Robust chemical bonding of PMMA microfluidic devices to porous PETE membranes for reliable cytotoxicity testing of drugs
Abstract
A GLYMO-based method enables robust fabrication of PMMA–PETE cell-culturing microfluidic devices, which permits more precise cytotoxicity response to lipophilic drugs.
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Kang's group developed a protocol using poly(methyl methacrylate) (PMMA) substrates chemically and robustly bound to porous orbitally etched polyethylene terephthalate (PETE) membranes to construct a microfluidic device that is impermeable to small lipophilic molecules.
“To solve this problem, Kang’s group developed a protocol using poly(methyl methacrylate) (PMMA) substrates chemically and robustly bound to porous orbitally etched polyethylene terephthalate (PETE) membranes to construct a microfluidic device that is impermeable to small lipophilic molecules164.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [164]
Compared with traditional PDMS chip model, organ chip using PMMA has more reliable cytotoxicity results.
“Compared with the traditional polydimethylsiloxane (PDMS) chip model, the organ chip using PMMA has more reliable cytotoxicity results, which has important research applications in drug screening.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [164]
PMMA organ chips have been demonstrated to show more reliable cytotoxicity results for vincristine using human lung adenocarcinoma cells.
“PMMA organ chips have been successfully demonstrated to show more reliable cytotoxicity results for vincristine using human lung adenocarcinoma cells.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [164]
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- Authors
- Nguyen, T., Jung, S. H., Lee, M. S., Park, T.-E., Ahn, S.-K., & Kang, J. H.
- Affiliations
- Ulsan National Institute of Science and Technology (KR)
- Pusan National University (KR)
- Corresponding author
- Ahn, Suk-kyun
- Kang, Joo H.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2019
- Volume
- 19
- Issue
- 21
- Pages
- 3706-3713
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2974375134
- Cited by
- 77
- References
- 33
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 9 · 2023: 9 · 2022: 17 · 2021: 13 · 2020: 11
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lab on a Chip (publishedVersion)
- PubMed (publishedVersion)
- Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
- Funders
- National Research Foundation of Korea (NRF-2017M3A9E2062136, NRF-2018K1A4A3A01063890)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Bio-sensing Technologies
- Keywords
- PMMA, track-etched membranes, cytotoxicity assay, organ-on-a-chip, vincristine, lung adenocarcinoma cells, drug testing
- MeSH terms
- A549 Cells, Drug Evaluation, Preclinical, Humans, Membranes, Artificial, Polyethylene Terephthalates, Porosity, Polymethyl Methacrylate, Lab-On-A-Chip Devices, Human Umbilical Vein Endothelial Cells
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