Cited by 116Trypanosoma species research and implicationsRNA Research and SplicingResearch on Leishmaniasis Studies

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Gene expression regulation in trypanosomatids

De Gaudenzi, Javier G., Noé, Griselda, Campo, Vanina A., Frasch, Alberto C., Cassola, Alejandro·2011·Essays in Biochemistry

DOI 10.1042/bse0510031

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Abstract

Trypanosomatids are protozoan micro-organisms that cause serious health problems in humans and domestic animals. In addition to their medical relevance, these pathogens have novel biological structures and processes. From nuclear DNA transcription to mRNA translation, trypanosomes use unusual mechanisms to control gene expression. For example, transcription by RNAPII (RNA polymerase II) is polycistronic, and only a few transcription initiation sites have been identified so far. The sequences present in the polycistronic units code for proteins having unrelated functions, that is, not involved in a similar metabolic pathway. Owing to these biological constraints, these micro-organisms regulate gene expression mostly by post-transcriptional events. Consequently, the function of proteins that recognize RNA elements preferentially at the 3′ UTR (untranslated region) of transcripts is central. It was recently shown that mRNP (messenger ribonucleoprotein) complexes are organized within post-transcriptional operons to co-ordinately regulate gene expression of functionally linked transcripts. In the present chapter we will focus on particular characteristics of gene expression in the so-called TriTryp parasites: Trypanosoma cruzi, Trypanosoma brucei and Leishmania major.

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Authors: De Gaudenzi, J. G., Noé, G., Campo, V. A., Frasch, A. C., & Cassola, A.
Affiliations: Instituto de Investigaciones Biotecnológicas – Instituto Tecnológico Chascomús, UNSAM-CONICET, Av. Gral. Paz 5445, INTI, Edificio 24, 1650 San Martín, Provincia de Buenos Aires, Argentina.
Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
ORCID: Campo, Vanina A.
Frasch, Alberto C.
Cassola, Alejandro
Venue: Essays in Biochemistry
Publisher: Portland Press Ltd.
Published: 2011-10-24
Volume: 51
Pages: 31-46
ISSN: 0071-1365 (ISSN-L)
1744-1358
DOI: 10.1042/bse0510031
OpenAlex: W2292320336
Cited by: 116
References: 51
Citations by year: 2026: 6 · 2025: 9 · 2024: 8 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 8 · 2018: 12 · 2017: 8 · 2016: 9 · 2015: 9 · 2014: 5 · 2013: 18 · 2012: 4
FWCI: 1.01
Type: journal article
Language: en
Open access: closed
Locations: Essays in Biochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI0600645)
Fogarty International Center (D43TW007888)
Topics: Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
Keywords: gene expression regulation, trypanosomatids, polycistronic transcription, RNA polymerase II, post-transcriptional regulation, 3' untranslated region, RNA-binding proteins, messenger ribonucleoprotein complexes, Trypanosoma cruzi, Trypanosoma brucei, Leishmania major
MeSH terms: Animals, Chromatin, Gene Expression Regulation, Ribonucleoproteins, RNA Polymerase II, RNA Processing, Post-Transcriptional, RNA, Messenger, Transcription, Genetic, Trypanosoma, DNA, Protozoan, RNA-Binding Proteins, Genome, 3' Untranslated Regions

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