Cited by 102RNA Research and SplicingRNA and protein synthesis mechanismsCancer-related molecular mechanisms research

The ribonome: a dominant force in co‐ordinating gene expression

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Mansfield, Kyle D., Keene, Jack D.·2009·Biology of the Cell

Abstract

The ribonome is the total cellular complement of RNAs and their regulatory factors functioning dynamically in time and space within ribonucleoprotein complexes. We theorize that the ribonome is an ancient central co-ordinator that has evolved to communicate on multiple levels to the proteome on the one hand (feed-forward), and the transcriptome and RNA processing machinery on the other (feed-back). Furthermore, the ribonome can potentially communicate to other cells horizontally with implications for biological information transfer and for the evolution of both RNA and DNA operating systems. The post-transcriptional RNA operon theory of co-regulated gene expression accounts for the co-ordinated dynamics of RNA-binding proteins within the cellular ribonome, thus allowing for the recombination and remodelling of the RNPs (ribonucleoproteins) to generate new combinations of functionally related proteins. Thus, post-transcriptional RNA operons form the core of the ribonomic operating system in which both their control and co-ordination govern outcomes. Within the ribonome, RNA-binding proteins control one another's mRNAs to keep the global mRNA environment in balance. We argue that these post-transcriptional ribonomic systems provide an information management and distribution centre for evolutionary expansion of multicellularity in tissues, organs, organisms, and their communities.

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Crossref · 10.1042/bc20080055

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  • HuD binds mRNAs of several RBPs, including its own, HuB, HuR, Cugbp2, Musashi 2, and Staufen 2, indicating a complex regulatory network between HuD and other components of the ribonome.

    “Of particular interest, this study also found that HuD binds mRNAs of several RBPs, including its own, HuB, HuR, Cugbp2, Musashi 2, and Staufen 2, indicating a complex regulatory network between HuD and other components of the ribonome (Pullmann et al. 2007; Mansfield and Keene 2009; Bolognani et al. 2010).”

    From Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction (2013) · cites this paper as Mansfield and Keene 2009

    The “Regulators of regulators” section (page unavailable) describes RBPs binding their own and one another’s mRNAs, supporting the idea of an interconnected ribonome. It discusses a group including HuR, not HuD; our copy does not report HuD binding the listed mRNAs (searched: HuD, Cugbp2, Musashi, Staufen). (LLM, conf=0.82)

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Authors
Mansfield, K. D., & Keene, J. D.
Affiliations
Duke University (US)
Corresponding author
Keene, Jack D.
Venue
Biology of the Cell
Publisher
Wiley
Published
2009-03
Volume
101
Issue
3
Pages
169-181
ISSN
  • 0248-4900 (ISSN-L)
  • 1768-322X
OpenAlex
W2033509582
Cited by
102
References
98
Citations by year
2024: 2 · 2022: 3 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 7 · 2016: 1 · 2015: 7 · 2014: 10 · 2013: 15 · 2012: 14
FWCI
1.07
Type
journal article
Language
en
Open access
Locations
  • Biology of the Cell (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5f32ns059100-02)
  • National Cancer Institute (R21CA094365, CA94365, R33CA094365)
  • National Institute of Neurological Disorders and Stroke (5F32NS059100, F32 NS059100)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords
ribonucleoprotein complexes, RNA-binding proteins, post-transcriptional regulation, transcriptome, evolution of multicellularity
MeSH terms
Animals, Gene Expression Regulation, Humans, Ribonucleoproteins, RNA, RNA-Binding Proteins, Gene Expression Profiling

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