Rational design of a chalcogenopyrylium-based surface-enhanced resonance Raman scattering nanoprobe with attomolar sensitivity
Open accessAbstract
High sensitivity and specificity are two desirable features in biomedical imaging. Raman imaging has surfaced as a promising optical modality that offers both. Here we report the design and synthesis of a group of near-infrared absorbing 2-thienyl-substituted chalcogenopyrylium dyes tailored to have high affinity for gold. When adsorbed onto gold nanoparticles, these dyes produce biocompatible SERRS nanoprobes with attomolar limits of detection amenable to ultrasensitive in vivo multiplexed tumour and disease marker detection. Raman imaging offers great potential in biomedical imaging due to the combination of specificity and sensitivity. Here, the authors show nanoparticles functionalized with a chalcogenopyrylium reporter molecule, giving bright probes with low limits of detection for in vivoimaging.
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“Pyrylium and xanthylium-based dyes represent some of the most sensitive Raman reporters synthesized to date [9, 11, 29].”
BackgroundMethodSelf-citationMultiplexing potential of NIR resonant and non-resonant Raman reporters for bio-imaging applications
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- Authors
- Harmsen, S., Bedics, M. A., Wall, M. A., Huang, R., Detty, M. R., & Kircher, M. F.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- University at Buffalo, State University of New York (US)
- Corresponding author
- Detty, Michael R.
- Kircher, Moritz F.
- Venue
- Nature Communications
- Published
- 2015-03-24
- Volume
- 6
- Issue
- 1
- Pages
- 6570-6570
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4372816
- OpenAlex
- W2075646173
- Cited by
- 137
- References
- 44
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 10 · 2023: 8 · 2022: 14 · 2021: 11 · 2020: 10 · 2019: 14 · 2018: 15 · 2017: 21 · 2016: 13 · 2015: 4
- FWCI
- 5.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- CUNY Academic Works (City University of New York) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Science Foundation (1151379, CA008748, P30 CA008748, 0965983)
- Damon Runyon Cancer Research Foundation (P30 CA008748, DRR‐29‐14)
- Dana Foundation
- Radiological Society of North America
- Memorial Sloan-Kettering Cancer Center (CA008748, P30 CA008748)
- Geoffrey Beene Cancer Research Center (P30 CA008748)
- Bayer HealthCare
- National Institutes of Health (NIH-R01, CA008748, EB017748)
- National Cancer Institute (K08CA163961, P30CA008748)
- National Institute of General Medical Sciences (GM-94367, R01GM094367)
- National Institute of Biomedical Imaging and Bioengineering (R01EB017748)
- Division of Graduate Education (0965983)
- Division of Chemistry (CHE-1151379, 1151379)
- Topics
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Keywords
- surface-enhanced Raman scattering, gold nanoparticles, Raman imaging, near-infrared dyes, attomolar detection, cancer detection, multiplexed imaging, in vivo imaging
- MeSH terms
- Adsorption, Coloring Agents, Gold, Heterocyclic Compounds, 3-Ring, Spectrum Analysis, Raman, Surface Properties, Chalcogens, Metal Nanoparticles
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