Spare respiratory capacity, oxidative stress and excitotoxicity

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The mitochondrial permeability transition from in vitro artifact to disease target

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Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development

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Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

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Fueling Immunity: Insights into Metabolism and Lymphocyte Function

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Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

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PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

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Mitochondria are the powerhouses of immunity

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Metabolic switching and fuel choice during T‐cell differentiation and memory development

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Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements

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CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability

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Analysis and Interpretation of Microplate-Based Oxygen Consumption and pH Data

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The Regulation and Physiology of Mitochondrial Proton Leak

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Brain lactate metabolism: the discoveries and the controversies

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Calcium‐dependent mitochondrial function and dysfunction in neurons

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Mitochondrial spare respiratory capacity: Mechanisms, regulation, and significance in non‐transformed and cancer cells

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Neuronal vulnerability, pathogenesis, and Parkinson's disease

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Loss of the Tumor Suppressor LKB1 Promotes Metabolic Reprogramming of Cancer Cells via HIF-1α

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Mitochondrial Dysfunction in Airway Disease

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Mitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival

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Role of sigma-1 receptors in neurodegenerative diseases

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Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder

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Measuring Bioenergetics in T Cells Using a Seahorse Extracellular Flux Analyzer

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Neuronal vulnerability, pathogenesis, and Parkinson's disease

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Oxidative Stress Induces Mitochondrial Dysfunction in a Subset of Autism Lymphoblastoid Cell Lines in a Well-Matched Case Control Cohort

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Fueling and Imaging Brain Activation

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Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus

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Determining Maximum Glycolytic Capacity Using Extracellular Flux Measurements

Mookerjee, S. A., Nicholls, D. G., & Brand, M. D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152016 · Cited by 167

Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy

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Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death

Divakaruni, A. S., Wallace, M., Buren, C., Martyniuk, K. M., Andreyev, A. Y., Li, E., Fields, J. A., Cordes, T., Reynolds, I. J., Bloodgood, B. L., et al. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201612067 · Cited by 169

Differential effects of AMPK agonists on cell growth and metabolism

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Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response

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A practical guide for the analysis, standardization and interpretation of oxygen consumption measurements

Divakaruni, A. S., & Jastroch, M. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00619-4 · Cited by 162

ARID5B regulates metabolic programming in human adaptive NK cells

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Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines

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Imaging of neurosphere oxygenation with phosphorescent probes

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Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders

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Ellagic acid antagonizes Bnip3-mediated mitochondrial injury and necrotic cell death of cardiac myocytes

Dhingra, A., Jayas, R., Afshar, P., Guberman, M., Maddaford, G. G., Gerstein, J., Lieberman, B., Nepon, H., Margulets, V., Dhingra, R., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.08.010 · Cited by 108

Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling

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Roles of Glucose in Photoreceptor Survival

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Preexisting High Frequencies of Memory CD8+ T Cells Favor Rapid Memory Differentiation and Preservation of Proliferative Potential upon Boosting

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Differential contribution of the mitochondrial translation pathway to the survival of diffuse large B-cell lymphoma subsets

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Changing the energy of an immune response.

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Role of serum albumin as a nanoparticulate carrier for nose-to-brain delivery of R-flurbiprofen: implications for the treatment of Alzheimer's disease

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Erratum: Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines

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The pathology roadmap in Parkinson disease

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Spare mitochondrial respiratory capacity permits human adipocytes to maintain ATP homeostasis under hypoglycemic conditions

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Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity

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Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines

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Mitochondria: key players in the neurotoxic effects of amphetamines

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Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes

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Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice

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Coenzyme Q10 Benefits Symptoms in Gulf War Veterans: Results of a Randomized Double-Blind Study

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The brominated flame retardant BDE 47 upregulates purine metabolism and mitochondrial respiration to promote adipocyte differentiation

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Investigation of Mitochondrial Dysfunction by Sequential Microplate-Based Respiration Measurements from Intact and Permeabilized Neurons

Clerc, P., & Polster, B. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034465 · Cited by 59

AIF, reactive oxygen species, and neurodegeneration: A “complex” problem

Polster, B. M. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.12.002 · Cited by 59

Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice

Maeda, A., Palczewska, G., Golczak, M., Kohno, H., Dong, Z., Maeda, T., & Palczewski, K. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317986111 · Cited by 58

Mitochondrial Oxidative Stress Reduces the Immunopotency of Mesenchymal Stromal Cells in Adults With Coronary Artery Disease

Mancini, Ö. K., Lora, M., Cuillerier, A., Shum‐Tim, D., Hamdy, R. C., Burelle, Y., Servant, M. J., Stochaj, U., & Colmegna, I. (2017) · Circulation Research · doi:10.1161/circresaha.117.311400 · Cited by 56

Innate Immune Nod1/RIP2 Signaling Is Essential for Cardiac Hypertrophy but Requires Mitochondrial Antiviral Signaling Protein for Signal Transductions and Energy Balance

Lin, H., Naito, K., Oh, Y., Farber, G., Kanaan, G. N., Valaperti, A., Dawood, F., Zhang, L., Li, G. H., Smyth, D. R., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.041213 · Cited by 54

Metabolic regulation of T cell differentiation and function

Park, B. V., & Pan, F. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.07.027 · Cited by 58

Functional Effects of Cigarette Smoke‐Induced Changes in Airway Smooth Muscle Mitochondrial Morphology

Aravamudan, B., Thompson, M., Sieck, G. C., Vassallo, R., Pabelick, C. M., & Prakash, Y. S. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25508 · Cited by 52

Hyperhomocysteinemia-induced death of retinal ganglion cells: The role of Müller glial cells and NRF2

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High density lipoproteins selectively promote the survival of human regulatory T cells

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A bioenergetic profile of non-transformed fibroblasts uncovers a link between death-resistance and enhanced spare respiratory capacity

Nickens, K. P., Wikström, J. D., Shirihai, O. S., Patierno, S. R., & Ceryak, S. M. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.09.005 · Cited by 54

Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies

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Increased Susceptibility to Ethylmercury-Induced Mitochondrial Dysfunction in a Subset of Autism Lymphoblastoid Cell Lines

Rose, S., Wynne, R. A., Frye, R. E., Melnyk, S., & James, S. J. (2015) · Journal of Toxicology · doi:10.1155/2015/573701 · Cited by 46

Magnesium Sulfate Protects Against the Bioenergetic Consequences of Chronic Glutamate Receptor Stimulation

Clerc, P., Young, C. A., Bordt, E. A., Grigore, A. M., Fiskum, G. M., & Polster, B. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079982 · Cited by 45

Regulation of T cell immunity by cellular metabolism

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Mitochondrial Function and Reactive Oxygen/Nitrogen Species in Skeletal Muscle

Chen, M., Li, Y., Deng, S., Zhao, Y., Lian, Z., & Yu, K. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.826981 · Cited by 49

Neuronal Glutamate and GABAA Receptor Function in Health and Disease

Moult, P. R. (2009) · Biochemical Society Transactions · doi:10.1042/bst0371317 · Cited by 43

Co-occurring KRAS mutation/LKB1 loss in non-small cell lung cancer cells results in enhanced metabolic activity susceptible to caloric restriction: an in vitro integrated multilevel approach

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Sex differences in the mitochondrial bioenergetics of astrocytes but not microglia at a physiologically relevant brain oxygen tension

Jaber, S. M., Bordt, E. A., Bhatt, N. M., Lewis, D. M., Gerecht, S., Fiskum, G., & Polster, B. M. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2017.09.003 · Cited by 40

Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCO2, and pO2

DiNuzzo, M., Dienel, G. A., Behar, K. L., Petroff, O. A. C., Benveniste, H., Hyder, F., Giove, F., Michaeli, S., Mangia, S., Herculano‐Houzel, S., et al. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15839 · Cited by 40

Succinate dehydrogenase/complex II activity obligatorily links mitochondrial reserve respiratory capacity to cell survival in cardiac myocytes

Dhingra, R., & Kirshenbaum, L. A. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.310 · Cited by 39

Metabolic reprogramming and apoptosis sensitivity: Defining the contours of a T cell response

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Targeting of chimeric antigen receptor T cell metabolism to improve therapeutic outcomes

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Mitochondrial bioenergetics and neuronal survival modelled in primary neuronal culture and isolated nerve terminals

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Circulation of gut-preactivated naïve CD8 + T cells enhances antitumor immunity in B cell-defective mice

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Comparative analysis of cytosolic and mitochondrial ATP synthesis in embryonic and postnatal hippocampal neuronal cultures

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To Eat or Not to Eat: Neuronal Metabolism, Mitophagy, and Parkinson's Disease

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Cystathionine beta synthase regulates mitochondrial dynamics and function in endothelial cells

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Metabolic Changes in Peripheral Blood Mononuclear Cells Isolated From Patients With End Stage Renal Disease

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Forces, Fluxes, and Fuels: Tracking mitochondrial metabolism by integrating measurements of membrane potential, respiration, and metabolites

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