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Cited by 991RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancerRNA Research and Splicing

Molecular mechanisms of translational control

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Gebauer, Fátima, Hentze, Matthias W.·2004·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm1488PMC PMC7097087
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Abstract

Translational control is widely used to regulate gene expression. This mode of regulation is especially relevant in situations where transcription is silent or when local control over protein accumulation is required. Although many examples of translational regulation have been described, only a few are beginning to be mechanistically understood. Instead of providing a comprehensive account of the examples that are known at present, we discuss instructive cases that serve as paradigms for different modes of translational control.

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  • Regulation of mRNA turnover plays a major role in the overall control of gene expression, and the mechanisms underlying steady-state levels of naturally expressed mRNAs in the cytoplasm have received considerable attention.

    “The mechanisms underlying the steady state levels of naturally expressed mRNAs in the cytoplasm have received considerable attention recently because the regulation of mRNA turnover plays a major role in the overall control of gene expression.26,27”

    From Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells (2006) · cites this paper as [26]

    The Main section discusses translational control of gene expression, including whether cytoplasmic mRNAs are actively translated. It does not address mRNA turnover as a determinant of steady-state mRNA levels or say that those mechanisms have received considerable attention (searched: mRNA turnover, steady-state levels, stability, degradation and decay). (LLM, conf=0.72)

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Cited by

Sorted by citations

Authors
Gebauer, F., & Hentze, M. W.
Affiliations
  • Centre for Genomic Regulation (ES)
  • European Molecular Biology Laboratory (DE)
ORCID
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2004-10-01
Volume
5
Issue
10
Pages
827-835
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
DOI
10.1038/nrm1488
PMC
PMC7097087
OpenAlex
W2045830695
Cited by
991
References
5
Citations by year
2026: 26 · 2025: 34 · 2024: 31 · 2023: 43 · 2022: 40 · 2021: 36 · 2020: 31 · 2019: 23 · 2018: 40 · 2017: 37 · 2016: 37 · 2015: 37 · 2014: 50 · 2013: 56 · 2012: 66
FWCI
4.42
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • “la Caixa” Foundation
  • European Commission
  • Deutsche Forschungsgemeinschaft
  • Ministerio de Ciencia y Tecnología
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords
translational regulation, gene expression regulation, post-transcriptional regulation, protein accumulation, protein synthesis inhibition, translation initiation, translation elongation, translation termination
MeSH terms
Animals, Gene Expression Regulation, Models, Genetic, Nucleic Acid Conformation, Ribosomes, RNA, Messenger, Protein Biosynthesis, Eukaryotic Initiation Factor-2, MicroRNAs, Eukaryotic Initiation Factor-4E, Macromolecular Substances

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