Making sense of epigenetics

Translating the Histone Code

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Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

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The language of covalent histone modifications

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Epigenetic programming by maternal behavior

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Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010

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Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,759 · see citing works

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

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Epigenetic Reprogramming in Mammalian Development

Reik, W., Dean, W., & Walter, J. (2001) · Science · doi:10.1126/science.1063443 · Cited by 3,078 · see citing works

Synaptic Plasticity and Memory: An Evaluation of the Hypothesis

Martin, S. J., Grimwood, P. D., & Morris, R. G. M. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.649 · Cited by 2,794 · see citing works

EUKARYOTIC CYTOSINE METHYLTRANSFERASES

Goll, M. G., & Bestor, T. H. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.010904.153721 · Cited by 2,066 · see citing works

Cytosine methylation and the ecology of intragenomic parasites

Yoder, J. A., Walsh, C. P., & Bestor, T. H. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)01181-5 · Cited by 1,941 · see citing works

Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions

Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., Pace, T. W. W., Mercer, K. B., Mayberg, H. S., Bradley, B., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3275 · Cited by 1,447 · see citing works

Parental olfactory experience influences behavior and neural structure in subsequent generations

Dias, B. G., & Ressler, K. J. (2014) · Nature Neuroscience · doi:10.1038/nn.3594 · Cited by 1,338 · see citing works

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

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Epigenetics: Regulation Through Repression

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Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

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Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

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The genetics of addictions: uncovering the genes

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Chromatin Acetylation, Memory, and LTP Are Impaired in CBP+/− Mice

Alarcón, J. M., Malleret, G., Touzani, K., Vronskaya, S., Ishii, S., Kandel, E. R., & Barco, A. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.021 · Cited by 892 · see citing works

Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation

Vecsey, C. G., Hawk, J. D., Lattal, K. M., Stein, J. M., Fabian, S., Attner, M. A., Cabrera, S. M., McDonough, C. B., Brindle, P. K., Abel, T. G., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0296-07.2007 · Cited by 828 · see citing works

Mutagenic deamination of cytosine residues in DNA

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Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation

Yehuda, R., Daskalakis, N. P., Bierer, L. M., Bader, H. N., Klengel, T., Holsboer, F., & Binder, E. B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.005 · Cited by 782 · see citing works

Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain

Gibbs, J. R., van der Brug, M. P., Hernandez, D. G., Traynor, B. J., Nalls, M. A., Lai, S.-L., Arepalli, S., Dillman, A., Rafferty, I. P., Troncoso, J., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000952 · Cited by 769 · see citing works

Role of paternal and maternal genomes in mouse development

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Epigenetics: A Historical Overview

Holliday, R. (2006) · Epigenetics · doi:10.4161/epi.1.2.2762 · Cited by 712 · see citing works

Untitled work

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Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity

Maze, I., Covington, H. E., Dietz, D. M., LaPlant, Q., Renthal, W., Russo, S. J., Mechanic, M., Mouzon, E., Neve, R. L., Haggarty, S. J., et al. (2010) · Science · doi:10.1126/science.1179438 · Cited by 665 · see citing works

Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood

Davies, M. N., Volta, M., Pidsley, R., Lunnon, K., Dixit, A., Lovestone, S., Coarfa, C., Harris, R. A., Milosavljevic, A., Troakes, C., et al. (2012) · Genome Biology · doi:10.1186/gb-2012-13-6-r43 · Cited by 630 · see citing works

Genes, Genetics, and Epigenetics: A Correspondence

Wu, C.-T., & Morris, J. R. (2001) · Science · doi:10.1126/science.293.5532.1103 · Cited by 577 · see citing works

SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

Michan, S., Li, Y., Chou, M. M.-H., Parrella, E., Ge, H., Long, J. M., Allard, J. S., Lewis, K., Miller, M., Xu, W., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0027-10.2010 · Cited by 541 · see citing works

HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation

McQuown, S. C., Barrett, R. M., Matheos, D. P., Post, R. J., Rogge, G. A., Alenghat, T., Mullican, S. E., Jones, S., Rusche, J. R., Lazar, M. A., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5052-10.2011 · Cited by 507 · see citing works

Epigenetic and transgenerational reprogramming of brain development

Bale, T. L. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3818 · Cited by 505 · see citing works

Mapping the Epigenetic Basis of Complex Traits

Cortijo, S., Wardenaar, R., Colomé‐Tatché, M., Gilly, A., Etcheverry, M., Labadie, K., Caillieux, E., Aury, J., Wincker, P., Roudier, F., et al. (2014) · Science · doi:10.1126/science.1248127 · Cited by 488 · see citing works

Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder

Dempster, E. L., Pidsley, R., Schalkwyk, L. C., Owens, S., Georgiades, A., Kane, F., Kalidindi, S., Picchioni, M., Kravariti, E., Toulopoulou, T., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr416 · Cited by 460 · see citing works

MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212

Im, H., Hollander, J. A., Bali, P., & Kenny, P. J. (2010) · Nature Neuroscience · doi:10.1038/nn.2615 · Cited by 435 · see citing works

Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction

Rudenko, A., Dawlaty, M. M., Seo, J., Cheng, A. W., Meng, J., Le, T. T., Faull, K. F., Jaenisch, R., & Tsai, L. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.003 · Cited by 435 · see citing works

Phosphorylation of histone H3 at serine 10 is correlated with chromosome condensation during mitosis and meiosis in Tetrahymena

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DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity

Miller, C. A., Campbell, S. L., & Sweatt, J. D. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.07.016 · Cited by 417 · see citing works

HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner

Malvaez, M., McQuown, S. C., Rogge, G. A., Astarabadi, M., Jacques, V., Carreiro, S. T., Rusche, J. R., & Wood, M. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213364110 · Cited by 400 · see citing works

Epigenetic mechanisms in drug addiction

Renthal, W. R., & Nestler, E. J. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.06.004 · Cited by 383 · see citing works

Epigenetic basis of mental illness

Nestler, E. J., Peña, C. J., Kundakovic, M., Mitchell, A., & Akbarian, S. (2016) · The Neuroscientist · doi:10.1177/1073858415608147 · Cited by 342 · see citing works

Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci

Hannon, E. J., Spiers, H., Viana, J. F., Pidsley, R., Burrage, J., Murphy, T. M., Troakes, C., Turecki, G., O’Donovan, M. C., Schalkwyk, L. C., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4182 · Cited by 336 · see citing works

The role of DNA methylation in stress-related psychiatric disorders

Klengel, T., Pape, J., Binder, E. B., & Mehta, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.013 · Cited by 309 · see citing works

Genome-wide DNA methylation analysis of human brain tissue from schizophrenia patients

Wockner, L. F., Noble, E. P., Lawford, B. R., Young, R. M., Morris, C. P., Whitehall, V., & Voisey, J. (2014) · Translational Psychiatry · doi:10.1038/tp.2013.111 · Cited by 306 · see citing works

From Epigenesis to Epigenetics

Speybroeck, L. V. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04912.x · Cited by 260 · see citing works

G9a/GLP Histone Lysine Dimethyltransferase Complex Activity in the Hippocampus and the Entorhinal Cortex Is Required for Gene Activation and Silencing during Memory Consolidation

Gupta, S., Franklin, A. V., DeRamus, T. P., Wheelock, M. D., Davis, R. L., McMahon, L. L., & Lubin, F. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0147-12.2012 · Cited by 224 · see citing works

From epigenesis to epigenetics: the case of C. H. Waddington.

Speybroeck, L. V. (2002) · PubMed · Cited by 208 · see citing works

The Mendelian disorders of the epigenetic machineryPreprint

Bjornsson, H. T. (2015) · Genome Research · doi:10.1101/gr.190629.115 · Cited by 192 · see citing works

Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins

Kuratomi, G., Iwamoto, K., Bundo, M., Kusumi, I., Kato, N., Iwata, N., Ozaki, N., & Kato, T. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002001 · Cited by 188 · see citing works

MAOA gene hypomethylation in panic disorder-reversibility of an epigenetic risk pattern by psychotherapy

Ziegler, C., Richter, J., Mahr, M., Gajewska, A., Schiele, M. A., Gehrmann, A., Schmidt, B., Lesch, K.-P., Lang, T., Helbig-Lang, S., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.41 · Cited by 183 · see citing works

Serotonin transporter gene hypomethylation predicts impaired antidepressant treatment response

Domschke, K., Tidow, N., Schwarte, K., Deckert, J., Lesch, K., Arolt, V., Zwanzger, P., & Baune, B. T. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571400039x · Cited by 179 · see citing works

Preconceptional fasting of fathers alters serum glucose in offspring of mice

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DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder

Nohesara, S., Ghadirivasfi, M., Mostafavi, S., Eskandari, M.-R., Ahmadkhaniha, H., Thiagalingam, S., & Abdolmaleky, H. M. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.06.013 · Cited by 168 · see citing works

Loss of Histone Deacetylase 2 Improves Working Memory and Accelerates Extinction Learning

Morris, M. J., Mahgoub, M., Na, E. S., Pranav, H., & Monteggia, L. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1001-12.2013 · Cited by 162 · see citing works

RNA epigenetics — chemical messages for posttranscriptional gene regulation

Roundtree, I. A., & He, C. (2015) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2015.10.024 · Cited by 161 · see citing works

Histone-Methyltransferase MLL2 (KMT2B) Is Required for Memory Formation in Mice

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DNA Modifications: Function and Applications in Normal and Disease States

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Annotation Molecular genetics of methylenetetrahydrofolate reductase deficiency

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Directed Genetic Change Model for X Chromosome Inactivation in Eutherian Mammals

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Nucleic acid modifications with epigenetic significance

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Smoking Induces Long-Lasting Effects through a Monoamine-Oxidase Epigenetic Regulation

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Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome

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Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics

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Genome-wide Methylomic Analysis of Monozygotic Twins Discordant for Adolescent Depression

Dempster, E. L., Wong, C. C. Y., Lester, K. J., Burrage, J., Gregory, A. M., Mill, J. S., & Eley, T. C. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.04.013 · Cited by 132 · see citing works

The epigenetics of birds

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Evidence that the methylation state of the monoamine oxidase A (<i><i>MAOA</i></i>) gene predicts brain activity of MAO A enzyme in healthy men

Shumay, E., Logan, J., Volkow, N. D., & Fowler, J. S. (2012) · Epigenetics · doi:10.4161/epi.21976 · Cited by 120 · see citing works

Serotonin tranporter methylation and response to cognitive behaviour therapy in children with anxiety disorders

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Molecular activity underlying working memoryPreprint

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Epigenetic landscape of amphetamine and methamphetamine addiction in rodents

Godino, A., Jayanthi, S., & Cadet, J. (2015) · Epigenetics · doi:10.1080/15592294.2015.1055441 · Cited by 107 · see citing works

Epigenetic Mechanisms Underlying the Role of Brain-Derived Neurotrophic Factor in Depression and Response to Antidepressants

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Hypermethylation in the ZBTB20 gene is associated with major depressive disorder

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MeCP2 modulates gene expression pathways in astrocytes

Yasui, D. H., Xu, H., Dunaway, K. W., LaSalle, J. M., Jin, L.-W., & Maezawa, I. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-3 · Cited by 90 · see citing works

Methamphetamine-Associated Memory Is Regulated by a Writer and an Eraser of Permissive Histone Methylation

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Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours

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Current and Future Prospects for Epigenetic Biomarkers of Substance Use Disorders

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DNA Methylation in Eukaryotic Cells

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Integrating Early Life Experience, Gene Expression, Brain Development, and Emergent Phenotypes

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Long-term genomic and epigenomic dysregulation as a consequence of prenatal alcohol exposure: a model for fetal alcohol spectrum disorders

Kleiber, M. L., Chater‐Diehl, E., Laufer, B. I., Mantha, K., Chokroborty-Hoque, A., Alberry, B., & Singh, S. M. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00161 · Cited by 73 · see citing works

A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome

Xu, X., Kozikowski, A. P., & Pozzo‐Miller, L. D. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00068 · Cited by 62 · see citing works

Mechanisms of epigenetic memory and addiction

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DNA methylation differences in monozygotic twin pairs discordant for schizophrenia identifies psychosis related genes and networks

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Histone deacetylase inhibition decreases preference without affecting aversion for nicotine

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The influence of metabolic syndrome, physical activity and genotype on catechol-O-methyl transferase promoter-region methylation in schizophrenia

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Transcription-Coupled DNA Repair

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Exploring the Complexity of Intellectual Disability in Fetal Alcohol Spectrum Disorders

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Reduced DNA methylation at the PEG3 DMR and KvDMR1 loci in children exposed to alcohol in utero: a South African Fetal Alcohol Syndrome cohort study

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Epigenetics of Depression

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Altered chromatin ultrastructure in neutrophils of schizophrenics

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Prenatal Nutritional Deficiency Reprogrammed Postnatal Gene Expression in Mammal Brains: Implications for Schizophrenia

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Epigenetic mechanisms regulating learning and long‐term memory

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Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses towards morphine- and morphine withdrawal-related cues

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Methylation of a CpG Site Near the ALDH 1A2 Gene is Associated with Loss of Control Over Drinking and Related Phenotypes

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