Peroxisomal fatty acid α- and β -oxidation in humans: enzymology, peroxisomal metabolite transporters and peroxisomal diseases

Biochemistry of mammalian peroxisomes revisited

Wanders, R. J. A., & Waterham, H. R. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133329 · Cited by 995 · see citing works

Peroxisomes: A Nexus for Lipid Metabolism and Cellular Signaling

Lodhi, I. J., & Semenkovich, C. F. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.002 · Cited by 605 · see citing works

Functions and Potential Applications of Glycolipid Biosurfactants — from Energy-Saving Materials to Gene Delivery Carriers —

Kitamoto, D., Isoda, H., & Nakahara, T. (2002) · Journal of Bioscience and Bioengineering · doi:10.1016/s1389-1723(02)80149-9 · Cited by 468 · see citing works

Control of mitochondrial β-oxidation flux

Eaton, S. D. (2002) · Progress in Lipid Research · doi:10.1016/s0163-7827(01)00024-8 · Cited by 410 · see citing works

Alpha-Methylacyl-CoA Racemase

Zhou, M., Chinnaiyan, A. M., Kleer, C. G., Lucas, P. C., & Rubin, M. A. (2002) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200207000-00012 · Cited by 296 · see citing works

Fatty acid synthase: A metabolic oncogene in prostate cancer?

Baron, A., Migita, T., Tang, D., & Loda, M. F. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10708 · Cited by 293 · see citing works

Outcomes after allogeneic hematopoietic cell transplantation for childhood cerebral adrenoleukodystrophy: the largest single-institution cohort report

Miller, W. P., Rothman, S. M., Nascene, D., Kivisto, T., DeFor, T. E., Ziegler, R. S., Eisengart, J., Leiser, K., Raymond, G., Lund, T. C., et al. (2011) · Blood · doi:10.1182/blood-2011-01-329235 · Cited by 290 · see citing works

Gene Expression Profiles in Rat Liver Treated With Perfluorooctanoic Acid (PFOA)

Guruge, K. S., Yeung, L. W. Y., Yamanaka, N., Miyazaki, S., Lam, P. K. S., Giesy, J. P., Jones, P. D., & Yamashita, N. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfj011 · Cited by 232 · see citing works

III. Peroxisomal β-oxidation, PPARα, and steatohepatitis

Reddy, J. K. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.6.g1333 · Cited by 235 · see citing works

Liver fatty acid-binding protein and obesity

Atshaves, B. P., Martin, G. G., Hostetler, H. A., McIntosh, A. L., Kier, A. B., & Schroeder, F. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.01.005 · Cited by 231 · see citing works

Identification of the peroxisomal β-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid

Ferdinandusse, S., Denis, S. W., Mooijer, P. A. W., Zhang, Z., Reddy, J. K., Spector, A. A., & Wanders, R. J. A. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31527-3 · Cited by 210 · see citing works

Mannosylerythritol lipids: a review

Arutchelvi, J., Bhaduri, S., Uppara, P. V., & Doble, M. (2008) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-008-0460-4 · Cited by 184 · see citing works

Metabolite transport across the peroxisomal membrane

Visser, W. F., van Roermund, C. W. T., IJlst, L., Waterham, H. R., & Wanders, R. J. A. (2006) · Biochemical Journal · doi:10.1042/bj20061352 · Cited by 169 · see citing works

PEX11β Deficiency Is Lethal and Impairs Neuronal Migration but Does Not Abrogate Peroxisome Function

Li, X., Baumgart, E., Morrell, J. C., Jimenez-Sanchez, G., Valle, D., & Gould, S. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4358-4365.2002 · Cited by 165 · see citing works

Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans

Zhang, S. O., Box, A., Xu, N., Men, J. L., Yu, J., Guo, F., Trimble, R., & Mak, H. Y. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912308107 · Cited by 160 · see citing works

PEX11 promotes peroxisome division independently of peroxisome metabolism

Li, X., & Gould, S. J. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200112028 · Cited by 159 · see citing works

PEX11α Is Required for Peroxisome Proliferation in Response to 4-Phenylbutyrate but Is Dispensable for Peroxisome Proliferator-Activated Receptor Alpha-Mediated Peroxisome Proliferation

Li, X., Baumgart‐Vogt, E., Dong, G.-X., Morrell, J. C., Jiménez‐Sánchez, G., Valle, D. L., Smith, K. D., & Gould, S. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.23.8226-8240.2002 · Cited by 157 · see citing works

Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency

Ferdinandusse, S., Denis, S., Hogenhout, E. M., Koster, J., van Roermund, C. W. T., IJlst, L., Moser, A. B., Wanders, R. J. A., & Waterham, H. R. (2007) · Human Mutation · doi:10.1002/humu.20535 · Cited by 156 · see citing works

Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth

Nagdas, S., Kashatus, J. A., Nascimento, A., Hussain, S. S., Trainor, R. E., Pollock, S. R., Adair, S. J., Michaels, A. D., Sesaki, H., Stelow, E. B., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.031 · Cited by 145 · see citing works

Radioisotopic determination of l-carnitine content in foods commonly eaten in Western countries

Demarquoy, J., Georges, B., Rigault, C., Royer, M.-C., Clairet, A., Soty, M., Lekounoungou, S., & Borgne, F. L. (2003) · Food Chemistry · doi:10.1016/j.foodchem.2003.09.023 · Cited by 148 · see citing works

Metabolic Plasticity in Resting and Thrombin Activated Platelets

Ravi, S., Chacko, B. K., Sawada, H., Kramer, P. A., Johnson, M. S., Benavides, G. A., O’Donnell, V. B., Marques, M. B., & Darley-Usmar, V. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123597 · Cited by 146 · see citing works

Effect of Maternal Obesity on Placental Lipid Metabolism

Calabuig-Navarro, V., Haghiac, M., Minium, J., Glazebrook, P. A., Ranasinghe, G. C., Hoppel, C. L., Mouzon, S. H., Catalano, P., & O’Tierney-Ginn, P. (2017) · Endocrinology · doi:10.1210/en.2017-00152 · Cited by 144 · see citing works

Identification of the peroxisomal β-oxidation enzymes involved in the degradation of long-chain dicarboxylic acids

Ferdinandusse, S., Denis, S. W., van Roermund, C. W. T., Wanders, R. J. A., & Dacremont, G. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300512-jlr200 · Cited by 144 · see citing works

Mitochondrial β‐oxidation in Aspergillus nidulans

Maggio‐Hall, L. A., & Keller, N. P. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04340.x · Cited by 144 · see citing works

Regulatory Genes Controlling Fatty Acid Catabolism and Peroxisomal Functions in the Filamentous Fungus Aspergillus nidulans

Hynes, M. J., Murray, S. L., Duncan, A. E., Khew, G. S.-W., & Davis, M. A. (2006) · Eukaryotic Cell · doi:10.1128/ec.5.5.794-805.2006 · Cited by 137 · see citing works

The hypotriglyceridemic effect of dietary n−3 FA is associated with increased β‐oxidation and reduced leptin expression

Ukropec, J., Reseland, J. E., Gašperíková, D., DEMCÁKOVÁ, E., Madsen, L., Berge, R. K., Rustan, A. C., Klimeś, I., Drevon, C. A., & ŠEBÖKOVÁ, E. (2003) · Lipids · doi:10.1007/s11745-006-1156-z · Cited by 133 · see citing works

Shared components of mitochondrial and peroxisomal division

Schrader, M. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.01.004 · Cited by 134 · see citing works

Mistargeting of Peroxisomal EHHADH and Inherited Renal Fanconi's Syndrome

Klootwijk, E. D., Reichold, M., Helip‐Wooley, A., Tolaymat, A., Broeker, C., Robinette, S. L., Reinders, J., Peindl, D. E., Renner, K., Eberhart, K., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1307581 · Cited by 129 · see citing works

Peroxisomal ABC transporters

Theodoulou, F. L., Holdsworth, M. J., & Baker, A. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.095 · Cited by 119 · see citing works

In Silico Prediction of the Peroxisomal Proteome in Fungi, Plants and Animals

Emanuelsson, O., Elofsson, A., von HEIJNE, G., & Cristóbal, S. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00553-9 · Cited by 117 · see citing works

Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degeneration

Hulshagen, L., Krysko, O., Bottelbergs, A., Huyghe, S., Klein, R., Van Veldhoven, P. P., De Deyn, P. P., D'Hooge, R., Hartmann, D., & Baes, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4968-07.2008 · Cited by 115 · see citing works

Mammalian peroxisomal ABC transporters: from endogenous substrates to pathology and clinical significance

Kemp, S., Theodoulou, F. L., & Wanders, R. J. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01435.x · Cited by 115 · see citing works

Peroxisomal-protein import: is it really that complex?

Gould, S. J., & Collins, C. S. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm807 · Cited by 114 · see citing works

A key role for the peroxisomal<i>ABCD2</i>transporter in fatty acid homeostasis

Fourcade, S., Ruiz, M., Camps, C., Schlüter, A., Houten, S. M., Mooyer, P. A. W., Pàmpols, T., Dacremont, G., Wanders, R. J. A., Giròs, M., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90736.2008 · Cited by 104 · see citing works

Arabidopsis Mutants in Short- and Medium-chain Acyl-CoA Oxidase Activities Accumulate Acyl-CoAs and Reveal That Fatty Acid β-Oxidation Is Essential for Embryo Development

Rylott, E. L., Rogers, C. A., Gilday, A. D., Edgell, T., Larson, T. R., & Graham, I. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300826200 · Cited by 104 · see citing works

Gas chromatography/mass spectrometry analysis of very long chain fatty acids, docosahexaenoic acid, phytanic acid and plasmalogen for the screening of peroxisomal disorders

Takemoto, Y., Suzuki, Y., Horibe, R., Shimozawa, N., Wanders, R. J. A., & Kondo, N. (2003) · Brain and Development · doi:10.1016/s0387-7604(03)00033-0 · Cited by 101 · see citing works

Is autism a disorder of fatty acid metabolism? Possible dysfunction of mitochondrial β-oxidation by long chain acyl-CoA dehydrogenase

Clark-Taylor, T., & Clark-Taylor, B. E. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.01.011 · Cited by 98 · see citing works

A novel case of ACOX2 deficiency leads to recognition of a third human peroxisomal acyl-CoA oxidase

Ferdinandusse, S., Denis, S. W., van Roermund, C. W. T., Preece, M. A., Koster, J., Ebberink, M. S., Waterham, H. R., & Wanders, R. J. A. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.12.032 · Cited by 96 · see citing works

Inhibition of Lactate Dehydrogenase Activity as an Approach to Cancer Therapy

FIUME, L., Manerba, M., Vettraino, M., & Stefano, G. D. (2014) · Future Medicinal Chemistry · doi:10.4155/fmc.13.206 · Cited by 96 · see citing works

Mitochondrial β‐oxidation regulates organellar integrity and is necessary for conidial germination and invasive growth in M agnaporthe oryzae

Patkar, R., Ramos‐Pamplona, M., Gupta, A. P., Yang, F., & Naqvi, N. I. (2012) · Molecular Microbiology · doi:10.1111/mmi.12060 · Cited by 96 · see citing works

Genomewide transcriptional signatures of migratory flight activity in a globally invasive insect pest

Jones, C. M., Papanicolaou, A., Mironidis, G. K., VONTAS, J. G., Yang, Y., Lim, K. S., Oakeshott, J. G., Bass, C., & Chapman, J. W. (2015) · Molecular Ecology · doi:10.1111/mec.13362 · Cited by 95 · see citing works

Biodegradation of Polyester Polyurethane by the Marine Fungus Cladosporium Halotolerans 6upa1

Zhang, K., Hu, J., Yang, S., Xu, W., Wang, Z., Zhuang, P., Grossart, H., & Luo, Z.-H. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129406 · Cited by 94 · see citing works

Peroxisomal multifunctional protein-2: The enzyme, the patients and the knockout mouse model.

Huyghe, S., Mannaerts, G. P., Baes, M., & Van Veldhoven, P. P. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.04.006 · Cited by 91 · see citing works

Neurodegeneration with Brain Iron Accumulation Disorders: Valuable Models Aimed at Understanding the Pathogenesis of Iron Deposition

Levi, S., & Tiranti, V. (2019) · Pharmaceuticals · doi:10.3390/ph12010027 · Cited by 90 · see citing works

Peroxisome Proliferators and Peroxisome Proliferator-Activated Receptor α

Reddy, J. K. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63787-x · Cited by 89 · see citing works

The ins and outs of peroxisomes: Co-ordination of membrane transport and peroxisomal metabolism

Rottensteiner, H., & Theodoulou, F. L. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.08.012 · Cited by 84 · see citing works

The rat liver peroxisomal membrane forms a permeability barrier for cofactors but not for small metabolites in vitro

Antonenkov, V. D., Sormunen, R. T., & Hiltunen, J. K. (2004) · Journal of Cell Science · doi:10.1242/jcs.01485 · Cited by 87 · see citing works

A mouse model for α-methylacyl-CoA racemase deficiency: adjustment of bile acid synthesis and intolerance to dietary methyl-branched lipids

Savolainen, K., Kotti, T. J., Schmitz, W., Savolainen, T. I., Sormunen, R. T., Ilves, M., Vainio, S. J., Conzelmann, E., & Hiltunen, J. K. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh107 · Cited by 83 · see citing works

Elevated α-Methylacyl-CoA Racemase Enzymatic Activity in Prostate Cancer

Kumar‐Sinha, C., Shah, R. B., Laxman, B., Tomlins, S. A., Harwood, J., Schmitz, W., Conzelmann, E., Sanda, M. G., Wei, J. T., Rubin, M. A., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63167-7 · Cited by 79 · see citing works

Metabolic reprogramming of clear cell renal cell carcinoma

Zhu, H., Wang, X., Lu, S., & Ou, K. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1195500 · Cited by 80 · see citing works

The chemical biology of branched-chain lipid metabolism

Mukherji, M., Schofield, C. J., Wierzbicki, A. S., Jansen, G. A., Wanders, R. J. A., & Lloyd, M. D. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00016-x · Cited by 77 · see citing works

The human metabolic reconstruction Recon 1 directs hypotheses of novel human metabolic functions

Rolfsson, Ó., Palsson, B. Ø., & Thiele, I. (2011) · BMC Systems Biology · doi:10.1186/1752-0509-5-155 · Cited by 74 · see citing works

Peroxisomal Multifunctional Protein 2 Is Essential for Lipid Homeostasis in Sertoli Cells and Male Fertility in Mice

Huyghe, S., Schmalbruch, H., Gendt, K. D., Verhoeven, G., Guillou, F., Veldhoven, P. P. V., & Baes, M. I. (2006) · Endocrinology · doi:10.1210/en.2005-1571 · Cited by 76 · see citing works

Classification and molecular pathogenesis of NBIA syndromes

Meo, I. D., & Tiranti, V. (2018) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2018.01.008 · Cited by 75 · see citing works

Gene expression changes controlling distinct adaptations in the heart and skeletal muscle of a hibernating mammal

Vermillion, K. L., Anderson, K. J., Hampton, M. E., & Andrews, M. T. (2015) · Physiological Genomics · doi:10.1152/physiolgenomics.00108.2014 · Cited by 74 · see citing works

A dietary enzyme: α-methylacyl-CoA racemase/P504S is overexpressed in colon carcinoma

Jiang, Z., Fanger, G. R., Banner, B. F., Woda, B. A., Algate, P. A., Dresser, K., Xu, J., Reed, S. G., Rock, K. L., & Chu, P. G. (2003) · Cancer Detection and Prevention · doi:10.1016/j.cdp.2003.07.003 · Cited by 74 · see citing works

Peroxisomal-mitochondrial oxidation in a rodent model of obesity-associated insulin resistance

Noland, R. C., Woodlief, T., Whitfield, B. R., Manning, S. M., Evans, J. R., Dudek, R. W., Lust, R. M., & Cortright, R. N. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00399.2006 · Cited by 68 · see citing works

Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice

Haque, J. A., McMahan, R. S., Campbell, J. S., Shimizu‐Albergine, M., Wilson, A. M., Botta, D., Bammler, T. K., Beyer, R. P., Montine, T. J., Yeh, M. M., et al. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.112 · Cited by 66 · see citing works

Peroxisomal and Mitochondrial β-Oxidation Pathways Influence the Virulence of the Pathogenic Fungus Cryptococcus neoformans

Kretschmer, M., Wang, J., & Kronstad, J. W. (2012) · Eukaryotic Cell · doi:10.1128/ec.00128-12 · Cited by 64 · see citing works

OCTN3 is a mammalian peroxisomal membrane carnitine transporter

Lamhonwah, A., Ackerley, C. A., Tilups, A., Edwards, V., Wanders, R. J. A., & Tein, I. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.170 · Cited by 65 · see citing works

Story behind meldonium–from pharmacology to performance enhancement: a narrative review

Schobersberger, W., Dünnwald, T., Gmeiner, G., & Blank, C. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2016-096357 · Cited by 61 · see citing works

Mechanism of toxicity of the branched‐chain fatty acid phytanic acid, a marker of Refsum disease, in astrocytes involves mitochondrial impairment

Reiser, G., Schönfeld, P., & Kahlert, S. (2006) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.11.002 · Cited by 63 · see citing works

The influence of the branched-chain fatty acids pristanic acid and Refsum disease-associated phytanic acid on mitochondrial functions and calcium regulation of hippocampal neurons, astrocytes, and oligodendrocytes

Rönicke, S., Kruska, N., Kahlert, S., & Reiser, G. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.08.005 · Cited by 62 · see citing works

In search for function of two human orphan SDR enzymes: Hydroxysteroid dehydrogenase like 2 (HSDL2) and short-chain dehydrogenase/reductase-orphan (SDR-O)

Kowalik, D., Haller, F., Adamski, J., & Möller, G. (2009) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.08.001 · Cited by 61 · see citing works

Localization of MCT 2 at peroxisomes is associated with malignant transformation in prostate cancer

Valença, I., Pértega‐Gomes, N., Vizcaino, J. R., Henrique, R., Lopes, C., Baltazar, F., & Ribeiro, D. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12481 · Cited by 59 · see citing works

Hyperpipecolic acidaemia: a diagnostic tool for peroxisomal disorders

Peduto, A., Baumgartner, M. R., Verhoeven‐Duif, N. M., Rabier, D., Spada, M., Nassogne, M., Poll‐The, B. T., Bonetti, G., Jakobs, C., & Saudubray, J. (2004) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2004.04.010 · Cited by 59 · see citing works

In Vitro and In Vivo Study of Octacosanol Metabolism

Menéndez, R., Marrero, D., Más, R., Fernández, I., González, L., & González, R. M. D. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2004.12.006 · Cited by 56 · see citing works

Peroxisomal oxidation of erucic acid suppresses mitochondrial fatty acid oxidation by stimulating malonyl-CoA formation in the rat liver

Chen, X., Shang, L., Deng, S., Li, P., Chen, K., Gao, T., Zhang, X., Chen, Z., & Zeng, J. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013583 · Cited by 54 · see citing works

Overexpression of Peroxisome Proliferator-activated Receptor-α (PPARα)-regulated Genes in Liver in the Absence of Peroxisome Proliferation in Mice Deficient in both l- and d-Forms of Enoyl-CoA Hydratase/Dehydrogenase Enzymes of Peroxisomal β-Oxidation System

Jia, Y., Qi, C., Zhang, Z., Hashimoto, T., Rao, M. S., Huyghe, S., Suzuki, Y., Veldhoven, P. P. V., Baes, M. I., & Reddy, J. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306363200 · Cited by 54 · see citing works

RNA interference of peroxisome-related genes inC. elegans: a new model for human peroxisomal disorders

Petriv, O. I., Pilgrim, D. B., Rachubinski, R. A., & Titorenko, V. I. (2002) · Physiological Genomics · doi:10.1152/physiolgenomics.00044.2002 · Cited by 53 · see citing works

Metabolic profiling analysis upon acylcarnitines in tissues of hepatocellular carcinoma revealed the inhibited carnitine shuttle system caused by the downregulated carnitine palmitoyltransferase 2

Lu, X., Zhang, X., Zhang, Y., Zhang, K., Zhan, C., Shi, X., Li, Y., Zhao, J., Bai, Y., Wang, Y., et al. (2019) · Molecular Carcinogenesis · doi:10.1002/mc.22967 · Cited by 53 · see citing works

Characteristic Acylcarnitine Profiles in Inherited Defects of Peroxisome Biogenesis: A Novel Tool for Screening Diagnosis Using Tandem Mass Spectrometry

Rizzo, C., Boenzi, S., Wanders, R. J. A., Durán, M., Caruso, U., & Dionisi‐Vici, C. (2003) · Pediatric Research · doi:10.1203/01.pdr.0000064902.59052.0f · Cited by 53 · see citing works

Anti-obesity and anti-diabetic effects of ethanol extract of Artemisia princeps in C57BL/6 mice fed a high-fat diet

Yamamoto, N., Kanemoto, Y., Ueda, M., Kawasaki, K., Fukuda, I., & Ashida, H. (2011) · Food Funct. · doi:10.1039/c0fo00129e · Cited by 52 · see citing works

Ashitaba (Angelica keiskei) extract prevents adiposity in high-fat diet-fed C57BL/6 mice

Zhang, T., Yamashita, Y., Yasuda, M. T., Yamamoto, N., & Ashida, H. (2014) · Food & Function · doi:10.1039/c4fo00525b · Cited by 52 · see citing works

Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants

Bülow, M. H., Wingen, C., Senyilmaz, D., Gosejacob, D., Sociale, M., Bauer, R., Schulze, H., Sandhoff, K., Teleman, A. A., Hoch, M., et al. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-08-0535 · Cited by 52 · see citing works

The Physiological and Pathological Role of Acyl-CoA Oxidation

Szrok-Jurga, S., Czumaj, A., Turyn, J., Hebanowska, A., Świerczyński, J., Śledziński, T., & Stelmańska, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914857 · Cited by 52 · see citing works

Targeting Carnitine Biosynthesis: Discovery of New Inhibitors against γ-Butyrobetaine Hydroxylase

Tārs, K., Leitāns, J., Kazāks, A., Zelencova-Gopejenko, D., Liepinsh, E., Kuka, J., Makrecka‐Kuka, M., Loļa, D., Andrianovs, V., Gustina, D., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm401603e · Cited by 51 · see citing works

Sequential Ordered Fatty Acid α Oxidation and Δ9 Desaturation Are Major Determinants of Lipid Storage and Utilization in Differentiating Adipocytes

Su, X., Han, X., Yang, J., Mancuso, D. J., Chen, J., Bickel, P. E., & Gross, R. W. (2004) · Biochemistry · doi:10.1021/bi035867z · Cited by 50 · see citing works

Stereochemistry of the peroxisomal branched-chain fatty acid α- and β-oxidation systems in patients suffering from different peroxisomal disorders

Ferdinandusse, S., Rusch, H., van Lint, A. E. M., Dacremont, G., Wanders, R. J. A., & Vreken, P. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30150-4 · Cited by 49 · see citing works

Looking Beyond Morphology: Cancer Gene Expression Profiling Using DNA Microarrays

Luo, J., Isaacs, W. B., Trent, J. M., & Duggan, D. J. (2003) · Cancer Investigation · doi:10.1081/cnv-120025096 · Cited by 49 · see citing works

Reinvestigation of Peroxisomal 3-Ketoacyl-CoA Thiolase Deficiency: Identification of the True Defect at the Level of d-Bifunctional Protein

Ferdinandusse, S., van Grunsven, E. G., Oostheim, W., Denis, S. W., Hogenhout, E. M., IJlst, L., van Roermund, C. W. T., Waterham, H. R., Goldfischer, S. L., & Wanders, R. J. A. (2002) · The American Journal of Human Genetics · doi:10.1086/340970 · Cited by 48 · see citing works

Developmental changes of bile acid composition and conjugation in L- and D-bifunctional protein single and double knockout mice

Ferdinandusse, S., Denis, S., Overmars, H., Van Eeckhoudt, L., Van Veldhoven, P. P., Duran, M., Wanders, R. J. A., & Baes, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414311200 · Cited by 47 · see citing works

Expression of α-methylacyl–coenzyme A racemase in dysplastic Barrett's epithelium

Lisovsky, M., Falkowski, O., & Bhuiya, T. A. (2006) · Human Pathology · doi:10.1016/j.humpath.2006.06.009 · Cited by 47 · see citing works

Metabolic dysfunctions in multiple sclerosis: implications as to causation, early detection, and treatment, a case control study

Senanayake, V. K., Jin, W., Mochizuki, A., Chitou, B., & Goodenowe, D. B. (2015) · BMC Neurology · doi:10.1186/s12883-015-0411-4 · Cited by 46 · see citing works

Peroxisomes and peroxisomal disorders: The main facts

Fidaleo, M. (2009) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2009.08.008 · Cited by 45 · see citing works

Mitochondrial fatty acid β‐oxidation is required for storage‐lipid catabolism in a marine diatom

Jallet, D., Xing, D., Hughes, A. R., Moosburner, M., Simmons, M. P., Allen, A. E., & Peers, G. (2020) · New Phytologist · doi:10.1111/nph.16744 · Cited by 45 · see citing works

Molecular Cloning and Characterization of Two Mouse Peroxisome Proliferator-activated Receptor α (PPARα)-regulated Peroxisomal Acyl-CoA Thioesterases

Westin, M., Alexson, S. E. H., & Hunt, M. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313863200 · Cited by 46 · see citing works

Defects in Mitochondrial and Peroxisomal β-Oxidation Influence Virulence in the Maize Pathogen Ustilago maydis

Kretschmer, M., Klose, J., & Kronstad, J. W. (2012) · Eukaryotic Cell · doi:10.1128/ec.00129-12 · Cited by 45 · see citing works

Straight-Chain Acyl-CoA Oxidase Knockout Mouse Accumulates Extremely Long Chain Fatty Acids from α-Linolenic Acid: Evidence for Runaway Carousel-Type Enzyme Kinetics in Peroxisomal β-Oxidation Diseases

Infante, J. P., Tschanz, C. L., Shaw, N., Michaud, A. L., Lawrence, P., & Brenna, J. T. (2002) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2001.3279 · Cited by 45 · see citing works

Hepatic Peroxisomal Fatty Acid β-Oxidation Is Regulated by Liver X Receptor α

Hu, T., FOXWORTHY, P. S., Siesky, A. M., FICORILLI, J. V., Gao, H. T., Li, S., Christe, M. E., Ryan, T., Cao, G., Eacho, P. I., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0591 · Cited by 45 · see citing works

Peroxisomal Multifunctional Protein-2 Deficiency Causes Motor Deficits and Glial Lesions in the Adult Central Nervous System

Huyghe, S., Schmalbruch, H., Hulshagen, L., Veldhoven, P. P. V., Baes, M. I., & Hartmann, D. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.041220 · Cited by 45 · see citing works

Serum levels of phytanic acid are associated with prostate cancer risk

Xu, J., Thornburg, T., Turner, A. R., Vitolins, M. Z., Case, D., Shadle, J., Hinson, L., Sun, J., Liu, W., Chang, B., et al. (2005) · The Prostate · doi:10.1002/pros.20233 · Cited by 45 · see citing works

Effect of the ACAA1 Gene on Preadipocyte Differentiation in Sheep

Wang, Y., Li, X., Cao, Y., Xiao, C., Liu, Y., Hai-guo, J., & Cao, Y. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.649140 · Cited by 44 · see citing works

Mass spectrometric analysis of ceramide perturbations in brain and fibroblasts of mice and human patients with peroxisomal disorders

Pettus, B. J., Baes, M. I., Busman, M., Hannun, Y. A., & Veldhoven, P. P. V. (2004) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1520 · Cited by 44 · see citing works

Conservation of targeting but divergence in function and quality control of peroxisomal ABC transporters: An analysis using cross-kingdom expression

Zhang, X., De Marcos Lousa, C., Schutte-Lensink, N., Ofman, R., Wanders, R. J., Baldwin, S. A., Baker, A., Kemp, S., & Theodoulou, F. L. (2011) · Biochemical Journal · doi:10.1042/bj20110249 · Cited by 43 · see citing works

Oxidation of fatty acids in eukaryotes

Schulz, H. (2008) · Elsevier eBooks · doi:10.1016/b978-044453219-0.50007-6 · Cited by 43 · see citing works

Agonists of the Peroxisome Proliferator–Activated Receptor Alpha Induce a Fiber-Type–Selective Transcriptional Response in Rat Skeletal Muscle

Souza, A. T. D., Cornwell, P. D., Dai, X., Caguyong, M. J., & Ulrich, R. G. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfl019 · Cited by 43 · see citing works

Fusion and Fission, the Evolution of Sterol Carrier Protein-2

Edqvist, J., & Blomqvist, K. (2006) · Journal of Molecular Evolution · doi:10.1007/s00239-005-0086-3 · Cited by 42 · see citing works

Metabolic engineering of β-oxidation in Penicillium chrysogenum for improved semi-synthetic cephalosporin biosynthesis

Veiga, T., Gombert, A. K., Landes, N., Verhoeven, M. D., Kiel, J. A. K. W., Krikken, A. M., Nijland, J. G., Touw, H., Luttik, M. A. H., van der Toorn, J. C., et al. (2012) · Metabolic Engineering · doi:10.1016/j.ymben.2012.02.004 · Cited by 40 · see citing works

A novel missense variant in ACAA1 contributes to early-onset Alzheimer’s disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline

Luo, R., Fan, Y., Yang, J., Ye, M., Zhang, D., Guo, K., Li, X., Bi, R., Xu, M., Yang, L.-X., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00748-4 · Cited by 41 · see citing works

Lipid metabolism in peroxisomes: enzymology, functions and dysfunctions of the fatty acid α- and β-oxidation systems in humans

Wanders, R. J. A., van Grunsven, E. G., & Jansen, G. A. (2000) · Biochemical Society Transactions · doi:10.1042/bst0280141 · Cited by 58 · see citing works

Peroxisomal fatty acid alpha- and beta-oxidation in humans: new insights into enzymology, substrate specificities, metabolite transport and peroxisomal diseases

Wanders, R. J. A., Ferdinandusse, S., Jansen, G. A., van Grusven, E. G., Waterham, H. R., van Roermund, C. W. T., & Vreken, P. (2001) · Biochemical Society Transactions · doi:10.1042/bst029a002a · Cited by 4 · see citing works

Fatty Acid Oxidation in Peroxisomes: Enzymology, Metabolic Crosstalk with Other Organelles and Peroxisomal Disorders

Wanders, R. J. A., Vaz, F. M., Waterham, H. R., & Ferdinandusse, S. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-60204-8_5 · Cited by 67 · see citing works

Peroxisomal Fatty Acid Alpha-and Beta-Oxidation in Health and Disease: New insights

Wanders, R. J. A., van Roermund, C. W. T., Visser, W. F., Ferdinandusse, S., Jansen, G. A., van den Brink, D. M., Gloerich, J., & Waterham, H. R. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9072-3_37 · Cited by 19 · see citing works

[31] Peroxisomal fatty acid oxidation and cellular redox

Singh, I. (2002) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(02)52033-4 · Cited by 11 · see citing works