The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Gene expression regulation in trypanosomatids
Abstract
Trypanosomatids are protozoan micro-organisms that cause serious health problems in humans and domestic animals. In addition to their medical relevance, these pathogens have novel biological structures and processes. From nuclear DNA transcription to mRNA translation, trypanosomes use unusual mechanisms to control gene expression. For example, transcription by RNAPII (RNA polymerase II) is polycistronic, and only a few transcription initiation sites have been identified so far. The sequences present in the polycistronic units code for proteins having unrelated functions, that is, not involved in a similar metabolic pathway. Owing to these biological constraints, these micro-organisms regulate gene expression mostly by post-transcriptional events. Consequently, the function of proteins that recognize RNA elements preferentially at the 3′ UTR (untranslated region) of transcripts is central. It was recently shown that mRNP (messenger ribonucleoprotein) complexes are organized within post-transcriptional operons to co-ordinately regulate gene expression of functionally linked transcripts. In the present chapter we will focus on particular characteristics of gene expression in the so-called TriTryp parasites: Trypanosoma cruzi, Trypanosoma brucei and Leishmania major.
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“There are virtually no data on the sequence preferences of RBPs in most organisms”
From A compendium of RNA-binding motifs for decoding gene regulation (2013) · cites this paper as [6]
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Metadata
- Authors
- De Gaudenzi, J. G., Noé, G., Campo, V. A., Frasch, A. C., & Cassola, A.
- Affiliations
- Instituto de Investigaciones Biotecnológicas – Instituto Tecnológico Chascomús, UNSAM-CONICET, Av. Gral. Paz 5445, INTI, Edificio 24, 1650 San Martín, Provincia de Buenos Aires, Argentina.
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Venue
- Essays in Biochemistry
- Publisher
- Portland Press Ltd.
- Published
- 2011-10-24
- Volume
- 51
- Pages
- 31-46
- ISSN
- 0071-1365 (ISSN-L)
- 1744-1358
- OpenAlex
- W2292320336
- Cited by
- 116
- References
- 51
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 8 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 8 · 2018: 12 · 2017: 8 · 2016: 9 · 2015: 9 · 2014: 5 · 2013: 18 · 2012: 4
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Essays in Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI0600645)
- Fogarty International Center (D43TW007888)
- Topics
- Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Keywords
- gene expression regulation, trypanosomatids, polycistronic transcription, RNA polymerase II, post-transcriptional regulation, 3' untranslated region, RNA-binding proteins, messenger ribonucleoprotein complexes, Trypanosoma cruzi, Trypanosoma brucei, Leishmania major
- MeSH terms
- Animals, Chromatin, Gene Expression Regulation, Ribonucleoproteins, RNA Polymerase II, RNA Processing, Post-Transcriptional, RNA, Messenger, Transcription, Genetic, Trypanosoma, DNA, Protozoan, RNA-Binding Proteins, Genome, 3' Untranslated Regions
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