Cited by 1,200Genomics, phytochemicals, and oxidative stressNF-κB Signaling PathwaysRedox biology and oxidative stress

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Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

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Wardyn, Joanna D., Ponsford, Amy H., Sanderson, Christopher M.·2015·Biochemical Society Transactions

DOI 10.1042/bst20150014PMC PMC4613495

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Abstract

In most tissues, cells are exposed to frequent changes in levels of oxidative stress and inflammation. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and nuclear factor-κB (NF-κB) are the two key transcription factors that regulate cellular responses to oxidative stress and inflammation respectively. Pharmacological and genetic studies suggest that there is functional cross-talk between these two important pathways. The absence of Nrf2 can exacerbate NF-κB activity leading to increased cytokine production, whereas NF-κB can modulate Nrf2 transcription and activity, having both positive and negative effects on the target gene expression. This review focuses on the potentially complex molecular mechanisms that link the Nrf2 and NF-κB pathways and the importance of designing more effective therapeutic strategies to prevent or treat a broad range of neurological disorders.

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1 retracted

Src Subfamily Kinases Regulate Nuclear Export and Degradation of Transcription Factor Nrf2 to Switch Off Nrf2-mediated Antioxidant Activation of Cytoprotective Gene Expression
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p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
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Background
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“upregulation) of the Keap1/Nrf2/ARE pathway inhibits NF-kB1 activation resulting in increased protection against oxidative stress and inflammation (Sahin et al., 2013; Wardyn et al., 2015; Lee at al., 2017; Huang and Lee, 2018).”
BackgroundInfluential
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“It can be suggested that the differentiation of the metabolic response of keratinocytes to different periods of CBD application may confirm its dependence simultaneously on two transcription factors (Nrf2 and NF-κB) that interact with each other [14,52].”
Background
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“…including NF-κB (nuclear factor kappa-lightchain-enhancer of activated B cells) or AMPK (5’ adenosine monophosphate-activated protein kinase) (Mo et al., 2014; Wardyn et al., 2015; Joo et al., 2016; Sivandzade et al., 2019), and thus Nrf2 acts as an oxidative stress signaling hub (Figure 2).”
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Background
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Background
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Background
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Background
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Background
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Background
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Background
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Background
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Background
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Background
Coriolus Versicolor Downregulates TLR4/NF-κB Signaling Cascade in Dinitrobenzenesulfonic Acid-Treated Mice: A Possible Mechanism for the Anti-Colitis Effect
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Background
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Background
Is Bitterness Only a Taste? The Expanding Area of Health Benefits of Brassica Vegetables and Potential for Bitter Taste Receptors to Support Health Benefits
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“Besides regulating the expression of antioxidative proteins/enzymes, activation of the Nrf2/ARE system also plays an important role in inhibiting the overproduction of proinflammatory cytokines, such as IL-6, TNFα, and Il1β [53], mainly through suppressing the NF-κB pathway [53,54].”
Background
Curcumin Ameliorates Particulate Matter-Induced Pulmonary Injury through Bimodal Regulation of Macrophage Inflammation via NF-κB and Nrf2
Lee, M. K., Kim, H. D., Lee, S. H., & Lee, J. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031858 · Cited by 29
“Since interference exists between these two pathways [46], the inhibition of NF-κB and induction of Nrf2 are considered the best approaches to prevent PM-induced inflammatory diseases.”
Advances in Nrf2 Signaling Pathway by Targeted Nanostructured-Based Drug Delivery Systems
Saha, S., Павловна, С. Н., Karamyan, A. S., Novikova, E., & Chubenko, T. V. (2024) · Biomedicines · doi:10.3390/biomedicines12020403 · Cited by 29
Phenolics and terpenoids with good anti-inflammatory activity from the fruits of Amomum villosum and the anti-inflammatory mechanism of active diterpene
Xu, Y., Sun, D., Xiong, L., Zhang, Z., Li, Y., Li, H., Li, H., & Chen, L. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107190 · Cited by 27
A marine-derived antioxidant astaxanthin as a potential neuroprotective and neurotherapeutic agent: A review of its efficacy on neurodegenerative conditions
Adıgüzel, E., & Ülger, T. G. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176706 · Cited by 28
Anti-neuroinflammatory effect of curcumin on Pam3CSK4-stimulated microglial cells
Jin, M., Park, S. Y., Shen, Q., Lai, Y., Ou, X., Mao, Z., Lin, D., Yu, Y., & Zhang, W. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3217 · Cited by 27
“Additionally, the NF-κ B subunit p65 may exert a negative effect on Nrf2 activity and ARE-linked gene expression (37).”
Sulforaphane Attenuated the Pro-Inflammatory State Induced by Hydrogen Peroxide in SH-SY5Y Cells Through the Nrf2/HO-1 Signaling Pathway
de Oliveira, M. R., Brasil, F. B., & Fürstenau, C. R. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9881-7 · Cited by 27
Systematic review and technological prospection: ethyl ferulate, a phenylpropanoid with antioxidant and neuroprotective actions
Cunha, F. V. M., Coêlho, A. G., Azevedo, P. S. D. S., da Silva, A. A., Oliveira, F. D. A., & Nunes, L. C. C. (2019) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2019.1568410 · Cited by 27
Oxidized LDL Modify the Human Adipocyte Phenotype to an Insulin Resistant, Proinflamatory and Proapoptotic Profile
Santiago‐Fernández, C., Martín‐Reyes, F., Tomé, M., Ocaña-Wilhelmi, L., Rivas-Becerra, J., Tatzber, F., Pursch, E., Tinahones, F. J., García‐Fuentes, E., & Garrido‐Sánchez, L. (2020) · Biomolecules · doi:10.3390/biom10040534 · Cited by 35
“Many biological effects of oxLDL are mediated through different transcription factors, such as NF-kB and Nrf2 [38], being interrelated between them [63].”
Background
AMPK is essential for IL-10 expression and for maintaining balance between inflammatory and cytoprotective signaling
Guragain, D., Gurung, P., Chang, J., Katila, N., Chang, H. W., Jeong, B., Choi, D., & Kim, J. (2020) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129631 · Cited by 27
Bu-Shen-Fang-Chuan formula attenuates cigarette smoke-induced inflammation by modulating the PI3K/Akt-Nrf2 and NF-κB signalling pathways
Li, Q., Wang, G., Xiong, S. H., Cao, Y., Liu, B., Sun, J., Li, L., Mohammadtursun, N., Yu, H., Dong, J., et al. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113095 · Cited by 28
Dysbacteriosis induces abnormal neurogenesis via LPS in a pathway requiring NF-κB/IL-6
Long, D., Liu, M., Li, H., Song, J., Jiang, X., Wang, G., & Yang, X. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105543 · Cited by 27
Reactive Oxygen Species in Acute Lymphoblastic Leukaemia: Reducing Radicals to Refine Responses
Mannan, A., Germon, Z. P., Chamberlain, J., Sillar, J. R., Nixon, B., & Dun, M. D. (2021) · Antioxidants · doi:10.3390/antiox10101616 · Cited by 27
“Indeed, NF-κB transcription factors are responsible for the expression of the ROS producing NADPH oxidase enzymes [179] (discussed in Sections 3, 5.”
Background
Rosmarinic Acid Inhibits Platelet Aggregation and Neointimal Hyperplasia In Vivo and Vascular Smooth Muscle Cell Dedifferentiation, Proliferation, and Migration In Vitro via Activation of the Keap1-Nrf2-ARE Antioxidant System
Chen, C., Ma, J., Xu, Z., Liang, C., Sun, B., Shi, Y., Miao, Y., Wu, T., Qin, M., Zhang, Y., et al. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c01176 · Cited by 27
Overview of Anti-Inflammatory and Anti-Nociceptive Effects of Polyphenols to Halt Osteoarthritis: From Preclinical Studies to New Clinical Insights
Gambari, L., Cellamare, A., Grassi, F., Grigolo, B., Panciera, A., Ruffilli, A., Faldini, C., & Desando, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415861 · Cited by 27
“In particular, it has been reported that Nrf2 and HO-1 could alleviate inflammation through the inhibition of p65 translocation, thus inhibiting NFKB pathways [27,119,120].”
The melatonin receptor agonist agomelatine protects against acute pancreatitis induced by cadmium by attenuating inflammation and oxidative stress and modulating Nrf2/HO-1 pathway
Alruhaimi, R. S., Hassanein, E. H. M., El‐Aziz, M. K. A., Abduh, M. S., Bin‐Ammar, A., Kamel, E. M., & Mahmoud, A. M. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110833 · Cited by 27
Combination of Hypertension Along with a High Fat and Cholesterol Diet Induces Severe Hepatic Inflammation in Rats via a Signaling Network Comprising NF-κB, MAPK, and Nrf2 Pathways
Yuan, Y., Naito, H., Jia, X., Kitamori, K., & Nakajima, T. (2017) · Nutrients · doi:10.3390/nu9091018 · Cited by 26
“In addition, the Nrf2 and NF-κB pathways are considered to inhibit each other [43,44].”
Background
Heme-Oxygenase-1 Expression Contributes to the Immunoregulation Induced by Fasciola hepatica and Promotes Infection
Carasi, P., Rodríguez, E., da Costa, V., Frigerio, S., Brossard, N., Noya, V., Robello, C., Anegón, I., & Freire, T. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00883 · Cited by 27
“Interestingly, HO-1 gene expression is regulated at the transcriptional level, by several transcriptional factors including activator protein-1 (49, 50), nuclear factor erythroid 2-related factor-2 (NRF2), nuclear factor-kappa B (50, 51), among others.”
Background
Changes of KEAP1/NRF2 and IKB/NF‐κB Expression Levels Induced by Cell‐Free DNA in Different Cell Types
Kostyuk, S. V., Porokhovnik, L. N., Ershova, E. S., Malinovskaya, E. M., Konkova, M. S., Kameneva, L. V., Dolgikh, O. А., Вейко, В. П., Писарев, В. М., Martynov, A. V., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1052413 · Cited by 27
Evaluation of the health impacts and deregulation of signaling pathways in humans induced by microplastics
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Role of Nrf2 in preventing oxidative stress induced chloride current alteration in human lung cells
Canella, R., Benedusi, M., Martini, M., Cervellati, F., Cavicchio, C., & Valacchi, G. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26416 · Cited by 26
Activation of Nrf2 attenuates delayed gastric emptying in obesity induced diabetic (T2DM) female mice
Sampath, C., Sprouse, J. C., Freeman, M. L., & Gangula, P. R. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.02.029 · Cited by 26
“Thus GSK-3β is also known to degrade Nrf2 in the nucleus via the β-TrCPGSK3β axis [44].”
Metformin sensitizes endometrial cancer cells to progestin by targeting TET1 to downregulate glyoxalase I expression
Jiang, Y., Chen, X., Wei, Y., Feng, Y., Zheng, W., & Zhang, Z. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108712 · Cited by 26
Sinapic acid ameliorates D-galactosamine/lipopolysaccharide-induced fulminant hepatitis in rats: Role of nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways
Ansari, M. A., Raish, M., Jardan, Y. A. B., Ahmad, A., Shahid, M., Ahmad, S. F., Haq, N., Khan, M. R., & Bakheet, S. A. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i7.592 · Cited by 26
Anti-Apoptotic and Anti-Inflammatory Role of Trans ε-Viniferin in a Neuron–Glia Co-Culture Cellular Model of Parkinson’s Disease
Sergi, D., Gélinas, A., Beaulieu, J., Renaud, J., Tardif-Pellerin, E., Guillard, J., & Martinoli, M. (2021) · Foods · doi:10.3390/foods10030586 · Cited by 26
“Particularly, in microglial cells, the activation of nrf2 by resveratrol may be responsible for the inhibition of NFκB via a cross-talk between these transcription factors [54], leading to the consequent downregulation of the inflammatory response elicited by LPS.”
Background
Transcription Factors Interplay Orchestrates the Immune-Metabolic Response of Leishmania Infected Macrophages
Bichiou, H., Bouabid, C., Rabhi, I., & Guizani-Tabbane, L. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.660415 · Cited by 29
“Indeed, NFkB can directly regulate the induction of Nrf2 transcription, but can also by interacting with Keap1 suppress the Nrf2-ARE pathway, resulting in the repression of various genes (Wardyn et al., 2015; Bellezza et al., 2018).”
Background
Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages
Wall, S. B., Li, R., Butler, B., Burg, A. R., Tse, H. M., Larson‐Casey, J. L., Carter, A. B., Wright, C. J., Rogers, L. K., & Tipple, T. E. (2021) · Antioxidants · doi:10.3390/antiox10050632 · Cited by 26
“Cross-talk between NRF2 and NFkB pathways has been extensively characterized (reviewed in [29]).”
Background
18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2
Chen, B., Zhu, D., Xie, C., Shi, Y., Ni, L., Zhang, H., Li, S., Lu, J., Xiao, J., Xia, W., et al. (2021) · Food & Function · doi:10.1039/d1fo01379c · Cited by 26
Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades
Herrera‐Arozamena, C., Estrada, M., López‐Caballero, P., Pérez, C., Morales-Garcia, J. A., Pérez‐Castillo, A., del Sastre, E., Fernández‐Mendívil, C., Duarte, P., Michalska, P., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01883 · Cited by 24
New Lanostane-Type Triterpenes with Anti-Inflammatory Activity from the Epidermis of Wolfiporia cocos
Bao, T., Long, G.-Q., Wang, Y., Wang, Q., Liu, X.-L., Hu, G., Gao, X., Wang, A., & Jia, J. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c00823 · Cited by 26
Guhong Injection Prevents Ischemic Stroke-Induced Neuro-Inflammation and Neuron Loss Through Regulation of C5ar1
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“Notably, ginaton treatment decreased IL-1β, TNF, IL6, MMP9, and MCP-1, but did not affect the ICAM-1 level in the rats with ischemic injury.”
BackgroundInfluential
Sanguinarine protects against indomethacin-induced small intestine injury in rats by regulating the Nrf2/NF-κB pathways
Lin, X.-L., Shi, Y., Cao, Y., Tan, X., Zeng, Y., Luo, S.-T., Li, Y., Li, Q., Xia, B., Fu, R.-G., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.960140 · Cited by 26
“Many studies showed the disorders of Nrf2 and NF-κB signaling pathways in IBD patients or NSAIDs-induced gastrointestinal damage, and Nrf2 activation was involved in the protective effect on indomethacin-induced damage of IEC-6 cells (Harada et al., 2015; Wardyn et al., 2015; Sivandzade et al., 2019).”
Background
NRF2 , a crucial modulator of skin cells protection against vitiligo, psoriasis, and cancer
Panieri, E., Telkoparan‐Akillilar, P., & Saso, L. (2022) · BioFactors · doi:10.1002/biof.1912 · Cited by 27
“44–46 Studies have identified a functional interrelation between NRF2 expression and inflammation, reinforcing the notion that NRF2 and nuclear factor-κB (NF-kB) cooperate to modulate both cellular stress response and cell homeostasis.(47) Of note, NRF2 and NF-kB can reciprocally regulate each other towards upregulati…”
Background
Effect of Sinapic Acid on Scopolamine-Induced Learning and Memory Impairment in SD Rats
Lee, I.-S., Choi, G.-Y., Sreelatha, I., Yoon, J., Youn, S.-H., Maeng, S., & Park, J. H. (2023) · Brain Sciences · doi:10.3390/brainsci13030427 · Cited by 26
“The absence of NRF2 can exacerbate NF-KB activity and increase cytokine production, whereas NF-KB can regulate NRF2 transcription and activity, affecting target gene expression [37].”
Background
Aging, NRF2, and TAU: A Perfect Match for Neurodegeneration?
Brackhan, M., Arribas-Blázquez, M., & Lastres‐Becker, I. (2023) · Antioxidants · doi:10.3390/antiox12081564 · Cited by 28
Protective effect of arbutin against cyclophosphamide-induced oxidative stress, inflammation, and hepatotoxicity via Nrf2/HO-1 pathway in rats
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“Besides counteracting ROS by activating antioxidants, Nrf2 and HO-1 suppress inflammation by diminishing NF-κB via direct and indirect mechanisms (Wardyn et al. 2015).”
Background
SPHK1 enhances olaparib resistance in ovarian cancer through the NFκB/NRF2/ferroptosis pathway
Teng, K., Ma, H., Gai, P., Zhao, X., & Qi, G. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02309-y · Cited by 27
α-Lipoic Acid Potentiates the Anti-Inflammatory Activity of Avocado/Soybean Unsaponifiables in Chondrocyte Cultures
Frondoza, C. G., Fortuno, L. V., Grzanna, M. W., Ownby, S. L., Au, A. Y., & Rashmir‐Raven, A. M. (2017) · Cartilage · doi:10.1177/1947603516686146 · Cited by 25
The anti‐inflammatory effect of 10‐oxo‐ trans ‐11‐octadecenoic acid (KetoC) on RAW 264.7 cells stimulated with Porphyromonas gingivalis lipopolysaccharide
Sulijaya, B., Takahashi, N., Yamada, M., Yokoji, M., Sato, K., Aoki‐Nonaka, Y., Nakajima, T. E., Kishino, S., Ogawa, J., & Yamazaki, K. (2018) · Journal of Periodontal Research · doi:10.1111/jre.12564 · Cited by 25
Andalucin from Artemisia lannta suppresses the neuroinflammation via the promotion of Nrf2-mediated HO-1 levels by blocking the p65–p300 interaction in LPS-activated BV2 microglia
Wang, X., Gai, Y., Li, B., & Huang, L. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.06.014 · Cited by 25
NRF2 Is One of the Players Involved in Bone Marrow Mediated Drug Resistance in Multiple Myeloma
Yen, C., & Hsiao, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113503 · Cited by 25
“Depletion of NRF2 enhances NF-κB activity and subsequently increases the production of inflammatory cytokines, which suggests an anti-inflammatory role of NRF2 [53].”
Background
Dietary Phytochemicals as Neurotherapeutics for Autism Spectrum Disorder: Plausible Mechanism and Evidence
Bhandari, R., Paliwal, J. K., & Kuhad, A. (2020) · Advances in neurobiology · doi:10.1007/978-3-030-30402-7_23 · Cited by 26
Oxidative stress and redox signaling in CRPC progression: therapeutic potential of clinically-tested Nrf2-activators
Mondal, D., Narwani, D., Notta, S., Ghaffar, D., Mardhekar, N. M., & Quadri, S. S. A. (2020) · Cancer Drug Resistance · doi:10.20517/cdr.2020.71 · Cited by 25
“The transcription factor Nrf-2 is known to be a potent inhibitor of NF-κB signaling, as evidenced with numerous phytochemicals and pharmaceuticals that have shown anticancer effects([22,182-184]).”
Background
Salidroside inhibits insulin resistance and hepatic steatosis by downregulating miR-21 and subsequent activation of AMPK and upregulation of PPARα in the liver and muscles of high fat diet-fed rats
Almohawes, Z. N., El-kott, A. F., Morsy, K., Shati, A. A., El-Kenawy, A. E.-M., Khalifa, H. S., Elsaid, F. G., Abd-Lateif, A.-E.-K. M., Abu-zaiton, A. S., Ebealy, E. R., et al. (2022) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2021.2024578 · Cited by 24
“Besides, SAL did not affect the structure of the hepatocytes and produced similar hepatic protective effects in control rats too, indicating potent hypoglycaemic, anti-adipogenic, anti-hyperlipidemic, and hepatoprotective effects mediated by improving glucose and insulin homeostasis, activating Nrf2, upregulating anti…”
BackgroundInfluential
Regulation of the immune response to contact sensitizers by Nrf2
Vallion, R., & Kerdine‐Römer, S. (2022) · Contact Dermatitis · doi:10.1111/cod.14073 · Cited by 25
“ARE interactions.49 The classical Nrf2-regulated gene, HO-1, participates in the inhibition of NF-κB.50 Its immunomodulatory function is very well established, it directly inhibits proinflammatory cytokines and acti- vates anti-inflammatory cytokines, thus balancing the inflammatory process51 (Figure 2).”
Background
Targeting NRF2 in Type 2 diabetes mellitus and depression: Efficacy of natural and synthetic compounds
Subba, R., Ahmad, M. H., Ghosh, B., & Mondal, A. C. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174993 · Cited by 26
The Protective Effect of α-Lipoic Acid against Gold Nanoparticles (AuNPs)-Mediated Liver Damage Is Associated with Upregulating Nrf2 and Suppressing NF-κB
Alshammari, G. M., Abdelhalim, M. A. K., Al-Ayed, M. S., Al‐Harbi, L. N., & Yahya, M. A. (2022) · Nutrients · doi:10.3390/nu14163327 · Cited by 25
“In addition, other studies have shown that the N-terminal area of the NF-κB p65 subunit is associated with an increased cytosolic keap-1 expression, leading to an increase in the degradation of Nrf2 in the cytoplasm and hence reduced nuclear levels [19,73].”
Background
CircFNDC3B regulates osteoarthritis and oxidative stress by targeting miR-525-5p/HO-1 axis
Chen, Z., Huang, Y., Chen, Y., Yang, X., Zhu, J., Xu, G., Shen, S., Hu, Z., Shi, P., Ma, Y., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-04569-9 · Cited by 25
“In addition, increases in HO-1 activity lead to the inhibition of the NF-κ B pathway 37 .”

Authors: Wardyn, J. D., Ponsford, A. H., & Sanderson, C. M.
Affiliations: University of Liverpool (GB)
Corresponding author: Sanderson, Christopher M.
ORCID: Ponsford, Amy H.
Sanderson, Christopher M.
Venue: Biochemical Society Transactions
Publisher: Portland Press Ltd.
Published: 2015-08-01
Volume: 43
Issue: 4
Pages: 621-626
ISSN: 0300-5127 (ISSN-L)
1470-8752
DOI: 10.1042/bst20150014
PMC: PMC4613495
OpenAlex: W2133584350
Cited by: 1,200
References: 53
Citations by year: 2026: 139 · 2025: 131 · 2024: 117 · 2023: 145 · 2022: 165 · 2021: 154 · 2020: 124 · 2019: 95 · 2018: 68 · 2017: 44 · 2016: 15 · 2015: 1
FWCI: 4.09
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biochemical Society Transactions (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (096564/Z/11/Z)
Directorate for Biological Sciences
Biotechnology and Biological Sciences Research Council (1222890, BB/J014516/1)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: Nrf2, NF-κB, oxidative stress, inflammation, cytokine production, neurological disorders, treatment options
MeSH terms: Animals, Gene Expression Regulation, Humans, Nervous System Diseases, Signal Transduction, Cytokines, NF-kappa B, Oxidative Stress, NF-E2-Related Factor 2

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Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

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