Drug-eluting contact lens containing cyclosporine-loaded cholesterol-hyaluronate micelles for dry eye syndrome
Open accessAbstract
drug release tests revealed the controlled delivery of cyclosporine for more than 12 days. Furthermore, the Schirmer tear test, corneal fluorescein staining, and MMP9 fluorescein analysis confirmed its therapeutic effect on dry eye syndrome in disease model rabbits.
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C-HA micelle-loaded CLs showed statistically significant improvements in wettability and mechanical strength while maintaining satisfactory optical transmittance.
“The C-HA micelle-loaded CLs showed statistically significant improvements in wettability and mechanical strength, thereby maintaining the satisfactory optical transmittance.”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [121]
In Results and discussion, the wettability section reports a significantly lower contact angle for the C-HA lenses than controls (Fig. 4), and the optical-transmittance section reports about 90% transmittance with visibility preserved. The tensile-strength section reports greater stretchability and elasticity, but does not report a statistically significant improvement in mechanical strength. The paper also says transmittance decreased slightly; it does not establish that the mechanical changes caused optical clarity to be maintained. (LLM, conf=0.87)
Experimental — accuracy not yet measuredC-HA micelle-loaded CLs realized controlled delivery of drug for more than 12 days and demonstrated profound therapeutic effects on a DED rabbit model.
“Drug release tests revealed that the C-HA micelle-loaded CLs realized the controlled delivery of drug for more than 12 days, and demonstrated profound therapeutic effects on DED rabbit model [121].”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [121]
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“Drug release tests revealed that the C-HA micelle-loaded CLs realized the controlled delivery of drug for more than 12 days, and demonstrated profound therapeutic effects on DED rabbit model [121].”
- Authors
- Mun, J., Mok, J. W., Jeong, S., Cho, S., Joo, C.-K., & Hahn, S. K.
- Affiliations
- Pohang University of Science and Technology (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Corresponding author
- Joo, Choun-Ki
- Hahn, Sei Kwang
- Venue
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2019
- Volume
- 9
- Issue
- 29
- Pages
- 16578-16585
- ISSN
- 2046-2069 (ISSN-L)
- PMC
- PMC9064448
- OpenAlex
- W2947214495
- Cited by
- 82
- References
- 28
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 11 · 2023: 22 · 2022: 11 · 2021: 12 · 2020: 7 · 2019: 1
- FWCI
- 7.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- RSC Advances (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Ministry of Science, ICT and Future Planning (2017M3A7B8065278, 2017R1E1A1A03070458)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ocular Surface and Contact Lens
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- dry eye, cyclosporine, controlled drug release, ocular drug delivery, corneal epithelial wound healing, MMP-9
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