Cited by 137Gold and Silver Nanoparticles Synthesis and ApplicationsSpectroscopy Techniques in Biomedical and Chemical ResearchLuminescence and Fluorescent Materials

Rational design of a chalcogenopyrylium-based surface-enhanced resonance Raman scattering nanoprobe with attomolar sensitivity

Open access
Harmsen, Stefan, Bedics, Matthew A., Wall, Matthew A., Huang, Ruimin, Detty, Michael R., Kircher, Moritz F.·2015·Nature Communications

Abstract

High sensitivity and specificity are two desirable features in biomedical imaging. Raman imaging has surfaced as a promising optical modality that offers both. Here we report the design and synthesis of a group of near-infrared absorbing 2-thienyl-substituted chalcogenopyrylium dyes tailored to have high affinity for gold. When adsorbed onto gold nanoparticles, these dyes produce biocompatible SERRS nanoprobes with attomolar limits of detection amenable to ultrasensitive in vivo multiplexed tumour and disease marker detection. Raman imaging offers great potential in biomedical imaging due to the combination of specificity and sensitivity. Here, the authors show nanoparticles functionalized with a chalcogenopyrylium reporter molecule, giving bright probes with low limits of detection for in vivoimaging.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/ncomms7570

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Harmsen, S., Bedics, M. A., Wall, M. A., Huang, R., Detty, M. R., & Kircher, M. F.
Affiliations
  • Memorial Sloan Kettering Cancer Center (US)
  • University at Buffalo, State University of New York (US)
Corresponding author
  • Detty, Michael R.
  • Kircher, Moritz F.
Venue
Nature Communications
Published
2015-03-24
Volume
6
Issue
1
Pages
6570-6570
ISSN
2041-1723 (ISSN-L)
OpenAlex
W2075646173
Cited by
137
References
44
Citations by year
2026: 7 · 2025: 10 · 2024: 10 · 2023: 8 · 2022: 14 · 2021: 11 · 2020: 10 · 2019: 14 · 2018: 15 · 2017: 21 · 2016: 13 · 2015: 4
FWCI
5.78
Type
journal article
Language
en
Open access
Locations
  • Nature Communications (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • CUNY Academic Works (City University of New York) (submittedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
  • National Science Foundation (1151379, CA008748, P30 CA008748, 0965983)
  • Damon Runyon Cancer Research Foundation (P30 CA008748, DRR‐29‐14)
  • Dana Foundation
  • Radiological Society of North America
  • Memorial Sloan-Kettering Cancer Center (CA008748, P30 CA008748)
  • Geoffrey Beene Cancer Research Center (P30 CA008748)
  • Bayer HealthCare
  • National Institutes of Health (NIH-R01, CA008748, EB017748)
  • National Cancer Institute (K08CA163961, P30CA008748)
  • National Institute of General Medical Sciences (GM-94367, R01GM094367)
  • National Institute of Biomedical Imaging and Bioengineering (R01EB017748)
  • Division of Graduate Education (0965983)
  • Division of Chemistry (CHE-1151379, 1151379)
Topics
  • Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
Keywords
surface-enhanced Raman scattering, gold nanoparticles, Raman imaging, near-infrared dyes, attomolar detection, cancer detection, multiplexed imaging, in vivo imaging
MeSH terms
Adsorption, Coloring Agents, Gold, Heterocyclic Compounds, 3-Ring, Spectrum Analysis, Raman, Surface Properties, Chalcogens, Metal Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review