Cited by 267Mitochondrial Function and PathologyCell death mechanisms and regulationCardiac Ischemia and Reperfusion

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Fluctuations in mitochondrial membrane potential caused by repetitive gating of the permeability transition pore

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HüSER, Jörg, BLATTER, Lothar A.·1999·Biochemical Journal

DOI 10.1042/bj3430311PMC PMC1220555

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Abstract

Confocal laser scanning microscopy and the potentiometric fluorescence probe tetramethylrhodamine ethyl ester were used to measure changes in membrane electrical potential (δΨm) in individual mitochondria after isolation or in the living cell. Recordings averaged over small mitochondrial populations revealed a gradual decline in δΨmcaused by the light-induced generation of free radicals. Depolarization was attenuated by dithiothreitol or acidification. In contrast, individual organelles displayed rapid spontaneous depolarizations caused by openings of the mitochondrial permeability transition pore (MTP). Repetitive openings and closings of the pore gave rise to marked fluctuations in δΨm between the fully charged and completely depolarized state. Rapid spontaneous fluctuations in δΨm were observed in mitochondria isolated from rat heart and in mitochondria in living endothelial cells. The loss of δΨm of mitochondria in the living cell coincided with swelling of the organelle and the breakdown of long mitochondrial filaments. In the individual mitochondrion, oxidative stress initially triggered pore openings of shorter duration, before prolonged openings caused the complete dissipation of δΨm and a measurable efflux of larger solutes. Generalizing this scheme, we suggest that under conditions of prolonged oxidative stress and/or cellular Ca2+ overload, short openings of MTP might serve as an emergency mechanism allowing the partial dissipation of δΨm, the fast release of accumulated Ca2+ ions and the decreased generation of endogenous oxygen radicals. In contrast, loss of matrix metabolites, swelling and other structural damage of the organelle render prolonged openings of the transition pore deleterious to mitochondria and to the cell.

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Authors: HüSER, J., & BLATTER, L. A.
Affiliations: Loyola University Chicago (US)
ORCID: HüSER, Jörg
BLATTER, Lothar A.
Venue: Biochemical Journal
Publisher: Portland Press Ltd.
Published: 1999-10-08
Volume: 343
Issue: 2
Pages: 311-317
ISSN: 0264-6021 (ISSN-L)
1470-8728
DOI: 10.1042/bj3430311
PMC: PMC1220555
OpenAlex: W2018776448
Cited by: 266
References: 28
Citations by year: 2026: 2 · 2025: 5 · 2024: 2 · 2023: 10 · 2022: 8 · 2021: 11 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 13 · 2016: 16 · 2015: 11 · 2014: 15 · 2013: 14 · 2012: 17
FWCI: 1.61
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biochemical Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Keywords: mitochondrial membrane potential, mitochondrial permeability transition pore, pore gating, membrane potential fluctuations, mitochondrial depolarization, oxidative stress, calcium overload, mitochondrial swelling, mitochondrial calcium release, oxygen free radicals, dithiothreitol, endothelial cells, heart mitochondria
MeSH terms: Mitochondrial Permeability Transition Pore, Animals, Calcium, Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone, Cattle, Cells, Cultured, Dithiothreitol, Electric Conductivity, Endothelium, Vascular, Fluorescence, Heart Ventricles, Hydrogen-Ion Concentration, Intracellular Membranes, Ion Channels, Membrane Potentials, Membrane Proteins, Mitochondria, Mitochondria, Heart, Permeability, Pulmonary Artery, Rhodamines, Oxidative Stress, Mitochondrial Membrane Transport Proteins, Rats

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Fluctuations in mitochondrial membrane potential caused by repetitive gating of the permeability transition pore

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