring the biophysical properties of ECM.

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Metadata

Authors
Guo, G., Jin, L., Wu, B., He, H., Yang, F., Xu, L., Lei, Y., & Wang, Y.
Affiliations
Sichuan University (CN)
Corresponding author
Wang, Yunbing
ORCID
Venue
Acta Biomaterialia
Publisher
Elsevier BV
Published
2021-01
Volume
119
Pages
89-100
ISSN
1742-7061 (ISSN-L)
DOI
10.1016/j.actbio.2020.10.029
OpenAlex
W3094421007
Cited by
45
References
6
Citations by year
2026: 2 · 2025: 11 · 2024: 6 · 2023: 9 · 2022: 9 · 2021: 8
FWCI
5.95
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Acta Biomaterialia (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
  • Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Keywords
bioprosthetic heart valves, extracellular matrix, in situ polymerization, glutaraldehyde crosslinking, endothelialization, human umbilical vein endothelial cells, valve calcification, immune response, biocompatibility
MeSH terms
Animals, Biocompatible Materials, Bioprosthesis, Extracellular Matrix, Heart Valve Prosthesis, Heart Valves, Humans, Inflammation, Rats, Sprague-Dawley, Endothelial Cells, Mice, Rats

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