The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling
Open accessAbstract
The Hippo pathway regulates the size of organs by controlling two opposing processes: proliferation and apoptosis. YAP2 (Yes kinase-associated protein 2), one of the three isoforms of YAP, is a WW domain-containing transcriptional co-activator that acts as the effector of the Hippo pathway in mammalian cells. In addition to WW domains, YAP2 has a PDZ-binding motif at its C-terminus. We reported previously that this motif was necessary for YAP2 localization in the nucleus and for promoting cell detachment and apoptosis. In the present study, we show that the tight junction protein ZO (zonula occludens)-2 uses its first PDZ domain to form a complex with YAP2. The endogenous ZO-2 and YAP2 proteins co-localize in the nucleus. We also found that ZO-2 facilitates the nuclear localization and pro-apoptotic function of YAP2, and that this activity of ZO-2 is PDZ-domain-dependent. The present paper is the first report on a PDZ-based nuclear translocation mechanism. Moreover, since the Hippo pathway acts as a tumour suppressor pathway, the YAP2–ZO-2 complex could represent a target for cancer therapy.
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The Salvador–Warts–Hippo pathway — an emerging tumour-suppressor network
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A Specificity Map for the PDZ Domain Family
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Self-citationThe WW domain: a signalling site in dystrophin?
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Cited by
Mechanobiology of YAP and TAZ in physiology and disease
Panciera, T., Azzolin, L., Cordenonsi, M., & Piccolo, S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.87 · Cited by 1,461
The Hippo pathway: regulators and regulations.
Yu, F.-X., & Guan, K.-L. (2013) · Genes & Development · doi:10.1101/gad.210773.112 · Cited by 1,231
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
Zhao, B., Tumaneng, K., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2303 · Cited by 1,205
The Hippo Signaling Pathway in Development and Disease
Zheng, Y., & Pan, D. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.06.003 · Cited by 867
Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions
Beutel, O., Maraspini, R., Pombo-García, K., Martin-Lemaitre, C., & Honigmann, A. (2019) · Cell · doi:10.1016/j.cell.2019.10.011 · Cited by 435
Metadata
- Authors
- Oka, T., Remue, E., Meerschaert, K., Vanloo, B., Boucherie, C., Gfeller, D., Bader, G. D., Sidhu, S. S., Vandekerckhove, J., Gettemans, J., & Sudol, M.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2010-11-25
- Volume
- 432
- Issue
- 3
- Pages
- 461-478
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2116234513
- Cited by
- 216
- References
- 9
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Oka, T., Remue, E., Meerschaert, K., Vanloo, B., Boucherie, C., Gfeller, D., Bader, G. D., Sidhu, S. S., Vandekerckhove, J., Gettemans, J., & Sudol, M. (2010). Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling. Biochemical Journal. https://doi.org/10.1042/bj20100870
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