The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Spare respiratory capacity, oxidative stress and excitotoxicity
Abstract
Chronic exposure to glutamate (glutamate excitotoxicity) exacerbates neuronal damage in the aftermath of stroke and is implicated in a variety of neurodegenerative disorders. Mitochondria play a central role in the survival or death of the exposed neuron. Calcium, oxidative stress and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures.
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“Under increased workload, stress, or nutrient limitation, cells engage this reserve capacity to generate more energy and promote cell viability (14, 15).”
From Fueling Immunity: Insights into Metabolism and Lymphocyte Function (2013) · cites this paper as [15]
Citations
Cites
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Korshunov, S. S., Skulachev, V. P., & Starkov, A. A. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01159-9 · Cited by 1,727
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NMDA-dependent superoxide production and neurotoxicity
Lafon‐Cazal, M., Pietri, S., Culcasi, M., & Bockaert, J. (1993) · Nature · doi:10.1038/364535a0 · Cited by 1,183
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Rossi, D. J., Oshima, T., & Attwell, D. (2000) · Nature · doi:10.1038/35002090 · Cited by 1,128
The release and uptake of excitatory amino acids
Nicholls, D. G., & Attwell, D. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90129-v · Cited by 1,092
Self-citationNovelli, A., Reilly, J. A., Lysko, P. G., & Henneberry, R. C. (1988) · Brain Research · doi:10.1016/0006-8993(88)90765-2 · Cited by 961
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Glutamate-induced neuron death requires mitochondrial calcium uptake
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The mitochondrial permeability transition from in vitro artifact to disease target
Bernardi, P., Krauskopf, A., Basso, E., Petronilli, V., Blalchy‐Dyson, E., Di Lisa, F., & Forte, M. A. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05213.x · Cited by 627
Research works printed but not linked: 1
- Wabnitz, 2006, The permeability transition pore is not a prerequisite for glutamate-induced calcium deregulation and mitochondrial depolarization in brain neurons, Biol. Membr., 22, 346
Cited by
Sorted by citations
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
van der Windt, G. J. W., Everts, B., Chang, C.-H., Curtis, J. D., Freitas, T. C., Amiel, E., Pearce, E. J., & Pearce, E. L. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.007 · Cited by 1,540
Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
Buck, M. D., O’Sullivan, D., Geltink, R. I. K., Curtis, J. D., Chang, C., Sanin, D. E., Qiu, J., Kretz, O., Braas, D., van der Windt, G. J. W., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.035 · Cited by 1,491
Fueling Immunity: Insights into Metabolism and Lymphocyte Function
Pearce, E. L., Poffenberger, M. C., Chang, C.-H., & Jones, R. G. (2013) · Science · doi:10.1126/science.1242454 · Cited by 1,363
Kawalekar, O. U., O’Connor, R. S., Fraietta, J. A., Guo, L., McGettigan, S. E., Posey, A. D., Patel, P. R., Guedan, S., Scholler, J., Keith, B., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.021 · Cited by 1,267
Patsoukis, N., Bardhan, K., Chatterjee, P., Sari, D., Liu, B., Bell, L. N., Karoly, E. D., Freeman, G. J., Petkova, V., Seth, P., et al. (2015) · Nature Communications · doi:10.1038/ncomms7692 · Cited by 1,249
Metadata
- Authors
- Nicholls, D. G.
- Affiliations
- Buck Institute for Research on Aging (US)
- Corresponding author
- Nicholls, David G.
- ORCID
- Nicholls, David G.
- Venue
- Biochemical Society Transactions
- Publisher
- Portland Press Ltd.
- Published
- 2009-11-19
- Volume
- 37
- Issue
- 6
- Pages
- 1385-1388
- ISSN
- 0300-5127 (ISSN-L)
- 1470-8752
- OpenAlex
- W2077752542
- Cited by
- 161
- References
- 32
- Citations by year
- 2026: 10 · 2025: 5 · 2024: 7 · 2023: 10 · 2022: 8 · 2021: 3 · 2020: 17 · 2019: 4 · 2018: 8 · 2017: 12 · 2016: 15 · 2015: 11 · 2014: 13 · 2013: 14 · 2012: 12
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Society Transactions (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- National Institute on Aging (R01 AG2 1440, P01AG025901)
- National Institute of Neurological Disorders and Stroke (R01 NS4 1908)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Keywords
- glutamate excitotoxicity, spare respiratory capacity, oxidative stress, mitochondria, stroke, neurodegeneration, calcium, neuronal survival, primary neuronal cultures
- MeSH terms
- Adenosine Triphosphate, Animals, Mitochondria, Neurons, Neurotoxins, Receptors, N-Methyl-D-Aspartate, Receptors, Glutamate, Oxidative Stress, Glutamic Acid, Cell Respiration
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