Is fat so bad? Modulation of endoplasmic reticulum stress by lipid droplet formation

Hapala, Ivan; Marza, Esther; Ferreira, Thierry

doi:10.1042/bc20100144

Cited by 125Lipid metabolism and biosynthesisEndoplasmic Reticulum Stress and DiseaseCancer, Lipids, and Metabolism

Is fat so bad? Modulation of endoplasmic reticulum stress by lipid droplet formation

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Hapala, Ivan, Marza, Esther, Ferreira, Thierry·2011·Biology of the Cell

DOI 10.1042/bc20100144

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Abstract

LDs (lipid droplets) have long been considered as inert particles used by the cells to store fatty acids and sterols as esterified non-toxic lipid species (i.e. triacylglycerols and steryl esters). However, accumulating evidence suggests that LDs behave as a dynamic compartment, which is involved in the regulation of several aspects of the homoeostasis of their originating organelle, namely the ER (endoplasmic reticulum). The ER is particularly sensitive to physiological/pathological stimuli, which can ultimately induce ER stress. In the present review, after considering the basic mechanisms of LD formation and the signal cascades leading to ER stress, we focus on the connections between these two pathways. Taking into consideration recent data from the literature, we will try to draw possible mechanisms for the role of LDs in the regulation of ER homoeostasis and in ER-stress-related diseases.

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Accumulation of lipid droplets is a common hallmark of ER stress.
“Accumulation of lipid droplets is a common hallmark of ER stress27,28.”
From APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes (2022) · cites this paper as [28]

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Authors: Hapala, I., Marza, E., & Ferreira, T.
Affiliations: Slovak Academy of Sciences (SK)
Inserm (FR)
Centre National de la Recherche Scientifique (FR)
Corresponding author: Ferreira, Thierry
ORCID: Hapala, Ivan
Marza, Esther
Ferreira, Thierry
Venue: Biology of the Cell
Publisher: Wiley
Published: 2011-06
Volume: 103
Issue: 6
Pages: 271-285
ISSN: 0248-4900 (ISSN-L)
DOI: 10.1042/bc20100144
OpenAlex: W2025366283
Cited by: 125
References: 103
Citations by year: 2026: 1 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 12 · 2021: 22 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 7 · 2016: 7 · 2015: 12 · 2014: 5 · 2013: 8 · 2012: 8
FWCI: 0.72
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1553 d)
Locations: Biology of the Cell (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords: lipid droplets, endoplasmic reticulum stress, ER homeostasis, lipid droplet formation, ER stress signaling, triglycerides, sterol esters
MeSH terms: Animals, Drosophila, Endoplasmic Reticulum, Fatty Acids, Homeostasis, Humans, Lipoproteins, Membrane Proteins, Phospholipids, Saccharomyces cerevisiae, Stress, Physiological, Triglycerides, Signal Transduction, Lipid Metabolism, Activating Transcription Factor 6, Unfolded Protein Response

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Is fat so bad? Modulation of endoplasmic reticulum stress by lipid droplet formation

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