Salvia hispanica L. (chia) seed improves liver inflammation and endothelial dysfunction in an experimental model of metabolic syndrome

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

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NF-κB signaling in inflammation

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Coated Charcoal Immunoassay of Insulin

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Non-alcoholic fatty liver disease

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An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

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Endothelial Dysfunction, Inflammation and Coronary Artery Disease: Potential Biomarkers and Promising Therapeutical Approaches

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Cell Type-Specific Roles of NF-κB Linking Inflammation and Thrombosis

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Role of free fatty acids in endothelial dysfunction

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Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review

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Quercetin Decreases Oxidative Stress, NF-κB Activation, and iNOS Overexpression in Liver of Streptozotocin-Induced Diabetic Rats

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Chia Seeds (Salvia Hispanica L.): An Overview—Phytochemical Profile, Isolation Methods, and Application

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Chia Seed ( <i>Salvia hispanica</i> L.) as a Source of Proteins and Bioactive Peptides with Health Benefits: A Review

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Nrf2: A Potential Target for New Therapeutics in Liver Disease

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F4/80 as a Major Macrophage Marker: The Case of the Peritoneum and Spleen

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Dietary chia seed (Salvia hispanicaL.) rich in α-linolenic acid improves adiposity and normalises hypertriacylglycerolaemia and insulin resistance in dyslipaemic rats

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Dapagliflozin slows the progression of the renal and liver fibrosis associated with type 2 diabetes

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Docosahexaenoic Acid Attenuates Hepatic Inflammation, Oxidative Stress, and Fibrosis without Decreasing Hepatosteatosis in a Ldlr Mouse Model of Western Diet-Induced Nonalcoholic Steatohepatitis

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Modulation of endothelium function by fatty acids

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Increased nitric oxide levels as an early sign of premature aging in diabetes

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NAFLD in the Elderly

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Mechanisms of obesity-induced metabolic and vascular dysfunctions

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Heart, liver, and skeletal muscle myeloperoxidase activity during exercise

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Perspectives in liver redox imbalance: Toxicological and pharmacological aspects underlying iron overloading, nonalcoholic fatty liver disease, and thyroid hormone action

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High-fat diet induces mouse liver steatosis with a concomitant decline in energy metabolism: attenuation by eicosapentaenoic acid (EPA) or hydroxytyrosol (HT) supplementation and the additive effects upon EPA and HT co-administration

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NAFLD in the Elderly

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The Role of Fructose in Non-Alcoholic Steatohepatitis: Old Relationship and New Insights

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HFD-induced hepatic lipid accumulation and inflammation are decreased in Factor D deficient mouse

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Curcumin protects radiation-induced liver damage in rats through the NF-κB signaling pathway

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Substitution of linoleic acid with α-linolenic acid or long chain n-3 polyunsaturated fatty acid prevents Western diet induced nonalcoholic steatohepatitis

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An overview of chia seed (Salvia hispanica L.) bioactive peptides’ derivation and utilization as an emerging nutraceutical food

Rabail, R., Khan, M. R., Mehwish, H. M., Rajoka, M. S. R., Lorenzo, J. M., Kieliszek, M., Khalid, A. R., Shabbir, M. A., & Aadil, R. M. (2021) · Frontiers in Bioscience-Landmark · doi:10.52586/4973 · Cited by 64 · see citing works

The Current State of Knowledge on Salvia hispanica and Salviae hispanicae semen (Chia Seeds)

Motyka, S., Koc, K., Ekiert, H., Blicharska, E., Czarnek, K., & Szopa, A. (2022) · Molecules · doi:10.3390/molecules27041207 · Cited by 58 · see citing works

Docosahexaenoic acid and hydroxytyrosol co‐administration fully prevents liver steatosis and related parameters in mice subjected to high‐fat diet: A molecular approach

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Effects of chia (Salvia hispanica L.) on calcium bioavailability and inflammation in Wistar rats

da Silva, B. P., Toledo, R. C. L., Grancieri, M., Moreira, M. E. D. C., Medina, N. R., Silva, R. R., Costa, N. M. B., & Martino, H. S. D. (2018) · Food Research International · doi:10.1016/j.foodres.2018.08.078 · Cited by 52 · see citing works

Effects of Berberine chloride on the liver of streptozotocin-induced diabetes in albino Wistar rats

Chandirasegaran, G., Elanchezhiyan, C., & Ghosh, K. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.01.007 · Cited by 49 · see citing works

Time course of adipose tissue dysfunction associated with antioxidant defense, inflammatory cytokines and oxidative stress in dyslipemic insulin resistant rats

D’Alessandro, M. E., Selenscig, D. A., Illesca, P., Chicco, A. G., & Lombardo, Y. B. (2015) · Food & Function · doi:10.1039/c4fo00903g · Cited by 45 · see citing works

Chia (Salvia hispanica)-supplemented diet ameliorates non-alcoholic fatty liver disease and its metabolic abnormalities in humans

Medina-Urrutia, A. X., López-Uribe, Á. R., Hafidi, M. E., González-Salazar, M. D. C., Posadas‐Sánchez, R., Galarza, E. J., del Valle‐Mondragón, L., & Juárez-Rojas, J. G. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01283-x · Cited by 45 · see citing works

Chia seed ( Salvia hispanica L .) effects and their molecular mechanisms on unbalanced diet experimental studies: A systematic review

Enes, B. N., Moreira, L. D. P. D., da Silva, B. P., Grancieri, M., Lúcio, H. G., Venâncio, V. P., Mertens‐Talcott, S. U., Rosa, C. D. O. B., & Martino, H. S. D. (2020) · Journal of Food Science · doi:10.1111/1750-3841.15003 · Cited by 43 · see citing works

Salvia hispanica L. (chia) seed promotes body fat depletion and modulates adipocyte lipid handling in sucrose-rich diet-fed rats

Oliva, M. E., Ferreira, M. D. R., Joubert, M. B. V., & D’Alessandro, M. E. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109842 · Cited by 43 · see citing works

Effects of eicosapentaenoic acid on the early stage of type 2 diabetic nephropathy in KKAy/Ta mice: involvement of anti-inflammation and antioxidative stress

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The effects of either resveratrol or exercise on macrophage infiltration and switching from M1 to M2 in high fat diet mice

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Acute uterine effects and long-term reproductive alterations in postnatally exposed female rats to a mixture of commercial formulations of endosulfan and glyphosate

Ingaramo, P. I., Schimpf, M. G., Milesi, M. M., Luque, E. H., & Varayoud, J. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.110832 · Cited by 33 · see citing works

Inducible Nitric Oxide Synthase Activity and Expression in Liver and Hepatocytes of Diabetic Rats

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Dietary DHA/EPA Ratio Changes Fatty Acid Composition and Attenuates Diet‐Induced Accumulation of Lipid in the Liver of ApoE−/− Mice

Liu, L., Hu, Q., Wu, H., Wang, X., Gao, C., Chen, G., Yao, P., & Gong, Z. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6256802 · Cited by 29 · see citing works

Chia (Salvia hispanica L.) Flour and Oil Ameliorate Metabolic Disorders in the Liver of Rats Fed a High-Fat and High Fructose Diet

Moreira, L. D. P. D., Enes, B. N., José, V. P. B. D. S., Toledo, R. C. L., Ladeira, L., Cardoso, R. R., Duarte, V. D. S., Hermsdorff, H. H. M., de Barros, F. A. R., & Martino, H. S. D. (2022) · Foods · doi:10.3390/foods11030285 · Cited by 29 · see citing works

<i>Salvia hispanica</i> L. (chia) seed ameliorates liver injury and oxidative stress by modulating NrF2 and NFκB expression in sucrose-rich diet-fed rats

Vega Joubert, M. B., Ingaramo, P., Oliva, M. E., & D'Alessandro, M. E. (2022) · Food &amp; Function · doi:10.1039/d2fo00642a · Cited by 25 · see citing works

Featured Article: Oxidative stress status and liver tissue defenses in diabetic rats during intensive subcutaneous insulin therapy

Dal-Ros, S., Jeandidier, N., Seyfritz, E., Bietiger, W., Péronet, C., Moreau, F., Pinget, M., Maillard, É., & Sigrist, S. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370215603837 · Cited by 23 · see citing works

Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism

Ferreira, M. D. R., Oliva, M. E., Aiassa, V., & D’Alessandro, M. E. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103775 · Cited by 23 · see citing works

Chia seeds oil enriched with phytosterols and mucilage as a cardioprotective dietary supplement towards inflammation, oxidative stress, and dyslipidemia

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Altered uterine angiogenesis in rats treated with a glyphosate-based herbicide

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Effects of Salvia hispanica L. (chia) seed on blood coagulation, endothelial dysfunction and liver fibrosis in an experimental model of Metabolic Syndrome

Oliva, M. E., Ingaramo, P. I., Joubert, M. B. V., Ferreira, M. D. R., & D’Alessandro, M. E. (2021) · Food & Function · doi:10.1039/d1fo02274a · Cited by 17 · see citing works

A Mixture of Algae and Extra Virgin Olive Oils Attenuates the Cardiometabolic Alterations Associated with Aging in Male Wistar Rats

González‐Hedström, D., Amor, S., de la Fuente‐Fernández, M., Tejera‐Muñoz, A., Priego, T., Martı́n, A. I., López‐Calderón, A., Inarejos-García, A. M., Garcı́a-Villalón, Á. L., & Granado, M. (2020) · Antioxidants · doi:10.3390/antiox9060483 · Cited by 16 · see citing works

Nonalcoholic Fatty Liver Disease

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Functional Foods for the Management of Non-Alcoholic Fatty Liver Disease

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New Modified Method for Determination of Nitric Oxide Synthase Activity in Plasma of Vitiligo Patients

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Effects of Methotrexateonil-6alphar, VCAM-1 and NF Kappa B Expression in a Rat Model of Metabolic Syndrome

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Nutritional and Functional New Perspectives and Potential Health Benefits of Quinoa and Chia Seeds

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Chia (Salvia hispanica L.), a functional ‘superfood’: new insights into its botanical, genetic and nutraceutical characteristics

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Astaxanthin improves lipotoxicity, lipid peroxidation and oxidative stress in kidney of sucrose-rich diet-fed rats

Joubert, M. B. V., Ingaramo, P. I., Collins, P., & D’Alessandro, M. E. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109779 · Cited by 15 · see citing works

Effects of Intra-Amniotic Administration of the Hydrolyzed Protein of Chia (Salvia hispanica L.) and Lacticaseibacillus paracasei on Intestinal Functionality, Morphology, and Bacterial Populations, In Vivo (Gallus gallus)

Mishima, M. D. V., Martino, H. S. D., Kolba, N., Shah, D. D., Grancieri, M., dos Santos, K. M. O., Lima, J. P., da Silva, B. P., de Mejı́a, E. G., & Tako, E. (2023) · Nutrients · doi:10.3390/nu15081831 · Cited by 14 · see citing works

The nutritional profile of chia seeds and sprouts: tailoring germination practices for enhancing health benefits-a comprehensive review

Huang, M., Xu, H., Zhou, Q., Xiao, J., Su, Y., & Wang, M. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2337220 · Cited by 12 · see citing works

Astaxanthin obtained from freshwater crustaceans mitigates visceral adiposity by modulating adipose tissue lipogenesis and ameliorates dyslipidemia in high-sucrose diet fed rats

Vargas, M. R., Ferreira, M. D. R., Collins, P., & D’Alessandro, M. E. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.109924 · Cited by 10 · see citing works

Effects of five cannabis oils with different CBD: THC ratios and terpenes on hypertension, dyslipidemia, hepatic steatosis, oxidative stress, and CB1 receptor in an experimental model

Degrave, V. M., Joubert, M. B. V., Filippa, C., Ingaramo, P. I., Torregiani, L., Caro, Y. S., Zan, M. M. D., D’Alessandro, M. E., & Oliva, M. E. (2025) · Journal of Cannabis Research · doi:10.1186/s42238-025-00286-8 · Cited by 10 · see citing works

The Effects of Chia Seed (Salvia hispanica L.) Consumption on Blood Pressure and Body Composition in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Saadh, M. J., Abosaoda, M. K., Baldaniya, L., Kalia, R., Arya, R., Mishra, S., Chauhan, A. S., Kumar, A., & Alizadeh, M. (2025) · Clinical Therapeutics · doi:10.1016/j.clinthera.2024.11.012 · Cited by 8 · see citing works

Supplementation of Salvia hispanica L. seed ameliorated liver function enzymes, hyperlipidemia, and oxidative stress in high fat diet fed Swiss albino mice

Haque, R., Islam, K., Paul, S., Chowdhury, F. I., Bary, M. A., Nayan, S. I., Rafia, S., Alam, M. A., Hassan, S. M. H., Chowdhury, A. K., et al. (2024) · Phytomedicine Plus · doi:10.1016/j.phyplu.2024.100576 · Cited by 6 · see citing works

A Critical Review of the Health Benefits Associated with Chia Seeds (Salvia Hispanica L.)

Al-Younis, Z. K., Al‐Shawi, S. G., Kareem, A. K., Rab, S. O., Renuka Jyothi, S., Mishra, S. S., Chauhan, A. S., Singh, U., Hossen, A., & Ahmed, A. (2025) · Plant Foods for Human Nutrition · doi:10.1007/s11130-025-01401-z · Cited by 6 · see citing works

Salvia hispanica L. (chia) seed have beneficial effects upon visceral adipose tissues extracellular matrix disorders and inflammation developed in a sucrose-rich diet-induced adiposity rodent model

Aiassa, V., Ferreira, M. D. R., Ingaramo, P. I., & D’Alessandro, M. E. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112438 · Cited by 5 · see citing works

Chia flour combined with a high fat diet increases propionic acid production and improves the microbial richness and diversity in female Wistar rats

Mishima, M. D. V., da Silva, B. P., Gomes, M. J. C., Toledo, R. C. L., Silva, R. R., Tako, E., Costa, N. M. B., & Martino, H. S. D. (2023) · Food & Function · doi:10.1039/d3fo01764h · Cited by 3 · see citing works

Hepatic restorative potential of Portulaca oleracea ethanolic extract and/or metformin in type II diabetes mellitus model induced by high-fat diet and STZ

Bahr, N., Nour, A. H. M., El-Kader, A. E.-K. M. A., Demellawy, M. E., & Ghareeb, D. A. (2025) · The Journal of Basic and Applied Zoology · doi:10.1186/s41936-025-00476-z · Cited by 1 · see citing works

α-Linolenic acid rich-chia seed improves glucose tolerance, modulates gluconeogenic pathway and hepatic insulin signaling in an experimental model of metabolic syndrome

Joubert, M. B. V., Oliva, M. E., Ingaramo, P. I., & D’Alessandro, M. E. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112643 · Cited by 1 · see citing works

Astaxanthin alleviates altered hepatic lipid metabolism and oxidative stress in animals fed a high-sucrose diet

Vargas, M., Ferreira, M. D. R., Ingaramo, P. I., Collins, P., & D’Alessandro, M. E. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1781406 · Cited by 1 · see citing works

Cannabis oil modulates liver alterations and endocannabinoid system changes in a female rat model of diet-induced MASLD

Degrave, V. M., Joubert, M. B. V., Ingaramo, P. I., Sedán, D., Andrinolo, D., Loughlin, T. M. M., D’Alessandro, M. E., & Oliva, M. E. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1770150 · Cited by 1 · see citing works

Counteractive effect of chia seed oil extract on 5-fluorouracil-induced hepatotoxicity through targeting the Nrf2/SLC7A11/GPX4 axis

Al-Athari, A. J. H., Hameed, Z. E., Aldhalmi, A. K., Shareef, S. M., Ridha‐Salman, H., & Alsaraf, K. M. (2026) · Comparative Clinical Pathology · doi:10.1007/s00580-026-03790-2 · Cited by 1 · see citing works

Lactiplantibacillus Plantarum YDJ-03 and Limosilactobacillus fermentum YDJ-6 Alleviate Metabolic Syndrome in Mice

Chen, S., Shi, M., Chen, X., Le, Q., & He, J. (2025) · International Journal for Vitamin and Nutrition Research · doi:10.31083/ijvnr31275 · Cited by 1 · see citing works

Functional properties of chia (Salvia hispanica L.) flour, its hydrolyzed protein and phenolic extract on microbiota and gut health in vivo

Mishima, M. D. V. (2023) · doi:10.47328/ufvbbt.2024.115

Chondroitin Sulfate from Halaelurus burgeri Skin Inhibits Hepatic Endoplasmic Reticulum Stress and Inflammation, and Regulates Gut Microbiota

Ren, Z., Gao, S., Hu, S., Chen, S., Jiang, W., & Ge, Y. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400501

Effects of Salvia hispanica L. (chia) seed on blood coagulation, endothelial dysfunction and liver fibrosis in an experimental model of Metabolic Syndrome

Oliva, M. E., Ingaramo, P. I., Joubert, M. B. V., Ferreira, M. D. R., & D’Alessandro, M. E. (2021) · Food & Function · doi:10.1039/d1fo02274a · Cited by 17 · see citing works

<i>Salvia hispanica</i> L. (chia) seed ameliorates liver injury and oxidative stress by modulating NrF2 and NFκB expression in sucrose-rich diet-fed rats

Vega Joubert, M. B., Ingaramo, P., Oliva, M. E., & D'Alessandro, M. E. (2022) · Food &amp; Function · doi:10.1039/d2fo00642a · Cited by 25 · see citing works

α-Linolenic acid rich-chia seed improves glucose tolerance, modulates gluconeogenic pathway and hepatic insulin signaling in an experimental model of metabolic syndrome

Joubert, M. B. V., Oliva, M. E., Ingaramo, P. I., & D’Alessandro, M. E. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112643 · Cited by 1 · see citing works

Dietary chia seeds (Salvia hispanica) improve acute dyslipidemia and steatohepatitis in rats

Fernández‐Martínez, E., Lira‐Islas, I. G., Cariño‐Cortés, R., Soria-Jasso, L. E., Pérez‐Hernández, E., & Pérez‐Hernández, N. (2019) · Journal of Food Biochemistry · doi:10.1111/jfbc.12986 · Cited by 45 · see citing works

Differential effect of oxidative and non-oxidative lipid metabolism on endothelin and PAI-1 serum levels in a population with elevated cardiovascular risk

Ugalde-Canitrot, A. (2002) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(02)80741-3