Mitochondrial reactive oxygen species and Ca 2+ signaling
Abstract
Mitochondria are an important source of reactive oxygen species (ROS) formed as a side product of oxidative phosphorylation. The main sites of oxidant production are complex I and complex III, where electrons flowing from reduced substrates are occasionally transferred to oxygen to form superoxide anion and derived products. These highly reactive compounds have a well-known role in pathological states and in some cellular responses. However, although their link with Ca 2+ is well studied in cell death, it has been hardly investigated in normal cytosolic calcium concentration ([Ca 2+ ] i ) signals. Several Ca 2+ transport systems are modulated by oxidation. Oxidation increases the activity of inositol 1,4,5-trisphosphate and ryanodine receptors, the main channels releasing Ca 2+ from intracellular stores in response to cellular stimulation. On the other hand, mitochondria are known to control [Ca 2+ ] i signals by Ca 2+ uptake and release during cytosolic calcium mobilization, specially in mitochondria situated close to Ca 2+ release channels. Mitochondrial inhibitors modify calcium signals in numerous cell types, including oscillations evoked by physiological stimulus. Although these inhibitors reduce mitochondrial Ca 2+ uptake, they also impair ROS production in several systems. In keeping with this effect, recent reports show that antioxidants or oxidant scavengers also inhibit physiological calcium signals. Furthermore, there is evidence that mitochondria generate ROS in response to cell stimulation, an effect suppressed by mitochondrial inhibitors that simultaneously block [Ca 2+ ] i signals. Together, the data reviewed here indicate that Ca 2+ -mobilizing stimulus generates mitochondrial ROS, which, in turn, facilitate [Ca 2+ ] i signals, a new aspect in the biology of mitochondria. Finally, the potential implications for biological modeling are discussed.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ROS are required to trigger the apoptotic mechanism.
“that ROS are required to trigger the apoptotic mechanism (68, 172, 207, 323)”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [68]
Cites
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works
Mitochondrial formation of reactive oxygen species
Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084 · see citing works
Calcium, ATP, and ROS: a mitochondrial love-hate triangle
Brookes, P. S., Yoon, Y., Robotham, J. L., Anders, M. W., & Sheu, S.-S. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00139.2004 · Cited by 2,575 · see citing works
Rizzuto, R., Pinton, P., Carrington, W., Fay, F. S., Fogarty, K. E., Lifshitz, L. M., Tuft, R. A., & Pozzan, T. (1998) · Science · doi:10.1126/science.280.5370.1763 · Cited by 2,257 · see citing works
Production of Reactive Oxygen Species by Mitochondria
Chen, Q., Vazquez, E. J., Moghaddas, S., Hoppel, C. L., & Lesnefsky, E. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304854200 · Cited by 1,616 · see citing works
The mitochondrial calcium uniporter is a highly selective ion channel
Kirichok, Y., Krapivinsky, G., & Clapham, D. E. (2004) · Nature · doi:10.1038/nature02246 · Cited by 1,409 · see citing works
Mitochondria and calcium: from cell signalling to cell death
Duchen, M. R. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00057.x · Cited by 1,261 · see citing works
Mitochondria and neuronal survival
Nicholls, D. G., & Budd, S. L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.315 · Cited by 1,243 · see citing works
Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria
Turrens, J. F., Alexandre, A., & Lehninger, A. L. (1985) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(85)90293-0 · Cited by 1,214 · see citing works
Rizzuto, R., Brini, M., Murgia, M., & Pozzan, T. (1993) · Science · doi:10.1126/science.8235595 · Cited by 1,207 · see citing works
Decoding of cytosolic calcium oscillations in the mitochondria
Hajnóczky, G., Gaspers, L. D., Seitz, M. B., & Thomas, A. P. (1995) · Cell · doi:10.1016/0092-8674(95)90430-1 · Cited by 1,110 · see citing works
Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin
Rizzuto, R., Simpson, A. W. M., Brini, M., & Pozzan, T. (1992) · Nature · doi:10.1038/358325a0 · Cited by 931 · see citing works
Kushnareva, Y., Murphy, A. N., & Andreyev, A. Y. (2002) · Biochemical Journal · doi:10.1042/bj20021121 · Cited by 677 · see citing works
Calcium sparks in smooth muscle
Jaggar, J. H., Porter, V. A., Lederer, W. J., & Nelson, M. T. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.2.c235 · Cited by 654 · see citing works
Interaction of reactive oxygen species with ion transport mechanisms
Kourie, J. I. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.275.1.c1 · Cited by 638 · see citing works
Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts
Nicholls, D. G., & Ward, M. W. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01534-9 · Cited by 563 · see citing works
Mitochondria as all‐round players of the calcium game
Rizzuto, R., Bernardi, P., & Pozzan, T. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00037.x · Cited by 562 · see citing works
Quasi‐synaptic calcium signal transmission between endoplasmic reticulum and mitochondria
Csordás, G., Thomas, A. P., & Hajnóczky, G. (1999) · The EMBO Journal · doi:10.1093/emboj/18.1.96 · Cited by 536 · see citing works
Aon, M. A., Cortassa, S., Marbán, E., & O'Rourke, B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302673200 · Cited by 521 · see citing works
Pueyo, M. E., Gonzalez, W., Nicoletti, A., Savoie, F., Arnal, J., & Michel, J. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.3.645 · Cited by 516 · see citing works
Mitochondrial Regulation of Store-operated Calcium Signaling in T Lymphocytes
Hoth, M., Fanger, C. M., & Lewis, R. S. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.3.633 · Cited by 505 · see citing works
Regulation of brain mitochondrial H 2 O 2 production by membrane potential and NAD(P)H redox state
Starkov, A. A., & Fiskum, G. M. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01908.x · Cited by 491 · see citing works
Dröge, W. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-8997-0_14 · Cited by 415 · see citing works
An Integrated Model of Cardiac Mitochondrial Energy Metabolism and Calcium Dynamics
Cortassa, S. C., Aon, M. A., Marbán, E., Winslow, R. L., & O'Rourke, B. P. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)75079-6 · Cited by 389 · see citing works
Mitochondrial calcium transport: mechanisms and functions
Gunter, T. E., Buntinas, L., Sparagna, G. C., Eliseev, R. A., & Gunter, K. K. (2000) · Cell Calcium · doi:10.1054/ceca.2000.0168 · Cited by 378 · see citing works
Spontaneous calcium release from inositol trisphosphate-sensitive calcium stores
Missiaen, L., Taylor, C. W., & Berridge, M. J. (1991) · Nature · doi:10.1038/352241a0 · Cited by 361 · see citing works
Tinel, H., Cancela, J., Mogami, H., Gerasimenko, J. V., Gerasimenko, O. V., Tepikin, A. V., & Petersen, O. H. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.4999 · Cited by 361 · see citing works
Pérez‐Campo, R., Lopez‐Torres, M., Cadenas, S., Rojas, C., & Barja, G. (1998) · Journal of Comparative Physiology B · doi:10.1007/s003600050131 · Cited by 356 · see citing works
Mitochondria and calcium signaling
Nicholls, D. G. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.06.011 · Cited by 349 · see citing works
Mitochondria as a source of reactive oxygen species during reductive stress in rat hepatocytes
Dawson, T. L., Gores, G. J., Nieminen, A. L., Herman, B., & Lemasters, J. J. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.264.4.c961 · Cited by 346 · see citing works
Kolísek, M., Beck, A., Fleig, A., & Penner, R. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.033 · Cited by 343 · see citing works
Flirting in Little Space: The ER/Mitochondria Ca 2+ Liaison
Rizzuto, R., Duchen, M. R., & Pozzan, T. (2004) · Science s STKE · doi:10.1126/stke.2152004re1 · Cited by 319 · see citing works
Park, M. K., Ashby, M. C., Erdemli, G., Petersen, O. H., & Tepikin, A. V. (2001) · The EMBO Journal · doi:10.1093/emboj/20.8.1863 · Cited by 318 · see citing works
Mitochondrial Calcium Uptake from Physiological-type Pulses of Calcium
Sparagna, G. C., Gunter, K. K., Sheu, S., & Gunter, T. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27510 · Cited by 309 · see citing works
Waypa, G. B., Marks, J. D., Mack, M. M., Boriboun, C., Mungai, P. T., & Schumacker, P. T. (2002) · Circulation Research · doi:10.1161/01.res.0000036751.04896.f1 · Cited by 286 · see citing works
Bootman, M. D., Taylor, C. W., & Berridge, M. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74013-7 · Cited by 268 · see citing works
HüSER, J., & BLATTER, L. A. (1999) · Biochemical Journal · doi:10.1042/bj3430311 · Cited by 266 · see citing works
Kimura, S., Zhang, G.-X., Nishiyama, A., Shokoji, T., Yao, L., Fan, Y.-Y., Rahman, M., Suzuki, T., Maeta, H., & Abe, Y. (2005) · Hypertension · doi:10.1161/01.hyp.0000163462.98381.7f · Cited by 264 · see citing works
Rutter, G. A., Burnett, P., Rizzuto, R., Brini, M., Murgia, M., Pozzan, T., Tavaré, J. M., & Denton, R. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.11.5489 · Cited by 241 · see citing works
Mittal, C. K., & Murad, F. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.10.4360 · Cited by 236 · see citing works
A Mitochondrial Oscillator Dependent on Reactive Oxygen Species
Cortassa, S., Aon, M. A., Winslow, R. L., & O’Rourke, B. (2004) · Biophysical Journal · doi:10.1529/biophysj.104.041749 · Cited by 235 · see citing works
Percolation and criticality in a mitochondrial network
Aon, M. A., Cortassa, S. C., & O'Rourke, B. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307156101 · Cited by 225 · see citing works
Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax
Starkov, A. A., Polster, B. M., & Fiskum, G. M. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01153.x · Cited by 225 · see citing works
Store‐operated Ca2+ entry depends on mitochondrial Ca2+ uptake
Glitsch, M. D., Bakowski, D., & Parekh, A. B. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf675 · Cited by 208 · see citing works
Mitochondria-Derived Reactive Oxygen Species and Vascular MAP Kinases
Kimura, S., Zhang, G., Nishiyama, A., Shokoji, T., Yao, L., Fan, Y.-Y., Rahman, M., & Abe, Y. (2005) · Hypertension · doi:10.1161/01.hyp.0000157169.27818.ae · Cited by 207 · see citing works
The machinery of local Ca2+ signalling between sarco‐endoplasmic reticulum and mitochondria
Hajnóczky, G., Csordás, G., Madesh, M., & Pacher, P. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00069.x · Cited by 203 · see citing works
Estrogen-Induced Mitochondrial Reactive Oxygen Species as Signal-Transducing Messengers
Felty, Q. H., Xiong, W., Sun, D., Sarkar, S., Singh, K. P., Parkash, J., & Roy, D. (2005) · Biochemistry · doi:10.1021/bi047629p · Cited by 199 · see citing works
Hsieh, T., Zhang, S., Filep, J. G., Tang, S., Ingelfinger, J. R., & Chan, J. S. D. (2002) · Endocrinology · doi:10.1210/endo.143.8.8931 · Cited by 190 · see citing works
Cancela, J., Coppenolle, F. V., Galione, A., Tepikin, A. V., & Petersen, O. H. (2002) · The EMBO Journal · doi:10.1093/emboj/21.5.909 · Cited by 182 · see citing works
Calcium Wave Propagation in Pancreatic Acinar Cells
Straub, S. V., Giovannucci, D. R., & Yule, D. I. (2000) · The Journal of General Physiology · doi:10.1085/jgp.116.4.547 · Cited by 175 · see citing works
Redox Regulation of Signal Transduction in Cardiac and Smooth Muscle
Suzuki, Y., & Ford, G. D. (1999) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1998.0872 · Cited by 170 · see citing works
Hypoxic pulmonary vasoconstriction: redox events in oxygen sensing
Waypa, G. B., & Schumacker, P. T. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00722.2004 · Cited by 162 · see citing works
Type 1 ryanodine receptor in cardiac mitochondria: Transducer of excitation–metabolism coupling
Beutner, G., Sharma, V. K., Lin, L., Ryu, S., Dirksen, R. T., & Sheu, S. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.09.016 · Cited by 161 · see citing works
Coelho, S. M., Taylor, A. R., Ryan, K. P., et al. (2002) · The Plant Cell · doi:10.1105/tpc.003285 · Cited by 160 · see citing works
Effects of reactive oxygen species on brain synaptic plasma membrane Ca2+-ATPase
Zaidi, A., & Michaelis, M. L. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00128-8 · Cited by 154 · see citing works
Mitochondria Support Inositol 1,4,5-Trisphosphate-mediated Ca2+ Waves in Cultured Oligodendrocytes
Simpson, P. B., & Russell, J. T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33493 · Cited by 147 · see citing works
Transmembrane Redox Sensor of Ryanodine Receptor Complex
Feng, W., Liu, G., Allen, P. D., & Pessah, I. N. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000523200 · Cited by 141 · see citing works
Missiaen, L., Taylor, C. W., & Berridge, M. J. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019319 · Cited by 140 · see citing works
Petersen, C. C. H., Toescu, E. C., & Petersen, O. H. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07979.x · Cited by 138 · see citing works
Kaplán, P., Babusikova, E., Lehotský, J., & Dobrota, D. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1024145212616 · Cited by 138 · see citing works
Quantitative Analysis of Spontaneous Mitochondrial Depolarizations
O’Reilly, C. M., Fogarty, K. E., Drummond, R. M., Tuft, R. A., & Walsh, J. V. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)74754-7 · Cited by 130 · see citing works
Mitochondria-Derived Reactive Oxygen Species Dilate Cerebral Arteries by Activating Ca 2+ Sparks
Xi, Q., Cheranov, S. Y., & Jaggar, J. H. (2005) · Circulation Research · doi:10.1161/01.res.0000177669.29525.78 · Cited by 127 · see citing works
Voronina, S. G., Barrow, S. L., Gerasimenko, O. V., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311698200 · Cited by 116 · see citing works
Estrogen, mitochondria, and growth of cancer and non-cancer cells.
Felty, Q. H., & Roy, D. (2005) · Journal of Carcinogenesis · doi:10.1186/1477-3163-4-1 · Cited by 113 · see citing works
Bultynck, G., Szlufcik, K., Kasri, N. N., et al. (2004) · Biochemical Journal · doi:10.1042/bj20040072 · Cited by 112 · see citing works
Cell signalling by oxidized lipids and the role of reactive oxygen species in the endothelium
Zmijewski, J. W., Landar, A., Watanabe, N., Dickinson, D. A., Noguchi, N., & Darley-Usmar, V. M. (2005) · Biochemical Society Transactions · doi:10.1042/bst20051385 · Cited by 112 · see citing works
Mitochondria Shape Hormonally Induced Cytoplasmic Calcium Oscillations and Modulate Exocytosis
Kaftan, E. J., Xu, T., Abercrombie, R. F., & Hille, B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000903200 · Cited by 111 · see citing works
Correlation of NADH and Ca2+ signals in mouse pancreatic acinar cells
Voronina, S. G., Sukhomlin, T. K., Johnson, P., et al. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013134 · Cited by 110 · see citing works
Izeradjene, K., Douglas, L., Tillman, D. M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2628 · Cited by 107 · see citing works
Mitochondrial Ca2+-induced Ca2+Release Mediated by the Ca2+Uniporter
Montero, M., Alonso, M. T., Albillos, A., Garcı́a-Sancho, J., & Álvarez, J. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.1.63 · Cited by 92 · see citing works
Abramson, J. J., Zable, A. C., Favero, T. G., & Salama, G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.50.29644 · Cited by 82 · see citing works
Mitochondrial redox state and Ca2+ sparks in permeabilized mammalian skeletal muscle
Isaeva, E., Shkryl, V. M., & Shirokova, N. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.086280 · Cited by 81 · see citing works
Hu, Q., Yu, Z., Ferrans, V. J., Takeda, K., Irani, K., & Ziegelstein, R. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201550200 · Cited by 78 · see citing works
Thorn, P., Brady, P., Llopis, J., et al. (1992) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00370417 · Cited by 70 · see citing works
Marhl, M., Schuster, S., & Brumen, M. (1998) · Biophysical Chemistry · doi:10.1016/s0301-4622(97)00139-7 · Cited by 67 · see citing works
Parkash, J., Felty, Q. H., & Roy, D. (2006) · Biochemistry · doi:10.1021/bi051855x · Cited by 58 · see citing works
Mitochondrial production of oxidants is necessary for physiological calcium oscillations
Camello‐Almaraz, C., Pozo, M. J., Murphy, M. P., & Camello, P. J. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20498 · Cited by 56 · see citing works
Self-citationIon transport systems as targets of free radicals during ischemia reperfusion injury.
Lehotský, J., Kaplán, P., Matejovičová, M., et al. (2002) · PubMed · Cited by 54 · see citing works
Fusi, F., Saponara, S., Gagov, H., et al. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704183 · Cited by 53 · see citing works
Respiratory uncoupling by UCP1 and UCP2 and superoxide generation in endothelial cell mitochondria
Fink, B. D., Reszka, K. J., Herlein, J. A., Mathahs, M. M., & Sivitz, W. I. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00332.2004 · Cited by 53 · see citing works
Okabe, E., Tsujimoto, Y., & Kobayashi, Y. (2000) · Antioxidants and Redox Signaling · doi:10.1089/ars.2000.2.1-47 · Cited by 48 · see citing works
Ca2+sparks and BK currents in gallbladder myocytes: role in CCK-induced response
Pozo, M. J., Pérez, G. J., Nelson, M. T., et al. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00326.2001 · Cited by 46 · see citing works
Self-citationVergun, O. V., & Reynolds, I. J. (2004) · Biophysical Journal · doi:10.1529/biophysj.104.042671 · Cited by 44 · see citing works
Role of mitochondria in Ca2+ oscillations and shape of Ca2+ signals in pancreatic acinar cells
Camello‐Almaraz, C., Salido, G. M., Pariente, J. A., et al. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00830-9 · Cited by 38 · see citing works
Self-citationHuschenbett, J., Zaidi, A., & Michaelis, M. L. (1998) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(98)00121-7 · Cited by 34 · see citing works
Foreman, M. A., Smith, J., & Publicover, S. J. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20521 · Cited by 33 · see citing works
González, A., Granados, M. P., Salido, G. M., & Pariente, J. A. (2003) · Cellular Signalling · doi:10.1016/s0898-6568(03)00067-6 · Cited by 31 · see citing works
Scanlon, J. M., Brocard, J. B., Stout, A. K., & Reynolds, I. J. (2000) · Cell Calcium · doi:10.1054/ceca.2000.0171 · Cited by 27 · see citing works
The effect of cytoplasmic Ca2+ signal on the redox state of mitochondrial pyridine nucleotides
Spät, A., & Pitter, J. G. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.11.004 · Cited by 22 · see citing works
Simpson, P. B. (2000) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1005552126516 · Cited by 21 · see citing works
Wu, J., Takeo, T., Kamimura, N., et al. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00646-1 · Cited by 19 · see citing works
Vanadate inhibits the calcium extrusion in rat pancreatic acinar cells
Lajas, A. I., Sierra, V., Camello, P. J., et al. (2001) · Cellular Signalling · doi:10.1016/s0898-6568(01)00161-9 · Cited by 11 · see citing works
Self-citationCamello, C., Camello, P. J., Pariente, J. A., et al. (2000) · Journal of Physiology and Biochemistry · doi:10.1007/bf03179784 · Cited by 9 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Calcium and ROS: A mutual interplay
Görlach, A., Bertram, K., Hudecova, S., & Krizanova, O. (2015) · Redox Biology · doi:10.1016/j.redox.2015.08.010 · Cited by 1,546 · see citing works
Mitochondria and Endothelial Function
Kluge, M. A., Fetterman, J. L., & Vita, J. A. (2013) · Circulation Research · doi:10.1161/circresaha.111.300233 · Cited by 508 · see citing works
Oxidative stress and aberrant signaling in aging and cognitive decline
Dröge, W., & Schipper, H. M. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00294.x · Cited by 479 · see citing works
Stowe, D. F., & Camara, A. K. S. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2331 · Cited by 471 · see citing works
Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation
Koopman, W. J. H., Nijtmans, L. G. J., Dieteren, C. E. J., Roestenberg, P., Valsecchi, F., Smeitink, J. A. M., & Willems, P. H. G. M. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2743 · Cited by 411 · see citing works
Irrcher, I., Ljubicic, V., & Hood, D. A. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00267.2007 · Cited by 356 · see citing works
Markers and Biomarkers of Endothelium: When Something Is Rotten in the State
Goncharov, N. V., Nadeev, A. D., Jenkins, R. O., & Avdonin, P. V. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9759735 · Cited by 190 · see citing works
- Authors
- Camello-Almaraz, C., Gomez-Pinilla, P. J., Pozo, M. J., & Camello, P. J.
- ORCID
- Camello, Pedro J.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2006-11
- Volume
- 291
- Issue
- 5
- Pages
- C1082-C1088
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2120504470
- Cited by
- 336
- References
- 93
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 9 · 2023: 9 · 2022: 21 · 2021: 14 · 2020: 19 · 2019: 19 · 2018: 12 · 2017: 9 · 2016: 15 · 2015: 27 · 2014: 20 · 2013: 16 · 2012: 22
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Cell Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- mitochondrial reactive oxygen species, calcium signaling, mitochondrial calcium uptake, calcium release channel, IP3 receptor, ryanodine receptor, superoxide, oxidative phosphorylation, mitochondrial inhibitors, antioxidants, calcium oscillations, mathematical biology
- MeSH terms
- Animals, Calcium, Homeostasis, Humans, Mitochondria, Reactive Oxygen Species, Calcium Signaling
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
