Photo-induced protein oxidation: mechanisms, consequences and medical applications
Abstract
Irradiation from the sun has played a crucial role in the origin and evolution of life on the earth. Due to the presence of ozone in the stratosphere most of the hazardous irradiation is absorbed, nonetheless UVB, UVA, and visible light reach the earth’s surface. The high abundance of proteins in most living organisms, and the presence of chromophores in the side chains of certain amino acids, explain why these macromolecules are principal targets when biological systems are illuminated. Light absorption triggers the formation of excited species that can initiate photo-modification of proteins. The major pathways involve modifications derived from direct irradiation and photo-sensitized reactions. In this review we explored the basic concepts behind these photochemical pathways, with special emphasis on the photosensitized mechanisms (type 1 and type 2) leading to protein oxidation, and how this affects protein structure and functions. Finally, a description of the photochemical reactions involved in some human diseases, and medical applications of protein oxidation are presented.
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The absorption of light by an endogenous/exogenous photosensitizer in the presence of oxygen in a live creature can produce photooxidation, which can lead to chemical and biological consequences.
“The absorption of light by the endogenous/exogenous photosensitizer in the presence of oxygen in a live creature can produce photooxidation, which can lead to chemical and biological consequences”
From Skin protection from solar ultraviolet radiation using natural compounds: a review (2024) · cites this paper as Fuentes-Lemus and López-Alarcón 2020
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Skin protection from solar ultraviolet radiation using natural compounds: a review
Verma, A., Zanoletti, A., Kareem, K. Y., Adelodun, B., Kumar, P., Ajibade, F. O., Silva, L. F. O., Phillips, A. J., Kartheeswaran, T., Bontempi, E., et al. (2024) · Environmental Chemistry Letters · doi:10.1007/s10311-023-01649-4 · Cited by 102 · see citing works
- Authors
- Fuentes-Lemus, E., & López-Alarcón, C.
- Affiliations
- Universidad de Santiago de Chile (CL)
- Departamento de Química Física, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago, Chile
- Venue
- Essays in Biochemistry
- Publisher
- Portland Press Ltd.
- Published
- 2019-12-17
- Volume
- 64
- Issue
- 1
- Pages
- 33-44
- ISSN
- 0071-1365 (ISSN-L)
- 1744-1358
- OpenAlex
- W3002561686
- Cited by
- 29
- References
- 8
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 3 · 2020: 2
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Essays in Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Photochemistry and Electron Transfer Studies
- Keywords
- photosensitized reactions, UV irradiation, protein structure-function relationship
- MeSH terms
- Animals, Humans, Light, Oxidation-Reduction, Photochemotherapy, Proteins
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