Cited by 773D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis ApplicationsMicrofluidic and Bio-sensing Technologies

Robust chemical bonding of PMMA microfluidic devices to porous PETE membranes for reliable cytotoxicity testing of drugs

Nguyen, Thao, Jung, Su Hyun, Lee, Min Seok, Park, Tae-Eun, Ahn, Suk-kyun, Kang, Joo H.·2019·Lab on a Chip

Abstract

A GLYMO-based method enables robust fabrication of PMMA–PETE cell-culturing microfluidic devices, which permits more precise cytotoxicity response to lipophilic drugs.

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Crossref · 10.1039/c9lc00338j

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33 of 33 references verified0 citation errors · 0 not checkable

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  • Kang's group developed a protocol using poly(methyl methacrylate) (PMMA) substrates chemically and robustly bound to porous orbitally etched polyethylene terephthalate (PETE) membranes to construct a microfluidic device that is impermeable to small lipophilic molecules.

    “To solve this problem, Kang’s group developed a protocol using poly(methyl methacrylate) (PMMA) substrates chemically and robustly bound to porous orbitally etched polyethylene terephthalate (PETE) membranes to construct a microfluidic device that is impermeable to small lipophilic molecules164.”
  • Compared with traditional PDMS chip model, organ chip using PMMA has more reliable cytotoxicity results.

    “Compared with the traditional polydimethylsiloxane (PDMS) chip model, the organ chip using PMMA has more reliable cytotoxicity results, which has important research applications in drug screening.”
  • PMMA organ chips have been demonstrated to show more reliable cytotoxicity results for vincristine using human lung adenocarcinoma cells.

    “PMMA organ chips have been successfully demonstrated to show more reliable cytotoxicity results for vincristine using human lung adenocarcinoma cells.”

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Authors
Nguyen, T., Jung, S. H., Lee, M. S., Park, T.-E., Ahn, S.-K., & Kang, J. H.
Affiliations
  • Ulsan National Institute of Science and Technology (KR)
  • Pusan National University (KR)
Corresponding author
  • Ahn, Suk-kyun
  • Kang, Joo H.
Venue
Lab on a Chip
Published
2019
Volume
19
Issue
21
Pages
3706-3713
ISSN
  • 1473-0189 (ISSN-L)
  • 1473-0197
OpenAlex
W2974375134
Cited by
77
References
33
Citations by year
2026: 6 · 2025: 12 · 2024: 9 · 2023: 9 · 2022: 17 · 2021: 13 · 2020: 11
FWCI
3.62
Type
journal article
Language
en
Open access
closed
Locations
  • Lab on a Chip (publishedVersion)
  • PubMed (publishedVersion)
  • Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
Funders
National Research Foundation of Korea (NRF-2017M3A9E2062136, NRF-2018K1A4A3A01063890)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Bio-sensing Technologies
Keywords
PMMA, track-etched membranes, cytotoxicity assay, organ-on-a-chip, vincristine, lung adenocarcinoma cells, drug testing
MeSH terms
A549 Cells, Drug Evaluation, Preclinical, Humans, Membranes, Artificial, Polyethylene Terephthalates, Porosity, Polymethyl Methacrylate, Lab-On-A-Chip Devices, Human Umbilical Vein Endothelial Cells

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