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Cited by 130Cardiovascular and exercise physiologyIon Transport and Channel RegulationExercise and Physiological Responses

Muscle pH regulation: role of training

JUEL, C.·1998·Acta Physiologica Scandinavica
DOI 10.1046/j.1365-201x.1998.0305f.x
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Abstract

In most cell types, including resting skeletal muscle fibers, internal pH (pH i) is kept constant at a relatively alkaline level. The high pH i is obtained in spite of a chronic acid load resulting from cellular metabolism and passive influx of protons driven by electrochemical forces. Regulation of pH i depends on continuous activity of membrane transport systems that mediate an outflux of H+ (or bicarbonate influx), whereby the acid load is counterbalanced. The transporters involved in muscle pH regulation at rest are the Na+/H+ exchange system as well as the Na+‐dependent and Na+‐independent Cl–bicarbonate transport systems. The Na+/H+ exchanger seems to be active at resting pH i levels in skeletal muscle. Therefore, pH homeostasis in skeletal muscle most likely involves an equilibrium between counter‐directed H+ fluxes. A minor fraction of H+ release during intense exercise is mediated by the Na+/H+ exchanger. The capacity of this system is increased with training and hypoxia in rat skeletal muscle. The dominant acid extruding system associated with intense exercise is the lactate/H+ co‐transporter. It has been demonstrated that the capacity of the lactate/H+ co‐transporter of rat skeletal muscle is upregulated with training and chronic electrical stimulation, and that it is reduced upon denervation and hindlimb unweighting. Moreover, athletes can have an elevated lactate/H+ co‐transport capacity, whereas the thigh muscle of spinal cord‐injured individuals has a lower transport capacity than the one of healthy untrained subjects. Thus, it appears that the capacity of the lactate/H+ transporter is affected by the level of muscle activity in both rats and humans. In addition, the rate of H+ release from muscle may also be influenced by capillarization and local blood flow. Finally the resulting pH displacement during acid accumulation is determined by the cellular buffer capacity, which may also undergo adaptive changes.

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  • Increased H+ and lactate accumulation serves as an effective stimulus to upregulate the number of these transporters.

    “Interestingly, increased H+and lactate accumulation serves as an effective stimulus to upregulate the number of these transporters19,32.”

    From Evaluating bioenergetic pathway contributions from single to multiple sprints (2024) · cites this paper as [32]

  • The removal of intracellular H+ and lactate during repeated sprints is facilitated by intracellular buffering systems and membrane transporters, particularly monocarboxylate transporters.

    “The removal of intracellular H+and lactate during repeated sprints is facilitated by intracellular buffering systems and membrane transporters, particularly monocarboxylate transporters32.”

    From Evaluating bioenergetic pathway contributions from single to multiple sprints (2024) · cites this paper as [32]

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Authors
JUEL, C.
Affiliations
University of Copenhagen (DK)
Corresponding author
JUEL, C.
ORCID
JUEL, C.
Venue
Acta Physiologica Scandinavica
Publisher
Wiley
Published
1998-02
Volume
162
Issue
3
Pages
359-366
ISSN
  • 0001-6772 (ISSN-L)
  • 1365-201X
DOI
10.1046/j.1365-201x.1998.0305f.x
OpenAlex
W2141313006
Cited by
130
References
45
Citations by year
2026: 2 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 6 · 2017: 7 · 2016: 8 · 2015: 5 · 2014: 4 · 2013: 5 · 2012: 3
FWCI
0.57
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1433 d)
Locations
  • Acta Physiologica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
skeletal muscle, training effects, Na+/H+ exchanger, bicarbonate transport, proton extrusion, exercise acidosis, hypoxia, denervation, hindlimb unloading, spinal cord injury, capillarization, chronic electrical stimulation
MeSH terms
Animals, Biological Transport, Hydrogen-Ion Concentration, Physical Conditioning, Animal, Protons, Sodium-Hydrogen Exchangers, Muscle, Skeletal

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