Cited by 82Liver physiology and pathologyMesenchymal stem cell researchLiver Disease and Transplantation

Stem cells for treatment of liver fibrosis/cirrhosis: clinical progress and therapeutic potential

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Liu, Pinyan, Mao, Yongcui, Xie, Ye, Wei, Jiayun, Yao, Jia·2022·Stem Cell Research & Therapy

Abstract

Cost-effective treatment strategies for liver fibrosis or cirrhosis are limited. Many clinical trials of stem cells for liver disease shown that stem cells might be a potential therapeutic approach. This review will summarize the published clinical trials of stem cells for the treatment of liver fibrosis/cirrhosis and provide the latest overview of various cell sources, cell doses, and delivery methods. We also describe the limitations and strengths of various stem cells in clinical applications. Furthermore, to clarify how stem cells play a therapeutic role in liver fibrosis, we discuss the molecular mechanisms of stem cells for treatment of liver fibrosis, including liver regeneration, immunoregulation, resistance to injury, myofibroblast repression, and extracellular matrix degradation. We provide a perspective for the prospects of future clinical implementation of stem cells.

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Authors
Liu, P., Mao, Y., Xie, Y., Wei, J., & Yao, J.
Affiliations
Lanzhou University (CN)
Corresponding author
Yao, Jia
Venue
Stem Cell Research & Therapy
Published
2022-07-26
Volume
13
Issue
1
Pages
356-356
ISSN
1757-6512 (ISSN-L)
OpenAlex
W4288068740
Cited by
82
References
148
Citations by year
2026: 12 · 2025: 20 · 2024: 31 · 2023: 15 · 2022: 3
FWCI
2.96
Type
journal article
Language
en
Open access
Locations
  • Stem Cell Research & Therapy (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Lanzhou University
  • National Natural Science Foundation of China (32160230)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Keywords
stem cell therapy, liver fibrosis, liver cirrhosis, clinical trials, cell sources, cell delivery, liver regeneration, immune regulation, extracellular matrix degradation
MeSH terms
Fibrosis, Humans, Liver, Liver Cirrhosis, Liver Regeneration, Mesenchymal Stem Cell Transplantation

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