Adipose derived mesenchymal stem cell-seeded regenerated silk fibroin scaffolds reverse liver fibrosis in mice
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Silk fibroin scaffolds loaded with adipose-derived mesenchymal stem cells reverse liver fibrosis by reducing inflammation and enhancing fatty acid metabolism pathways.
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A regenerated silk fibroin scaffold loaded with AD-MSCs reduced fibrosis in mouse models.
“A recent research reported that a regenerated silk fibroin scaffold (RSF) loaded with AD-MSCs reduced fibrosis in mouse models [368].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [368]
Unlike other biomaterials, RSF promoted the formation of functional blood vessels and bile ducts.
“Different from other biomaterials used previously, which are unable to form liver-like tissues with complex structures, RSF promoted the formation of functional blood vessels and bile ducts.”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [368]
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“A recent research reported that a regenerated silk fibroin scaffold (RSF) loaded with AD-MSCs reduced fibrosis in mouse models [368].”
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Self-citation
- Authors
- Li, W., Shi, X., Zhang, D., Hu, J., Zhao, S., Ye, S., Wang, J., Liu, X., Zhang, Q., Wang, Z., Zhang, Y., & Yan, L.
- Affiliations
- Chinese PLA General Hospital (CN)
- Aerospace Center Hospital (CN)
- The Second Medical Center and National Clinical Research Center of Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, PR China
- Donghua University (CN)
- Lanzhou University (CN)
- Corresponding author
- Wang, Zhanbo
- Zhang, Yaopeng
- Yan, Li
- Venue
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2025
- Volume
- 13
- Issue
- 13
- Pages
- 4201-4213
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- OpenAlex
- W4407983475
- Cited by
- 5
- References
- 52
- Citations by year
- 2026: 2 · 2025: 3
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Materials Chemistry B (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31971263)
- National Key Research and Development Program of China (2019yfa0110600)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- adipose-derived stem cells, silk fibroin scaffolds, liver fibrosis, chronic liver fibrosis, tissue engineering, cell-seeded scaffolds, Wnt/β-catenin signaling
- MeSH terms
- Adipose Tissue, Animals, Carbon Tetrachloride, Fibroins, Liver Cirrhosis, Male, Mice, Inbred C57BL, Mesenchymal Stem Cell Transplantation, Mice, Tissue Scaffolds, Mesenchymal Stem Cells
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