The ribonome: a dominant force in co‐ordinating gene expression
Open accessAbstract
The ribonome is the total cellular complement of RNAs and their regulatory factors functioning dynamically in time and space within ribonucleoprotein complexes. We theorize that the ribonome is an ancient central co-ordinator that has evolved to communicate on multiple levels to the proteome on the one hand (feed-forward), and the transcriptome and RNA processing machinery on the other (feed-back). Furthermore, the ribonome can potentially communicate to other cells horizontally with implications for biological information transfer and for the evolution of both RNA and DNA operating systems. The post-transcriptional RNA operon theory of co-regulated gene expression accounts for the co-ordinated dynamics of RNA-binding proteins within the cellular ribonome, thus allowing for the recombination and remodelling of the RNPs (ribonucleoproteins) to generate new combinations of functionally related proteins. Thus, post-transcriptional RNA operons form the core of the ribonomic operating system in which both their control and co-ordination govern outcomes. Within the ribonome, RNA-binding proteins control one another's mRNAs to keep the global mRNA environment in balance. We argue that these post-transcriptional ribonomic systems provide an information management and distribution centre for evolutionary expansion of multicellularity in tissues, organs, organisms, and their communities.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
HuD binds mRNAs of several RBPs, including its own, HuB, HuR, Cugbp2, Musashi 2, and Staufen 2, indicating a complex regulatory network between HuD and other components of the ribonome.
“Of particular interest, this study also found that HuD binds mRNAs of several RBPs, including its own, HuB, HuR, Cugbp2, Musashi 2, and Staufen 2, indicating a complex regulatory network between HuD and other components of the ribonome (Pullmann et al. 2007; Mansfield and Keene 2009; Bolognani et al. 2010).”
From Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction (2013) · cites this paper as Mansfield and Keene 2009
The “Regulators of regulators” section (page unavailable) describes RBPs binding their own and one another’s mRNAs, supporting the idea of an interconnected ribonome. It discusses a group including HuR, not HuD; our copy does not report HuD binding the listed mRNAs (searched: HuD, Cugbp2, Musashi, Staufen). (LLM, conf=0.82)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Gherzi, R., Trabucchi, M., Ponassi, M., Ruggiero, T., Corte, G., Moroni, C., Chen, C., Khabar, K. S. A., Andersen, J., & Briata, P. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0050005 · Cited by 148 · see citing works
RetractedBartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714 · see citing works
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works
Correlation between Protein and mRNA Abundance in Yeast
Gygi, S. P., Rochon, Y., Franza, B. R., & Aebersold, R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.1720 · Cited by 3,819 · see citing works
Transcriptional regulatory code of a eukaryotic genome
Harbison, C. T., Gordon, D. B., Lee, T. I., Rinaldi, N. J., MacIsaac, K. D., Danford, T., Hannett, N. M., Tagne, J., Reynolds, D. B., Yoo, J. Y., et al. (2004) · Nature · doi:10.1038/nature02800 · Cited by 2,116 · see citing works
Ratajczak, J., Miękus, K., Kucia, M., Zhang, J., Reca, R., Dvořák, P., & Ratajczak, M. Z. (2006) · Leukemia · doi:10.1038/sj.leu.2404132 · Cited by 1,630 · see citing works
Relief of microRNA-Mediated Translational Repression in Human Cells Subjected to Stress
Bhattacharyya, S. N., Habermacher, R., Martiné, U., Closs, E. I., & Filipowicz, W. (2006) · Cell · doi:10.1016/j.cell.2006.04.031 · Cited by 1,332 · see citing works
RNA regulons: coordination of post-transcriptional events
Keene, J. D. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2111 · Cited by 1,321 · see citing works
Self-citationRNA-binding proteins in human genetic disease
Gebauer, F., Schwarzl, T., Valcárcel, J., & Hentze, M. W. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-00302-y · Cited by 1,174 · see citing works
Lu, P., Vogel, C., Wang, R., Yao, X., & Marcotte, E. M. (2007) · Nature Biotechnology · doi:10.1038/nbt1270 · Cited by 1,139 · see citing works
CLIP Identifies Nova-Regulated RNA Networks in the Brain
Ule, J., Jensen, K. B., Ruggiu, M., Mele, A., Ule, A., & Darnell, R. B. (2003) · Science · doi:10.1126/science.1090095 · Cited by 1,120 · see citing works
Exosomes: endosomal-derived vesicles shipping extracellular messages
Février, B., & Raposo, G. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.06.003 · Cited by 1,013 · see citing works
From Birth to Death: The Complex Lives of Eukaryotic mRNAs
Moore, M. J. (2005) · Science · doi:10.1126/science.1111443 · Cited by 1,003 · see citing works
The spliceosome deposits multiple proteins 20–24 nucleotides upstream of mRNA exon–exon junctions
Hir, H. L., Izaurralde, E., Maquat, L. E., & Moore, M. J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.24.6860 · Cited by 970 · see citing works
A Unified Theory of Gene Expression
Orphanides, G., & Reinberg, D. (2002) · Cell · doi:10.1016/s0092-8674(02)00655-4 · Cited by 898 · see citing works
Involvement of MicroRNA in AU-Rich Element-Mediated mRNA Instability
Jing, Q., Huang, S., Guth, S., Zarubin, T., Motoyama, A. B., Chen, J., Padova, F. D., Lin, S., Gram, H., & Han, J. (2005) · Cell · doi:10.1016/j.cell.2004.12.038 · Cited by 849 · see citing works
Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm
Piñol-Roma, S., & Dreyfuss, G. (1992) · Nature · doi:10.1038/355730a0 · Cited by 842 · see citing works
Movement of Eukaryotic mRNAs Between Polysomes and Cytoplasmic Processing Bodies
Brengues, M., Teixeira, D., & Parker, R. (2005) · Science · doi:10.1126/science.1115791 · Cited by 796 · see citing works
Integrated Genomic and Proteomic Analyses of Gene Expression in Mammalian Cells
Tian, Q., Stepaniants, S., Mao, M., Weng, L., Feetham, M. C., Doyle, M. J., Yi, E. C., Dai, H. A., Thórsson, V., Eng, J. K., et al. (2004) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m400055-mcp200 · Cited by 778 · see citing works
Precision and functional specificity in mRNA decay
Wang, Y., Liu, C. L., Storey, J. D., Tibshirani, R. J., Herschlag, D., & Brown, P. O. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092538799 · Cited by 708 · see citing works
The Regulation of Exosome Secretion: a Novel Function of the p53 Protein
Yu, X., Harris, S. L., & Levine, A. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4579 · Cited by 688 · see citing works
Griffin, T. J., Gygi, S. P., Ideker, T. E., Rist, B., Eng, J. K., Hood, L., & Aebersold, R. H. (2002) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m200001-mcp200 · Cited by 663 · see citing works
Gerber, A. P., Herschlag, D., & Brown, P. O. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020079 · Cited by 651 · see citing works
RNA-binding proteins in human genetic disease
Lukong, K. E., Chang, K.-W., Khandjian, E. W., & Richard, S. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.05.004 · Cited by 649 · see citing works
Gould, S. J., Booth, A. M., & Hildreth, J. E. K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1831413100 · Cited by 638 · see citing works
Keene, J. D., Komisarow, J. M., & Friedersdorf, M. B. (2006) · Nature Protocols · doi:10.1038/nprot.2006.47 · Cited by 612 · see citing works
Self-citationHogan, D. J., Riordan, D. P., Gerber, A. P., Herschlag, D., & Brown, P. O. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060255 · Cited by 609 · see citing works
Decay Rates of Human mRNAs: Correlation With Functional Characteristics and Sequence AttributesPreprint
Yang, E., van Nimwegen, E., Zavolan, M., Rajewsky, N., Schroeder, M., Magnasco, M., & Darnell, J. E., Jr. (2003) · Genome Research · doi:10.1101/gr.1272403 · Cited by 598 · see citing works
Phosphorylation of HuR by Chk2 Regulates SIRT1 Expression
Abdelmohsen, K., Pullmann, R., Lal, A., Kim, H. H., Galbán, S., Yang, X., Blethrow, J. D., Walker, M., Shubert, J., Gillespie, D. A., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.011 · Cited by 527 · see citing works
Introns and the origin of nucleus–cytosol compartmentalization
Martin, W. F., & Koonin, E. V. (2006) · Nature · doi:10.1038/nature04531 · Cited by 497 · see citing works
Transcription Factors Bind Thousands of Active and Inactive Regions in the Drosophila Blastoderm
Li, X., MacArthur, S., Bourgon, R., Nix, D. A., Pollard, D. A., Iyer, V. N., Hechmer, A., Simirenko, L., Stapleton, M., Hendriks, C. L. L., et al. (2008) · eScholarship (California Digital Library) · doi:10.1371/journal.pbio.0060027 · Cited by 479 · see citing works
Eukaryotic mRNPs May Represent Posttranscriptional Operons
Keene, J. D., & Tenenbaum, S. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00559-2 · Cited by 457 · see citing works
Self-citationRNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation
Mazan-Mamczarz, K., Galbán, S., de Silanes, I. L., Martindale, J. L., Atasoy, U., Keene, J. D., & Gorospe, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432104100 · Cited by 445 · see citing works
Self-citationRajasekhar, V. K., Viale, A., Socci, N. D., Wiedmann, M., Hu, X., & Holland, E. C. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00395-2 · Cited by 420 · see citing works
Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays
Tenenbaum, S. A., Carson, C. C., Lager, P. J., & Keene, J. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.26.14085 · Cited by 397 · see citing works
Self-citationBaj‐Krzyworzeka, M., Szatanek, R., Węglarczyk, K., Baran, J., Urbanowicz, B., Brański, P., Ratajczak, M. Z., & Zembala, M. (2005) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-005-0075-9 · Cited by 397 · see citing works
Functional Specificity among Ribosomal Proteins Regulates Gene Expression
Komili, S., Farny, N. G., Roth, F. P., & Silver, P. A. (2007) · Cell · doi:10.1016/j.cell.2007.08.037 · Cited by 390 · see citing works
Wang, T., Zeng, J., Lowe, C. B., Sellers, R. G., Salama, S. R., Yang, M., Burgess, S. M., Brachmann, R. K., & Haussler, D. H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703637104 · Cited by 389 · see citing works
Lam, L. T., Pickeral, O. K., Peng, A. C., Rosenwald, A., Hurt, E. M., Giltnane, J. M., Averett, L., Zhao, H. G., Davis, R. E., Sathyamoorthy, M., et al. (2001) · Genome biology · doi:10.1186/gb-2001-2-10-research0041 · Cited by 371 · see citing works
Landthaler, M., Gaidatzis, D., Rothballer, A., Chen, P., Soll, S. J., Dinic, L., Ojo, T., Hafner, M., Zavolan, M., & Tuschl, T. (2008) · RNA · doi:10.1261/rna.1351608 · Cited by 355 · see citing works
Washburn, M. P., Koller, A. A., Oshiro, G., Ulaszek, R. R., Plouffe, D., Deciu, C., Winzeler, E. A., & Yates, J. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0634629100 · Cited by 354 · see citing works
Grigull, J., Mnaimneh, S., Pootoolal, J., Robinson, M. D., & Hughes, T. R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.12.5534-5547.2004 · Cited by 342 · see citing works
HuR binding to cytoplasmic mRNA is perturbed by heat shock
Gallouzi, I., Brennan, C. M., Stenberg, M. G., Swanson, M. S., Eversole, A., Maizels, N., & STEITZ, J. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3073 · Cited by 326 · see citing works
Origin of retroviruses from cellular moveable genetic elements
Temin, H. M. (1980) · Cell · doi:10.1016/0092-8674(80)90420-1 · Cited by 307 · see citing works
A Universal Framework for Regulatory Element Discovery across All Genomes and Data Types
Elemento, O., Slonim, N., & Tavazoie, S. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.027 · Cited by 306 · see citing works
Multilevel Regulation of Gene Expression by MicroRNAs
Makeyev, E. V., & Maniatis, T. (2008) · Science · doi:10.1126/science.1152326 · Cited by 300 · see citing works
Why is Hu where? Shuttling of early-response-gene messenger RNA subsets
Keene, J. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.1.5 · Cited by 294 · see citing works
Self-citationGerber, A. P., Luschnig, S., Krasnow, M. A., Brown, P. O., & Herschlag, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509260103 · Cited by 277 · see citing works
Galgano, A., Forrer, M., Jaśkiewicz, Ł., Kanitz, A., Zavolan, M., & Gerber, A. P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003164 · Cited by 266 · see citing works
The ribosome filter hypothesis
Mauro, V. P., & Edelman, G. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192442499 · Cited by 260 · see citing works
Abdelmohsen, K., Kuwano, Y., Kim, H. H., & Gorospe, M. (2008) · Biological Chemistry · doi:10.1515/bc.2008.022 · Cited by 258 · see citing works
Reprogramming fibroblasts to express T-cell functions using cell extracts
Håkelien, A.-M., Landsverk, H. B., Robl, J. M., Skålhegg, B. S., & Collas, P. (2002) · Nature Biotechnology · doi:10.1038/nbt0502-460 · Cited by 237 · see citing works
Briata, P., Forcales, S. V., Ponassi, M., Corte, G., Chen, C., Karin, M., Puri, P., & Gherzi, R. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.10.021 · Cited by 236 · see citing works
Lipopolysaccharide-induced Methylation of HuR, an mRNA-stabilizing Protein, by CARM1
Li, H., Park, S., Kilburn, B., Jelinek, M. A., Henschen-Edman, A. H., Aswad, D. W., Stallcup, M. R., & Laird‐Offringa, I. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206187200 · Cited by 233 · see citing works
Keene, J. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111145598 · Cited by 230 · see citing works
Self-citationGlobal analysis of Escherichia coli RNA degradosome function using DNA microarrays
Bernstein, J. A., Lin, P.-H., Cohen, S. N., & Lin‐Chao, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308747101 · Cited by 230 · see citing works
Yeast Mitochondrial Biogenesis: A Role for the PUF RNA-Binding Protein Puf3p in mRNA Localization
Saint-Georges, Y., Garcia, M., Delaveau, T., Jourdren, L., Crom, S. L., Lemoine, S., Tanty, V., Devaux, F., & Jacq, C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002293 · Cited by 230 · see citing works
Coupling and coordination in gene expression processes: a systems biology view
Komili, S., & Silver, P. A. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2223 · Cited by 218 · see citing works
Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR
Doller, A., Pfeilschifter, J. M., & Eberhardt, W. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.05.007 · Cited by 215 · see citing works
AMP-Activated Kinase Regulates Cytoplasmic HuR
Wang, W., Fan, J., Yang, X., Fürer-Galbán, S., de Silanes, I. L., von Kobbe, C., Guo, J., Georas, S. N., Foufelle, F., Hardie, D. G., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.10.3425-3436.2002 · Cited by 208 · see citing works
Pullmann, R., Kim, H. H., Abdelmohsen, K., Lal, A., Martindale, J. L., Yang, X., & Gorospe, M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00500-07 · Cited by 199 · see citing works
Post-transcriptional gene regulation: From genome-wide studies to principles
Halbeisen, R. E., Galgano, A., Scherrer, T., & Gerber, A. P. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7447-6 · Cited by 195 · see citing works
Doller, A., Huwiler, A., Müller, R., Radeke, H. H., Pfeilschifter, J. M., & Eberhardt, W. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-09-0850 · Cited by 191 · see citing works
Aliotta, J. M., Sanchez-Guijo, F. M., Dooner, G. J., Johnson, K. W., Dooner, M. S., Greer, K., Greer, D. A., Pimentel, J., Kolankiewicz, L. M., Puente, N. A., et al. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0128 · Cited by 180 · see citing works
Integrating gene and protein expression data: pattern analysis and profile mining
Cox, B., Kislinger, T., & Emili, A. (2005) · Methods · doi:10.1016/j.ymeth.2004.08.021 · Cited by 176 · see citing works
Search for organising principles: understanding in systems biology
Mesarović, M., Keene, J. D., & Sreenath, S. N. (2004) · Systems Biology · doi:10.1049/sb:20045010 · Cited by 168 · see citing works
Self-citationA systems view of mRNP biologyPreprint
Hieronymus, H., & Silver, P. A. (2004) · Genes & Development · doi:10.1101/gad.1256904 · Cited by 157 · see citing works
Gao, F., Carson, C. C., Levine, T., & Keene, J. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11207 · Cited by 156 · see citing works
Self-citationMorris, A. R., Mukherjee, N., & Keene, J. D. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00155-08 · Cited by 155 · see citing works
Self-citationEarly evolution of histone mRNA 3′ end processing
López, M. D., & Samuelsson, T. (2007) · RNA · doi:10.1261/rna.782308 · Cited by 152 · see citing works
Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes
Lerner, R. S., Seiser, R. M., Zheng, T., Lager, P. J., Reedy, M. C., Keene, J. D., & Nicchitta, C. V. (2003) · RNA · doi:10.1261/rna.5610403 · Cited by 150 · see citing works
Self-citationHendrickson, D. G., Hogan, D. J., Herschlag, D., Ferrell, J. E., & Brown, P. O. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002126 · Cited by 143 · see citing works
Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum
Pyhtila, B. M., Zheng, T., Lager, P. J., Keene, J. D., Reedy, M. C., & Nicchitta, C. V. (2008) · RNA · doi:10.1261/rna.721108 · Cited by 141 · see citing works
Self-citationThe ARE‐dependent mRNA‐destabilizing activity of BRF1 is regulated by protein kinase B
Schmidlin, M., Lu, M., Leuenberger, S. A., Stoecklin, G., Mallaun, M., Gross, B., Gherzi, R., Heß, D., Hemmings, B. A., & Moroni, C. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600477 · Cited by 138 · see citing works
AMP-activated Protein Kinase-regulated Phosphorylation and Acetylation of Importin α1
Wang, W., Yang, X., Kawai, T., de Silanes, I. L., Mazan-Mamczarz, K., Chen, P., Chook, Y. M., Quensel, C., Köhler, M., & Gorospe, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409014200 · Cited by 126 · see citing works
HuR in the Mammalian Genotoxic Response: Post-Transcriptional Multitasking
Gorospe, M. (2003) · Cell Cycle · doi:10.4161/cc.2.5.491 · Cited by 121 · see citing works
Intine, R. V. A., Tenenbaum, S. A., Sakulich, A. L., Keene, J. D., & Maraia, R. J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00429-5 · Cited by 114 · see citing works
Self-citationBenjamin, D., Schmidlin, M., Lu, M., Gross, B., & Moroni, C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01099-06 · Cited by 91 · see citing works
Global analysis of mRNA stability in the archaeon Sulfolobus
Andersson, A. F., Lundgren, M., Eriksson, S., Rosenlund, M., Bernander, R., & Nilsson, P. (2006) · Genome biology · doi:10.1186/gb-2006-7-10-r99 · Cited by 90 · see citing works
Mijalski, T., Harder, A., Halder, T., Kersten, M., Horsch, M., Strom, T. M., Liebscher, V., Lottspeich, F., de Angelis, M. H., & Beckers, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407672102 · Cited by 88 · see citing works
Stephens, S. B., Dodd, R. D., Brewer, J. W., Lager, P. J., Keene, J. D., & Nicchitta, C. V. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-07-0685 · Cited by 86 · see citing works
Self-citationPhosphorylated HuR shuttles in cycles
Kim, H. H., & Gorospe, M. (2008) · Cell Cycle · doi:10.4161/cc.7.20.6884 · Cited by 84 · see citing works
Immediate early response of the circadian polyA ribonuclease nocturnin to two extracellular stimuli
Garbarino‐Pico, E., Niu, S., Rollag, M. D., Strayer, C. A., Besharse, J. C., & Green, C. B. (2007) · RNA · doi:10.1261/rna.286507 · Cited by 82 · see citing works
Robson, S. C. (1987) · ResearchOnline - JCU (James Cook University) · Cited by 82 · see citing works
Moore, M. J., Schwartzfarb, E. M., Silver, P. A., & Yu, M. C. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.12.006 · Cited by 70 · see citing works
Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling
Ruggiero, T., Trabucchi, M., Ponassi, M., Corte, G., Chen, C., Al‐Haj, L., Khabar, K. S. A., Briata, P., & Gherzi, R. (2007) · BMC Molecular Biology · doi:10.1186/1471-2199-8-28 · Cited by 63 · see citing works
Translation arrest and ribonomics in post‐ischemic brain: layers and layers of players
DeGracia, D. J., Jamison, J. T., Szymanski, J. J., & Lewis, M. K. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05561.x · Cited by 58 · see citing works
Raghavan, A., Dhalla, M., Bakheet, T. M., Ogilvie, R. L., Louis, I. V.-S., Khabar, K. S. A., Williams, B. R. G., & Bohjanen, P. R. (2004) · Genomics · doi:10.1016/j.ygeno.2004.08.007 · Cited by 57 · see citing works
Davidson, E. A., & Ellington, A. D. (2006) · Nature Chemical Biology · doi:10.1038/nchembio846 · Cited by 56 · see citing works
Nicchitta, C. V., Lerner, R. S., Stephens, S. B., Dodd, R. D., & Pyhtila, B. M. (2005) · Biochemistry and Cell Biology · doi:10.1139/o05-147 · Cited by 50 · see citing works
Global Analysis of HuR-Regulated Gene Expression in Colon Cancer Systems of Reducing Complexity
de Silanes, I. L., Fan, J., Galbán, C. J., Spencer, R. G. S., Becker, K. G., & Gorospe, M. (2004) · Gene Expression · doi:10.3727/000000004783992215 · Cited by 41 · see citing works
Mazan-Mamczarz, K., Hagner, P. R., Dai, B., Wood, W. H., Zhang, Y., Becker, K. G., Liu, Z., & Gartenhaus, R. B. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2393 · Cited by 40 · see citing works
Biological Clocks and the Coordination Theory of RNA Operons and RegulonsPreprint
Keene, J. D. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.013 · Cited by 35 · see citing works
Self-citationPenalva, L. O. F., Burdick, M. D., Lin, S. M., Sutterlüty, H., & Keene, J. D. (2004) · Molecular Cancer · doi:10.1186/1476-4598-3-24 · Cited by 34 · see citing works
Self-citationBiological Rhythms Workshop I: Introduction to ChronobiologyPreprint
Kuhlman, S. J., Mackey, S. R., & Duffy, J. F. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.059 · Cited by 27 · see citing works
Cammas, A., Lewis, S. M., Vagner, S., & Holčı́k, M. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.05.022 · Cited by 25 · see citing works
Origin of the Eukaryotic Nucleus
Sandman, K., & Reeve, J. N. (1998) · Science · doi:10.1126/science.280.5363.499d · Cited by 19 · see citing works
Chromosomal Organization: Mingling with the Neighbors
Aten, J. A., & Kanaar, R. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040155 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mukherjee, N., Corcoran, D. L., Nusbaum, J. D., Reid, D. W., Georgiev, S., Hafner, M., Ascano, M., Tuschl, T., Ohler, U., & Keene, J. D. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.007 · Cited by 654 · see citing works
Self-citationEmerging roles of non-coding RNAs in brain evolution, development, plasticity and disease
Qureshi, I., & Mehler, M. F. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3234 · Cited by 561 · see citing works
Fallini, C., Bassell, G. J., & Rossoll, W. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds205 · Cited by 247 · see citing works
Sequence-non-specific effects of RNA interference triggers and microRNA regulators
Olejniczak, M., Galka-Marciniak, P., & Krzyżosiak, W. J. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp829 · Cited by 201 · see citing works
Lipovich, L., Johnson, R., & Lin, C. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.10.001 · Cited by 201 · see citing works
Reid, D. W., & Nicchitta, C. V. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.312280 · Cited by 177 · see citing works
Roles of Puf proteins in mRNA degradation and translation
Miller, M. A., & Olivas, W. M. (2010) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.69 · Cited by 147 · see citing works
PRIDB: a protein-RNA interface database
Lewis, B. A., Walia, R. R., Terribilini, M., Ferguson, J., Zheng, C. Y., Honavar, V., & Dobbs, D. L. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1108 · Cited by 147 · see citing works
Mechanisms coordinating ELAV/Hu mRNA regulons
Simone, L. E., & Keene, J. D. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.12.006 · Cited by 143 · see citing works
Self-citationTebaldi, T., Re, A., Viero, G., Pegoretti, I., Passerini, A., Blanzieri, E., & Quattrone, A. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-220 · Cited by 131 · see citing works
Bronicki, L. M., & Jasmin, B. J. (2013) · RNA · doi:10.1261/rna.039164.113 · Cited by 126 · see citing works
Mansfield, K. D., & Keene, J. D. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr1114 · Cited by 112 · see citing works
Self-citationSystematic analysis of posttranscriptional gene expression
Morris, A. R., Mukherjee, N., & Keene, J. D. (2009) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.54 · Cited by 109 · see citing works
Self-citationN 6 -methyladenosine is required for the hypoxic stabilization of specific mRNAs
Fry, N. J., Law, B. A., Ilkayeva, O., Holley, C. L., & Mansfield, K. D. (2017) · RNA · doi:10.1261/rna.061044.117 · Cited by 110 · see citing works
Self-citationMicroRNAs in rheumatoid arthritis
Ceribelli, A., Nahid, M. A., Satoh, M., & Chan, E. K. L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.020 · Cited by 104 · see citing works
Cytoplasmic ribonucleoprotein (RNP) bodies and their relationship to GW/P bodies
Moser, J. J., & Fritzler, M. J. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.11.018 · Cited by 97 · see citing works
Post-transcriptional RNA regulons affecting cell cycle and proliferation
Blackinton, J. G., & Keene, J. D. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.05.014 · Cited by 95 · see citing works
Self-citationMinireview: Global Regulation and Dynamics of Ribonucleic Acid
Keene, J. D. (2010) · Endocrinology · doi:10.1210/en.2009-1250 · Cited by 90 · see citing works
Self-citationRNA–protein analysis using a conditional CRISPR nuclease
Lee, H., Haurwitz, R. E., Apffel, A., Zhou, K., Smart, B., Wenger, C. D., Laderman, S. S., Bruhn, L., & Doudna, J. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302807110 · Cited by 89 · see citing works
Ceribelli, A., Satoh, M., & Chan, E. K. L. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.07.011 · Cited by 86 · see citing works
Regulation of non-coding RNA networks in the nervous system—What's the REST of the story?
Qureshi, I., & Mehler, M. F. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.07.093 · Cited by 85 · see citing works
Coordinated posttranscriptional mRNA population dynamics during T‐cell activation
Mukherjee, N., Lager, P. J., Friedersdorf, M. B., Thompson, M. A., & Keene, J. D. (2009) · Molecular Systems Biology · doi:10.1038/msb.2009.44 · Cited by 86 · see citing works
Self-citationMechanisms governing the control of mRNA translation
Livingstone, M., Atas, E., Meller, A., & Sonenberg, N. (2010) · Physical Biology · doi:10.1088/1478-3975/7/2/021001 · Cited by 85 · see citing works
Aiding and abetting cancer: mRNA export and the nuclear pore
Čuljković, B., & Borden, K. L. B. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.03.004 · Cited by 79 · see citing works
Coordinate regulation of mRNA decay networks by GU-rich elements and CELF1
Louis, I. V.-S., & Bohjanen, P. R. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2011.03.002 · Cited by 73 · see citing works
ELAV proteins along evolution: Back to the nucleus?
Colombrita, C., Silani, V., & Ratti, A. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.02.003 · Cited by 69 · see citing works
Local translation of TC10 is required for membrane expansion during axon outgrowth
Gracias, N. G., Shirkey, N. J., & Hengst, U. (2014) · Nature Communications · doi:10.1038/ncomms4506 · Cited by 58 · see citing works
Ribosome-associated ncRNAs: An emerging class of translation regulators
Pircher, A., Gebetsberger, J., & Polacek, N. (2014) · RNA Biology · doi:10.1080/15476286.2014.996459 · Cited by 57 · see citing works
A nonredundant structure dataset for benchmarking protein‐RNA computational docking
Huang, S., & Zou, X. (2012) · Journal of Computational Chemistry · doi:10.1002/jcc.23149 · Cited by 57 · see citing works
Rapid Cross-Linking of an RNA Internal Loop by the Anticancer Drug Cisplatin
Hostetter, A. A., Chapman, E. G., & DeRose, V. J. (2009) · Journal of the American Chemical Society · doi:10.1021/ja809637e · Cited by 54 · see citing works
The Architecture of the Human RNA-Binding Protein Regulatory Network
Quattrone, A., & Dassi, E. (2019) · iScience · doi:10.1016/j.isci.2019.10.058 · Cited by 53 · see citing works
Plass, M., Rasmussen, S. H., & Krogh, A. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005460 · Cited by 51 · see citing works
The influence of microRNAs and poly(A) tail length on endogenous mRNA–protein complexes
Rissland, O. S., Subtelny, A. O., Wang, M., Lugowski, A., Nicholson, B. L., Laver, J. D., Sidhu, S. S., Smibert, C. A., Lipshitz, H. D., & Bartel, D. P. (2017) · Genome biology · doi:10.1186/s13059-017-1330-z · Cited by 48 · see citing works
Post-Transcriptional Regulation of Cytokine Signaling by AU-Rich and GU-Rich Elements
Louis, I. V.-S., & Bohjanen, P. R. (2014) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2013.0108 · Cited by 44 · see citing works
The Emerging Role of Epigenetics in Stroke
Qureshi, I., & Mehler, M. F. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.300 · Cited by 44 · see citing works
Ribonomic approaches to study the RNA‐binding proteome
Faoro, C., & Ataide, S. F. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.07.039 · Cited by 44 · see citing works
Single and Combined Methods to Specifically or Bulk-Purify RNA–Protein Complexes
Ende, R. V., Balzarini, S., & Geuten, K. P. (2020) · Biomolecules · doi:10.3390/biom10081160 · Cited by 41 · see citing works
Targeting Axonal Protein Synthesis in Neuroregeneration and Degeneration
Baleriola, J., & Hengst, U. (2014) · Neurotherapeutics · doi:10.1007/s13311-014-0308-8 · Cited by 37 · see citing works
Hu Antigen R (HuR) Is a Positive Regulator of the RNA-binding Proteins TDP-43 and FUS/TLS
Lu, L., Zheng, L., Si, Y., Luo, W., Dujardin, G., Kwan, T., Potochick, N. R., Thompson, S. R., Schneider, D. A., & King, P. H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.573246 · Cited by 37 · see citing works
Yeast Cth2 protein represses the translation of ARE-containing mRNAs in response to iron deficiency
Ramos-Alonso, L., Romero, A. M., Soler, M. À., Perea‐García, A., Alepuz, P. M., Puig, S., & Martínez‐Pastor, M. T. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007476 · Cited by 34 · see citing works
Gaudenzi, J. G. D., Carmona, S. J., Agüero, F., & Frasch, A. C. C. (2013) · PeerJ · doi:10.7717/peerj.118 · Cited by 33 · see citing works
Shatoff, E., & Bundschuh, R. A. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007852 · Cited by 35 · see citing works
Scp160p is required for translational efficiency of codon-optimized mRNAs in yeast
Hirschmann, W. D., Westendorf, H., Mayer, A., Cannarozzi, G. M., Cramer, P., & Jansen, R. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1392 · Cited by 31 · see citing works
Functional coordination and HuR-mediated regulation of mRNA stability during T cell activation
Blackinton, J. G., & Keene, J. D. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1066 · Cited by 31 · see citing works
Self-citationSchwertz, H., Rowley, J. W., Schumann, G. G., Thorack, U., Campbell, R. A., Manne, B. K., Zimmerman, G. A., Weyrich, A. S., & Rondina, M. T. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.310552 · Cited by 31 · see citing works
Li, Z., Gaudenzi, J. G. D., Álvarez, V. E., Mendiondo, N., Wang, H., Kissinger, J. C., Frasch, A. C. C., & Docampo, R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.338699 · Cited by 29 · see citing works
Translation regulation by ribosomes: Increased complexity and expanded scope
Mauro, V. P., & Matsuda, D. (2015) · RNA Biology · doi:10.1080/15476286.2015.1107701 · Cited by 28 · see citing works
Toponomics: studying protein–protein interactions and protein networks in intact tissue
Pierre, S. C., & Scholich, K. (2010) · Molecular BioSystems · doi:10.1039/b910653g · Cited by 28 · see citing works
Functional genomics of human brain development and implications for autism spectrum disorders
Ziats, M. N., Grosvenor, L. P., & Rennert, O. M. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.153 · Cited by 26 · see citing works
Relationship of Other Cytoplasmic Ribonucleoprotein Bodies (cRNPB) to GW/P Bodies
Moser, J. J., & Fritzler, M. J. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5107-5_13 · Cited by 27 · see citing works
Kanitz, A., & Gerber, A. P. (2009) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.55 · Cited by 26 · see citing works
Qureshi, I., & Mehler, M. F. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05718.x · Cited by 23 · see citing works
Hypoxic stabilization of mRNA is HIF-independent but requires mtROS
Fortenbery, G. W., Sarathy, B., Carraway, K., & Mansfield, K. D. (2018) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-018-0112-2 · Cited by 21 · see citing works
Self-citationNuclear PKM2 binds pre-mRNA at folded G-quadruplexes and reveals their gene regulatory role
Anastasakis, D. G., Apostolidi, M., Garman, K. A., Polash, A. H., Umar, M. I., Meng, Q., Scutenaire, J., Jarvis, J. E., Wang, X., Haase, A. D. D., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.07.025 · Cited by 20 · see citing works
Koziorowska, A. M., Drzewiecka, E. M., Romerowicz‐Misielak, M., Zglejc‐Waszak, K., & Franczak, A. (2018) · Theriogenology · doi:10.1016/j.theriogenology.2017.12.041 · Cited by 20 · see citing works
The Effects of Single Nucleotide Polymorphisms in Cancer RNAi Therapies
Gebert, M., Jaśkiewicz, M., Moszyńska, A., Collawn, J. F., & Bartoszewski, R. (2020) · Cancers · doi:10.3390/cancers12113119 · Cited by 20 · see citing works
Guerra-Slompo, E. P., Probst, C., Pavoni, D. P., Goldenberg, S., Krieger, M. A., & Dallagiovanna, B. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.02.154 · Cited by 18 · see citing works
Hypoxia and Hypoglycemia synergistically regulate mRNA stability
Carraway, K., Johnson, E. M., Kauffmann, T. C., Fry, N. J., & Mansfield, K. D. (2017) · RNA Biology · doi:10.1080/15476286.2017.1311456 · Cited by 18 · see citing works
Self-citationSabalette, K. B., Romaniuk, M. A., Noé, G., Cassola, A., Campo, V. A., & Gaudenzi, J. G. D. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.007123 · Cited by 18 · see citing works
Setting the Stage: The First Round of Spermatogenesis
Geyer, C. B. (2017) · Springer eBooks · doi:10.1007/978-1-4939-7505-1_3 · Cited by 18 · see citing works
The Post-transcriptional Operon
Tenenbaum, S. A., Christiansen, J., & Nielsen, H. (2010) · Methods in molecular biology · doi:10.1007/978-1-59745-248-9_16 · Cited by 16 · see citing works
HuR's role in gemcitabine efficacy: an exception or opportunity?
Brody, J. R., & Gonye, G. E. (2010) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.62 · Cited by 15 · see citing works
Ribosome-Associated ncRNAs (rancRNAs) Adjust Translation and Shape Proteomes
Pecoraro, V., Rosina, A., & Polacek, N. (2022) · Non-Coding RNA · doi:10.3390/ncrna8020022 · Cited by 13 · see citing works
Snf1-Dependent Transcription Confers Glucose-Induced Decay upon the mRNA Product
Braun, K. A., Dombek, K. M., & Young, E. T. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00436-15 · Cited by 13 · see citing works
Gaudenzi, J. G. D., Jäger, A. V., Izcovich, R., & Campo, V. A. (2015) · Journal of Eukaryotic Microbiology · doi:10.1111/jeu.12288 · Cited by 13 · see citing works
Emerging Molecular Targets for Brain Repair after Stroke
Krupiński, J., & SLEVIN, M. A. (2013) · Stroke Research and Treatment · doi:10.1155/2013/473416 · Cited by 13 · see citing works
Evolution of the Neocortex Through RNA-Binding Proteins and Post-transcriptional Regulation
Salamon, I., & Rašin, M. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.803107 · Cited by 11 · see citing works
Iruarrizaga‐Lejarreta, M., Varela‐Rey, M., Lozano, J. J., Fernández‐Ramos, D., Rodríguez‐Ezpeleta, N., Embade, N., Lu, S. C.-L., van der Kraan, P. M., Davidson, E. N. B., Gorospe, M., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5868-11.2012 · Cited by 12 · see citing works
Emmerich, A. C., Wellstein, J., Ossipova, E., Baumann, I., Lengqvist, J., Kultima, K., Jakobsson, P., Steinhilber, D., & Saul, M. J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00196 · Cited by 12 · see citing works
Hochberg, M., Gilead, L., Markel, G., Nemlich, Y., Feiler, Y., Enk, C. D., Denichenko, P., Karni, R., & Ingber, A. (2013) · Archives of Dermatological Research · doi:10.1007/s00403-013-1338-5 · Cited by 11 · see citing works
Constant Splice-Isoform Ratios in Human Lymphoblastoid Cells Support the Concept of a Splico-Stat
Kramer, M., Huse, K., Menzel, U., Backhaus, O., Rosenstiel, P. C., Schreiber, S., Hampe, J., & Platzer, M. (2011) · Genetics · doi:10.1534/genetics.110.125096 · Cited by 10 · see citing works
CELF1, a Multifunctional Regulator of Posttranscriptional Networks
Beisang, D. J., Paul, R., & Louis, I. V.-S. (2012) · InTech eBooks · doi:10.5772/48780 · Cited by 10 · see citing works
Ras Post-transcriptionally Enhances a Pre-malignantly Primed EMT to Promote Invasion
Bisogno, L. S., Friedersdorf, M. B., & Keene, J. D. (2018) · iScience · doi:10.1016/j.isci.2018.05.011 · Cited by 9 · see citing works
Self-citationKSRP silencing favors neural differentiation of P19 teratocarcinoma cells
Giovarelli, M., Bucci, G., Pasero, M., Gherzi, R., & Briata, P. (2013) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2013.02.008 · Cited by 8 · see citing works
Bisogno, L. S., & Keene, J. D. (2017) · Methods · doi:10.1016/j.ymeth.2017.05.012 · Cited by 7 · see citing works
Self-citationMINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans
Sendoel, A., Šubašić, D., Ducoli, L., Keller, M., Michel, E., Köhler, I., Singh, K. D., Zheng, X., Brümmer, A., Imig, J., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0291-z · Cited by 6 · see citing works
Emerging Themes in Epigenetics: Implications for Understanding and Treating Nervous System Disorders
Qureshi, I., & Mehler, M. F. (2010) · Epigenomics · doi:10.2217/epi.10.17 · Cited by 6 · see citing works
Modular protein-RNA interactions regulating mRNA metabolism: a role for NMR
Cukier, C. D., & Ramos, A. (2011) · European Biophysics Journal · doi:10.1007/s00249-011-0698-z · Cited by 6 · see citing works
Secondary and Tertiary Endosymbiosis and Kleptoplasty
Gross, J., Bhattacharya, D., Pelletreau, K. N., Rumpho, M. E., & Reyes‐Prieto, A. (2012) · Advances in photosynthesis and respiration · doi:10.1007/978-94-007-2920-9_2 · Cited by 5 · see citing works
Ochs, M. J., Ossipova, E., Oliynyk, G., Steinhilber, D., Suess, B., & Jakobsson, P. (2013) · Journal of Proteome Research · doi:10.1021/pr301193f · Cited by 4 · see citing works
Interplay between single-stranded binding proteins on RNA secondary structure
Lin, Y., & Bundschuh, R. A. (2013) · Physical Review E · doi:10.1103/physreve.88.052707 · Cited by 4 · see citing works
Kafasla, P., Karakasiliοtis, I., & Kontoyiannis, D. L. (2012) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1179 · Cited by 3 · see citing works
Post-transcriptional Regulation of Cytokine Signaling During Inflammatory Responses
Louis, I. V.-S., & Bohjanen, P. R. (2015) · Springer eBooks · doi:10.1007/978-3-319-25124-0_3 · Cited by 3 · see citing works
Nauphal, M., & Baraka, A. (2008) · PubMed · Cited by 3 · see citing works
mRNA Export and Its Dysregulation in Disease
Borden, K. L. B., & Culjkovic‐Kraljacic, B. (2018) · Nucleic acids and molecular biology · doi:10.1007/978-3-319-77309-4_8 · Cited by 3 · see citing works
PAR-CLIP: A Genomic Technique to Dissect RNA-Protein Interactions
Dutka, T., Sarshad, A. A., & Hafner, M. (2016) · Springer eBooks · doi:10.1007/978-3-319-31350-4_11 · Cited by 2 · see citing works
Nuclear PKM2 Promotes Pre-mRNA Processing by Binding G-QuadruplexesPreprint
Anastasakis, D. G., Apostolidi, M., Rinehart, J., & Hafner, M. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3942850 · Cited by 2 · see citing works
Mechanisms of persistent translation arrest following global brain ischemia & reperfusion
Jamison, J. T. (2011) · Cited by 1 · see citing works
Foci of Future Studies on Abiotic Stress Tolerance of Maize in the Era of Post-Genomics
Li, Y., Fan, X., & Jiang-xiong, L. I. A. O. (2012) · Journal of Integrative Agriculture · doi:10.1016/s2095-3119(12)60120-8 · Cited by 1 · see citing works
Le monde complexe et mouvant des ARN. Première partie
Lamoril, J., Ameziane, N., Deybach, J., Bouizegarène, P., & Bogard, M. (2010) · Immuno-analyse & Biologie Spécialisée · doi:10.1016/j.immbio.2010.01.002 · Cited by 1 · see citing works
Segregation of Protein Synthesis Between the Cytoplasm and Endoplasmic Reticulum of Eukaryotic Cells
Reid, D. W. (2014) · DukeSpace (Duke University)
Characterization of GW/P Body Components in Astrocyte and Astrocytoma Cells
Moser, J. J. (2013) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/25275
THE ROLE OF N6-METHYLADENOSINE IN HYPOXIA AND CELLULAR TRANSFORMATION
Fry, N. J. (2017) · The Scholarship East Carolina University's Institutional Repository (East Carolina University)
Olejniczak, M., Galka-Marciniak, P., & Krzyżosiak, W. J. (2009)
Posttranscriptional Gene Regulation: From Global Models to Functional Mechanisms
Thompson, M. A. (2014) · DukeSpace (Duke University)
Nuclear PKM2 promotes pre-mRNA processing by binding folded RNA G-quadruplexesPreprint
Anastasakis, D. G., Apostolidi, M., Rinehart, J., & Hafner, M. (2022) · Research Square · doi:10.21203/rs.3.rs-1495021/v1
- Authors
- Mansfield, K. D., & Keene, J. D.
- Affiliations
- Duke University (US)
- Corresponding author
- Keene, Jack D.
- ORCID
- Mansfield, Kyle D.
- Venue
- Biology of the Cell
- Publisher
- Wiley
- Published
- 2009-03
- Volume
- 101
- Issue
- 3
- Pages
- 169-181
- ISSN
- 0248-4900 (ISSN-L)
- 1768-322X
- PMC
- PMC4332539
- OpenAlex
- W2033509582
- Cited by
- 102
- References
- 98
- Citations by year
- 2024: 2 · 2022: 3 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 7 · 2016: 1 · 2015: 7 · 2014: 10 · 2013: 15 · 2012: 14
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biology of the Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5f32ns059100-02)
- National Cancer Institute (R21CA094365, CA94365, R33CA094365)
- National Institute of Neurological Disorders and Stroke (5F32NS059100, F32 NS059100)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- ribonucleoprotein complexes, RNA-binding proteins, post-transcriptional regulation, transcriptome, evolution of multicellularity
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Ribonucleoproteins, RNA, RNA-Binding Proteins, Gene Expression Profiling
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review