Stem cells for treatment of liver fibrosis/cirrhosis: clinical progress and therapeutic potential
Open accessAbstract
Cost-effective treatment strategies for liver fibrosis or cirrhosis are limited. Many clinical trials of stem cells for liver disease shown that stem cells might be a potential therapeutic approach. This review will summarize the published clinical trials of stem cells for the treatment of liver fibrosis/cirrhosis and provide the latest overview of various cell sources, cell doses, and delivery methods. We also describe the limitations and strengths of various stem cells in clinical applications. Furthermore, to clarify how stem cells play a therapeutic role in liver fibrosis, we discuss the molecular mechanisms of stem cells for treatment of liver fibrosis, including liver regeneration, immunoregulation, resistance to injury, myofibroblast repression, and extracellular matrix degradation. We provide a perspective for the prospects of future clinical implementation of stem cells.
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MSCs also play a role in mediating ECM rearrangement to exert anti-fibrotic effects.
“In addition to reducing ECM deposition, MSCs also play a role in mediating ECM rearrangement to exert anti-fibrotic effects [109].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [109]
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Liver Injury and Regeneration: Current Understanding, New Approaches, and Future Perspectives
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- Authors
- Liu, P., Mao, Y., Xie, Y., Wei, J., & Yao, J.
- Affiliations
- Lanzhou University (CN)
- Corresponding author
- Yao, Jia
- ORCID
- Venue
- Stem Cell Research & Therapy
- Published
- 2022-07-26
- Volume
- 13
- Issue
- 1
- Pages
- 356-356
- ISSN
- 1757-6512 (ISSN-L)
- PMC
- PMC9327386
- OpenAlex
- W4288068740
- Cited by
- 82
- References
- 148
- Citations by year
- 2026: 12 · 2025: 20 · 2024: 31 · 2023: 15 · 2022: 3
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Stem Cell Research & Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Lanzhou University
- National Natural Science Foundation of China (32160230)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- stem cell therapy, liver fibrosis, liver cirrhosis, clinical trials, cell sources, cell delivery, liver regeneration, immune regulation, extracellular matrix degradation
- MeSH terms
- Fibrosis, Humans, Liver, Liver Cirrhosis, Liver Regeneration, Mesenchymal Stem Cell Transplantation
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