Spare respiratory capacity, oxidative stress and excitotoxicity

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

Rothman, S. M., & Olney, J. W. (1986) · Annals of Neurology · doi:10.1002/ana.410190202 · Cited by 2,428

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

Korshunov, S. S., Skulachev, V. P., & Starkov, A. A. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01159-9 · Cited by 1,727

Glutamate neurotoxicity in cortical cell culture

Choi, D. W., Maulucci-Gedde, M., & Kriegstein, A. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-02-00357.1987 · Cited by 1,506

NMDA-dependent superoxide production and neurotoxicity

Lafon‐Cazal, M., Pietri, S., Culcasi, M., & Bockaert, J. (1993) · Nature · doi:10.1038/364535a0 · Cited by 1,183

Glutamate release in severe brain ischaemia is mainly by reversed uptake

Rossi, D. J., Oshima, T., & Attwell, D. (2000) · Nature · doi:10.1038/35002090 · Cited by 1,128

The release and uptake of excitatory amino acids

Nicholls, D. G., & Attwell, D. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90129-v · Cited by 1,092

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

Novelli, A., Reilly, J. A., Lysko, P. G., & Henneberry, R. C. (1988) · Brain Research · doi:10.1016/0006-8993(88)90765-2 · Cited by 961

Permeation and block of N‐methyl‐D‐aspartic acid receptor channels by divalent cations in mouse cultured central neurones.

Mayer, M. L., & Westbrook, G. L. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016883 · Cited by 943

Glutamate-induced neuron death requires mitochondrial calcium uptake

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The mitochondrial permeability transition from in vitro artifact to disease target

Bernardi, P., Krauskopf, A., Basso, E., Petronilli, V., Blalchy‐Dyson, E., Di Lisa, F., & Forte, M. A. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05213.x · Cited by 627

Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons

Tymianski, M., Charlton, M. P., Carlen, P. L., & Tator, C. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-05-02085.1993 · Cited by 567

Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons

Werth, J. L., & Thayer, S. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-01-00348.1994 · Cited by 479

Mitochondria, Calcium Regulation, and Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

Budd, S. L., & Nicholls, D. G. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67062282.x · Cited by 435

Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons

Randall, R. D., & Thayer, S. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-05-01882.1992 · Cited by 408

Glutamate Decreases Mitochondrial Size and Movement in Primary Forebrain Neurons

Rintoul, G. L., Filiano, A. J., Brocard, J. B., Kress, G. J., & Reynolds, I. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07881.2003 · Cited by 326

Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity

Caldeira da Silva, C. C., Cerqueira, F. M., Barbosa, L. F., Medeiros, M. H. G., & Kowaltowski, A. J. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00407.x · Cited by 306

Mitochondrial Membrane Potential and Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

Ward, M. W., Rego, A. C., Frenguelli, B. G., & Nicholls, D. G. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07208.2000 · Cited by 304

Spare Respiratory Capacity Rather Than Oxidative Stress Regulates Glutamate Excitotoxicity after Partial Respiratory Inhibition of Mitochondrial Complex I with Rotenone

Yadava, N., & Nicholls, D. G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0212-07.2007 · Cited by 272

Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease

Nicholls, D. G. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00077-8 · Cited by 244

Mitochondrial Control of Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

Castilho, R. F., Hansson, O., Ward, M. W., Budd, S. L., & Nicholls, D. G. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10277.1998 · Cited by 197

‘Mild Uncoupling’ does not decrease mitochondrial superoxide levels in cultured cerebellar granule neurons but decreases spare respiratory capacity and increases toxicity to glutamate and oxidative stress

Johnson-Cadwell, L. I., Jekabsons, M. B., Wang, A., Polster, B. M., & Nicholls, D. G. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04516.x · Cited by 164

The regulation of brain mitochondrial calcium-ion transport. The role of ATP in the discrimination between kinetic and membrane-potential-dependent calcium-ion efflux mechanisms

Nicholls, D. G., & SCOTT, I. D. (1980) · Biochemical Journal · doi:10.1042/bj1860833 · Cited by 161

Excitotoxic Calcium Overload in a Subpopulation of Mitochondria Triggers Delayed Death in Hippocampal Neurons

Pivovarova, N. B., Nguyen, H. V., Winters, C. A., Brantner, C. A., Smith, C. L., & Andrews, S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0531-04.2004 · Cited by 145

In Situ Respiration and Bioenergetic Status of Mitochondria in Primary Cerebellar Granule Neuronal Cultures Exposed Continuously to Glutamate

Jekabsons, M. B., & Nicholls, D. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401540200 · Cited by 140

Acute Glutathione Depletion Restricts Mitochondrial ATP Export in Cerebellar Granule Neurons

Vesce, S., Jekabsons, M. B., Johnson-Cadwell, L. I., & Nicholls, D. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506575200 · Cited by 89

Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation

Alano, C. C., Beutner, G., Dirksen, R. T., Gross, R. A., & Sheu, S. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00738.x · Cited by 72

Glutamate-induced intracellular calcium changes and neurotoxicity in cortical neuronsin vitro: Effect of chemical ischemia

Rajdev, S., & Reynolds, I. J. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90468-5 · Cited by 67

Relationships between superoxide levels and delayed calcium deregulation in cultured cerebellar granule cells exposed continuously to glutamate

Vesce, S., Kirk, L., & Nicholls, D. G. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02516.x · Cited by 64

Intracellular sodium concentration in cultured cerebellar granule cells challenged with glutamate.

Kiedrowski, L., Wroblewski, J. T., & Costa, E. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10185-5 · Cited by 62

Mitochondria Control AMPA/Kainate Receptor-Induced Cytoplasmic Calcium Deregulation in Rat Cerebellar Granule Cells

Rego, A. C., Ward, M. W., & Nicholls, D. G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-01893.2001 · Cited by 59

Brevetoxins Cause Acute Excitotoxicity in Primary Cultures of Rat Cerebellar Granule Neurons

Berman, F. W., & Murray, T. F. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)34918-3 · Cited by 56

Uncoupling is without an effect on the production of reactive oxygen species by in situ synaptic mitochondria

Tretter, L., & Ádám‐Vizi, V. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04891.x · Cited by 50

Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development

van der Windt, G. J. W., Everts, B., Chang, C.-H., Curtis, J. D., Freitas, T. C., Amiel, E., Pearce, E. J., & Pearce, E. L. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.007 · Cited by 1,540

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

Buck, M. D., O’Sullivan, D., Geltink, R. I. K., Curtis, J. D., Chang, C., Sanin, D. E., Qiu, J., Kretz, O., Braas, D., van der Windt, G. J. W., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.035 · Cited by 1,491

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

Pearce, E. L., Poffenberger, M. C., Chang, C.-H., & Jones, R. G. (2013) · Science · doi:10.1126/science.1242454 · Cited by 1,363

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

Kawalekar, O. U., O’Connor, R. S., Fraietta, J. A., Guo, L., McGettigan, S. E., Posey, A. D., Patel, P. R., Guedan, S., Scholler, J., Keith, B., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.021 · Cited by 1,267

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

Patsoukis, N., Bardhan, K., Chatterjee, P., Sari, D., Liu, B., Bell, L. N., Karoly, E. D., Freeman, G. J., Petkova, V., Seth, P., et al. (2015) · Nature Communications · doi:10.1038/ncomms7692 · Cited by 1,249

Excitotoxicity and mitochondria

Nicholls, D. G., Budd, S. L., Ward, M. W., & Castilho, R. F. (1999) · Biochemical Society Symposia · doi:10.1042/bss0660055 · Cited by 63

Bioenergetics of mitochondria in cultured neurons and their role in glutamate excitotoxicity

Nicholls, D. G., Johnson-Cadwell, L. I., Vesce, S., Jekabsons, M. B., & Yadava, N. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21290 · Cited by 173

In Situ Respiration and Bioenergetic Status of Mitochondria in Primary Cerebellar Granule Neuronal Cultures Exposed Continuously to Glutamate

Jekabsons, M. B., & Nicholls, D. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401540200 · Cited by 140

Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity

Schinder, A. F., Olson, E. C., Spitzer, N. C., & Montal, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-19-06125.1996 · Cited by 770

Excitotoxic Injury to Mitochondria Isolated from Cultured Neurons

Kushnareva, Y. E., Wiley, S. E., Ward, M. W., Andreyev, A. Y., & Murphy, A. N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503090200 · Cited by 76