Biofunctionalization of zirconia with cell-adhesion peptides via polydopamine crosslinking for soft tissue engineering: effects on the biological behaviors of human gingival fibroblasts and oral bacteria
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Biofunctionalization of zirconia with cell-adhesion peptides via polydopamine and its effect on HGFs/bacterial adhesion for enhanced soft tissue seal.
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Deposition of a nanoscale PDA coating on titanium or zirconia implants markedly enhances their surface bioactivity and overall biological performance.
“Numerous studies have demonstrated that the deposition of a nanoscale PDA coating on titanium or zirconia implants markedly enhances their surface bioactivity and overall biological performance.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [5]
The Introduction (page unavailable) says PDA coating improves gingival fibroblast adherence on zirconia to a certain extent and has antibacterial properties, but also says PDA alone does not sufficiently promote fibroblast behavior. The Results and discussion section on HGF responses (page unavailable) reports increased attachment after PDA coating, with further gains after RGD functionalization. The paper therefore supports some benefit on zirconia, but not the claim that a nanoscale PDA coating alone markedly improves overall biological performance on titanium or zirconia implants. (LLM, conf=0.87)
Experimental — accuracy not yet measuredThese studies support the roles of PDA in improving wet adhesion, cell attachment, antioxidative protection, and localized drug delivery.
“These studies support the roles of PDA in improving wet adhesion, cell attachment, antioxidative protection, and localized drug delivery.5,59”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [5]
The Introduction describes strong adhesive interactions of PDA coatings and improved adherence of human gingival fibroblasts; the Conclusions report improved cell attachment with PDA-mediated RGD functionalization. The paper does not establish improved wet adhesion specifically, and its full text does not address antioxidative protection or localized drug delivery (searched for those terms and related delivery terminology). Page numbers were not available in our copy. (LLM, conf=0.87)
Experimental — accuracy not yet measuredThrough this dual regulatory effect, a favorable balance is achieved between the promotion of soft tissue integration and the prevention of peri-implant infection.
“Through this dual regulatory effect, a favorable balance is achieved between the promotion of soft tissue integration and the prevention of peri-implant infection.5,50”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [5]
The Results and discussion (Bacterial responses) report improved gingival fibroblast responses and reduced bacterial colonization on the modified zirconia surface. But the Conclusions describe improved peri-implant soft tissue integration as a promise requiring further in vivo study; the paper does not establish that soft tissue integration and prevention of peri-implant infection were achieved clinically. (LLM, conf=0.84)
Experimental — accuracy not yet measuredCell culture, antibacterial adhesion assays, and mucosal/wound healing models indicate that PDA-based coatings or hydrogels can improve wet adhesion, antioxidative protection, localized drug delivery, inflammation regulation, and wound healing.
“Cell culture, antibacterial adhesion assays, and mucosal/wound healing models indicate that PDA-based coatings or hydrogels can improve wet adhesion, antioxidative protection, localized drug delivery, inflammation regulation, and wound healing.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [5]
The Results and discussion sections on HGF and bacterial responses report improved fibroblast adhesion and reduced bacterial colonization on PDA-modified zirconia; they suggest these effects could facilitate early soft-tissue healing. The study used cell culture and bacterial adhesion assays, not mucosal or wound-healing models. Our copy does not establish improved wet adhesion, antioxidative protection, localized drug delivery, or inflammation regulation. (LLM, conf=0.90)
Experimental — accuracy not yet measuredThermal annealing of PDA at 150 °C under an inert atmosphere for 2 h induces partial graphitization and prolongs the degradation half-life.
“Alternatively, thermal annealing of PDA at 150 °C under an inert atmosphere for 2 h has been employed to induce partial graphitization.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [5]
The Materials and methods section (Preparation of substrates; page unavailable) describes forming the PDA coating at room temperature and drying it under a nitrogen stream, but does not describe annealing it at 150 °C for 2 h. The Results and discussion section (Bacterial responses; page unavailable) says coating longevity still needs investigation. Searches for thermal annealing, partial graphitization, and degradation half-life found no passage addressing the attributed claim. (LLM, conf=0.77)
Experimental — accuracy not yet measured
The introduction of 0.5% (3-aminopropyl)triethoxysilane during self-polymerization forms organic-inorganic hybrid layers that prolong the degradation half-life of PDA.
“One approach involves the introduction of 0.5% (3-aminopropyl)triethoxysilane during the self-polymerization process to form organic–inorganic hybrid layers.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [5]
The Materials and methods section (Preparation of substrates; page not provided) describes coating zirconia with dopamine and then adding RGD peptides. Neither it nor the Introduction passages address adding 0.5% (3-aminopropyl)triethoxysilane during self-polymerization, forming organic–inorganic hybrid layers by that method, or prolonging PDA’s degradation half-life. Searches for those terms found no supporting passage in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measuredHigh-temperature treatment inevitably reduces the density of surface-active functional groups.
“However, high-temperature treatment inevitably reduces the density of surface-active functional groups, highlighting the need to balance long-term stability against the preservation of functionalization capacity.5,109”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [5]
The Materials and methods sections describe drying zirconia disks at 50 °C and applying the polydopamine and peptide coatings at room temperature. The Functionalization characterization section reports surface composition after coating, but does not assess whether high-temperature treatment reduces surface-active functional groups. Searches for heating, sintering, and loss of functional groups found no passage establishing the claim. (LLM, conf=0.76)
Experimental — accuracy not yet measuredThese stabilization strategies were shown to prolong the degradation half-life from approximately 45 days to 90 days and 160 days, respectively.
“These strategies were shown to prolong the degradation half-life from approximately 45 days to 90 days and 160 days, respectively.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [5]
The Results and discussion sections say that cyclic peptide structure can protect against degradation, but they report no degradation half-lives. The Bacterial responses section says the coatings' longevity still needs investigation. A search for the claimed 45-, 90-, and 160-day values found no supporting passage in our copy; page numbers were unavailable. (LLM, conf=0.78)
Experimental — accuracy not yet measured
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- Authors
- Yang, Z., Liu, M., Yang, Y., Zheng, M., Yang, Y., Liu, X., & Tan, J.
- Affiliations
- Peking University (CN)
- Peking University Third Hospital (CN)
- Corresponding author
- Tan, Jianguo
- Venue
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2020
- Volume
- 10
- Issue
- 11
- Pages
- 6200-6212
- ISSN
- 2046-2069 (ISSN-L)
- PMC
- PMC9049673
- OpenAlex
- W3005155715
- Cited by
- 58
- References
- 69
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 13 · 2023: 10 · 2022: 3 · 2021: 6 · 2020: 3
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- RSC Advances (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81701001, 81701003)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Dentistry › Orthodontics › Dental materials and restorations
- Keywords
- zirconia, biofunctionalization, polydopamine, RGD peptide, cell adhesion peptides, gingival fibroblasts, human gingival fibroblasts, oral bacteria, bacterial adhesion, antimicrobial activity, soft tissue engineering, dental implants, soft tissue integration
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