Jumping the barrier: VE‐cadherin, VEGF and other angiogenic modifiers in cancer

Cancer-related inflammation

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Molecular mechanisms and clinical applications of angiogenesis

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VEGF receptor signalling ? in control of vascular function

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Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

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EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

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Multifunctional strands in tight junctions

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Paradoxical roles of the immune system during cancer development

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High Interstitial Fluid Pressure - an Obstacle in Cancer Therapy

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Normalization of the Vasculature for Treatment of Cancer and Other Diseases

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G-protein-coupled receptors and cancer

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Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

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Angiopoietin-1 protects the adult vasculature against plasma leakage

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Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis

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Angiogenesis

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Glioblastoma stem-like cells give rise to tumour endothelium

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Endothelial cell–cell junctions: happy together

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VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin

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TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

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Selective Requirement for Src Kinases during VEGF-Induced Angiogenesis and Vascular Permeability

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Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells

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Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival <i>in vivo</i>

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Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5

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Excess Circulating Angiopoietin-2 May Contribute to Pulmonary Vascular Leak in Sepsis in Humans

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Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments

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Angiopoietin-1 Is an Antipermeability and Anti-Inflammatory Agent In Vitro and Targets Cell Junctions

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Angiogenic Effects of Interleukin 8 (CXCL8) in Human Intestinal Microvascular Endothelial Cells Are Mediated by CXCR2

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Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis

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Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

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Angiopoietin-1 Prevents VEGF-Induced Endothelial Permeability by Sequestering Src through mDia

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Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

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α-catenin: at the junction of intercellular adhesion and actin dynamics

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Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1

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Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes

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Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1

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Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions.

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Role of Chemokines in Angiogenesis: CXCL12/SDF-1 and CXCR4 Interaction, a Key Regulator of Endothelial Cell Responses

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VE-cadherin antibody accelerates neutrophil recruitment in vivo

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VE‐PTP and VE‐cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts

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Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player

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Stromal cell–derived factor 1 promotes angiogenesis via a heme oxygenase 1–dependent mechanism

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Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages

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Involvement of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1alpha in breast cancer cell migration through human brain microvascular endothelial cells.

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IL-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways

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Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer.

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Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness

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Complementary Actions of Inhibitors of Angiopoietin-2 and VEGF on Tumor Angiogenesis and Growth

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VE-Cadherin Regulates Endothelial Actin Activating Rac and Increasing Membrane Association of Tiam

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Involvement of the Chemokine Receptor CXCR4 and Its Ligand Stromal Cell-Derived Factor 1α in Breast Cancer Cell Migration Through Human Brain Microvascular Endothelial Cells

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Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor

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VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF

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An essential role for Rac1 in endothelial cell function and vascular development

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Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site

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Semaphorin-3F Is an Inhibitor of Tumor Angiogenesis

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The SDF‐1‐CXCR4 Axis Stimulates VEGF Secretion and Activates Integrins but does not Affect Proliferation and Survival in Lymphohematopoietic Cells

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Transactivation of Vascular Endothelial Growth Factor Receptor-2 by Interleukin-8 (IL-8/CXCL8) Is Required for IL-8/CXCL8-induced Endothelial Permeability

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Stromal cell-derived factor-1 and CXCR4 receptor interaction in tumor growth and metastasis of breast cancer

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Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B

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A monoclonal antibody to vascular endothelial–cadherin inhibits tumor angiogenesis without side effects on endothelial permeability

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Angiopoietin 2 Induces Glioma Cell Invasion by Stimulating Matrix Metalloprotease 2 Expression through the αvβ1 Integrin and Focal Adhesion Kinase Signaling Pathway

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MT1-MMP Controls Tumor-induced Angiogenesis through the Release of Semaphorin 4D

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Semaphorin 3E Initiates Antiangiogenic Signaling through Plexin D1 by Regulating Arf6 and R-Ras

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Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin–mediated cell–cell contacts

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EphB4 controls blood vascular morphogenesis during postnatal angiogenesis

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Breaking the VE‐cadherin bonds

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Semaphorin-3B Is an Angiogenesis Inhibitor That Is Inactivated by Furin-Like Pro-Protein Convertases

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Monoclonal antibody to vascular endothelial-cadherin is a potent inhibitor of angiogenesis, tumor growth, and metastasis.

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CXCR4 Regulates the Early Extravasation of Metastatic Tumor Cells In Vivo

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Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun

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Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcoma

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Vascular Endothelial Cadherin Promotes Breast Cancer Progression via Transforming Growth Factor β Signaling

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Protecting your tail: regulation of cadherin degradation by p120–catenin

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Leaking Capillaries and White Lung in Sepsis—Is Angiopoietin 2 the Culprit?

Parikh, S. M., Mammoto, T., Schultz, A., Yuan, H. T., Christiani, D. C., Karumanchi, S. A., & Sukhatme, V. P. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006030259 · Cited by 94 · see citing works

Serum Response Factor Is Required for Sprouting Angiogenesis and Vascular Integrity

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Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature

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Structure and Binding Mechanism of Vascular Endothelial Cadherin: A Divergent Classical Cadherin

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VE-cadherin and β-catenin binding dynamics during histamine-induced endothelial hyperpermeability

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Mechanism of homophilic cadherin adhesion

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Robo4 Signaling in Endothelial Cells Implies Attraction Guidance Mechanisms

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A Role for a CXCR2/Phosphatidylinositol 3-Kinase γ Signaling Axis in Acute and Chronic Vascular Permeability

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Endothelial EphA receptor stimulation increases lung vascular permeability

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EphrinA1 Inhibits Vascular Endothelial Growth Factor-Induced Intracellular Signaling and Suppresses Retinal Neovascularization and Blood-Retinal Barrier Breakdown

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VE-cadherin-induced Cdc42 Signaling Regulates Formation of Membrane Protrusions in Endothelial Cells

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Additional file 4 of Proteomics and metabolomics profiling reveal panels of circulating diagnostic biomarkers and molecular subtypes in stable COPD

Zhang, Z., Wang, J., Li, Y., Liu, F., Chen, L., He, S., Lin, F., Wei, X., Fang, Y., Li, Q., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22620959

Additional file 5 of Proteomics and metabolomics profiling reveal panels of circulating diagnostic biomarkers and molecular subtypes in stable COPD

Zhang, Z., Wang, J., Li, Y., Liu, F., Chen, L., He, S., Lin, F., Wei, X., Fang, Y., Li, Q., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22620962

Additional file 9 of Proteomics and metabolomics profiling reveal panels of circulating diagnostic biomarkers and molecular subtypes in stable COPD

Zhang, Z., Wang, J., Li, Y., Liu, F., Chen, L., He, S., Lin, F., Wei, X., Fang, Y., Li, Q., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22620974

Additional file 1 of Proteomics and metabolomics profiling reveal panels of circulating diagnostic biomarkers and molecular subtypes in stable COPD

Zhang, Z., Wang, J., Li, Y., Liu, F., Chen, L., He, S., Lin, F., Wei, X., Fang, Y., Li, Q., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22620947

Additional file 7 of Proteomics and metabolomics profiling reveal panels of circulating diagnostic biomarkers and molecular subtypes in stable COPD

Zhang, Z., Wang, J., Li, Y., Liu, F., Chen, L., He, S., Lin, F., Wei, X., Fang, Y., Li, Q., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22620968

Additional file 6 of Proteomics and metabolomics profiling reveal panels of circulating diagnostic biomarkers and molecular subtypes in stable COPD

Zhang, Z., Wang, J., Li, Y., Liu, F., Chen, L., He, S., Lin, F., Wei, X., Fang, Y., Li, Q., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22620965

Additional file 3 of Proteomics and metabolomics profiling reveal panels of circulating diagnostic biomarkers and molecular subtypes in stable COPD

Zhang, Z., Wang, J., Li, Y., Liu, F., Chen, L., He, S., Lin, F., Wei, X., Fang, Y., Li, Q., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22620953

Additional file 8 of Proteomics and metabolomics profiling reveal panels of circulating diagnostic biomarkers and molecular subtypes in stable COPD

Zhang, Z., Wang, J., Li, Y., Liu, F., Chen, L., He, S., Lin, F., Wei, X., Fang, Y., Li, Q., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22620971

Additional file 2 of Proteomics and metabolomics profiling reveal panels of circulating diagnostic biomarkers and molecular subtypes in stable COPD

Zhang, Z., Wang, J., Li, Y., Liu, F., Chen, L., He, S., Lin, F., Wei, X., Fang, Y., Li, Q., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22620950

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