Use of pyrazoles as ligands greatly enhances the catalytic activity of titanium iso-propoxide for the ring-opening polymerization of l -lactide: a cooperation effect
Open accessAbstract
Using TiO i Pr 4 with a pyrazole ligand for one-pot LA polymerization improved catalytic activity compared with using TiO i Pr 4 only.
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The high catalytic activity of complex 51 with the intramolecular transesterification was ascribed to the cooperation between two Zr centers.
“The high catalytic activity of complex 51 with the intramolecular transesterification was ascribed to the cooperation between two Zr centers as shown in Fig. 26.”
From Multinuclear metal catalysts in ring-opening polymerization of ε‑caprolactone and lactide: Cooperative and electronic effects between metal centers (2023) · cites this paper as [87]
The Introduction and Results and discussion describe cooperation between two Ti centers in lactide polymerization, not two Zr centers. The Polymerization of LA section mentions transesterification as a possible consequence of prolonged polymerization, not as the explanation for high catalytic activity. (LLM, conf=0.88)
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Experimental — accuracy not yet measuredThe TOF of complex 51 (194 h−1) was 2-fold higher than that of complex 52 (90 h−1).
“The TOF of complex 51 (194 h À1 ) was 2-fold higher than that of complex 52 (90 h À1 ).”
From Multinuclear metal catalysts in ring-opening polymerization of ε‑caprolactone and lactide: Cooperative and electronic effects between metal centers (2023) · cites this paper as [87]
The Polymerization of LA tables report conversion, time and observed rate constants, but do not identify complexes 51 and 52 or give TOFs of 194 and 90 h−1. Searches for those numbers and for TOF found no passage in our copy that addresses the comparison. (LLM, conf=0.72)
Experimental — accuracy not yet measuredAfter 30 min, the conversion of rac-LA polymerization at 100 °C was 97 % for complex 51 but 90 % after 60 min for complex 52.
“After 30 min, the conversion of rac-LA polymerization at 100 °C was 97 % for complex 51 but 90 % after 60 min for complex 52.”
From Multinuclear metal catalysts in ring-opening polymerization of ε‑caprolactone and lactide: Cooperative and electronic effects between metal centers (2023) · cites this paper as [87]
The Results and discussion, ‘Polymerization of LA’ (page unavailable), reports l-lactide conversion at 100 °C after 240 minutes using TiOiPr4 with or without furPz. Searches for rac-LA, complexes 51 and 52, and the claimed 30- and 60-minute conversions found no passage addressing those results. The reported values concern different catalysts and do not establish a contradiction. (LLM, conf=0.77)
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Cites
Plastic waste inputs from land into the ocean
Jambeck, J. R., Geyer, R., Wilcox, C., Siegler, T. R., Perryman, M., Andrady, A., Narayan, R., & Law, K. L. (2015) · Science · doi:10.1126/science.1260352 · Cited by 13,163 · see citing works
The return of a forgotten polymer—Polycaprolactone in the 21st century
Woodruff, M. A., & Hutmacher, D. W. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.04.002 · Cited by 4,033 · see citing works
Kamaly, N., Yameen, B., Wu, J., & Farokhzad, O. C. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00346 · Cited by 3,070 · see citing works
Sustainable polymers from renewable resources
Zhu, Y., Romain, C., & Williams, C. K. (2016) · Nature · doi:10.1038/nature21001 · Cited by 2,762 · see citing works
Controlled Ring-Opening Polymerization of Lactide and Glycolide
Dechy-Cabaret, O., Martin-Vaca, B., & Bourissou, D. (2004) · Chemical Reviews · doi:10.1021/cr040002s · Cited by 2,257 · see citing works
Plastic Resin Pellets as a Transport Medium for Toxic Chemicals in the Marine Environment
Mato, Y., Isobe, T., Takada, H., Kanehiro, H., OHTAKE, C., & Kaminuma, T. (2000) · Environmental Science & Technology · doi:10.1021/es0010498 · Cited by 1,898 · see citing works
Organocatalytic Ring-Opening Polymerization
Kamber, N. E., Jeong, W., Waymouth, R. M., Pratt, R. C., Lohmeijer, B. G. G., & Hedrick, J. L. (2007) · Chemical Reviews · doi:10.1021/cr068415b · Cited by 1,489 · see citing works
New emerging trends in synthetic biodegradable polymers—Polylactide: A critique
Gupta, A. P., & Kumar, V. (2007) · European Polymer Journal · doi:10.1016/j.eurpolymj.2007.06.045 · Cited by 941 · see citing works
Plastic waste associated with disease on coral reefs
Lamb, J. B., Willis, B. L., Fiorenza, E. A., Couch, C. S., Howard, R., Rader, D. N., True, J. D., Kelly, L. A., Ahmad, A., Jompa, J., et al. (2018) · Science · doi:10.1126/science.aar3320 · Cited by 862 · see citing works
Nanoscopic Metal Particles − Synthetic Methods and Potential Applications
Bönnemann, H., & Richards, R. M. (2001) · European Journal of Inorganic Chemistry · doi:10.1002/1099-0682(200109)2001:10 · Cited by 774 · see citing works
Bioinspired polymer vesicles and membranes for biological and medical applications
Palivan, C. G., Goers, R., Najer, A., Zhang, X., Car, A., & Meier, W. P. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00569h · Cited by 585 · see citing works
Biocompatibility and safety of PLA and its copolymers.
Ramot, Y., Haim-Zada, M., Domb, A., & Nyska, A. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.03.012 · Cited by 525 · see citing works
Impacts of Discarded Plastic Bags on Marine Assemblages and Ecosystem Functioning
Green, D. S., Boots, B., Blockley, D., Rocha, C., & Thompson, R. C. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b00277 · Cited by 243 · see citing works
Titanium Alkoxides as Initiators for the Controlled Polymerization of Lactide
Kim, Y., Jnaneshwara, G. K., & Verkade, J. G. (2003) · Inorganic Chemistry · doi:10.1021/ic026139n · Cited by 198 · see citing works
Carbohydrate-based amphiphilic nano delivery systems for cancer therapy
Liu, K., Jiang, X., & Hunziker, P. (2016) · Nanoscale · doi:10.1039/c6nr04489a · Cited by 187 · see citing works
Strong, Resilient, and Sustainable Aliphatic Polyester Thermoplastic Elastomers
Watts, A., Kurokawa, N., & Hillmyer, M. A. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b00283 · Cited by 187 · see citing works
Recent progress on the synthesis of cyclic polymers via ring‐expansion strategies
Chang, Y. A., & Waymouth, R. M. (2017) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.28635 · Cited by 157 · see citing works
Dinuclear catalysts for the ring opening polymerization of lactide
Kremer, A. B., & Mehrkhodavandi, P. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.09.008 · Cited by 152 · see citing works
Zelikoff, A. L., Kopilov, J., Goldberg, I., Coates, G. W., & Kol, M. (2009) · Chemical Communications · doi:10.1039/b915211c · Cited by 129 · see citing works
Aluminum alkyl complexes: synthesis, structure, and application in ROP of cyclic esters
Wei, Y., Wang, S., & Zhou, S. (2016) · Dalton Transactions · doi:10.1039/c5dt04240b · Cited by 122 · see citing works
Carosio, F., Colonna, S., Fina, A., Rydzek, G., Hemmerlé, J., Jierry, L., Schaaf, P., & Boulmedais, F. (2014) · Chemistry of Materials · doi:10.1021/cm501359e · Cited by 111 · see citing works
Romain, C., Karmazin‐Brelot, L., Bellemin‐Laponnaz, S., & Dagorne, S. (2010) · Organometallics · doi:10.1021/om901084n · Cited by 106 · see citing works
Catalytic metal-based systems for controlled statistical copolymerisation of lactide with a lactone
Stirling, E., Champouret, Y., & Visseaux, M. (2018) · Polymer Chemistry · doi:10.1039/c8py00310f · Cited by 101 · see citing works
Indium Catalysts for Ring Opening Polymerization: Exploring the Importance of Catalyst Aggregation
Osten, K. M., & Mehrkhodavandi, P. (2017) · Accounts of Chemical Research · doi:10.1021/acs.accounts.7b00447 · Cited by 96 · see citing works
Chen, H.-Y., Liu, M.-Y., Sutar, A. K., & Lin, C.-C. (2010) · Inorganic Chemistry · doi:10.1021/ic901938e · Cited by 95 · see citing works
3D printed structures for delivery of biomolecules and cells: tissue repair and regeneration
Park, J. Y., Gao, G., Jang, J., & Cho, D. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb01662f · Cited by 93 · see citing works
Chuck, C. J., Davidson, M. G., Jones, M. D., Kociok-Köhn, G. I., Lunn, M. D., & Wu, S. G. (2006) · Inorganic Chemistry · doi:10.1021/ic060969+ · Cited by 90 · see citing works
Ligny, R., Hänninen, M. M., Guillaume, S. M., & Carpentier, J.-F. (2018) · Chemical Communications · doi:10.1039/c8cc03842b · Cited by 88 · see citing works
Fuoco, T., & Pappalardo, D. (2017) · Catalysts · doi:10.3390/catal7020064 · Cited by 83 · see citing works
Skotak, M., Leonov, A. P., Larsen, G. F., Noriega, S. E., & Subramanian, A. (2008) · Biomacromolecules · doi:10.1021/bm800158c · Cited by 77 · see citing works
Redshaw, C. (2017) · Catalysts · doi:10.3390/catal7050165 · Cited by 77 · see citing works
Huang, B.-H., Tsai, C.-Y., Chen, C.-T., & Ko, B.-T. (2016) · Dalton Transactions · doi:10.1039/c6dt03384a · Cited by 75 · see citing works
Birnin-Yauri, A. U., Ibrahim, N. A., Zainuddin, N., Abdan, K., Then, Y. Y., & Chieng, B. W. (2017) · Polymers · doi:10.3390/polym9050165 · Cited by 74 · see citing works
Curcumin-bortezomib loaded polymeric nanoparticles for synergistic cancer therapy
Medel, S., Syrová, Z., Kováčik, Ľ., Hrdý, J., Hornáček, M., Jäger, E., Hrubý, M., Lund, R., Cmarko, D., Štěpánek, P., et al. (2017) · European Polymer Journal · doi:10.1016/j.eurpolymj.2017.05.036 · Cited by 70 · see citing works
Titanium pyridonates and amidates: novel catalysts for the synthesis of random copolymers
Webster, R. L., Noroozi, N., Hatzikiriakos, S. G., Thomson, J. A., & Schafer, L. L. (2012) · Chemical Communications · doi:10.1039/c2cc37201k · Cited by 67 · see citing works
Li, C.-Y., Yu, C.-J., & Ko, B.-T. (2013) · Organometallics · doi:10.1021/om300962k · Cited by 67 · see citing works
Biodegradable polymeric nanostructures in therapeutic applications: opportunities and challenges
Shukla, S. K., Shukla, S. K., Govender, P. P., & Giri, N. G. (2016) · RSC Advances · doi:10.1039/c6ra15764e · Cited by 60 · see citing works
Brown, L. A., Rhinehart, J. L., & Long, B. K. (2015) · ACS Catalysis · doi:10.1021/acscatal.5b01434 · Cited by 58 · see citing works
Saha, T., Mandal, M., Chakraborty, D., & Ramkumar, V. (2013) · New Journal of Chemistry · doi:10.1039/c3nj40916c · Cited by 54 · see citing works
Bhowmick, S., Thanusha, A. V., Kumar, A., Scharnweber, D., Rother, S., & Koul, V. (2018) · RSC Advances · doi:10.1039/c8ra01489b · Cited by 53 · see citing works
Amador, A. G., Watts, A., Neitzel, A. E., & Hillmyer, M. A. (2019) · Macromolecules · doi:10.1021/acs.macromol.9b00065 · Cited by 53 · see citing works
Lowe, M. Y., Shu, S., Quan, S. M., & Diaconescu, P. L. (2017) · Inorganic Chemistry Frontiers · doi:10.1039/c7qi00227k · Cited by 47 · see citing works
Modeling of Molecular Weight Distribution in Ring-Opening Polymerization of l , l -Lactide
Yu, Y., Fischer, E., Storti, G., & Morbidelli, M. (2014) · Industrial & Engineering Chemistry Research · doi:10.1021/ie4028999 · Cited by 46 · see citing works
Slater, B. D., Wong, S.-O., Duckworth, A., White, A. J. P., Hill, M. R., & Ladewig, B. P. (2019) · Chemical Communications · doi:10.1039/c9cc02861g · Cited by 46 · see citing works
Titanium pyridonates for the homo- and copolymerization of rac-lactide and ε-caprolactone
Gilmour, D. J., Webster, R. L., Perry, M. R., & Schafer, L. L. (2015) · Dalton Transactions · doi:10.1039/c5dt01162k · Cited by 44 · see citing works
Hancock, S. L., Mahon, M. F., & Jones, M. D. (2011) · Dalton Transactions · doi:10.1039/c0dt01542c · Cited by 44 · see citing works
Durr, C. B., & Williams, C. K. (2018) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.8b02271 · Cited by 44 · see citing works
Tseng, H.-C., Chen, H.-Y., Huang, Y.-T., Lu, W.-Y., Chang, Y.-L., Chiang, M. Y., Lai, Y.-C., & Chen, H.-Y. (2016) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.5b02590 · Cited by 42 · see citing works
Gao, B., Li, X., Duan, R., & Pang, X. (2015) · New Journal of Chemistry · doi:10.1039/c4nj02266a · Cited by 41 · see citing works
Metallocalixarene catalysts: α-olefin polymerization and ROP of cyclic esters
Redshaw, C. (2016) · Dalton Transactions · doi:10.1039/c6dt01529h · Cited by 40 · see citing works
Gowda, R. R., Chakraborty, D., & Ramkumar, V. (2009) · European Journal of Inorganic Chemistry · doi:10.1002/ejic.200900280 · Cited by 36 · see citing works
Xiang, C., & Acevedo, N. C. (2017) · Polymers · doi:10.3390/polym9050179 · Cited by 35 · see citing works
Use of titanocalix[4]arenes in the ring opening polymerization of cyclic esters
Sun, Z., Zhao, Y., Santoro, O., Elsegood, M. R. J., Bedwell, E. V., Zahra, K. M., Walton, A. S., & Redshaw, C. (2020) · Catalysis Science & Technology · doi:10.1039/c9cy02571e · Cited by 34 · see citing works
Santoro, O., & Redshaw, C. (2020) · Catalysts · doi:10.3390/catal10020210 · Cited by 34 · see citing works
Kim, S. H., Lee, J., Kim, D. J., Moon, J. H., Yoon, S., Oh, H. J., Do, Y., Ko, Y. S., Yim, J., & Kim, Y. (2009) · Journal of Organometallic Chemistry · doi:10.1016/j.jorganchem.2009.06.037 · Cited by 32 · see citing works
Xu, X., Luo, G., Hou, Z., Diaconescu, P. L., & Luo, Y. (2020) · Inorganic Chemistry Frontiers · doi:10.1039/c9qi01466g · Cited by 32 · see citing works
Mandal, D., Chakraborty, D., Ramkumar, V., & Chand, D. K. (2016) · RSC Advances · doi:10.1039/c5ra26721h · Cited by 30 · see citing works
Controlling the Ring‐Opening Polymerization Process Using External Stimuli
Chen, M., & Chen, C. (2019) · Chinese Journal of Chemistry · doi:10.1002/cjoc.201900358 · Cited by 30 · see citing works
Liang, L., Lin, S., & Chien, C.-C. (2013) · Inorganic Chemistry · doi:10.1021/ic301551v · Cited by 28 · see citing works
Group 4 Complexes of atert-Butylphosphine-Bridged Biphenolate Ligand
Liang, L., Hsu, Y., & Lin, S. (2011) · Inorganic Chemistry · doi:10.1021/ic102194z · Cited by 26 · see citing works
Jeong Go, M., Min Lee, J., Mun Lee, K., Hwa Oh, C., Park, K. H., Kim, S. H., Kim, M., Park, H.-R., Park, M. H., Kim, Y., et al. (2014) · Polyhedron · doi:10.1016/j.poly.2013.09.017 · Cited by 25 · see citing works
Gowda, R. R., Chakraborty, D., & Ramkumar, V. (2011) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2011.08.008 · Cited by 21 · see citing works
Rapid ring‐opening polymerization of 1,4‐dioxan‐2‐one initiated by titanium alkoxides
Zeng, J., Srinivansan, M., Li, Y., Narayan, R., & Wang, Y. (2010) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.24399 · Cited by 21 · see citing works
Dinuclear group 4 alkoxides: Excellent initiators for ring-opening polymerization of cyclic esters
He, J.-X., Duan, Y.-L., Kou, X., Zhang, Y., Wang, W., Yang, Y., & Huang, Y. (2015) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2015.09.012 · Cited by 19 · see citing works
Ou, H., Chen, H., Tseng, H.-C., Hsiao, M.-W., Chang, Y., Jheng, N., Lai, Y., Shih, T.-Y., Lin, Y., & Chen, H. (2014) · Journal of Molecular Catalysis A Chemical · doi:10.1016/j.molcata.2014.07.003 · Cited by 17 · see citing works
Liu, D.-C., Li, C.-Y., Lin, P.-H., Chen, J., Tsai, C., Lin, C., & Ko, B. (2018) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2018.01.018 · Cited by 16 · see citing works
Liu, J., Cao, Y., Li, L., Pei, H., Chen, Y., Hu, J., Qin, Y., Li, Y., Li, W., & Liu, W. (2014) · RSC Advances · doi:10.1039/c4ra14692a · Cited by 14 · see citing works
Ring‐Opening Polymerization of Lactide Catalyzed by Bimetallic Salen‐Type Titanium Complexes
Duan, R., Qu, Z., Pang, X., Zhang, Y., Sun, Z., Zhang, H., Bian, X., & Chen, X. (2017) · Chinese Journal of Chemistry · doi:10.1002/cjoc.201600580 · Cited by 14 · see citing works
Jiang, M.-T., Kosuru, S. R., Lee, Y. H., Lu, W.-Y., Vandavasi, J. K., Lai, Y.-C., Chiang, M. Y.-N., & Hy, C. (2017) · eXPRESS Polymer Letters · doi:10.3144/expresspolymlett.2018.11 · Cited by 13 · see citing works
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- Authors
- Wang, T.-F., Kosuru, S. R., Yu, S.-C., Chang, Y.-C., Lai, H.-Y., Chang, Y.-L., Wu, K.-H., Ding, S., & Chen, H.-Y.
- Affiliations
- Kaohsiung Medical University (TW)
- Tamkang University (TW)
- National Sun Yat-sen University (TW)
- Corresponding author
- Chen, Hsuan-Ying
- Venue
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2020
- Volume
- 10
- Issue
- 67
- Pages
- 40690-40696
- ISSN
- 2046-2069 (ISSN-L)
- PMC
- PMC9057761
- OpenAlex
- W3154049314
- Cited by
- 9
- References
- 69
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2022: 1 · 2021: 3
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- RSC Advances (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Kaohsiung Medical University (KMU-DK109004, NSYSUKMU 107-P010)
- Ministry of Science and Technology, Taiwan (MOST 108-2113-M-037-017)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Chemical Engineering › Process Chemistry and Technology › Carbon dioxide utilization in catalysis
- Physical Sciences › Chemistry › Organic Chemistry › Organometallic Complex Synthesis and Catalysis
- Keywords
- pyrazole ligands, titanium isopropoxide, ring-opening polymerization, L-lactide, polylactic acid, catalytic activity enhancement, one-pot polymerization, stereospecific polymerization
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