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In vitro functional models for human liver diseases and drug screening: beyond animal testing
Open accessAbstract
models have been proposed as an alternative to pre-clinical animal models. These systems have been successfully employed for the investigation of the etiology and dynamics of liver diseases, for drug screening, and - more recently - to design patient-tailored therapies, resulting in potentially higher efficacy and reduced costs compared to other methods. Here, we review the most recent advances in this rapidly evolving field with particular attention to organoid cultures, liver-on-a-chip platforms, and engineered scaffold-based approaches.
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“Physiological relevant in vitro models provide a promising platform for modelling the physiochemical conditions of the hepatic microenvironment (Janani and Mandal, 2021;Kostrzewski et al., 2021;Paradiso et al., 2023).”
From Fast formation and maturation enhancement of human liver organoids using a liver-organoid-on-a-chip (2024) · cites this paper as Paradiso et al., 2023
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Metadata
- Authors
- Paradiso, A., Volpi, M., Rinoldi, C., Celikkin, N., Contessi Negrini, N., Bilgen, M., Dallera, G., Pierini, F., Costantini, M., Święszkowski, W., & Farè, S.
- Affiliations
- Warsaw University of Technology (PL)
- Institute of Fundamental Technological Research (PL)
- Institute of Physical Chemistry (PL)
- Department of Chemistry, Materials and Chemical Engineering “G. Natta”, Politecnico di Milano, Milan, Italy
- Politecnico di Milano (IT)
- National Interuniversity Consortium of Materials Science and Technology (IT)
- Corresponding author
- Święszkowski, Wojciech
- Farè, Silvia
- ORCID
- Venue
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2023
- Volume
- 11
- Issue
- 9
- Pages
- 2988-3015
- ISSN
- 2047-4830 (ISSN-L)
- 2047-4849
- OpenAlex
- W4310705293
- Cited by
- 40
- References
- 230
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 10 · 2023: 4
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Biomaterials Science (publishedVersion, cc-by)
- PubMed (publishedVersion)
- CeON Repository (Centre for Evaluation in Education and Science) (submittedVersion, cc-by)
- Virtual Community of Pathological Anatomy (University of Castilla La Mancha) (submittedVersion, cc-by)
- Funders
- Politechnika Warszawska
- European Regional Development Fund
- Ministerstwo Edukacji i Nauki
- Fundacja na rzecz Nauki Polskiej (POIR.04.04.00-00-5ED7/18-00)
- Narodowe Centrum Nauki (2018/31/D/ST8/03647, 2020/37/N/ST5/03272)
- Narodowe Centrum Badań i Rozwoju (PL-TW/VI/3/2019, STRATEGMED3/305813/2/NCBR/2017)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- in vitro liver models, drug screening, alternatives to animal testing, organoids, liver-on-a-chip, engineered scaffolds, patient-tailored therapy, liver disease modeling
- MeSH terms
- Animals, Drug Evaluation, Preclinical, Humans, Organoids, Liver Failure, Acute, Models, Animal
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