Salvia hispanica L. (chia) seed ameliorates liver injury and oxidative stress by modulating NrF2 and NFκB expression in sucrose-rich diet-fed rats

Vega Joubert, Michelle Berenice; Ingaramo, Paola; Oliva, María Eugenia; D'Alessandro, María Eugenia

doi:10.1039/d2fo00642a

Cited by 27Diet, Metabolism, and DiseaseLiver Disease Diagnosis and TreatmentGenomics, phytochemicals, and oxidative stress

Salvia hispanica L. (chia) seed ameliorates liver injury and oxidative stress by modulating NrF2 and NFκB expression in sucrose-rich diet-fed rats

Vega Joubert, Michelle Berenice, Ingaramo, Paola, Oliva, María Eugenia, D'Alessandro, María Eugenia·2022·Food & Function

DOI 10.1039/d2fo00642a

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Abstract

The aim of this study was to analyze the liver injury and oxidative stress in an experimental model of Metabolic Syndrome (MS) induced by chronic administration of a sucrose-rich diet (SRD) and to evaluate the effects of chia seed as a therapeutic strategy. Male Wistar rats were fed with a reference diet (RD) -6 months- or a SRD -3 months. Then, the latter group was randomly divided into two subgroups. One subgroup continued receiving the SRD for up to 6 months and the other was fed with a SRD where whole chia seed was incorporated as a source of dietary fat for the next 3 months (SRD+CHIA). The results showed that rats fed with a SRD for a long period of time developed dyslipidemia, hyperglycemia, hepatic lipid accumulation, liver injury, hepatic lipid peroxidation and oxidative stress. Hepatic NrF2 expression was significantly decreased. In addition, a significant increase in hepatic NFκB p65 expression and a positive correlation of this with plasma TNFα levels were found. The administration of chia seed for 3 months reversed dyslipidemia, hyperglycemia, lipid accumulation, liver injury, lipid peroxidation and oxidative stress. In the liver tissue, NrF2 expression was normalized and NFκB p65 expression was decreased, the latter was associated with a decrease in plasma TNFα levels. The present study showed new aspects of liver damage, lipid peroxidation and oxidative stress in dyslipidemic insulin resistant rats chronically fed with a sucrose-rich diet. However, we demonstrated new properties and molecular mechanisms associated with the beneficial anti-oxidant effects of chia seed consumption.

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Chia seeds ameliorate endothelial dysfunction in metabolic syndrome, liver inflammation or injury, and oxidative stress.
“In addition, chia seeds ameliorate endothelial dysfunction in metabolic syndrome, liver inflammation or injury, and oxidative stress [138,139].”
From Nutritional and Functional New Perspectives and Potential Health Benefits of Quinoa and Chia Seeds (2023) · cites this paper as [139]

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Authors: Vega Joubert, M. B., Ingaramo, P., Oliva, M. E., & D'Alessandro, M. E.
Affiliations: Laboratorio de Estudio de Enfermedades Metabólicas relacionadas con la Nutrición, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Santa Fe, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
ORCID: Ingaramo, Paola
Oliva, María Eugenia
D'Alessandro, María Eugenia
Venue: Food & Function
Publisher: Royal Society of Chemistry (RSC)
Published: 2022
Volume: 13
Issue: 13
Pages: 7333-7345
ISSN: 2042-6496 (ISSN-L)
2042-650X
DOI: 10.1039/d2fo00642a
OpenAlex: W4283265701
Cited by: 25
References: 46
Citations by year: 2026: 7 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 2
FWCI: 3.35
Type: journal article
Language: en
Open access: closed
Licence: rsc.li/journals-terms-of-use (am, 514 d)
Locations: Food & Function (publishedVersion)
PubMed (publishedVersion)
Funders: Universidad Nacional del Litoral (CAI+D #50620190100008LI)
Fondo para la Investigación Científica y Tecnológica (Grant PICT #2018-01344)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords: Salvia hispanica, liver injury, oxidative stress, metabolic syndrome, sucrose-rich diet, Nrf2, NF-κB p65, TNF-α, dyslipidemia, hyperglycemia, hepatic lipid peroxidation, hepatic lipid accumulation, insulin resistance, antioxidant activity
MeSH terms: Salvia hispanica, Animals, Diet, Hyperglycemia, Lipids, Liver, Male, Seeds, Sucrose, Tumor Necrosis Factor-alpha, NF-kappa B, Rats, Wistar, Oxidative Stress, Salvia, Dyslipidemias, NF-E2-Related Factor 2, Rats

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Salvia hispanica L. (chia) seed ameliorates liver injury and oxidative stress by modulating NrF2 and NFκB expression in sucrose-rich diet-fed rats

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