The DOI matches its Crossref record; 161 of the 161 references it cites were found in a registry or an index.
Antioxidant and bioenergetic coupling between neurons and astrocytes
Abstract
Oxidative and nitrosative stress underlie the pathogenesis of a broad range of human diseases, in particular neurodegenerative disorders. Within the brain, neurons are the cells most vulnerable to excess reactive oxygen and nitrogen species; their survival relies on the antioxidant protection promoted by neighbouring astrocytes. However, neurons are also intrinsically equipped with a biochemical mechanism that links glucose metabolism to antioxidant defence. Neurons actively metabolize glucose through the pentose phosphate pathway, which maintains the antioxidant glutathione in its reduced state, hence exerting neuroprotection. This process is tightly controlled by a key glycolysis-promoting enzyme and is dependent on an appropriate supply of energy substrates from astrocytes. Thus brain bioenergetic and antioxidant defence is coupled between neurons and astrocytes. A better understanding of the regulation of this intercellular coupling should be important for identifying novel targets for future therapeutic interventions.
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“GSH levels have been shown to be lower in chronic schizophrenia, as measured in the CSF and post-mortem brain, and by MRS-based in vivo imaging 41,42 and the GSH system enzymes glutathione peroxidase (GPX) and glutathione reductase (GR) are also dysregulated 36 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [36]
In the citing paper
“Evidence for oxidative stress has been found in patients with schizophrenia, including increased lipid and protein oxidation in blood, cerebrospinal fluid (CSF) and post-mortem tissue 36,37 , as well as altered levels of plasma antioxidants (such as vitamins C and E, catalase, GSH and GSH-peroxidase) 36,38 and CSF superoxide dismutase-1 levels 39 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [36]
Citations
Cites
How mitochondria produce reactive oxygen species
Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196
Ischemic Cell Death in Brain Neurons
Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043
Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927
Nitric oxide synthases in mammals
Knowles, R. G., & Moncada, S. (1994) · Biochemical Journal · doi:10.1042/bj2980249 · Cited by 2,752
Oxidative stress and neurodegeneration: where are we now?
Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614
Molecular dissection of reactive astrogliosis and glial scar formation
Sofroniew, M. V. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.08.002 · Cited by 2,594
Garthwaite, J., Charles, S. L., & Chess‐Williams, R. (1988) · Nature · doi:10.1038/336385a0 · Cited by 2,540
Glial and neuronal control of brain blood flow
Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A. (2010) · Nature · doi:10.1038/nature09613 · Cited by 2,511
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Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M. C., Campbell, K., Cheung, E., Olin‐Sandoval, V., Grüning, N., Krüger, A., Tauqeer Alam, M., et al. (2015) · Biological Reviews · doi:10.1111/brv.12140 · Cited by 1,576
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López-Fabuel, I., Douce, J. L., Logan, A., James, A. M., Bonvento, G., Murphy, M. P., Almeida, Á., & Bolaños, J. P. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613701113 · Cited by 474
Self-citationShort Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts
Milković, L., Gašparović, A. Č., Cindrić, M., Mouthuy, P., & Žarković, N. (2019) · Cells · doi:10.3390/cells8080793 · Cited by 330
The role of astrocytes in oxidative stress of central nervous system: A mixed blessing
Chen, Y., Chen, Q., Huang, J., Tang, X., Liu, C., Huang, K., Xu, J., Guo, G. F., Tong, A., & Zhou, L. (2020) · Cell Proliferation · doi:10.1111/cpr.12781 · Cited by 322
Metadata
- Authors
- Fernandez-Fernandez, S., Almeida, A., & Bolaños, J. P.
- Affiliations
- Department of Biochemistry and Molecular Biology, Institute of Neurosciences of Castilla y León, University of Salamanca, Salamanca 37007, Spain
- Universidad de Salamanca (ES)
- ORCID
- Bolaños, Juan P.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2012-03-14
- Volume
- 443
- Issue
- 1
- Pages
- 3-11
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2005896958
- Cited by
- 247
- References
- 161
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 9 · 2023: 19 · 2022: 20 · 2021: 20 · 2020: 25 · 2019: 12 · 2018: 18 · 2017: 17 · 2016: 20 · 2015: 26 · 2014: 19 · 2013: 24 · 2012: 7
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Keywords
- astrocytes, neurons, oxidative stress, nitrosative stress, reactive oxygen species, reactive nitrogen species, pentose phosphate pathway, glutathione, glucose metabolism, bioenergetics, neuroprotection, neurodegenerative diseases, glycolysis
- MeSH terms
- Animals, Antioxidants, Astrocytes, Energy Metabolism, Glutathione, Humans, Neurons, Oxidation-Reduction, Oxidative Stress, Carbohydrate Metabolism
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