Ferroptosis: bug or feature?

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691 · see citing works

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673 · see citing works

Immunity, Inflammation, and Cancer

Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755 · see citing works

Regulation of Ferroptotic Cancer Cell Death by GPX4

Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713 · see citing works

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659 · see citing works

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

Oltval, Z. N., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)90509-o · Cited by 6,003 · see citing works

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293 · see citing works

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732 · see citing works

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686 · see citing works

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., El-Deiry, W. S., Golstein, P., Green, D. R., et al. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.150 · Cited by 3,399 · see citing works

Ferroptosis as a p53-mediated activity during tumour suppression

Jiang, L., Kon, N., Li, T., Wang, S.-J., Su, T., Hibshoosh, H., Baer, R., & Gu, W. (2015) · Nature · doi:10.1038/nature14344 · Cited by 3,398 · see citing works

Apoptosis, oncosis, and necrosis. An overview of cell death.

Majno, G., & Joris, I. (1995) · PubMed · Cited by 3,328 · see citing works

Ferroptosis: Death by Lipid Peroxidation

Yang, W. S., & Stockwell, B. R. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.10.014 · Cited by 3,088 · see citing works

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Kagan, V. E., Mao, G., Qu, F., Angeli, J. P. F., Doll, S., Croix, C. S., Dar, H. H., Liu, B., Tyurin, V. A., Ritov, V. B., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2238 · Cited by 3,029 · see citing works

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

Sun, L., Wang, H., Wang, Z., He, S., Chen, S., Liao, D., Wang, L., Yan, J., Liu, W., Lei, X., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.031 · Cited by 2,698 · see citing works

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

Ji, Y. (1993) · Cell · doi:10.1016/0092-8674(93)90485-9 · Cited by 2,497 · see citing works

Autophagy promotes ferroptosis by degradation of ferritin

Hou, W., Xie, Y., Song, X., Sun, X., Lotze, M. T., Zeh, H. J., Kang, R., & Tang, D. (2016) · Autophagy · doi:10.1080/15548627.2016.1187366 · Cited by 2,332 · see citing works

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Yang, W. S., Kim, K. J., Gaschler, M. M., Patel, M., Shchepinov, M. S., & Stockwell, B. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603244113 · Cited by 2,329 · see citing works

Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

Dixon, S. J., Patel, D. N., Welsch, M., Skouta, R., Lee, E. D., Hayano, M., Thomas, A. G., Gleason, C. E., Tatonetti, N. P., Slusher, B. S., et al. (2014) · eLife · doi:10.7554/elife.02523 · Cited by 2,088 · see citing works

Glutaminolysis and transferrin regulate ferroptosis

Gao, M., Monian, P., Quadri, N., Ramasamy, R., & Jiang, X. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.011 · Cited by 2,069 · see citing works

Programmed Cell Death in Animal Development and Disease

Fuchs, Y., & Steller, H. (2011) · Cell · doi:10.1016/j.cell.2011.10.033 · Cited by 1,915 · see citing works

Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.

Yang, W. S., & Stockwell, B. R. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.02.010 · Cited by 1,876 · see citing works

How dying cells alert the immune system to danger

Kono, H., & Rock, K. L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2215 · Cited by 1,737 · see citing works

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

Berghe, T. V., Linkermann, A., Jouan-Lanhouet, S., Walczak, H., & Vandenabeele, P. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3737 · Cited by 1,735 · see citing works

RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels

Yagoda, N., von Rechenberg, M., Zaganjor, E., Bauer, A. J., Yang, W. S., Fridman, D. J., Wolpaw, A. J., Smukste, I., Peltier, J. M., Boniface, J. J., et al. (2007) · Nature · doi:10.1038/nature05859 · Cited by 1,631 · see citing works

Mechanisms of ferroptosis

Cao, J. Y., & Dixon, S. J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2194-1 · Cited by 1,515 · see citing works

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

Seiler, A., Schneider, M., Förster, H., Roth, S., Wirth, E. K., Culmsee, C., Plesnila, N., Kremmer, E., Rådmark, O., Wurst, W., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.005 · Cited by 1,470 · see citing works

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

Dolma, S., Lessnick, S. L., Hahn, W. C., & Stockwell, B. R. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00050-3 · Cited by 1,446 · see citing works

T cell metabolism drives immunity

Buck, M. D., O’Sullivan, D., & Pearce, E. L. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20151159 · Cited by 1,190 · see citing works

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

Skouta, R., Dixon, S. J., Wang, J., Dunn, D. E., Orman, M., Shimada, K., Rosenberg, P. A., Lo, D. C., Weinberg, J. M., Linkermann, A., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja411006a · Cited by 1,146 · see citing works

Synchronized renal tubular cell death involves ferroptosis

Linkermann, A., Skouta, R., Himmerkus, N., Mulay, S. R., Dewitz, C., De Zen, F., Prokai, A., Zuchtriegel, G., Krombach, F., Welz, P.-S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415518111 · Cited by 1,126 · see citing works

Cloning and Expression of a Plasma Membrane Cystine/Glutamate Exchange Transporter Composed of Two Distinct Proteins

Sato, H., Tamba, M., Ishii, T., & Bannai, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11455 · Cited by 1,111 · see citing works

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

Dixon, S. J., Winter, G. E., Musavi, L. S., Lee, E. D., Snijder, B., Rebsamen, M., Superti-Furga, G., & Stockwell, B. R. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00245 · Cited by 1,043 · see citing works

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

Eliasson, M. J. L., Sampei, K., Mandir, A. S., Hurn, P. D., Traystman, R. J., Bao, J., Pieper, A. A., Wang, Z., Dawson, T. M., Snyder, S. H., et al. (1997) · Nature Medicine · doi:10.1038/nm1097-1089 · Cited by 1,019 · see citing works

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

Shimada, K., Skouta, R., Kaplan, A., Yang, W. S., Hayano, M., Dixon, S. J., Brown, L. M., Valenzuela, C. A., Wolpaw, A. J., & Stockwell, B. R. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2079 · Cited by 1,017 · see citing works

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Alnemri, E. S., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.137 · Cited by 1,002 · see citing works

The selenoenzyme phospholipid hydroperoxide glutathione peroxidase

Ursini, F., Maiorino, M., & Gregolin, C. (1985) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(85)90182-5 · Cited by 992 · see citing works

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

Kaufmann, S. H. (1989) · PubMed · Cited by 922 · see citing works

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

Ha, H. C., & Snyder, S. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13978 · Cited by 904 · see citing works

Shrinkage necrosis: A distinct mode of cellular death

Kerr, J. R. (1971) · Journal of Pathology · doi:10.1002/path.1711050103 · Cited by 897 · see citing works

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

Maurer, U., Charvet, C., Wagman, A. S., Dejardin, E., & Green, D. R. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.02.009 · Cited by 881 · see citing works

The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life

Thornalley, P. J. (1990) · Biochemical Journal · doi:10.1042/bj2690001 · Cited by 819 · see citing works

Alarmins: chemotactic activators of immune responses

Oppenheim, J. J., & Yang, D. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.06.002 · Cited by 780 · see citing works

Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses

Ou, Y., Wang, S.-J., Li, D., Chu, B., & Gu, W. J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607152113 · Cited by 775 · see citing works

SYSTEMIC GLUTATHIONE DEFICIENCY IN SYMPTOM-FREE HIV-SEROPOSITIVE INDIVIDUALS

Buhl, R., Holroyd, K. J., Mastrangeli, A., Cantin, A. M., Jaffe, H., Wells, F. B., Saltini, C., & Crystal, R. G. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91909-0 · Cited by 723 · see citing works

To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate

Green, D. R., & Levine, B. (2014) · Cell · doi:10.1016/j.cell.2014.02.049 · Cited by 687 · see citing works

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

Matsushita, M., Freigang, S., Schneider, C., Conrad, M., Bornkamm, G. W., & Kopf, M. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20140857 · Cited by 672 · see citing works

Multiple Functions of BCL-2 Family ProteinsPreprint

Hardwick, J. M., & Soane, L. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008722 · Cited by 670 · see citing works

Metabolic control of cell death

Green, D. R., Galluzzi, L., & Kroemer, G. (2014) · Science · doi:10.1126/science.1250256 · Cited by 661 · see citing works

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

Kim, S. E., Zhang, L., Ma, K., Riegman, M., Chen, F., Ingold, I., Conrad, M., Turker, M. Z., Gao, M., Jiang, X., et al. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.164 · Cited by 622 · see citing works

Alkylating DNA damage stimulates a regulated form of necrotic cell deathPreprint

Zong, W., Ditsworth, D., Bauer, D. E., Wang, Z., & Thompson, C. B. (2004) · Genes & Development · doi:10.1101/gad.1199904 · Cited by 618 · see citing works

Autosis is a Na ⁺ ,K ⁺ -ATPase–regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia–ischemia

Liu, Y., Shoji-Kawata, S., Sumpter, R. M., Wei, Y., Ginet, V., Zhang, L., Posner, B., Tran, K. A., Green, D. R., Xavier, R. J., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319661110 · Cited by 607 · see citing works

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

Ito, Y., Ofengeim, D., Najafov, A., Das, S., Saberi, S., Li, Y., Hitomi, J., Zhu, H., Chen, H., Mayo, L., et al. (2016) · Science · doi:10.1126/science.aaf6803 · Cited by 606 · see citing works

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

Rickard, J. A., O’Donnell, J. A., Evans, J. M., Lalaoui, N., Poh, A. R., Rogers, T., Vince, J. E., Lawlor, K. E., Ninnis, R. L., Anderton, H., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.019 · Cited by 589 · see citing works

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

Lu, M., Lawrence, D. A., Marsters, S. A., Acosta‐Alvear, D., Kimmig, P., Mendez, A. S., Paton, A. W., Paton, J. C., Walter, P., & Ashkenazi, A. (2014) · Science · doi:10.1126/science.1254312 · Cited by 569 · see citing works

Mechanism of Action of Camptothecin

Liu, L. F., Duann, P., Lin, C., D’Arpa, P., & Wu, J. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb26375.x · Cited by 517 · see citing works

Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis

Li, K., Li, Y., Shelton, J. M., Richardson, J. A., Spencer, E., Chen, Z. J., Wang, X., & Williams, R. S. (2000) · Cell · doi:10.1016/s0092-8674(00)80849-1 · Cited by 509 · see citing works

Absolute quantification of matrix metabolites reveals the dynamics of mitochondrial metabolism

Chen, W. W., Freinkman, E., Wang, T., Birsoy, K., & Sabatini, D. M. (2016) · Cell · doi:10.1016/j.cell.2016.07.040 · Cited by 500 · see citing works

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

Chen, L., Hambright, W. S., Na, R., & Ran, Q. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.680090 · Cited by 498 · see citing works

Mechanism of Action of Camptothecin

Liu, L. F., Desai, S. D., Li, T., Mao, Y., Sun, M., & Sim, S.-P. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb07020.x · Cited by 476 · see citing works

Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion

Zhang, J., Fan, J., Venneti, S., Cross, J. R., Takagi, T., Bhinder, B., Djaballah, H., Kanai, M., Cheng, E. H., Judkins, A. R., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.018 · Cited by 439 · see citing works

NAD ⁺ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

Alano, C. C., Garnier, P., Ying, W., Higashi, Y., Kauppinen, T. M., & Swanson, R. A. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5552-09.2010 · Cited by 439 · see citing works

Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors.

Lachaier, E., Louandre, C., Godin, C., Saidak, Z., Baert, M., Diouf, M., Chauffert, B., & Galmiche, A. (2014) · PubMed · Cited by 396 · see citing works

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

Qing, G., Li, B., Vu, A., Skuli, N., Walton, Z. E., Liu, X., Mayes, P. A., Wise, D. R., Thompson, C. B., Maris, J. M., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.09.021 · Cited by 375 · see citing works

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

Kim, D., Fiske, B. P., Birsoy, K., Freinkman, E., Kami, K., Possemato, R. L., Chudnovsky, Y., Pacold, M. E., Chen, W. W., Cantor, J. R., et al. (2015) · Nature · doi:10.1038/nature14363 · Cited by 368 · see citing works

Bortezomib Inhibits PKR-Like Endoplasmic Reticulum (ER) Kinase and Induces Apoptosis via ER Stress in Human Pancreatic Cancer Cells

Nawrocki, S. T., Carew, J. S., Dunner, K., Boise, L., Chiao, P. J., Huang, P., Abbruzzese, J. L., & McConkey, D. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2394 · Cited by 326 · see citing works

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

Carlson, B. A., Tobe, R., Yefremova, E., Tsuji, P. A., Hoffmann, V. J., Schweizer, U., Gladyshev, V. N., Hatfield, D. L., & Conrad, M. (2016) · Redox Biology · doi:10.1016/j.redox.2016.05.003 · Cited by 316 · see citing works

Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities

Kerr, E. M., Gaude, E., Turrell, F. K., Frezza, C., & Martins, C. P. (2016) · Nature · doi:10.1038/nature16967 · Cited by 308 · see citing works

Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis

Andrabi, S. A., Umanah, G. K. E., Chang, C., Stevens, D. A., Karuppagounder, S. S., Gagné, J.-P., Poirier, G. G., Dawson, V. L., & Dawson, T. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405158111 · Cited by 307 · see citing works

RNA Viruses: ROS-Mediated Cell Death

Reshi, L., Su, Y.-C., & Hong, J. (2014) · International Journal of Cell Biology · doi:10.1155/2014/467452 · Cited by 303 · see citing works

Endocannabinoid Oxygenation by Cyclooxygenases, Lipoxygenases, and Cytochromes P450: Cross-Talk between the Eicosanoid and Endocannabinoid Signaling Pathways

Rouzer, C. A., & Marnett, L. J. (2011) · Chemical Reviews · doi:10.1021/cr2002799 · Cited by 301 · see citing works

Cell-Line Selectivity Improves the Predictive Power of Pharmacogenomic Analyses and Helps Identify NADPH as Biomarker for Ferroptosis Sensitivity

Shimada, K., Hayano, M., Pagano, N. C., & Stockwell, B. R. (2016) · Cell chemical biology · doi:10.1016/j.chembiol.2015.11.016 · Cited by 300 · see citing works

Failure of Amino Acid Homeostasis Causes Cell Death following Proteasome Inhibition

Suraweera, A., Münch, C., Hanssum, A., & Bertolotti, A. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.08.003 · Cited by 299 · see citing works

Alternative cell death mechanisms in development and beyondPreprint

Yuan, J., & Kroemer, G. (2010) · Genes & Development · doi:10.1101/gad.1984410 · Cited by 290 · see citing works

Regulated Cell Death: Signaling and Mechanisms

Ashkenazi, A., & Salvesen, G. S. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013226 · Cited by 276 · see citing works

Metabolite damage and its repair or pre-emption

Linster, C. L., SCHAFTINGEN, E. V., & Hanson, A. D. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1141 · Cited by 269 · see citing works

Heat stress induces ferroptosis-like cell death in plants

Distéfano, A. M., Martin, M. V., Córdoba, J. P., Bellido, A. M., D’Ippólito, S., Colman, S. L., Soto, D., Roldán, J. A., Bartoli, C. G., Zabaleta, E. J., et al. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201605110 · Cited by 268 · see citing works

NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling

Biton, S., & Ashkenazi, A. (2011) · Cell · doi:10.1016/j.cell.2011.02.023 · Cited by 262 · see citing works

The transsulfuration pathway: a source of cysteine for glutathione in astrocytes

McBean, G. J. (2011) · Amino Acids · doi:10.1007/s00726-011-0864-8 · Cited by 247 · see citing works

Defective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo

Sheen, J.-H., Zoncu, R., Kim, D., & Sabatini, D. M. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.03.012 · Cited by 241 · see citing works

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

Weïwer, M., Bittker, J. A., Lewis, T. A., Shimada, K., Yang, W. S., MacPherson, L., Dandapani, S., Palmer, M., Stockwell, B. R., Schreiber, S. L., et al. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.09.047 · Cited by 237 · see citing works

Failure of Poly(ADP-Ribose) Polymerase Cleavage by Caspases Leads to Induction of Necrosis and Enhanced Apoptosis

Herceg, Z., & Wang, Z. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.5124 · Cited by 235 · see citing works

Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers

Liu, X., Romero, I. L., Litchfield, L. M., Lengyel, E. R., & Locasale, J. W. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.005 · Cited by 228 · see citing works

Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss

Lee, Y., Karuppagounder, S. S., Shin, J.-H., Lee, Y.-I., Ko, H. S., Swing, D., Jiang, H., Kang, S.-U., Lee, B. D., Kang, H. C., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3500 · Cited by 214 · see citing works

Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cells

Chintala, S., Li, W., Lamoreux, M. L., Ito, S., Wakamatsu, K., Sviderskaya, E. V., Bennett, D. C., Park, Y., Gahl, W. A., Huizing, M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502856102 · Cited by 214 · see citing works

A Perspective on Mammalian Caspases as Positive and Negative Regulators of Inflammation

Martin, S. J., Henry, C. M., & Cullen, S. P. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.04.026 · Cited by 206 · see citing works

Redox Regulation of Caspase-3(-like) Protease Activity: Regulatory Roles of Thioredoxin and Cytochrome c

Ueda, S., Nakamura, H., Masutani, H., et al. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.12.6689 · Cited by 175 · see citing works

Effect of Glutathione Depletion on Antitumor Drug Toxicity (Apoptosis and Necrosis) in U-937 Human Promonocytic Cells

Troyano, A., Fernández, C., Sancho, P., de Blas, E., & Aller, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104516200 · Cited by 163 · see citing works

Molecular Mechanism of Decreased Glutathione Content in Human Immunodeficiency Virus Type 1 Tat-transgenic Mice

Choi, J., Liu, R.-M., Kundu, R. K., Sangiorgi, F. O., Wu, W., Maxson, R. E., & Forman, H. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3693 · Cited by 162 · see citing works

Discrimination between primary necrosis and apoptosis by necrostatin-1 in Annexin V-positive/propidium iodide-negative cells

Sawai, H., & Domae, N. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.06.186 · Cited by 161 · see citing works

The DegraBase: A Database of Proteolysis in Healthy and Apoptotic Human Cells

Crawford, E. D., Seaman, J. E., Agard, N. J., Hsu, G. W., Julien, O., Mahrus, S., Nguyen, H. C. X., Shimbo, K., Yoshihara, H. A. I., Zhuang, M., et al. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.o112.024372 · Cited by 146 · see citing works

Dicarbonyl proteome and genome damage in metabolic and vascular disease

Rabbani, N., & Thornalley, P. J. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140018 · Cited by 140 · see citing works

Effect of antioxidants on cultured human diploid fibroblasts exposed to cystine-free medium

Bannai, S., Tsukeda, H., & Okumura, H. (1977) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(77)90623-4 · Cited by 139 · see citing works

On the discovery of glutathione

Meister, A. (1988) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(88)90148-x · Cited by 137 · see citing works

Correlations between S and G2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells.

Goldwasser, F., Shimizu, T., Jackman, J., Hoki, Y., O'Connor, P. M., Kohn, K. W., & Pommier, Y. G. (1996) · PubMed · Cited by 135 · see citing works

Caspase-independent Mitochondrial Cell Death Results from Loss of Respiration, Not Cytotoxic Protein Release

Lartigue, L., Kushnareva, Y., Seong, Y., Lin, H. H., Faustin, B., & Newmeyer, D. D. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-07-0649 · Cited by 134 · see citing works

Modulatory profiling identifies mechanisms of small molecule-induced cell death

Wolpaw, A. J., Shimada, K., Skouta, R., Welsch, M. E., Akavia, U. D., Pe'er, D., Shaik, F., Bulinski, J. C., & Stockwell, B. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106149108 · Cited by 133 · see citing works

Induction of cystine transport activity in human fibroblasts by oxygen

Bannai, S., Sato, H., Ishii, T., & Sugita, Y. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51491-5 · Cited by 121 · see citing works

Cancerostatic Action of Methylglyoxal

Együud, L. G., & Szent‐Györgyi, A. (1968) · Science · doi:10.1126/science.160.3832.1140 · Cited by 102 · see citing works

ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate

Shin, S., Buel, G. R., Wolgamott, L., Plas, D. R., Asara, J. M., Blenis, J., & Yoon, S.-O. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.020 · Cited by 96 · see citing works

Non‐classical MHC class I molecules on intestinal epithelial cells: mediators of mucosal crosstalk

Shao, L., Kamalu, O., & Mayer, L. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00295.x · Cited by 93 · see citing works

Programmed cell death 50 (and beyond)

Lockshin, R. A. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.126 · Cited by 92 · see citing works

Therapeutic Agents Triggering Nonapoptotic Cancer Cell Death

Kornienko, A., Mathieu, V., Rastogi, S. K., Lefranc, F., & Robert Kiss, A. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400136m · Cited by 90 · see citing works

Effect of Oxygen on Induction of the Cystine Transporter by Bacterial Lipopolysaccharide in Mouse Peritoneal Macrophages

Sato, H., Kuriyama-Matsumura, K., Hashimoto, T., Sasaki, H., Wang, H., Ishii, T., Mann, G. E., & Bannai, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007216200 · Cited by 89 · see citing works

DNA Alkylating Therapy Induces Tumor Regression through an HMGB1-Mediated Activation of Innate Immunity

Guerriero, J. L., Ditsworth, D., Catanzaro, J. M., Sabino, G. J., Furie, M. B., Kew, R. R., Crawford, H. C., & Zong, W. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003267 · Cited by 88 · see citing works

Structure and interaction with phospholipids of a prokaryotic lipoxygenase from Pseudomonas aeruginosa

Garreta, A., Val-Moraes, S. P., García‐Fernández, Q., Busquets, M., Juan, C., Oliver, A., Ortiz, A., Gaffney, B. J., Fita, I., Manresa, Á., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-235952 · Cited by 79 · see citing works

Glutathione Dependence of Caspase-8 Activation at the Death-inducing Signaling Complex

Hentze, H., Schmitz, I., Latta, M. R., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110766200 · Cited by 75 · see citing works

The pantheon of the fallen: why are there so many forms of cell death?

Green, D. R., & Victor, B. C. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.08.008 · Cited by 71 · see citing works

The Environment of the Lipoxygenase Iron Binding Site Explored with Novel Hydroxypyridinone Iron Chelators

Abeysinghe, R. D., Roberts, P. J., Cooper, C. E., MacLean, K. H., Hider, R. C., & Porter, J. B. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.14.7965 · Cited by 70 · see citing works

The topoisomerase inhibitors camptothecin and etoposide induce a CD95-independent apoptosis of activated peripheral lymphocytes

Ferraro‐Peyret, C., Quéméneur, L., Fournel, S., Prigent, A.-F., Révillard, J. P., & Bonnefoy, N. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400595 · Cited by 67 · see citing works

Chemotherapy Induces Tumor Clearance Independent of Apoptosis

Guerriero, J. L., Ditsworth, D., Fan, Y., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2452 · Cited by 57 · see citing works

Glyoxalase I in Tumor Cell Proliferation and Survival and as a Potential Target for Anticancer Therapy

Geng, X., Ma, J., Zhang, F., & Xu, C. (2014) · Oncology Research and Treatment · doi:10.1159/000367800 · Cited by 40 · see citing works

xCT, not just an amino-acid transporter: a multi-functional regulator of microbial infection and associated diseases

Dai, L., Noverr, M. C., Parsons, C. H., Kaleeba, J. A. R., & Qin, Z. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00120 · Cited by 20 · see citing works

Non-apoptotic routes to defeat cancer

Guerriero, J. L., Ditsworth, D., & Zong, W. (2012) · OncoImmunology · doi:10.4161/onci.1.1.17885 · Cited by 9 · see citing works

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works

The multifaceted role of reactive oxygen species in tumorigenesis

Kirtonia, A., Sethi, G., & Garg, M. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03536-5 · Cited by 452 · see citing works

B1 and marginal zone B cells but not follicular B2 cells require Gpx4 to prevent lipid peroxidation and ferroptosis

Muri, J., Thut, H., Bornkamm, G. W., & Kopf, M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.070 · Cited by 198 · see citing works

Iron Pathophysiology in Alzheimer’s Diseases

Wang, T., Xu, S.-F., Fan, Y.-G., Li, L.-B., & Guo, C. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9589-5_5 · Cited by 64 · see citing works

ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ

Атабекова, Б. Б. (2024) · Habaršy. Pedagogika ġylymdary seriâsy · doi:10.51889/2959-5762.2023.80.4.019

Cloning and Characterization of Rat BAT3 cDNA

Ozaki, T., Hanaoka, E., Naka, M., et al. (1999) · DNA and Cell Biology · doi:10.1089/104454999315222 · Cited by 22 · see citing works

EFFECT OF THE NEMATODE PHASMARHABDITIS HERMAPHRODITA ON YOUNG STAGES OF THE PEST SLUG ARION LUSITANICUS

Grimm, B. (2002) · Journal of Molluscan Studies · doi:10.1093/mollus/68.1.25 · Cited by 41 · see citing works

HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53Preprint

Sasaki, T., Gan, E. C., Wakeham, A. C., Kornbluth, S. A., Mak, T. W., & Okada, H. (2007) · Genes & Development · doi:10.1101/gad.1534107 · Cited by 127 · see citing works

Anthoxanthum Mosaic Virus

Catherall, P. L. (1970) · Plant Pathology · doi:10.1111/j.1365-3059.1970.tb00999.x · Cited by 6 · see citing works