Cited by 1,200Genomics, phytochemicals, and oxidative stressNF-κB Signaling PathwaysRedox biology and oxidative stress

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Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

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Wardyn, Joanna D., Ponsford, Amy H., Sanderson, Christopher M.·2015·Biochemical Society Transactions

DOI 10.1042/bst20150014PMC PMC4613495

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Abstract

In most tissues, cells are exposed to frequent changes in levels of oxidative stress and inflammation. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and nuclear factor-κB (NF-κB) are the two key transcription factors that regulate cellular responses to oxidative stress and inflammation respectively. Pharmacological and genetic studies suggest that there is functional cross-talk between these two important pathways. The absence of Nrf2 can exacerbate NF-κB activity leading to increased cytokine production, whereas NF-κB can modulate Nrf2 transcription and activity, having both positive and negative effects on the target gene expression. This review focuses on the potentially complex molecular mechanisms that link the Nrf2 and NF-κB pathways and the importance of designing more effective therapeutic strategies to prevent or treat a broad range of neurological disorders.

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1 retracted

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Background
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Authors: Wardyn, J. D., Ponsford, A. H., & Sanderson, C. M.
Affiliations: University of Liverpool (GB)
Corresponding author: Sanderson, Christopher M.
ORCID: Ponsford, Amy H.
Sanderson, Christopher M.
Venue: Biochemical Society Transactions
Publisher: Portland Press Ltd.
Published: 2015-08-01
Volume: 43
Issue: 4
Pages: 621-626
ISSN: 0300-5127 (ISSN-L)
1470-8752
DOI: 10.1042/bst20150014
PMC: PMC4613495
OpenAlex: W2133584350
Cited by: 1,200
References: 53
Citations by year: 2026: 139 · 2025: 131 · 2024: 117 · 2023: 145 · 2022: 165 · 2021: 154 · 2020: 124 · 2019: 95 · 2018: 68 · 2017: 44 · 2016: 15 · 2015: 1
FWCI: 4.09
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biochemical Society Transactions (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (096564/Z/11/Z)
Directorate for Biological Sciences
Biotechnology and Biological Sciences Research Council (1222890, BB/J014516/1)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: Nrf2, NF-κB, oxidative stress, inflammation, cytokine production, neurological disorders, treatment options
MeSH terms: Animals, Gene Expression Regulation, Humans, Nervous System Diseases, Signal Transduction, Cytokines, NF-kappa B, Oxidative Stress, NF-E2-Related Factor 2

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Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

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