Cellular aging of skeletal muscle: telomeric and free radical evidence that physical inactivity is responsible and not age
Open accessAbstract
Telomeres play an essential role in maintaining chromosomal integrity in the face of physiological stressors. Although the age-related shortening of TL (telomere length) in highly proliferative tissue is predominantly due to the replication process, the mechanism for telomere shortening in skeletal muscle, which is minimally proliferative, is unclear. By studying TL in both the upper and lower limbs of the young, old-mobile and old-immobile subjects and by virtue of the bipedal nature of human locomotion, which declines with age, it may be possible to elucidate the mechanism(s) responsible for cellular aging of skeletal muscle. With this approach, we revealed that TL (~15 kb) in arm skeletal muscle is unaffected by age. In contrast TL fell progressively in the legs across the young (~15 kb), the old mobile (~13 kb) and old immobile (~11 kb) subjects. Interestingly, there was a reciprocal increase in leg muscle free radicals across these groups that was correlated with TL (r=0.7), with no such relationship in the arm (r=0.09). Our results document that chronological age does not affect the cellular aging of skeletal muscle, but reveals that physical inactivity, probably mediated by free radicals, has a profound effect upon this process.
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Skeletal muscle from older adults exhibits several initiators of the senescence program, including high levels of ROS and telomere damage.
“Skeletal muscle from older adults exhibits several initiators of the senescence program, including high levels of ROS and telomere damage”
From Skeletal muscle aging, cellular senescence, and senotherapeutics: current knowledge and future directions (2021) · cites this paper as Venturelli et al., 2014
Telomere length shortens progressively in human skeletal muscle with advancing age and is concomitant with increased free radical production.
“Telomere length shortens progressively in human skeletal muscle with advancing age and is concomitant with increased free radical production”
From Skeletal muscle aging, cellular senescence, and senotherapeutics: current knowledge and future directions (2021) · cites this paper as Venturelli et al., 2014
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- Authors
- Venturelli, M., Morgan, G. R., Donato, A. J., Reese, V., Bottura, R., Tarperi, C., Milanese, C., Schena, F., Reggiani, C., Naro, F., Cawthon, R. M., & Richardson, R. S.
- Affiliations
- University of Verona (IT)
- University of Utah (US)
- Fondazione Mons Arrigo Mazzali (IT)
- University of Padua (IT)
- Sapienza University of Rome (IT)
- Corresponding author
- Venturelli, Massimo
- Reese, Van
- Naro, Fabio
- ORCID
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 2014-06-04
- Volume
- 127
- Issue
- 6
- Pages
- 415-421
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- PMC
- PMC4757470
- OpenAlex
- W2003125782
- Cited by
- 50
- References
- 27
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 6 · 2015: 3
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- National Institute on Aging (K01AG029337, K02AG045339, L30 AG026885, R01AG040297)
- National Heart, Lung, and Blood Institute (P01 HL, 09830)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- skeletal muscle aging, telomere length, physical inactivity, free radicals, oxidative stress, limb asymmetry, chronological age
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Female, Free Radicals, Humans, Male, Telomere, Cellular Senescence, Muscle, Skeletal, Telomerase, Young Adult
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