The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
l-Serine in disease and development
Open accessAbstract
The amino acid l-serine, one of the so-called non-essential amino acids, plays a central role in cellular proliferation. l-Serine is the predominant source of one-carbon groups for the de novo synthesis of purine nucleotides and deoxythymidine monophosphate. It has long been recognized that, in cell cultures, l-serine is a conditional essential amino acid, because it cannot be synthesized in sufficient quantities to meet the cellular demands for its utilization. In recent years, l-serine and the products of its metabolism have been recognized not only to be essential for cell proliferation, but also to be necessary for specific functions in the central nervous system. The findings of altered levels of serine and glycine in patients with psychiatric disorders and the severe neurological abnormalities in patients with defects of l-serine synthesis underscore the importance of l-serine in brain development and function. This paper reviews these recent insights into the role of l-serine and the pathways of l-serine utilization in disease and during development, in particular of the central nervous system.
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Cites
Amino acid metabolism in Mammalian cell cultures
Eagle, H. (1959) · Science · doi:10.1126/science.130.3373.432 · Cited by 4,011
Glycine potentiates the NMDA response in cultured mouse brain neurons
Johnson, J. W., & Ascher, P. (1987) · Nature · doi:10.1038/325529a0 · Cited by 3,139
Functions of Ceramide in Coordinating Cellular Responses to Stress
Hannun, Y. A. (1996) · Science · doi:10.1126/science.274.5294.1855 · Cited by 1,617
Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation
Hannun, Y. A., & Bell, R. M. (1989) · Science · doi:10.1126/science.2643164 · Cited by 1,251
Glutamine Synthetase: Glial Localization in Brain
Martinez-Hernandez, A., Bell, K. P., & Norenberg, M. D. (1977) · Science · doi:10.1126/science.14400 · Cited by 1,180
d -Serine is an endogenous ligand for the glycine site of the N -methyl- d -aspartate receptor
Mothet, J.-P., Parent, A. T., Wolosker, H., Brady, R. O., Linden, D. J., Ferris, C. D., Rogawski, M. A., & Snyder, S. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4926 · Cited by 1,137
Chumakov, I., Blumenfeld, M., Guerassimenko, O., Cavarec, L., Palicio, M., Abderrahim, H., Bougueleret, L., Barry, C., Tanaka, H., La Rosa, P., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182412499 · Cited by 829
Wolosker, H., Blackshaw, S., & Snyder, S. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13409 · Cited by 811
REGULATION OF CERAMIDE PRODUCTION AND APOPTOSIS
Kolesnick, R. N., & Krönke, M. (1998) · Annual Review of Physiology · doi:10.1146/annurev.physiol.60.1.643 · Cited by 803
Felig, P. (1975) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.44.070175.004441 · Cited by 789
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Glycine metabolism in animals and humans: implications for nutrition and health
Wang, W., Wu, Z., Dai, Z., Yang, Y., Wang, J., & Wu, G. (2013) · Amino Acids · doi:10.1007/s00726-013-1493-1 · Cited by 766
Serine is a natural ligand and allosteric activator of pyruvate kinase M2
Chaneton, B., Hillmann, P., Zheng, L., Martin, A. C. L., Maddocks, O. D. K., Chokkathukalam, A., Coyle, J. E., Jankevics, A., Holding, F. P., Vousden, K. H., et al. (2012) · Nature · doi:10.1038/nature11540 · Cited by 661
Inflammation, vitamin B6 and related pathways
Ueland, P. M., McCann, A., Midttun, Ø., & Ulvik, A. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.08.001 · Cited by 382
Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect
Sun, L., Suo, C., Li, S.-T., Zhang, H., & Gao, P. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.06.005 · Cited by 363
Metadata
- Authors
- de KONING, T. J., SNELL, K., DURAN, M., BERGER, R., POLL-THE, B.-T., & SURTEES, R.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2003-05-01
- Volume
- 371
- Issue
- 3
- Pages
- 653-661
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2107925005
- Cited by
- 295
- References
- 98
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- green
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- de KONING, T. J., SNELL, K., DURAN, M., BERGER, R., POLL-THE, B.-T., & SURTEES, R. (2003). l-Serine in disease and development. Biochemical Journal. https://doi.org/10.1042/bj20021785
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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