The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Molecular mechanisms of metabolic regulation by insulin in Drosophila
Abstract
The insulin signalling pathway is highly conserved from mammals to Drosophila. Insulin signalling in the fly, as in mammals, regulates a number of physiological functions, including carbohydrate and lipid metabolism, tissue growth and longevity. In the present review, I discuss the molecular mechanisms by which insulin signalling regulates metabolism in Drosophila, comparing and contrasting with the mammalian system. I discuss both the intracellular signalling network, as well as the communication between organs in the fly.
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Autophagy regulates lipid metabolism
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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
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The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., et al. (2004) · Nature · doi:10.1038/nature02866 · Cited by 1,677
Regulation of TORC1 by Rag GTPases in nutrient response
Kim, E., Goraksha-Hicks, P., Li, L., Neufeld, T. P., & Guan, K.-L. (2008) · Nature Cell Biology · doi:10.1038/ncb1753 · Cited by 1,349
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
Sancak, Y., Thoreen, C. C., Peterson, T. R., Lindquist, R. A., Kang, S. A., Spooner, E., Carr, S. A., & Sabatini, D. M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.003 · Cited by 1,236
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Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration
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A Mechanism of Extreme Growth and Reliable Signaling in Sexually Selected Ornaments and Weapons
Emlen, D. J., Warren, I. A., Johns, A., Dworkin, I., & Lavine, L. C. (2012) · Science · doi:10.1126/science.1224286 · Cited by 454
Methods for studying metabolism in Drosophila
Tennessen, J. M., Barry, W. E., Cox, J., & Thummel, C. S. (2014) · Methods · doi:10.1016/j.ymeth.2014.02.034 · Cited by 445
Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior
Nässel, D. R., & Zandawala, M. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.02.003 · Cited by 355
Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network
Partridge, L., Alic, N., Bjedov, I., & Piper, M. D. W. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2010.09.003 · Cited by 316
Eat to reproduce: a key role for the insulin signaling pathway in adult insects
Badisco, L., Van Wielendaele, P., & Vanden Broeck, J. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00202 · Cited by 173
Metadata
- Authors
- Teleman, A. A.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2009-12-14
- Volume
- 425
- Issue
- 1
- Pages
- 13-26
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2033682352
- Cited by
- 384
- References
- 9
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- closed
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