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Cited by 120Curcumin's Biomedical ApplicationsOsteoarthritis Treatment and MechanismsPharmacological Effects of Medicinal Plants

The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis

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Zeng, Liuting, Yu, Ganpeng, Hao, Wensa, Yang, Kailin, Chen, Hua·2021·Bioscience Reports
DOI 10.1042/bsr20210817PMC PMC8202067
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Abstract

Objective: To assess the efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis (OA). Methods: The databases such as Pubmed and Cochrane Library were searched to collect the article about Curcuma longa extract and curcumin in the treatment of OA. Then, randomized controlled trials (RCTs) were selected and their data were extracted. Finally, the RevMan5.3 was utilized for risk of bias assessment and meta-analysis, the STATA15.0 were utilized for publication bias assessment, and GRADE tool were used for the evidence quality assessment of primary outcomes. Results: A total of 15 RCTs involving 1621 participants were included. (1) Compared with placebo, Curcuma longa extract and curcumin (C.) can decrease the visual analog scale (VAS) and The Western Ontario and McMaster Universities (WOMAC) score-pain, the WOMAC score-function and the WOMAC score-stiffness. In terms of adverse events, Curcuma longa extract and curcumin are comparable with those of placebo. (2) Compared with non-steroidal anti-inflammatory drugs (NSAIDs), Curcuma longa extract and curcumin have similar effects on joint pain, function and stiffness. The incidence of adverse events in Curcuma longa extract and curcumin was lower. (3) Compared with the NSAIDs group, C.+NSAIDs can also decrease the VAS and WOMAC score-pain, the WOMAC score-function and the WOMAC score-stiffness. In terms of adverse events, the addition of Curcuma longa extract and curcumin to NSAIDs did not increase adverse events. Conclusion: Curcuma longa extract and curcumin may be a safer and effective supplement for OA patients. It is recommended to use Curcuma longa extract and curcumin supplement for OA patients for more than 12 weeks.

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  • Evidence to reveal the clinical significance of CURs alone for knee OA is insufficient.

    “Thus far, the therapeutic effects of CURs for knee osteoarthritis (OA) uncovered by multiple reviews remained uncertain due to broadly involving trials with different agents-combined or CURs-free interventions [8, 24–26], and evidence to reveal the clinical significance of CURs alone for knee OA is insufficient.”

    From Efficacy and safety of curcuminoids alone in alleviating pain and dysfunction for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials (2022) · cites this paper as [26]

    The Introduction says earlier evidence was too limited for definite clinical recommendations, but the paper presents its updated analysis as addressing that gap. In Results > Primary outcomes, curcumin or Curcuma longa extract alone reduced pain versus placebo; the Conclusion recommends supplementation for patients with OA. Thus, the paper does not present evidence for these interventions alone as insufficient, although its conclusion addresses OA generally rather than knee OA specifically. (LLM, conf=0.82)

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  • The therapeutic effects of CURs for knee OA uncovered by multiple reviews remained uncertain because reviews broadly involved trials with different agents-combined or CURs-free interventions.

    “Thus far, the therapeutic effects of CURs for knee osteoarthritis (OA) uncovered by multiple reviews remained uncertain due to broadly involving trials with different agents-combined or CURs-free interventions [8, 24–26], and evidence to reveal the clinical significance of CURs alone for knee OA is insufficient.”

    From Efficacy and safety of curcuminoids alone in alleviating pain and dysfunction for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials (2022) · cites this paper as [26]

    The Introduction says earlier evidence was too limited for definite clinical recommendations, and the Methods (Selection criteria) allow curcumin either alone or combined with conventional therapy. But the paper does not say that reviews’ uncertainty was caused by including curcumin-free interventions; its own eligibility criteria require curcumin. Page numbers are unavailable in our copy. (LLM, conf=0.82)

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Research works printed but not linked: 63

  1. [1]Vina E.R. and Kwoh C.K. (2018) Epidemiology of osteoarthritis: literature update. Curr. Opin. Rheumatol. 30, 160– 167 10.1097/BOR.0000000000000479 29227353 PMC5832048 · DOI
  2. [2]Sun X., Zhen X., Hu X., Li Y., Gu S., Gu Y. et al. (2019) Osteoarthritis in the middle-aged and elderly in China: prevalence and influencing factors. Int. J. Environ. Res. Public Health 16, 4701, PMCID: PMC6926632, 10.3390/ijerph16234701 PMC6926632 31779104 · DOI
  3. [3]Hu H., Luan L., Yang K. and Li S.C. (2018) Burden of rheumatoid arthritis from a societal perspective: A prevalence-based study on cost of this illness for patients in China. Int. J. Rheum. Dis. 21, 1572– 1580 10.1111/1756-185X.13028 28211251 · DOI
  4. [4]Sacitharan P.K. (2019) Ageing and osteoarthritis. Subcell. Biochem. 91, 123– 159 10.1007/978-981-13-3681-2_6 30888652 · DOI
  5. [5]Roos E.M. and Arden N.K. (2016) Strategies for the prevention of knee osteoarthritis. Nat. Rev. Rheumatol. 12, 92– 101 10.1038/nrrheum.2015.135 26439406 · DOI
  6. [6]Abramoff B. and Caldera F.E. (2020) Osteoarthritis: pathology, diagnosis, and treatment options. Med. Clin. North Am. 104, 293– 311 10.1016/j.mcna.2019.10.007 32035570 · DOI · Paper page
  7. [7]Nelson A.E. (2018) Osteoarthritis year in review 2017: clinical. Osteoarthritis Cartilage 26, 319– 325 10.1016/j.joca.2017.11.014 29229563 PMC5835411 · DOI
  8. [8]Pereira D., Ramos E. and Branco J. (2015) Osteoarthritis. Acta Med. Port. 28, 99– 106 10.20344/amp.5477 25817486 · DOI
  9. [9]Barnett R. (2018) Osteoarthritis. Lancet 391, 1985 10.1016/S0140-6736(18)31064-X 29864015 · DOI
  10. [10]Zavodovsky B.V. and Sivordova L.E. (2018) Cardiovascular safety of non-steroidal anti-inflammatory drugs in chronic inflammatory rheumatic diseases. Ter. Arkh. 90, 101– 106 30701944
  11. [11]Bindu S., Mazumder S. and Bandyopadhyay U. (2020) Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective. Biochem. Pharmacol. 180, 114147 10.1016/j.bcp.2020.114147 32653589 PMC7347500 · DOI
  12. [12]Kocaadam B. and Şanlier N. (2017) Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit. Rev. Food Sci. Nutr. 57, 2889– 2895 10.1080/10408398.2015.1077195 26528921 · DOI
  13. [13]Soleimani V., Sahebkar A. and Hosseinzadeh H. (2018) Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: review. Phytother. Res. 32, 985– 995 10.1002/ptr.6054 29480523 · DOI
  14. [14]Wu J., Lv M. and Zhou Y. (2019) Efficacy and side effect of curcumin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials. Pak. J. Pharm. Sci. 32, 43– 51 30772789
  15. [15]Bannuru R.R., Osani M.C., Al-Eid F. and Wang C. (2018) Efficacy of curcumin and Boswellia for knee osteoarthritis: systematic review and meta-analysis. Semin. Arthritis Rheum. 48, 416– 429 10.1016/j.semarthrit.2018.03.001 29622343 PMC6131088 · DOI · Paper page
  16. [16]Wang Z., Jones G., Winzenberg T., Cai G., Laslett L.L., Aitken D. et al. (2020) Effectiveness of Curcuma longa extract for the treatment of symptoms and effusion-synovitis of knee osteoarthritis: a randomized trial. Ann. Intern. Med. 173, 861– 869 10.7326/M20-0990 32926799 · DOI · Paper page
  17. [17]Jamali N., Adib-Hajbaghery M. and Soleimani A. (2020) The effect of curcumin ointment on knee pain in older adults with osteoarthritis: a randomized placebo trial. BMC Complement. Med. Ther. 20, 305 10.1186/s12906-020-03105-0 33032585 PMC7545864 · DOI
  18. [18]Henrotin Y., Malaise M., Wittoek R., de Vlam K., Brasseur J.P., Luyten F.P. et al. (2019) Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study. Arthritis Res. Ther. 21, 179 10.1186/s13075-019-1960-5 31351488 PMC6661105 · DOI
  19. [19]Hashemzadeh K., Davoudian N., Jaafari M.R. and Mirfeizi Z. (2020) The effect of nanocurcumin in improvement of knee osteoarthritis: a randomized clinical trial. Curr. Rheumatol. Rev. 16, 158– 164 10.2174/1874471013666191223152658 31868149 · DOI · Paper page
  20. [20]Shep D., Khanwelkar C., Gade P. and Karad S. (2019) Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study. Trials 20, 214 10.1186/s13063-019-3327-2 30975196 PMC6460672 · DOI
  21. [21]Deeks J.J., Higgins J.P. and Altman D.G. (2020) Chapter 8: assessing risk of bias in included studies. In Cochrane Handbook or Systematic Reviews of Interventions Version 6.1.0(Higgins J.P. and Green S., eds), The Cochrane Collaboration, U.K.
  22. [23]Karlapudi V., Prasad Mungara A.V.V., Sengupta K., Davis B.A. and Raychaudhuri S.P. (2018) A placebo-controlled double-blind study demonstrates the clinical efficacy of a novel herbal formulation for relieving joint discomfort in human subjects with osteoarthritis of knee. J. Med. Food 21, 511– 520 10.1089/jmf.2017.0065 29708818 · DOI
  23. [24]Heidari-Beni M., Moravejolahkami A.R., Gorgian P., Askari G., Tarrahi M.J. and Bahreini-Esfahani N. (2020) Herbal formulation “turmeric extract, black pepper, and ginger” versus Naproxen for chronic knee osteoarthritis: a randomized, double-blind, controlled clinical trial. Phytother. Res. 34, 2067– 2073 10.1002/ptr.6671 32180294 · DOI
  24. [25]Badria F.A. et al. (2002) Boswellia-curcumin preparation for treating knee osteoarthritis: a clinical evaluation. Altern. Complement. Ther. 2, 110– 112 10.1089/107628002761574635 · DOI
  25. [26]Kizhakkedath R. (2013) Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis. Mol. Med. Rep. 8, 1542– 1548 10.3892/mmr.2013.1661 24002213 · DOI
  26. [27]Belcaro G., Cesarone M.R., Dugall M., Pellegrini L., Ledda A., Grossi M.G. et al. (2010) Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern. Med. Rev. 15, 337– 344 21194249
  27. [28]Belcaro G., Dugall M., Luzzi R., Ledda A., Pellegrini L., Cesarone M.R. et al. (2014) Meriva®+Glucosamine versus Condroitin+Glucosamine in patients with knee osteoarthritis: an observational study. Eur. Rev. Med. Pharmacol. Sci. 18, 3959– 3963 25555891
  28. [29]Ross S.M. (2016) Turmeric (Curcuma longa): effects of curcuma longa extracts compared with ibuprofen for reduction of pain and functional improvement in patients with knee osteoarthritis. Holist. Nurs. Pract. 30, 183– 186 10.1097/HNP.0000000000000152 27078813 · DOI
  29. [30]Panahi Y., Alishiri G.H., Parvin S. and Sahebkar A. (2016) Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: results of a randomized controlled trial. J. Diet Suppl. 13, 209– 220 10.3109/19390211.2015.1008611 25688638 · DOI
  30. [31]Haroyan A., Mukuchyan V., Mkrtchyan N., Minasyan N., Gasparyan S., Sargsyan A. et al. (2018) Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study. BMC Complement. Altern. Med. 18, 7 10.1186/s12906-017-2062-z 29316908 PMC5761198 · DOI · Paper page
  31. [32]Kertia N., Asdie A.H., Rochmah W. and Marsetyawan. (2012) Ability of curcuminoid compared to diclofenac sodium in reducing the secretion of cycloxygenase-2 enzyme by synovial fluid's monocytes of patients with osteoarthritis. Acta Med. Indones 44, 105– 113 22745140
  32. [33]Kuptniratsaikul V., Thanakhumtorn S., Chinswangwatanakul P., Wattanamongkonsil L. and Thamlikitkul V. (2009) Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis. J. Altern. Complement. Med. 15, 891– 897 10.1089/acm.2008.0186 19678780 · DOI
  33. [34]Panahi Y., Rahimnia A.R., Sharafi M., Alishiri G., Saburi A. and Sahebkar A. (2014) Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial. Phytother. Res. 28, 1625– 1631 10.1002/ptr.5174 24853120 · DOI · Paper page
  34. [35]Kuptniratsaikul V., Dajpratham P., Taechaarpornkul W., Buntragulpoontawee M., Lukkanapichonchut P., Chootip C. et al. (2014) Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin. Interv. Aging 9, 451– 458 10.2147/CIA.S58535 24672232 PMC3964021 · DOI
  35. [36]Nakagawa Y., Mukai S., Yamada S., Matsuoka M., Tarumi E., Hashimoto T. et al. (2014) Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. J. Orthop. Sci. 19, 933– 939 10.1007/s00776-014-0633-0 25308211 PMC4244558 · DOI
  36. [37]Pinsornsak P. and Niempoog S. (2012) The efficacy of Curcuma longa L. extract as an adjuvant therapy in primary knee osteoarthritis: a randomized control trial. J. Med. Assoc. Thai. 95, S51– S58 23964444
  37. [38]Madhu K., Chanda K. and Saji M.J. (2013) Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial. Inflammopharmacology 21, 129– 136 10.1007/s10787-012-0163-3 23242572 · DOI
  38. [39]Srivastava S., Saksena A.K., Khattri S., Kumar S. and Dagur R.S. (2016) Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trial. Inflammopharmacology 24, 377– 388 10.1007/s10787-016-0289-9 27761693 · DOI · Paper page
  39. [40]Tsuda T. (2018) Curcumin as a functional food-derived factor: degradation products, metabolites, bioactivity, and future perspectives. Food Funct. 9, 705– 714 10.1039/C7FO01242J 29206254 · DOI
  40. [41]Kunnumakkara A.B., Bordoloi D., Padmavathi G., Monisha J., Roy N.K., Prasad S. et al. (2017) Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. Br. J. Pharmacol. 174, 1325– 1348, 10.1111/bph.13621 27638428 PMC5429333 · DOI
  41. [42]Kotha R.R. and Luthria D.L. (2019) Curcumin: Biological, pharmaceutical, nutraceutical, and analytical aspects. Molecules 24, 2930 10.3390/molecules24162930 PMC6720683 31412624 · DOI
  42. [43]Liu X., Machado G.C., Eyles J.P., Ravi V. and Hunter D.J. (2018) Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. Br. J. Sports Med. 52, 167– 175 10.1136/bjsports-2016-097333 29018060 · DOI
  43. [44]Chin K.Y. (2016) The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis. Drug Des. Devel. Ther. 10, 3029– 3042, PMCID: PMC5036591 10.2147/DDDT.S117432 27703331 PMC5036591 · DOI
  44. [45]Feng K., Ge Y., Chen Z., Li X., Liu Z., Li X. et al. (2019) Curcumin Inhibits the PERK-eIF2α-CHOP pathway through promoting SIRT1 expression in oxidative stress-induced rat chondrocytes and ameliorates osteoarthritis progression in a rat model. Oxid. Med. Cell Longev. 2019, 8574386, PMCID: PMC6541984 10.1155/2019/8574386 31223428 PMC6541984 · DOI
  45. [46]Liczbiński P., Michałowicz J. and Bukowska B. (2020) Molecular mechanism of curcumin action in signaling pathways: Review of the latest research. Phytother. Res. 34, 1992– 2005, 10.1002/ptr.6663 32141677 · DOI
  46. [47]Mun S.H., Kim H.S., Kim J.W. et al. (2009) Oral administration of curcumin suppresses production of Matrix Metalloproteinase (MMP) -1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCδ/JNK/c-Jun pathway. J. Pharmacol. Sci. 73, 13– 21 10.1254/jphs.09134FP 19763044 · DOI
  47. [48]Shakibaei M., John T., Schulze-tanzil G. et al. (2007) Suppression of NFkappaB activation by curcumin leads to inhibition of expression of cyclooxygenase-2 and matrix me-talloproteinase-9 in human articular chondrocytes: implications for the treatment of osteoarthritis. Biochem. Pharmacol. 73, 1434– 1445 10.1016/j.bcp.2007.01.005 17291458 · DOI
  48. [49]Mathy H.M., Jacquemond C.I., Priem F. et al. (2009) Curcumin inhibits proinflammatory mediators and metalloproteinase-3 production by chondrocytes. Inflamm. Res. 58, 899– 908 10.1007/s00011-009-0063-1 19579007 · DOI
  49. [50]Balogun E., Hoque M., Gong P. et al. (2003) Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidantresponsive element. Biochem. J. 371, 887– 895 10.1042/bj20021619 12570874 PMC1223348 · DOI
  50. [51]Andreadi C.K., Howells L.M., Atherfold P.A. et al. (2006) Involvement of Nrf2, p38, B-Raf, and nuclear factor- κB, but not phosphatidylinositol 3- kinase,in induction of hemeo-xygenase-1 by dietary polyphenols. Mol. Pharmacol. 69, 1033– 1040 10.1124/mol.105.018374 16354769 · DOI
  51. [52]Karlowicz-Bodalska K., Han S., Freier J., Smolenski M. and Bodalska A. (2017) Curcuma longa as medicinal herb in the treatment of diabetic complications. Acta Pol. Pharm. 74, 605– 610 29624265
  52. [53]Sun W., Wang S., Zhao W., Wu C., Guo S., Gao H. et al. (2017) Chemical constituents and biological research on plants in the genus Curcuma. Crit. Rev. Food Sci. Nutr. 57, 1451– 1523 10.1080/10408398.2016.1176554 27229295 · DOI
  53. [54]Dosoky N.S. and Setzer W.N. (2018) Chemical composition and biological activities of essential oils of Curcuma species. Nutrients 10, 1196, PMCID: PMC6164907 10.3390/nu10091196 PMC6164907 30200410 · DOI
  54. [55]Ghiamati Yazdi F., Soleimanian-Zad S., van den Worm E. and Folkerts G. (2019) Turmeric extract: potential use as a prebiotic and anti-inflammatory compound? Plant Foods Hum. Nutr. 74, 293– 299 10.1007/s11130-019-00733-x 31098880 · DOI
  55. [56]Uddin S.J., Hasan M.F., Afroz M., Sarker D.K., Rouf R., Islam M.T. et al. (2021) Curcumin and its multi-target function against pain and inflammation: an update of pre-clinical data. Curr. Drug Targets 22, 656– 671 10.2174/1389450121666200925150022 (Epub ahead of print) 32981501 · DOI
  56. [57]Gupta S.C., Sung B., Kim J.H., Prasad S., Li S. and Aggarwal B.B. (2013) Multitargeting by turmeric, the golden spice: From kitchen to clinic. Mol. Nutr. Food Res. 57, 1510– 1528, 10.1002/mnfr.201100741 22887802 · DOI
  57. [58]Wei M.M., Zhao S.J., Dong X.M., Wang Y.J., Fang C., Wu P. et al. (2021) A combination index and glycoproteomics-based approach revealed synergistic anticancer effects of curcuminoids of turmeric against prostate cancer PC3 cells. J. Ethnopharmacol. 267, 113467, 10.1016/j.jep.2020.113467 33058923 · DOI
  58. [59]Orona-Ortiz A., Velázquez-Moyado J.A., Pineda-Peña E.A., Balderas-López J.L., Tavares Carvalho J.C. and Navarrete A. (2019) Effect of the proportion of curcuminoids on the gastroprotective action of Curcuma longa L. in rats. Nat. Prod. Res. 1– 6, Epub ahead of print 10.1080/14786419.2019.1644504 31339383 · DOI
  59. [60]Lao C.D., Ruffin M.T., Normolle D. et al. (2006) Dose escalation of a curcuminoid formulation. BMC Complement. Altern. Med. 6, 10 10.1186/1472-6882-6-10 16545122 PMC1434783 · DOI
  60. [62]Suresh D. and Srinivasan K. (2010) Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats. Indian J. Med. Res. 131, 682– 691 20516541
  61. [63]Kaur H., He B., Zhang C., Rodriguez E., Hage D.S. and Moreau R. (2018) Piperine potentiates curcumin-mediated repression of mTORC1 signaling in human intestinal epithelial cells: implications for the inhibition of protein synthesis and TNFα signaling. J. Nutr. Biochem. 57, 276– 286, 10.1016/j.jnutbio.2018.04.010 29800814 · DOI
  62. [64]Abdul Manap A.S., Wei Tan A.C., Leong W.H., Yin Chia A.Y., Vijayabalan S., Arya A. et al. (2019) Synergistic effects of curcumin and piperine as potent acetylcholine and amyloidogenic inhibitors with significant neuroprotective activity in SH-SY5Y cells via computational molecular modeling and in vitro assay. Front. Aging Neurosci. 11, 206, PMCID: PMC6718453 10.3389/fnagi.2019.00206 31507403 PMC6718453 · DOI
  63. [68]Prieto-Alhambra D., Judge A., Javaid M.K., Cooper C., Diez-Perez A. and Arden N.K. (2014) Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints. Ann. Rheum. Dis. 73, 1659– 1664, PMCID: PMC3875433 10.1136/annrheumdis-2013-203355 23744977 PMC3875433 · DOI

Cited by

Sorted by citations

Authors
Zeng, L., Yu, G., Hao, W., Yang, K., & Chen, H.
Affiliations
  • Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
  • The Department of Orthopaedics, People's Hospital of Ningxiang City, Ningxiang, Hunan Province, China
  • Capital Medical University (CN)
Corresponding author
  • Zeng, Liuting
  • Yu, Ganpeng
  • Chen, Hua
ORCID
Venue
Bioscience Reports
Publisher
Portland Press Ltd.
Published
2021-06
Volume
41
Issue
6
ISSN
  • 0144-8463 (ISSN-L)
  • 1573-4935
DOI
10.1042/bsr20210817
PMC
PMC8202067
OpenAlex
W3163033591
Cited by
120
References
2
Citations by year
2026: 25 · 2025: 25 · 2024: 31 · 2023: 9 · 2022: 29 · 2021: 1
FWCI
1.29
Type
journal article
Language
en
Open access
Licence
Locations
  • Bioscience Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Health Sciences › Medicine › Pharmacology › Pharmacological Effects of Medicinal Plants
Keywords
Curcuma longa extract, curcumin, osteoarthritis, dietary supplements, nonsteroidal anti-inflammatory drugs, joint pain, joint stiffness, joint function, adverse events, supplement safety
MeSH terms
Adult, Aged, Female, Humans, Male, Middle Aged, Osteoarthritis, Pain Measurement, Plant Extracts, Time Factors, Randomized Controlled Trials as Topic, Treatment Outcome, Antirheumatic Agents, Dietary Supplements, Curcuma, Young Adult

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