Photodynamic Therapy and Non-Melanoma Skin Cancer

Griffin, Liezel; Lear, John

doi:10.3390/cancers8100098

Cited by 81Nonmelanoma Skin Cancer StudiesPhotodynamic Therapy Research StudiesSkin Protection and Aging

Photodynamic Therapy and Non-Melanoma Skin Cancer

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Griffin, Liezel, Lear, John·2016·Cancers

DOI 10.3390/cancers8100098PMC PMC5082388

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Abstract

Non-melanoma skin cancer (NMSC) is the most common malignancy among the Caucasian population. Photodynamic therapy (PDT) is gaining popularity for the treatment of basal cell carcinoma (BCC), Bowen’s disease (BD) and actinic keratosis (AK). A topical or systemic exogenous photosensitiser, results in selective uptake by malignant cells. Protoporphyrin IX (PpIX) is produced then activated by the introduction of a light source. Daylight-mediated MAL (methyl aminolaevulinate) PDT for AKs has the advantage of decreased pain and better patient tolerance. PDT is an effective treatment for superficial BCC, BD and both individual and field treatment of AKs. Excellent cosmesis can be achieved with high patient satisfaction. Variable results have been reported for nodular BCC, with improved outcomes following pretreatment and repeated PDT cycles. The more aggressive basisquamous, morphoeic infiltrating subtypes of BCC and invasive squamous cell carcinoma (SCC) are not suitable for PDT. Prevention of “field cancerization” in organ transplant recipients on long-term immunosuppression and patients with Gorlin syndrome (naevoid basal cell carcinoma syndrome) is a promising development. The optimisation of PDT techniques with improved photosensitiser delivery to target tissues, new generation photosensitisers and novel light sources may expand the future role of PDT in NMSC management.

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The majority of published work on PDT for nonmelanoma skin cancers has studied efficacy in people with FST I-II.
“Where PDT has been used to treat nonmelanoma skin cancers, including BCC, SCC, Bowen’s disease, and AK, the majority of the published work has studied efficacy in people with FST I–II.112,122–125”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [112]
MAL is more lipophilic than ALA, so it is absorbed more deeply into the skin and is commonly used in conjunction with red light, which penetrates more deeply into the skin than blue light.
“Because MAL is more lipophilic than ALA it is absorbed more deeply into the skin and is therefore commonly used in conjunction with red light, which penetrates more deeply into the skin than blue light.112”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [112]
Treatment with MAL-PDT has most commonly been associated with treatment of nonmelanoma skin cancers and, more recently, acne.
“Treatment with MAL-PDT has most commonly been associated with treatment of nonmelanoma skin cancers and, more recently, acne.112,113”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [112]

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Gilaberte, Y., Sanabria, L. N. M., Salazar, N., Vera‐Álvarez, J., Kourani, O., Damián, A., Rivarola, V. A., Roca, M. J., Espada, J., González, S., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.178 · Cited by 52 · see citing works
Consensus recommendations for the treatment of basal cell carcinomas in G orlin syndrome with topical methylaminolaevulinate‐photodynamic therapy
Basset‐Séguin, N., Bissonnette, R., Girard, C., Hædersdal, M., Lear, J. T., Paul, C. F., & Piaserico, S. (2013) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12150 · Cited by 48 · see citing works
Self-citation
Efficacy of Photodynamic Therapy as a Treatment for Gorlin Syndrome-related Basal Cell Carcinomas
Loncaster, J. A., Swindell, R., Slevin, F., Sheridan, L., Allan, D., & Allan, E. (2009) · Clinical Oncology · doi:10.1016/j.clon.2009.03.004 · Cited by 48 · see citing works
Daylight photodynamic therapy with MAL cream for large‐scale photodamaged skin based on the concept of ‘actinic field damage’: recommendations of an international expert group
Philipp‐Dormston, W. G., Sanclemente, G., Torezan, L. A. R., Clementoni, M. T., Pillouer-Prost, A. L., Cartier, H., Szeimies, R., & Bjerring, P. (2015) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13327 · Cited by 45 · see citing works
Photodynamic therapy in the treatment of extensive Bowen's disease
López, N., Meyer-González, T., Acosta, E. H., Bosch, R. J., Castillo, R., & Herrera, E. (2011) · Journal of Dermatological Treatment · doi:10.3109/09546634.2011.590789 · Cited by 44 · see citing works
Facial Basal Cell Carcinomas Recurring after Photodynamic Therapy: A Retrospective Analysis of Histological Subtypes
Fiechter, S., Skaria, A., Nievergelt, H., Anex, R., Borradori, L., & Parmentier, L. (2012) · Dermatology · doi:10.1159/000339335 · Cited by 40 · see citing works
Fractional carbon dioxide laser‐assisted photodynamic therapy for patients with actinic keratosis
Song, H. S., Jung, S., Jang, Y. H., Kang, H. Y., Lee, E., & Kim, Y. C. (2015) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/phpp.12184 · Cited by 40 · see citing works
Photodynamic Therapy as Adjuvant Treatment of Extensive Basal Cell Carcinoma Treated with Mohs Micrographic Surgery
KUIJPERS, D. I. M., Smeets, N. W. J., Krekels, G. A. M., & Thissen, M. R. T. M. (2004) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2004.30221.x · Cited by 33 · see citing works
Results of an Investigator-Initiated Single-Blind Split-Face Comparison of Photodynamic Therapy and 5% Imiquimod Cream for the Treatment of Actinic Keratoses
Hadley, J. C., Tristani‐Firouzi, P., Hull, C. M., Florell, S. R., Cotter, M. A., & Hadley, M. (2012) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2012.02340.x · Cited by 33 · see citing works
Multiple Large-Surface Photodynamic Therapy Sessions with Topical or Systemic Aminolevulinic Acid and Blue Light in UV-Exposed Hairless Mice
Liu, Y., Viau, G., & Bissonnette, R. (2004) · Journal of Cutaneous Medicine and Surgery · doi:10.1007/s10227-004-0117-5 · Cited by 32 · see citing works
A randomized, half‐side comparative study of aminolaevulinate photodynamic therapy vs. CO 2 laser ablation in immunocompetent patients with multiple actinic keratoses
Scola, N., Terras, S., Georgas, D., Othlinghaus, N., Matip, R., Pantelaki, I., Möllenhoff, K., Stücker, M., Altmeyer, P. J., Kreuter, A., et al. (2012) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2012.11103.x · Cited by 31 · see citing works
Tumor thickness and adnexal extension of superficial basal cell carcinoma (sBCC) as determinants of treatment failure for methylaminolevulinate (MAL)-photodynamic therapy (PDT), imiquimod, and 5-fluorouracil (FU)
Roozeboom, M. H., van Kleef, L., Arits, A. H. M. M., Mosterd, K., Winnepenninckx, V. J. L., Marion, A. M. W. V., Nelemans, P. J., & Kelleners-Smeets, N. W. J. (2015) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2015.03.048 · Cited by 30 · see citing works
Use of Photodynamic Therapy for Treatment of Actinic Keratoses in Organ Transplant Recipients
Wlodek, C., Ali, F. R., & Lear, J. T. (2012) · BioMed Research International · doi:10.1155/2013/349526 · Cited by 29 · see citing works
Self-citation
Photodynamic therapy with topical methyl‐ and hexylaminolevulinate for prophylaxis and treatment of UV‐induced SCC in hairless mice
Togsverd‐Bo, K., Lerche, C. M., Poulsen, T., Wulf, H. C., & Hædersdal, M. (2010) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.01035.x · Cited by 28 · see citing works
Photodynamic Therapy in Bowen's Disease: Influence of Histological Features and Clinical Characteristics on Its Success
Westers‐Attema, A., Lohman, B. G. P. M., van den Heijkant, F., Nelemans, P. J., Winnepenninckx, V. J. L., Kelleners-Smeets, N. W. J., & Mosterd, K. (2014) · Dermatology · doi:10.1159/000366500 · Cited by 26 · see citing works
Treatment of Gorlin syndrome (nevoid basal cell carcinoma syndrome) with methylaminolevulinate photodynamic therapy in seven patients, including two children: interest of tumescent anesthesia for pain control in children
Girard, C., Debu, A., Bessis, D., Blatière, V., Dereure, O., & Guillot, B. (2012) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2012.04538.x · Cited by 25 · see citing works
mTHPC mediated, systemic photodynamic therapy (PDT) for nonmelanoma skin cancers: Case and literature review
Horlings, R. K., Terra, J. B., & Witjes, M. J. H. (2015) · Lasers in Surgery and Medicine · doi:10.1002/lsm.22429 · Cited by 23 · see citing works
Retrospective analysis evaluating the effect of a keratolytic and physical pretreatment with salicylic acid, urea and curettage on the efficacy and safety of photodynamic therapy of actinic keratoses with methylaminolaevulinate
Gholam, P., Fink, C., Bosselmann, I., & Enk, A. H. (2015) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13449 · Cited by 21 · see citing works
Photodynamic therapy followed by Mohs micrographic surgery compared to Mohs micrographic surgery alone for the treatment of basal cell carcinoma: Results of a pilot single-blinded randomised controlled trial
Al‐Niaimi, F., Sheth, N., Kurwa, H. A., & Mallipeddi, R. (2015) · Journal of Cutaneous and Aesthetic Surgery · doi:10.4103/0974-2077.158443 · Cited by 20 · see citing works
Pre-Treatment Deep Curettage Can Significantly Reduce Tumour Thickness in Thick Basal Cell Carcinoma While Maintaining a Favourable Cosmetic Outcome When Used in Combination with Topical Photodynamic Therapy
Christensen, E., Mørk, C., & Foss, O. A. (2011) · Journal of Skin Cancer · doi:10.1155/2011/240340 · Cited by 20 · see citing works
Pain during topical photodynamic therapy of actinic keratoses with 5‐aminolevulinic acid and red light source: randomized controlled trial
Buinauskaitė, E., Žalinkevičius, R., Buinauskienė, J., & Valiukevičienė, S. (2013) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/phpp.12044 · Cited by 20 · see citing works
Photodynamic therapy for basal cell carcinomas in organ-transplant recipients
Guleng, G., & Helsing, P. (2012) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.2011.04248.x · Cited by 19 · see citing works
Hexyl-5-aminolaevulinate 0·2% vs. methyl-5-aminolaevulinate 16% daylight photodynamic therapy for treatment of actinic keratoses: results of a randomized double-blinded pilot trial
Neittaanmäki, N., Grönroos, M., Karppinen, T. T., Tani, T. T., & Snellman, E. (2015) · British Journal of Dermatology · doi:10.1111/bjd.13924 · Cited by 19 · see citing works
Photodynamic therapy with intralesional photosensitizer and laser beam application: An alternative treatment for nodular basal cell carcinoma
Rodríguez-Prieto, M. Á., Gonzalez‐Sixto, B., Pérez-Bustillo, A., Alonso‐Alonso, T., Ortega-Valín, L., Martínez-Valderrábano, V., González‐Morán, A., & García-Doval, I. (2012) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2011.10.021 · Cited by 18 · see citing works
Methylaminolaevulinate Photodynamic Therapy in Patients with Multiple Basal Cell Carcinomas in the Setting of Gorlin-Goltz Syndrome or after Radiotherapy
Mougel, F., Debarbieux, S., Ronger-Savle, S., Dalle, S., & Thomas, L. (2009) · Dermatology · doi:10.1159/000228316 · Cited by 17 · see citing works
Efficacy of photodynamic therapy for treatment of basal cell carcinoma in organ transplant recipients
Collier, N. J., Ali, F. R., & Lear, J. T. (2013) · Lasers in Medical Science · doi:10.1007/s10103-013-1454-7 · Cited by 16 · see citing works
Self-citation
Multiple Large-Surface Photodynamic Therapy Sessions with Topical or Systemic Aminolevulinic Acid and Blue Light in UV-Exposed Hairless Mice
Liu, Y., Viau, G., & Bissonnette, R. (2004) · Journal of Cutaneous Medicine and Surgery · doi:10.1177/120347540400800210 · Cited by 16 · see citing works
Daylight-Photodynamic Therapy for the Treatment of Actinic Keratosis in Different Seasons.
Cantisani, C., Paolino, G., Bottoni, U., & Calvieri, S. (2015) · PubMed · Cited by 14 · see citing works
Photodynamic therapy simplified: nonprepared, moderate-grade actinic keratosis lesions respond equally well to 5-aminolaevulinic acid patch photodynamic therapy as do mild lesions
Szeimies, R., Hauschild, A., Ortland, C., Moor, A. C. E., Stocker, M., & Surber, C. (2015) · British Journal of Dermatology · doi:10.1111/bjd.13889 · Cited by 11 · see citing works
Terapia fotodinâmica para tratamento de múltiplas lesões no couro cabeludo na síndrome do nevobasocelular: relato de caso
Neves, D. R., Ramos, D. G., Magalhães, G. M., Rodrigues, R. D. C., & de Souza, J. B. A. (2010) · Anais Brasileiros de Dermatologia · doi:10.1590/s0365-05962010000400019 · Cited by 10 · see citing works
Systemic photodynamic therapy with Photofrin for naevoid basal cell carcinoma syndrome—A pilot study
Madan, V., Loncaster, J. A., Allan, D., Lear, J. T., Sheridan, L., Leach, C., & Allan, E. (2005) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/s1572-1000(05)00101-8 · Cited by 9 · see citing works
Self-citation
Successful treatment of sequential therapy in digital Bowen's disease with methyl aminolevulinate photodynamic therapy and topical diclofenac 3% in hyaluronan 2.5% gel
Gracia‐Cazaña, T., López, M. T. G., Oncíns, R., & Gilaberte, Y. (2015) · Dermatologic Therapy · doi:10.1111/dth.12270 · Cited by 6 · see citing works
Photodynamic therapy using topical methyl aminolaevulinate versus cryotherapy for treatment of primary superficial basal cell carcinoma : results of a five-year prospective randomized trial
Basset‐Séguin, N., Ibbotson, L., Emtestam, L., Tarstedt, M., Morton, C. A., Maroti, M., Calzavara‐Pinton, P., Varma, S., Roelandts, R., & Wolf, P. (2006) · British Journal of Dermatology · Cited by 6 · see citing works
Photodynamic therapy: increasing acceptance through reduction of adverse reactions
Braathen, L. R. (2014) · British Journal of Dermatology · doi:10.1111/bjd.13395 · Cited by 5 · see citing works
The Future of Photodynamic Therapy
Alexiades‐Armenakas, M. (2011) · Springer eBooks · doi:10.1007/978-1-4419-1298-5_17 · Cited by 4 · see citing works
Comparison of topical methylaminolevulinate photodynamic therapy versus placebo photodynamic therapy in nodular basal cell carcinoma
Tope, W. D., Menter, A., el‐Azhary, R. A., & Lowe, N. J. (2004) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2003.10.419 · Cited by 4 · see citing works
Daylight photodynamic therapy for the treatment of actinic keratosis
(2015) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2015.02.866 · Cited by 1 · see citing works
Clinicopathological features of Bowen’s disease resistance to methyl aminolevulinate photodynamic therapy
(2017) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2017.04.306 · Cited by 1 · see citing works

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Photodynamic Therapy: A Compendium of Latest Reviews
Algorri, J. F., Ochoa, M., Roldán-Varona, P., Cobo, L. R., & Higuera, J. M. L. (2021) · Cancers · doi:10.3390/cancers13174447 · Cited by 264 · see citing works
Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures
Khan, N. H., Mir, M., Qian, L., Baloch, M., Khan, M. F. A., Rehman, A. U., Ngowi, E. E., Wu, D., & Ji, X. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.06.014 · Cited by 239 · see citing works
Updates on the Management of Non-Melanoma Skin Cancer (NMSC)
Fahradyan, A., Howell, A. C., Wolfswinkel, E. M., Tsuha, M., Sheth, P., & Wong, A. K. (2017) · Healthcare · doi:10.3390/healthcare5040082 · Cited by 194 · see citing works
Photodynamic therapy and pain: A systematic review
Ang, J. M., Riaz, I. B., Kamal, M. U., Paragh, G., & Zeitouni, N. C. (2017) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2017.07.002 · Cited by 150 · see citing works
Advances in the Understanding of Skin Cancer: Ultraviolet Radiation, Mutations, and Antisense Oligonucleotides as Anticancer Drugs
Laikova, K. V., Oberemok, V. V., Krasnodubets, A. M., Gal’chinsky, N. V., Useinov, R. Z., Novikov, I. A., Temirova, Z. Z., Владимирович, Г. М., Shved, N. A., Kumeiko, V. V., et al. (2019) · Molecules · doi:10.3390/molecules24081516 · Cited by 111 · see citing works
Implications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically
Sobhani, N., & Samadani, A. A. (2021) · Journal of the Egyptian National Cancer Institute · doi:10.1186/s43046-021-00093-1 · Cited by 87 · see citing works
Effect of skin color on optical properties and the implications for medical optical technologies: a review
Setchfield, K., Gorman, A., Simpson, A. H. R. W., Somekh, M. G., & Wright, A. J. (2024) · Journal of Biomedical Optics · doi:10.1117/1.jbo.29.1.010901 · Cited by 72 · see citing works
Photodynamic therapy: A hot topic in dermato-oncology (Review)
Tampa, M., Sarbu, M.-I., Matei, C., Mitran, C.-I., Mitran, M.-I., Caruntu, C., Constantin, C., Neagu, M., & Georgescu, S.-R. (2019) · Oncology Letters · doi:10.3892/ol.2019.9939 · Cited by 72 · see citing works
Management of Non-melanoma Skin Cancer in Transplant Recipients
Collins, L. B., Asfour, L., Stephany, M., Lear, J. T., & Stasko, T. (2019) · Clinical Oncology · doi:10.1016/j.clon.2019.08.005 · Cited by 67 · see citing works
Self-citation
The Photosensitizer Temoporfin ( m THPC ) – Chemical, Pre‐clinical and Clinical Developments in the Last Decade † ‡
Wiehe, A., & Senge, M. O. (2022) · Photochemistry and Photobiology · doi:10.1111/php.13730 · Cited by 68 · see citing works
Latest Innovations and Nanotechnologies with Curcumin as a Nature-Inspired Photosensitizer Applied in the Photodynamic Therapy of Cancer
Ailioaie, L. M., Ailioaie, C., & Litscher, G. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101562 · Cited by 65 · see citing works
A method to assess the protective efficacy of sunscreens against visible light‐induced pigmentation
Duteil, L., Esdaile, J., Maubert, Y., Cathelineau, A., Bouloc, A., Queille-Roussel, C., & Passeron, T. (2017) · Photodermatology, Photoimmunology & Photomedicine · doi:10.1111/phpp.12325 · Cited by 59 · see citing works
Advances in Photodynamic Therapy for the Treatment of Actinic Keratosis and Nonmelanoma Skin Cancer: A Narrative Review
Farberg, A. S., Marson, J. W., & Soleymani, T. (2023) · Dermatology and Therapy · doi:10.1007/s13555-023-00888-1 · Cited by 51 · see citing works
Upconversion rare Earths nanomaterials applied to photodynamic therapy and bioimaging
Rezende, T. K. D. L., Barbosa, H. P., dos Santos, L. F., Lima, K. D. O., de Matos, P. A., Tsubone, T. M., Gonçalves, R. R., & Ferrari, J. L. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.1035449 · Cited by 47 · see citing works
Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study
Gubarkova, E. V., Feldchtein, F. I., Вадимовна, З. Е., Gamayunov, S. V., Sirotkina, M. A., Sedova, E. S., Kuznetsov, S. S., Moiseev, A. A., Matveev, L. A., Zaitsev, V. Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-55215-6 · Cited by 34 · see citing works
Immune consequences induced by photodynamic therapy in non-melanoma skin cancers: a review
Yu, X., Zheng, H., Chan, M. T. V., & Wu, W. K. K. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-2426-z · Cited by 33 · see citing works
Síndrome de Gorlin
Palacios‐Álvarez, I., González‐Sarmiento, R., & Fernández‐López, E. (2018) · Actas Dermo-Sifiliográficas · doi:10.1016/j.ad.2017.07.018 · Cited by 32 · see citing works
Photo-induced protein oxidation: mechanisms, consequences and medical applications
Fuentes-Lemus, E., & López-Alarcón, C. (2020) · Essays in Biochemistry · doi:10.1042/ebc20190044 · Cited by 29 · see citing works
Interventions to Prevent Nonmelanoma Skin Cancers in Recipients of a Solid Organ Transplant: Systematic Review of Randomized Controlled Trials
Chung, E. Y. M., Palmer, S. C., & Strippoli, G. F. (2019) · Transplantation · doi:10.1097/tp.0000000000002641 · Cited by 27 · see citing works
Anticancer agents based on metal organic cages
Sun, D., Feng, X., Zhu, X., Wang, Y., & Yang, J. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215546 · Cited by 25 · see citing works
Comparison of Blue and White Lamp Light with Sunlight for Daylight‐Mediated, 5‐ ALA Photodynamic Therapy, in vivo
Marra, K. A., LaRochelle, E. P. M., Chapman, M. S., Hoopes, P. J., Lukovits, K., Maytin, E. V., Hasan, T. G., & Pogue, B. W. (2018) · Photochemistry and Photobiology · doi:10.1111/php.12923 · Cited by 24 · see citing works
Dissolving microneedles containing aminolevulinic acid improves protoporphyrin IX distribution
Requena, M. B., Permana, A. D., Vollet‐Filho, J. D., González‐Vázquez, P., Garcia, M. R., de Faria, C. M. G., Pratavieira, S., Donnelly, R. F., & Bagnato, V. S. (2020) · Journal of Biophotonics · doi:10.1002/jbio.202000128 · Cited by 24 · see citing works
Efficacy and safety of ALA-PDT in treatment of diabetic foot ulcer with infection
Li, X., Kou, H., Zhao, C., Zhu, F., Yang, Y., & Lu, Y. (2022) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2022.102822 · Cited by 21 · see citing works
Mitotic Catastrophe Induced in HeLa Tumor Cells by Photodynamic Therapy with Methyl-aminolevulinate
Mascaraque, M., Delgado‐Wicke, P., Damián, A., Lucena, S., Carrasco, E., & Juarranz, Á. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051229 · Cited by 20 · see citing works
Long‐term efficacy of photodynamic therapy with methyl aminolevulinate in treating Bowen's disease in clinical practice: A retrospective cohort study (2006‐2017)
Aguilar-Bernier, M., Rodríguez‐Barón, D., Rivas‐Ruiz, F., Segura-Palacios, J. M., & de Troya-Martín, M. (2019) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/phpp.12453 · Cited by 19 · see citing works
Natural product-loaded lipid-based nanocarriers for skin cancer treatment: An overview
Chaurasiya, M., Kumar, G., Paul, S., Verma, S. S., & Rawal, R. K. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123043 · Cited by 17 · see citing works
Preclinical Evaluation of White Led-Activated Non-porphyrinic Photosensitizer OR141 in 3D Tumor Spheroids and Mouse Skin Lesions
Doix, B., Bastien, E., Rambaud, A., Pinto, A., Louis, C., Grégoire, V., Riant, O., & Féron, O. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00393 · Cited by 17 · see citing works
Efficacy of photodynamic therapy for the treatment of Bowen’s disease: An updated systematic review and meta-analysis of randomized controlled trials
Zhong, S., Zhang, R., Mei, X., & Wang, L. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.102037 · Cited by 17 · see citing works
Photodynamic therapy: An option in mycosis fungoides
Pileri, A., Sgubbi, P., Agostinelli, C., Infusino, S. D., Vaccari, S., & Patrizi, A. (2017) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2017.09.004 · Cited by 16 · see citing works
Application of fractal dimension analysis and photodynamic diagnosis in the case of differentiation between lichen planus and leukoplakia: A preliminary study
Jurczyszyn, K., Kazubowska, K., Kubasiewicz−Ross, P., Ziolkowski, P. P., & Dominiak, M. (2018) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/80831 · Cited by 13 · see citing works
Polymeric nanoparticles favor the in vitro dermal accumulation of Protoporphyrin IX (PpIX) with optimal biocompatibility and cellular recovery in culture of healthy dermal fibroblasts after Photodynamic Therapy
Miguel, J. D. O., da Silva, D. B., da Silva, G. C. C., Corrêa, R. J., Miguel, N. C. D. O., Lione, V. D. O. F., & Pierre, M. B. R. (2019) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2019.112109 · Cited by 13 · see citing works
Photodynamic Therapy Using a New Painless Light-Emitting Fabrics Device in the Treatment of Extramammary Paget Disease of the Vulva (the PAGETEX Study): Protocol for an Interventional Efficacy and Safety Trial
Lecomte, F., Thécua, E., Ziane, L., Deleporte, P., Duhamel, A., Maire, C., Staumont-Sallé, D., Mordon, S. R., & Mortier, L. (2019) · JMIR Research Protocols · doi:10.2196/15026 · Cited by 9 · see citing works
Nanoparticles and skin cancer
Gour, V., Agrawal, P., Pandey, V., Kanwar, I. L., Haider, T., Tiwari, R., & Soni, V. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819793-6.00011-4 · Cited by 8 · see citing works
Deciphering the role of vitamin D on skin cancers and tumour microenvironment
Nautiyal, R., & Bhatnagar, P. (2023) · Indian Journal of Dermatology Venereology and Leprology · doi:10.25259/ijdvl_1236_2021 · Cited by 7 · see citing works
Comparative Analysis of Tetra(2-naphthyl)tetracyano-porphyrazine and Its Iron Complex as Photosensitizers for Anticancer Photodynamic Therapy
Shestakova, L. N., Lyubova, T. S., Lermontova, S. A., Belotelov, A. O., Peskova, N. N., Klapshina, L. G., Владимировна, Б. И., & Shilyagina, N. Y. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122655 · Cited by 7 · see citing works
Quercetin Nano-formulations as a Potential Approach for Skin Cancer
Kapare, H. S., Kanadje, S., & Bhole, R. P. (2024) · Pharmaceutical Nanotechnology · doi:10.2174/0122117385332427241112034005 · Cited by 6 · see citing works
Efficacy and safety of 5-aminolevulinic acid photodynamic therapy for the treatment of ulcerative squamous cell carcinoma
Dong, L., Li, X., Shen, X., Zhang, W., Zhang, J., Wang, Y., & Lu, Y. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.101710 · Cited by 6 · see citing works
Anticancer pentamethinium salt is a potent photosensitizer inducing mitochondrial disintegration and apoptosis upon red light illumination
Krejčíř, R., Briza, T., Sterba, M., Šimončík, O., Müller, P., Coates, P. J., Pavel Martasek, E., Vojtěšek, B., & Zatloukalová, P. (2020) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2020.111939 · Cited by 6 · see citing works
Nonmelanoma skin cancer in the setting of erosive pustular dermatosis of the scalp: A case series and comment on management implications
Negbenebor, N., Shayegan, L. H., Cohen, L. M., & Kroumpouzos, G. (2022) · Dermatologic Therapy · doi:10.1111/dth.15584 · Cited by 6 · see citing works
Photodynamic Reactions for the Treatment of Oral-Facial Lesions and Microbiological Control
Geralde, M. C., Requena, M. B., de Faria, C. M. G., Kurachi, C., Pratavieira, S., & Bagnato, V. S. (2020) · Springer eBooks · doi:10.1007/978-3-030-29604-9_5 · Cited by 6 · see citing works
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Authors: Griffin, L., & Lear, J.
Affiliations: Manchester Academic Health Science Centre (GB)
Corresponding author: Lear, John
ORCID: Griffin, Liezel
Lear, John
Venue: Cancers
Publisher: MDPI AG
Published: 2016-10-22
Volume: 8
Issue: 10
Pages: 98
ISSN: 2072-6694 (ISSN-L)
DOI: 10.3390/cancers8100098
PMC: PMC5082388
OpenAlex: W2532872607
Cited by: 81
References: 99
Citations by year: 2026: 6 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 10 · 2020: 11 · 2019: 13 · 2018: 10 · 2017: 6
FWCI: 1.31
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Cancers (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: National Institute for Health and Care Research (ACF-2013-06-004)
Topics: Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords: photodynamic therapy, non-melanoma skin cancer, basal cell carcinoma, Bowen's disease, actinic keratosis, methyl aminolaevulinate, protoporphyrin IX, photosensitizers, field cancerization, immunosuppression, Gorlin syndrome, nodular basal cell carcinoma, squamous cell carcinoma, cosmetic outcome

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