The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Re‐programming of translation following cell stress allows IRES‐mediated translation to predominate
Abstract
There is now an overwhelming body of evidence to suggest that internal ribosome entry is required to maintain the expression of specific proteins during patho‐physiological situations when cap‐dependent translation is compromised, for example, following heat shock or during mitosis, hypoxia, differentiation and apoptosis. Translational profiling has been used by several groups to assess the extent to which alternative mechanisms of translation initiation selectively recruit mRNAs to polysomes during cell stress. The data from these studies have shown that under each condition 3–5% of coding mRNAs remain associated with the polysomes. Importantly, the genes identified in each of these studies do not show a significant amount of overlap, suggesting that 10–15% of all mRNAs have the capability for their initiation to occur via alternative mechanism(s).
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Molecular mechanisms of translational control
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Cited by
Extensive translation of circular RNAs driven by N6-methyladenosine
Yang, Y., Fan, X., Mao, M., Song, X., Wu, P., Zhang, Y., Jin, Y., Yang, Y., Chen, L.-L., Wang, Y., et al. (2017) · Cell Research · doi:10.1038/cr.2017.31 · Cited by 1,855
Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
Leppek, K., Das, R., & Barna, M. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.103 · Cited by 949
Hogan, D. J., Riordan, D. P., Gerber, A. P., Herschlag, D., & Brown, P. O. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060255 · Cited by 609
In Posidonia oceanica cadmium induces changes in DNA methylation and chromatin patterning
Greco, M., Chiappetta, A., Bruno, L., & Bitonti, M. B. (2012) · Journal of Experimental Botany · doi:10.1093/jxb/err313 · Cited by 538
Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein
Sawicka, K., Bushell, M., Spriggs, K. A., & Willis, A. E. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360641 · Cited by 332
Self-citation
Metadata
- Authors
- Spriggs, K. A., Stoneley, M., Bushell, M., & Willis, A. E.
- Venue
- Biology of the Cell
- Publisher
- Wiley
- Published
- 2008-01
- Volume
- 100
- Issue
- 1
- Pages
- 27-38
- ISSN
- 0248-4900 (ISSN-L)
- 1768-322X
- OpenAlex
- W1964221844
- Cited by
- 294
- References
- 7
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- closed
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