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The genetic basis of disease

Jackson, Maria, Marks, Leah, May, Gerhard H.W., Wilson, Joanna B.·2018·Essays in Biochemistry
DOI 10.1042/ebc20170053PMC PMC6279436
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Abstract

Genetics plays a role, to a greater or lesser extent, in all diseases. Variations in our DNA and differences in how that DNA functions (alone or in combinations), alongside the environment (which encompasses lifestyle), contribute to disease processes. This review explores the genetic basis of human disease, including single gene disorders, chromosomal imbalances, epigenetics, cancer and complex disorders, and considers how our understanding and technological advances can be applied to provision of appropriate diagnosis, management and therapy for patients.

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Metadata

Authors
Jackson, M., Marks, L., May, G. H. W., & Wilson, J. B.
Affiliations
  • School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K.
  • School of Life Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K.
ORCID
May, Gerhard H.W.
Venue
Essays in Biochemistry
Publisher
Portland Press Ltd.
Published
2018-12-03
Volume
62
Issue
5
Pages
643-723
ISSN
  • 0071-1365
  • 1744-1358
DOI
10.1042/ebc20170053
PMC
PMC6279436
Cited by
295
References
6
Language
en
Update notices
correction (2020-07-28)
Licence
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 234 d)

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